Regulation of energy rheostasis by the melanocortin-3 receptor.

abstract：:Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...

journal_title：Science advances

authors： Tsatskis Y,Rosenfeld R,Pearson JD,Boswell C,Qu Y,Kim K,Fabian L,Mohammad A,Wang X,Robson MI,Krchma K,Wu J,Gonçalves J,Hodzic D,Wu S,Potter D,Pelletier L,Dunham WH,Gingras AC,Sun Y,Meng J,Godt D,Schedl T,Ciru

更新日期：2020-08-28 00:00:00

abstract：:Dust condensation and coagulation in the early solar system are the first steps toward forming the terrestrial planets, but the time scales of these processes remain poorly constrained. Through isotopic analysis of small Ca-Al-rich inclusions (CAIs) (30 to 100 μm in size) found in one of the most pristine chondrites, ...

journal_title：Science advances

authors： Liu MC,Han J,Brearley AJ,Hertwig AT

更新日期：2019-09-11 00:00:00

abstract：:Correlating spatial chemical information with the morphology of closely packed nanostructures remains a challenge for the scientific community. For example, supramolecular self-assembly, which provides a powerful and low-cost way to create nanoscale patterns and engineered nanostructures, is not easily interrogated in...

journal_title：Science advances

authors： Nowak D,Morrison W,Wickramasinghe HK,Jahng J,Potma E,Wan L,Ruiz R,Albrecht TR,Schmidt K,Frommer J,Sanders DP,Park S

更新日期：2016-03-25 00:00:00

abstract：:Nitrogen oxides (NO x ) emitted from human activities are believed to regulate the atmospheric oxidation capacity of the troposphere. However, observational evidence is limited for the low-to-median NO x concentrations prevalen...

journal_title：Science advances

authors： Liu Y,Seco R,Kim S,Guenther AB,Goldstein AH,Keutsch FN,Springston SR,Watson TB,Artaxo P,Souza RAF,McKinney KA,Martin ST

更新日期：2018-04-11 00:00:00

abstract：:Revealing physical interactions in complex systems from observed collective dynamics constitutes a fundamental inverse problem in science. Current reconstruction methods require access to a system's model or dynamical data at a level of detail often not available. We exploit changes in invariant measures, in particula...

journal_title：Science advances

authors： Nitzan M,Casadiego J,Timme M

更新日期：2017-02-10 00:00:00

abstract：:In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibodies to more closely...

journal_title：Science advances

authors： Smirnov IV,Golovin AV,Chatziefthimiou SD,Stepanova AV,Peng Y,Zolotareva OI,Belogurov AA Jr,Kurkova IN,Ponomarenko NA,Wilmanns M,Blackburn GM,Gabibov AG,Lerner RA

更新日期：2016-10-19 00:00:00

abstract：:Driven by advances in materials and computer science, researchers are attempting to design systems where the computer and material are one and the same entity. Using theoretical and computational modeling, we design a hybrid material system that can autonomously transduce chemical, mechanical, and electrical energy to...

journal_title：Science advances

authors： Fang Y,Yashin VV,Levitan SP,Balazs AC

更新日期：2016-09-02 00:00:00

abstract：:Inputs of nitrogen into terrestrial ecosystems, mainly via the use of ammonium-based fertilizers in agroecosystems, are enormous, but the fate of this nitrogen under elevated atmospheric carbon dioxide (CO2) is not well understood. We have taken advantage of a 15-year free-air CO2 enrichment study to investigate the i...

journal_title：Science advances

authors： Xu C,Zhang K,Zhu W,Xiao J,Zhu C,Zhang N,Yu F,Li S,Zhu C,Tu Q,Chen X,Zhu J,Hu S,Koide RT,Firestone MK,Cheng L

更新日期：2020-10-16 00:00:00

abstract：:B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...

journal_title：Science advances

authors： Zhao X,Xie H,Zhao M,Ahsan A,Li X,Wang F,Yi J,Yang Z,Wu C,Raman I,Li QZ,Kim TJ,Liu W

更新日期：2019-07-17 00:00:00

abstract：:Resistances that exceed the Mott-Ioffe-Regel limit (known as bad metal behavior) and non-Fermi liquid behavior are ubiquitous features of the normal state of many strongly correlated materials. We establish the conditions that lead to bad metal and non-Fermi liquid phases in NdNiO3, which exhibits a prototype bandwidt...

journal_title：Science advances

authors： Mikheev E,Hauser AJ,Himmetoglu B,Moreno NE,Janotti A,Van de Walle CG,Stemmer S

更新日期：2015-11-06 00:00:00

abstract：:N6-methyladenine (6mdA) is a widespread DNA modification in bacteria. More recently, 6mdA has also been characterized in mammalian DNA. However, measurements of 6mdA abundance and profiles are often very dissimilar between studies, even when performed on DNA from identical mammalian cell types. Using comprehensive bio...

journal_title：Science advances

authors： Douvlataniotis K,Bensberg M,Lentini A,Gylemo B,Nestor CE

更新日期：2020-03-18 00:00:00

abstract：:Quantum walks, in virtue of the coherent superposition and quantum interference, have exponential superiority over their classical counterpart in applications of quantum searching and quantum simulation. The quantum-enhanced power is highly related to the state space of quantum walks, which can be expanded by enlargin...

journal_title：Science advances

authors： Tang H,Lin XF,Feng Z,Chen JY,Gao J,Sun K,Wang CY,Lai PC,Xu XY,Wang Y,Qiao LF,Yang AL,Jin XM

更新日期：2018-05-11 00:00:00

abstract：:Two-dimensional (2D) semiconductors have shown great potential for electronic and optoelectronic applications. However, their development is limited by a large Schottky barrier (SB) at the metal-semiconductor junction (MSJ), which is difficult to tune by using conventional metals because of the effect of strong Fermi ...

journal_title：Science advances

authors： Liu Y,Stradins P,Wei SH

更新日期：2016-04-22 00:00:00

abstract：:Micrometer-scale acoustic waves are highly useful for refined optomechanical and acoustofluidic manipulation, where these fields are spatially localized along the transducer aperture but not along the acoustic propagation direction. In the case of acoustic tweezers, such a conventional acoustic standing wave results i...

journal_title：Science advances

authors： Collins DJ,Devendran C,Ma Z,Ng JW,Neild A,Ai Y

更新日期：2016-07-13 00:00:00

abstract：:NSF (N-ethylmaleimide-sensitive factor) and α-SNAP (α-soluble NSF attachment protein) bind to the SNARE (soluble NSF attachment protein receptor) complex, the minimum machinery to mediate membrane fusion, to form a 20S complex, which disassembles the SNARE complex for reuse. We report the cryo-EM structures of the α-S...

journal_title：Science advances

authors： Huang X,Sun S,Wang X,Fan F,Zhou Q,Lu S,Cao Y,Wang QW,Dong MQ,Yao J,Sui SF

更新日期：2019-04-10 00:00:00

abstract：:In 2015, more than 200,000 saiga antelopes died in 3 weeks in central Kazakhstan. The proximate cause of death is confirmed as hemorrhagic septicemia caused by the bacterium Pasteurella multocida type B, based on multiple strands of evidence. Statistical modeling suggests that there was unusually high relative humidit...

journal_title：Science advances

authors： Kock RA,Orynbayev M,Robinson S,Zuther S,Singh NJ,Beauvais W,Morgan ER,Kerimbayev A,Khomenko S,Martineau HM,Rystaeva R,Omarova Z,Wolfs S,Hawotte F,Radoux J,Milner-Gulland EJ

更新日期：2018-01-17 00:00:00

abstract：:Cellular cross-talk between ubiquitination and other posttranslational modifications contributes to the regulation of numerous processes. One example is ADP-ribosylation of the carboxyl terminus of ubiquitin by the E3 DTX3L/ADP-ribosyltransferase PARP9 heterodimer, but the mechanism remains elusive. Here, we show that...

journal_title：Science advances

authors： Chatrin C,Gabrielsen M,Buetow L,Nakasone MA,Ahmed SF,Sumpton D,Sibbet GJ,Smith BO,Huang DT

更新日期：2020-09-18 00:00:00

abstract：:Organic carbonyl compounds represent a promising class of electrode materials for secondary batteries; however, the storage mechanism still remains unclear. We take Na2C6H2O4 as an example to unravel the mechanism. It consists of alternating Na-O octahedral inorganic layer and π-stacked benzene organic layer in spatia...

journal_title：Science advances

authors： Wu X,Jin S,Zhang Z,Jiang L,Mu L,Hu YS,Li H,Chen X,Armand M,Chen L,Huang X

更新日期：2015-09-18 00:00:00

abstract：:The Mott transition-a metal-insulator transition caused by repulsive Coulomb interactions between electrons-is a central issue in condensed matter physics because it is the mother earth of various attractive phenomena. Outstanding examples are high-Tc (critical temperature) cuprates and manganites exhibiting colossal ...

journal_title：Science advances

authors： Itou T,Watanabe E,Maegawa S,Tajima A,Tajima N,Kubo K,Kato R,Kanoda K

更新日期：2017-08-11 00:00:00

abstract：:Cheater viruses, also known as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type upon coinfection. While there is growing interest in using cheaters as antiviral therapeutics, the mechanisms underlying cheating have been rarely explored. During experimental evolution ...

journal_title：Science advances

authors： Meir M,Harel N,Miller D,Gelbart M,Eldar A,Gophna U,Stern A

更新日期：2020-08-21 00:00:00

abstract：:Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...

journal_title：Science advances

authors： Qi H,Sahabudeen H,Liang B,Položij M,Addicoat MA,Gorelik TE,Hambsch M,Mundszinger M,Park S,Lotsch BV,Mannsfeld SCB,Zheng Z,Dong R,Heine T,Feng X,Kaiser U

更新日期：2020-08-14 00:00:00

abstract：:Adjacent neurons in visual cortex have overlapping receptive fields within and across area boundaries, an arrangement theorized to minimize wiring cost. This constraint is traditionally thought to create retinotopic maps of opposing field signs (mirror and nonmirror visual field representations) in adjacent areas, a c...

journal_title：Science advances

authors： Yu HH,Rowley DP,Price NSC,Rosa MGP,Zavitz E

更新日期：2020-10-28 00:00:00

abstract：:Homologous recombination is exquisitely activated only during specific cell phases. In the G1 phase, homologous recombination activity is completely suppressed. According to previous reports, the activation of homologous recombination during specific cell phases depends on the kinase activity of cyclin-dependent kinas...

journal_title：Science advances

authors： Lim G,Chang Y,Huh WK

更新日期：2020-02-07 00:00:00

abstract：:Charge order is universal among high-Tc cuprates, but its relation to superconductivity is unclear. While static order competes with superconductivity, dynamic order may be favorable and even contribute to Cooper pairing. Using time-resolved resonant soft x-ray scattering at a free-electron laser, we show that the cha...

journal_title：Science advances

authors： Mitrano M,Lee S,Husain AA,Delacretaz L,Zhu M,de la Peña Munoz G,Sun SX,Joe YI,Reid AH,Wandel SF,Coslovich G,Schlotter W,van Driel T,Schneeloch J,Gu GD,Hartnoll S,Goldenfeld N,Abbamonte P

更新日期：2019-08-16 00:00:00

abstract：:Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA) against various cancer cells was reported. This study was aimed at assessing the translational value of n-HA both as a bone-regenerating material ...

journal_title：Science advances

authors： Zhang K,Zhou Y,Xiao C,Zhao W,Wu H,Tang J,Li Z,Yu S,Li X,Min L,Yu Z,Wang G,Wang L,Zhang K,Yang X,Zhu X,Tu C,Zhang X

更新日期：2019-08-02 00:00:00

abstract：:Noble metal foams (NMFs) are a new class of functional materials featuring properties of both noble metals and monolithic porous materials, providing impressive prospects in diverse fields. Among reported synthetic methods, the sol-gel approach manifests overwhelming advantages for versatile synthesis of nanostructure...

journal_title：Science advances

authors： Du R,Hu Y,Hübner R,Joswig JO,Fan X,Schneider K,Eychmüller A

更新日期：2019-05-24 00:00:00

abstract：:Predicted changes in the intensity and frequency of climate extremes urge a better mechanistic understanding of the stress response of microbially mediated carbon (C) and nutrient cycling processes. We analyzed the resistance and resilience of microbial C, nitrogen (N), and phosphorus (P) cycling processes and microbi...

journal_title：Science advances

authors： Mooshammer M,Hofhansl F,Frank AH,Wanek W,Hämmerle I,Leitner S,Schnecker J,Wild B,Watzka M,Keiblinger KM,Zechmeister-Boltenstern S,Richter A

更新日期：2017-05-03 00:00:00

abstract：:Oocyte numbers, a critical determinant of female reproductive fitness, are highly regulated, yet the mechanisms underlying this regulation remain largely undefined. In the Caenorhabditis elegans gonad, RAS/extracellular signal-regulated kinase (ERK) signaling regulates oocyte numbers; mechanisms are unknown. We show t...

journal_title：Science advances

authors： Das D,Chen SY,Arur S

更新日期：2020-10-30 00:00:00

abstract：:Perovskite oxides with poor conductivity call for three-dimensional (3D) conductive scaffolds to demonstrate their superb reactivities for oxygen evolution reaction (OER). However, perovskite formation usually requires high-temperature annealing at 600° to 900°C in air, under which most of the used conductive framewor...

journal_title：Science advances

authors： Li BQ,Tang C,Wang HF,Zhu XL,Zhang Q

更新日期：2016-10-21 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) infection results in a spectrum of clinical and histopathologic manifestations. It has been proposed that the environmental and immune pressures associated with different contexts of infection have different consequences for the associated bacterial populations, affecting drug suscepti...

journal_title：Science advances

authors： Liu Q,Wei J,Li Y,Wang M,Su J,Lu Y,López MG,Qian X,Zhu Z,Wang H,Gan M,Jiang Q,Fu YX,Takiff HE,Comas I,Li F,Lu X,Fortune SM,Gao Q

更新日期：2020-05-29 00:00:00