Saigas on the brink: Multidisciplinary analysis of the factors influencing mass mortality events.

abstract：:The social bond between parents and offspring is characterized by coadaptation and balance between altruistic and selfish tendencies. However, its underlying genetic mechanism remains poorly understood. Using transcriptomic screens in the subsocial European earwig, Forficula auricularia, we found the expression of mor...

journal_title：Science advances

authors： Wu M,Walser JC,Sun L,Kölliker M

更新日期：2020-01-03 00:00:00

abstract：:When a dynamic system undergoes a cyclic evolution, a geometric phase that depends only on the path traversed in parameter space can arise in addition to the normal dynamical phase. These geometric phases have profound impacts in both quantum and classical physics. In addition to the geometric phase associated with ba...

journal_title：Science advances

authors： Wang S,Ma G,Chan CT

更新日期：2018-02-16 00:00:00

abstract：:Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was mediated through TOR s...

journal_title：Science advances

authors： Yu R,Sun L,Sun Y,Han X,Qin L,Dang W

更新日期：2019-07-10 00:00:00

abstract：:The structure of many real-world systems is best captured by networks consisting of several interaction layers. Understanding how a multilayered structure of connections affects the synchronization properties of dynamical systems evolving on top of it is a highly relevant endeavor in mathematics and physics and has po...

journal_title：Science advances

authors： Del Genio CI,Gómez-Gardeñes J,Bonamassa I,Boccaletti S

更新日期：2016-11-16 00:00:00

abstract：:Multicellular organisms are composed of tissues that have distinct functions requiring specialized proteomes. To define the proteome of a live animal with tissue and subcellular resolution, we adapted a localized proteomics technology for use in the multicellular model organism Caenorhabditis elegans. This approach co...

journal_title：Science advances

authors： Reinke AW,Mak R,Troemel ER,Bennett EJ

更新日期：2017-05-10 00:00:00

abstract：:By experimentally studying high-order harmonic beams generated in gases, we show how the spatial characteristics of these ultrashort extreme-ultraviolet (XUV) beams can be finely controlled when a single fundamental beam generates harmonics in a thin gas medium. We demonstrate that these XUV beams can be emitted as co...

journal_title：Science advances

authors： Quintard L,Strelkov V,Vabek J,Hort O,Dubrouil A,Descamps D,Burgy F,Péjot C,Mével E,Catoire F,Constant E

更新日期：2019-04-05 00:00:00

abstract：:The lipid bilayer membrane, which is the foundation of life on Earth, is not viable outside of biology based on liquid water. This fact has caused astronomers who seek conditions suitable for life to search for exoplanets within the "habitable zone," the narrow band in which liquid water can exist. However, can cell m...

journal_title：Science advances

authors： Stevenson J,Lunine J,Clancy P

更新日期：2015-02-27 00:00:00

abstract：:Skin-mountable microelectronics are garnering substantial interest for various promising applications including human-machine interfaces, biointegrated devices, and personalized medicine. However, it remains a critical challenge to develop e-skins to mimic the human somatosensory system in full working range. Here, we...

journal_title：Science advances

authors： Cai Y,Shen J,Yang CW,Wan Y,Tang HL,Aljarb AA,Chen C,Fu JH,Wei X,Huang KW,Han Y,Jonas SJ,Dong X,Tung V

更新日期：2020-11-27 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent. However, molecular targets relevant to its therapeutic actions remain enigmatic. Sulfide-quinone oxidoreductase (SQR) irreversibly oxidizes H2S. Therefore, SQR is assumed to inhibit H2S signaling. We now report that SQR-mediated oxidation o...

journal_title：Science advances

authors： Jia J,Wang Z,Zhang M,Huang C,Song Y,Xu F,Zhang J,Li J,He M,Li Y,Ao G,Hong C,Cao Y,Chin YE,Hua ZC,Cheng J

更新日期：2020-08-26 00:00:00

abstract：:Tropical forest fragmentation results in habitat and biodiversity loss and increased carbon emissions. Here, we link an increased likelihood of tropical forest loss to decreasing fragment size, particularly in primary forests. The relationship holds for protected areas, albeit with half the rate of loss compared with ...

journal_title：Science advances

authors： Hansen MC,Wang L,Song XP,Tyukavina A,Turubanova S,Potapov PV,Stehman SV

更新日期：2020-03-11 00:00:00

abstract：:Cell chirality is a newly discovered intrinsic property of the cell, reflecting the bias of the cell to polarize in the left-right axis. Despite increasing evidence on its substantial role in the asymmetric development of embryos, little is known about implications of cell chirality in physiology and disease. We demon...

journal_title：Science advances

authors： Fan J,Ray P,Lu YW,Kaur G,Schwarz JJ,Wan LQ

更新日期：2018-10-24 00:00:00

abstract：:Transistors with exfoliated two-dimensional (2D) materials on a SiO2/Si substrate have been applied and have been proven effective in a wide range of applications, such as circuits, memory, photodetectors, gas sensors, optical modulators, valleytronics, and spintronics. However, these devices usually suffer from limit...

journal_title：Science advances

authors： Xu J,Chen L,Dai YW,Cao Q,Sun QQ,Ding SJ,Zhu H,Zhang DW

更新日期：2017-05-19 00:00:00

abstract：:Materials with a stochastic microstructure, like foams, typically exhibit low mechanical stiffness, whereas lattices with a designed microarchitecture often show notably improved stiffness. These periodic architected materials have previously been designed by rule, using the Maxwell criterion to ensure that their defo...

journal_title：Science advances

authors： Chen W,Watts S,Jackson JA,Smith WL,Tortorelli DA,Spadaccini CM

更新日期：2019-09-27 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) infection results in a spectrum of clinical and histopathologic manifestations. It has been proposed that the environmental and immune pressures associated with different contexts of infection have different consequences for the associated bacterial populations, affecting drug suscepti...

journal_title：Science advances

authors： Liu Q,Wei J,Li Y,Wang M,Su J,Lu Y,López MG,Qian X,Zhu Z,Wang H,Gan M,Jiang Q,Fu YX,Takiff HE,Comas I,Li F,Lu X,Fortune SM,Gao Q

更新日期：2020-05-29 00:00:00

abstract：:Recently, the complexity behind manipulations of reflected fields by metasurfaces has been addressed, showing that, even in the simplest scenarios, nonlocal response and excitation of auxiliary evanescent fields are required for perfect field control. In this work, we introduce purely local reflective metasurfaces for...

journal_title：Science advances

authors： Díaz-Rubio A,Li J,Shen C,Cummer SA,Tretyakov SA

更新日期：2019-02-15 00:00:00

abstract：:In a recent paper, Lechner, Hauke, and Zoller (LHZ) described a means to translate a Hamiltonian of N spin-1/2 particles with "all-to-all" interactions into a larger physical lattice with only on-site energies and local parity constraints. LHZ used this mapping to propose a novel form of quantum annealing. We provide ...

journal_title：Science advances

authors： Rocchetto A,Benjamin SC,Li Y

更新日期：2016-10-21 00:00:00

abstract：:Proinflammatory activation and accumulation of adipose tissue macrophages (ATMs) are associated with increased risk of insulin resistance in obesity. Here, we described the previously unidentified role of selenocysteine insertion sequence-binding protein 2 (SBP2) in maintaining insulin sensitivity in obesity. SBP2 was...

journal_title：Science advances

authors： Wang N,Tan HY,Li S,Wang D,Xu Y,Zhang C,Xia W,Che CM,Feng Y

更新日期：2019-08-14 00:00:00

abstract：:Active materials are capable of converting free energy into directional motion, giving rise to notable dynamical phenomena. Developing a general understanding of their structure in relation to the underlying nonequilibrium physics would provide a route toward control of their dynamic behavior and pave the way for pote...

journal_title：Science advances

authors： Kumar N,Zhang R,de Pablo JJ,Gardel ML

更新日期：2018-10-12 00:00:00

abstract：:To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host receptors. Many nAbs bin...

journal_title：Science advances

authors： Tzarum N,Giang E,Kadam RU,Chen F,Nagy K,Augestad EH,Velázquez-Moctezuma R,Keck ZY,Hua Y,Stanfield RL,Dreux M,Prentoe J,Foung SKH,Bukh J,Wilson IA,Law M

更新日期：2020-07-24 00:00:00

abstract：:Chronic suppurative otitis media (CSOM) is a neglected pediatric disease affecting 330 million worldwide for which no new drugs have been introduced for over a decade. We developed a mouse model with utility in preclinical drug evaluation and antimicrobial discovery. Our model used immune-competent mice, tympanic memb...

journal_title：Science advances

authors： Khomtchouk KM,Kouhi A,Xia A,Bekale LA,Massa SM,Sweere JM,Pletzer D,Hancock RE,Bollyky PL,Santa Maria PL

更新日期：2020-08-14 00:00:00

abstract：:We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria, and tumors in the mouse body and brain. We developed machine learning-based software for commercial ima...

journal_title：Science advances

authors： Mishra K,Stankevych M,Fuenzalida-Werner JP,Grassmann S,Gujrati V,Huang Y,Klemm U,Buchholz VR,Ntziachristos V,Stiel AC

更新日期：2020-06-12 00:00:00

abstract：:Animals, humans, and multi-robot systems operate in dynamic environments, where the ability to respond to changing circumstances is paramount. An effective collective response requires suitable information transfer among agents and thus critically depends on the interaction network. To investigate the influence of the...

journal_title：Science advances

authors： Mateo D,Horsevad N,Hassani V,Chamanbaz M,Bouffanais R

更新日期：2019-04-03 00:00:00

abstract：:The natural, prehuman abundance of most large predators is unknown because of the lack of historical data and a limited understanding of the natural factors that control their populations. Determining the supportable predator biomass at a given location (that is, the predator carrying capacity) would help managers to ...

journal_title：Science advances

authors： Valdivia A,Cox CE,Bruno JF

更新日期：2017-03-01 00:00:00

abstract：:Characterizing and understanding the emergence of multiple macroscopically ordered electronic phases through subtle tuning of temperature, pressure, and chemical doping has been a long-standing central issue for complex materials research. We report the first comprehensive studies of optical doping-induced emergence o...

journal_title：Science advances

authors： Han TR,Zhou F,Malliakas CD,Duxbury PM,Mahanti SD,Kanatzidis MG,Ruan CY

更新日期：2015-06-26 00:00:00

abstract：:Concern on the impacts of ocean acidification on calcifiers, such as bivalves, sea urchins, and foraminifers, has led to efforts to understand the controls on pH in their habitats, which include kelp forests and seagrass meadows. The metabolism of these habitats can lead to diel fluctuation in pH with increases during...

journal_title：Science advances

authors： Krause-Jensen D,Marbà N,Sanz-Martin M,Hendriks IE,Thyrring J,Carstensen J,Sejr MK,Duarte CM

更新日期：2016-12-14 00:00:00

abstract：:Transplanting beneficial bacteria to the gut microbiome can positively modulate the bacterial composition and remains of great interest in prevention and treatment. However, environmental assaults and rapid transit times in the gastrointestinal (GI) tract result in low oral bioavailability and limited intestinal colon...

journal_title：Science advances

authors： Wang X,Cao Z,Zhang M,Meng L,Ming Z,Liu J

更新日期：2020-06-24 00:00:00

abstract：:Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...

journal_title：Science advances

authors： Wang L,Yu C,Chang T,Zhang M,Song S,Xiong C,Su P,Xiang W

更新日期：2020-05-22 00:00:00

abstract：:Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with uniqu...

journal_title：Science advances

authors： Lee J,Liu Z,Suzuki PH,Ahrens JF,Lai S,Lu X,Guan S,St-Pierre F

更新日期：2020-10-23 00:00:00

abstract：:The polar nature of the C═O bond commonly allows it to undergo direct attack by nucleophiles at the electrophilic carbon atom in which ketones and aldehydes act as alkyl carbocation equivalents. In contrast, transformations in which ketones and aldehydes act as alkyl radical equivalents (generated in carbonyl carbon) ...

journal_title：Science advances

authors： Dong J,Wang Z,Wang X,Song H,Liu Y,Wang Q

更新日期：2019-10-11 00:00:00

abstract：:The Late Paleogene surface height and paleoenvironment for the core area of the Qinghai-Tibetan Plateau (QTP) remain critically unresolved. Here, we report the discovery of the youngest well-preserved fossil palm leaves from Tibet. They were recovered from the Late Paleogene (Chattian), ca. 25.5 ± 0.5 million years, p...

journal_title：Science advances

authors： Su T,Farnsworth A,Spicer RA,Huang J,Wu FX,Liu J,Li SF,Xing YW,Huang YJ,Deng WY,Tang H,Xu CL,Zhao F,Srivastava G,Valdes PJ,Deng T,Zhou ZK

更新日期：2019-03-06 00:00:00