Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect.

abstract：:Topological superconductors are exotic phases of matter featuring robust surface states that could be leveraged for topological quantum computation. A useful guiding principle for the search of topological superconductors is to relate the topological invariants with the behavior of the pairing order parameter on the n...

journal_title：Science advances

authors： Ono S,Po HC,Watanabe H

更新日期：2020-05-01 00:00:00

abstract：:Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly t...

journal_title：Science advances

authors： Kim T,Shen N,Hsiang JC,Johnson KP,Kerschensteiner D

更新日期：2020-11-18 00:00:00

abstract：:Projections of ice sheet behavior hinge on how ice flow velocity evolves and the extent to which marine-based grounding lines are stable. Ice flow and grounding line retreat are variably governed by the coupling between the ice and underlying terrain. We ask to what degree catchment-scale bed characteristics determine...

journal_title：Science advances

authors： Greenwood SL,Simkins LM,Winsborrow MCM,Bjarnadóttir LR

更新日期：2021-01-13 00:00:00

abstract：:Homologous recombination is exquisitely activated only during specific cell phases. In the G1 phase, homologous recombination activity is completely suppressed. According to previous reports, the activation of homologous recombination during specific cell phases depends on the kinase activity of cyclin-dependent kinas...

journal_title：Science advances

authors： Lim G,Chang Y,Huh WK

更新日期：2020-02-07 00:00:00

abstract：:There have been increasing attempts to reverse habitat degradation through active restoration, but few large-scale successes are reported to guide these efforts. Here, we report outcomes from a unique and very successful seagrass restoration project: Since 1999, over 70 million seeds of a marine angiosperm, eelgrass (...

journal_title：Science advances

authors： Orth RJ,Lefcheck JS,McGlathery KS,Aoki L,Luckenbach MW,Moore KA,Oreska MPJ,Snyder R,Wilcox DJ,Lusk B

更新日期：2020-10-07 00:00:00

abstract：:Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS-targeting IgG antibody, inRas37, which directly targets the intracellularly activated form of various...

journal_title：Science advances

authors： Shin SM,Kim JS,Park SW,Jun SY,Kweon HJ,Choi DK,Lee D,Cho YB,Kim YS

更新日期：2020-01-15 00:00:00

abstract：:The wiring of vertebrate and invertebrate brains provides the anatomical skeleton for cognition and behavior. Connections among brain regions are characterized by heterogeneous strength that is parsimoniously described by the wiring cost and homophily principles. Moreover, brains exhibit a characteristic global networ...

journal_title：Science advances

authors： Goulas A,Betzel RF,Hilgetag CC

更新日期：2019-06-12 00:00:00

abstract：:Nucleosynthetic isotope variability among solar system objects provides insights into the accretion history of terrestrial planets. We report on the nucleosynthetic Fe isotope composition (μ54Fe) of various meteorites and show that the only material matching the terrestrial composition is CI (Ivuna-type) carbonaceous ...

journal_title：Science advances

authors： Schiller M,Bizzarro M,Siebert J

更新日期：2020-02-12 00:00:00

abstract：:Stimulation of Escherichia coli by exponential ramps of chemoattractants generates step changes in the concentration of the response regulator, CheY-P. Because flagellar motors are ultrasensitive, this should change the fraction of time that motors spin clockwise, the CWbias. However, early work failed to show changes...

journal_title：Science advances

authors： Lele PP,Shrivastava A,Roland T,Berg HC

更新日期：2015-10-16 00:00:00

abstract：:Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...

journal_title：Science advances

authors： Naffouti M,Backofen R,Salvalaglio M,Bottein T,Lodari M,Voigt A,David T,Benkouider A,Fraj I,Favre L,Ronda A,Berbezier I,Grosso D,Abbarchi M,Bollani M

更新日期：2017-11-10 00:00:00

abstract：:Campylobacter coli and Campylobacter jejuni are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, Campylobacter vaccine development has been hampered by the lack of animal models that ...

journal_title：Science advances

authors： Quintel BK,Prongay K,Lewis AD,Raué HP,Hendrickson S,Rhoades NS,Messaoudi I,Gao L,Slifka MK,Amanna IJ

更新日期：2020-06-24 00:00:00

abstract：:When a dynamic system undergoes a cyclic evolution, a geometric phase that depends only on the path traversed in parameter space can arise in addition to the normal dynamical phase. These geometric phases have profound impacts in both quantum and classical physics. In addition to the geometric phase associated with ba...

journal_title：Science advances

authors： Wang S,Ma G,Chan CT

更新日期：2018-02-16 00:00:00

abstract：:Retreat from some areas will become unavoidable under intensifying climate change. Existing deployments of managed retreat are at small scale compared to potential future needs, leaving open questions about where, when, and how retreat under climate change will occur. Here, we analyze more than 40,000 voluntary buyout...

journal_title：Science advances

authors： Mach KJ,Kraan CM,Hino M,Siders AR,Johnston EM,Field CB

更新日期：2019-10-09 00:00:00

abstract：:An understanding of the normal state in the high-temperature superconducting cuprates is crucial to the ultimate understanding of the long-standing problem of the origin of the superconductivity itself. This so-called "strange metal" state is thought to be associated with a quantum critical point (QCP) hidden beneath ...

journal_title：Science advances

authors： Sarkar T,Mandal PR,Poniatowski NR,Chan MK,Greene RL

更新日期：2019-05-17 00:00:00

abstract：:Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...

journal_title：Science advances

authors： Brydegaard M,Jansson S,Malmqvist E,Mlacha YP,Gebru A,Okumu F,Killeen GF,Kirkeby C

更新日期：2020-05-13 00:00:00

abstract：:Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...

journal_title：Science advances

authors： Qi H,Sahabudeen H,Liang B,Položij M,Addicoat MA,Gorelik TE,Hambsch M,Mundszinger M,Park S,Lotsch BV,Mannsfeld SCB,Zheng Z,Dong R,Heine T,Feng X,Kaiser U

更新日期：2020-08-14 00:00:00

abstract：:Understanding how surfaces direct nucleation is a complex problem that limits our ability to predict and control crystal formation. We here address this challenge using high-speed imaging to identify and quantify the sites at which ice nucleates in water droplets on the two natural cleavage faces of macroscopic feldsp...

journal_title：Science advances

authors： Holden MA,Whale TF,Tarn MD,O'Sullivan D,Walshaw RD,Murray BJ,Meldrum FC,Christenson HK

更新日期：2019-02-01 00:00:00

abstract：:Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal metabolism in vivo are poorly understood. Here, we profiled the cell-specific proteome of Purkinje neurons undergoin...

journal_title：Science advances

authors： Motori E,Atanassov I,Kochan SMV,Folz-Donahue K,Sakthivelu V,Giavalisco P,Toni N,Puyal J,Larsson NG

更新日期：2020-08-28 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis or management despite global efforts to find biomarkers of disease. We considered the possibility...

journal_title：Science advances

authors： Hornig M,Montoya JG,Klimas NG,Levine S,Felsenstein D,Bateman L,Peterson DL,Gottschalk CG,Schultz AF,Che X,Eddy ML,Komaroff AL,Lipkin WI

更新日期：2015-02-01 00:00:00

abstract：:The wings of the black butterfly, Pachliopta aristolochiae, are covered by micro- and nanostructured scales that harvest sunlight over a wide spectral and angular range. Considering that these properties are particularly attractive for photovoltaic applications, we analyze the contribution of these micro- and nanostru...

journal_title：Science advances

authors： Siddique RH,Donie YJ,Gomard G,Yalamanchili S,Merdzhanova T,Lemmer U,Hölscher H

更新日期：2017-10-20 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, litt...

journal_title：Science advances

authors： Qin Y,Chen W,Jiang G,Zhou L,Yang X,Li H,He X,Wang HL,Zhou YB,Huang S,Liu S

更新日期：2020-02-19 00:00:00

abstract：:Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the deve...

journal_title：Science advances

authors： Liang Z,Zhang S,Li X,Wang T,Huang Y,Hang W,Yang Z,Li J,Tian Z

更新日期：2017-12-08 00:00:00

abstract：:Skin-mountable microelectronics are garnering substantial interest for various promising applications including human-machine interfaces, biointegrated devices, and personalized medicine. However, it remains a critical challenge to develop e-skins to mimic the human somatosensory system in full working range. Here, we...

journal_title：Science advances

authors： Cai Y,Shen J,Yang CW,Wan Y,Tang HL,Aljarb AA,Chen C,Fu JH,Wei X,Huang KW,Han Y,Jonas SJ,Dong X,Tung V

更新日期：2020-11-27 00:00:00

abstract：:Preventing the degradation of metal perovskite solar cells (PSCs) by humid air poses a substantial challenge for their future deployment. We introduce here a two-dimensional (2D) A2PbI4 perovskite layer using pentafluorophenylethylammonium (FEA) as a fluoroarene cation inserted between the 3D light-harvesting perovski...

journal_title：Science advances

authors： Liu Y,Akin S,Pan L,Uchida R,Arora N,Milić JV,Hinderhofer A,Schreiber F,Uhl AR,Zakeeruddin SM,Hagfeldt A,Dar MI,Grätzel M

更新日期：2019-06-07 00:00:00

abstract：:Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine triphosphate to adenosine monophosphate (AMP) and AMP to adenosine, respectively. Despite the relevance of CD39/CD73 t...

journal_title：Science advances

authors： Shih YV,Liu M,Kwon SK,Iida M,Gong Y,Sangaj N,Varghese S

更新日期：2019-08-21 00:00:00

abstract：:[This corrects the article e1602026 in vol. 3, PMID: 28246641.]. ...

journal_title：Science advances

authors：

更新日期：2017-09-29 00:00:00

abstract：:To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...

journal_title：Science advances

authors： Turner TC,Sok MCP,Hymel LA,Pittman FS,York WY,Mac QD,Vyshnya S,Lim HS,Kwong GA,Qiu P,Botchwey EA

更新日期：2020-10-30 00:00:00

abstract：:Fluctuations in biodiversity, large and small, pervade the fossil record, yet we do not understand the processes generating them. Here, we extend theory from nonequilibrium statistical physics to describe the fat-tailed form of fluctuations in Phanerozoic marine invertebrate richness. Using this theory, known as super...

journal_title：Science advances

authors： Rominger AJ,Fuentes MA,Marquet PA

更新日期：2019-06-26 00:00:00

abstract：:Recently, the complexity behind manipulations of reflected fields by metasurfaces has been addressed, showing that, even in the simplest scenarios, nonlocal response and excitation of auxiliary evanescent fields are required for perfect field control. In this work, we introduce purely local reflective metasurfaces for...

journal_title：Science advances

authors： Díaz-Rubio A,Li J,Shen C,Cummer SA,Tretyakov SA

更新日期：2019-02-15 00:00:00

abstract：:Changes in CO2 emissions during the COVID-19 pandemic have been estimated from indicators on activities like transportation and electricity generation. Here, we instead use satellite observations together with bottom-up information to track the daily dynamics of CO2 emissions during the pandemic. Unlike activity data,...

journal_title：Science advances

authors： Zheng B,Geng G,Ciais P,Davis SJ,Martin RV,Meng J,Wu N,Chevallier F,Broquet G,Boersma F,van der A R,Lin J,Guan D,Lei Y,He K,Zhang Q

更新日期：2020-12-02 00:00:00