Abrupt recent trend changes in atmospheric nitrogen dioxide over the Middle East.

abstract：:Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard...

journal_title：Science advances

authors： Castle MJ,Cheng Y,Asokan A,Tuszynski MH

更新日期：2018-11-14 00:00:00

abstract：:Engineered surfaces with reversibly switching interfacial properties, such as wettability and liquid repellency, are highly desirable in diverse application fields but are rare. We have developed a general concept to prepare metallic porous surfaces with exceptionally powerful wettability switch capabilities and liqui...

journal_title：Science advances

authors： Liu Y,Zhao L,Lin J,Yang S

更新日期：2019-11-01 00:00:00

abstract：:Dynamic modulation of soft helix in terms of the molecular organization, handedness, and pitch length could result in a sophisticated control over its functions, opening numerous possibilities toward the exploration of previously unidentified applications. Here, we report a dynamic and reversible transformation of a s...

journal_title：Science advances

authors： Yuan CL,Huang W,Zheng ZG,Liu B,Bisoyi HK,Li Y,Shen D,Lu Y,Li Q

更新日期：2019-10-04 00:00:00

abstract：:Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase (telogen). Current pharmacologic therapies have been largely unsuccessful in targeting pathways that can be selectively modulated to i...

journal_title：Science advances

authors： Harel S,Higgins CA,Cerise JE,Dai Z,Chen JC,Clynes R,Christiano AM

更新日期：2015-10-23 00:00:00

abstract：:We propose a method to use artificial neural networks to approximate light scattering by multilayer nanoparticles. We find that the network needs to be trained on only a small sampling of the data to approximate the simulation to high precision. Once the neural network is trained, it can simulate such optical processe...

journal_title：Science advances

authors： Peurifoy J,Shen Y,Jing L,Yang Y,Cano-Renteria F,DeLacy BG,Joannopoulos JD,Tegmark M,Soljačić M

更新日期：2018-06-01 00:00:00

abstract：:We report a dual-mode organic photodetector (OPD) that has a trilayer visible light absorber/optical spacer/near-infrared (NIR) light absorber configuration. In the presence of NIR light, photocurrent is produced in the NIR light-absorbing layer due to the trap-assisted charge injection at the organic/cathode interfac...

journal_title：Science advances

authors： Lan Z,Lei Y,Chan WKE,Chen S,Luo D,Zhu F

更新日期：2020-01-31 00:00:00

abstract：:Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...

journal_title：Science advances

authors： Tsatskis Y,Rosenfeld R,Pearson JD,Boswell C,Qu Y,Kim K,Fabian L,Mohammad A,Wang X,Robson MI,Krchma K,Wu J,Gonçalves J,Hodzic D,Wu S,Potter D,Pelletier L,Dunham WH,Gingras AC,Sun Y,Meng J,Godt D,Schedl T,Ciru

更新日期：2020-08-28 00:00:00

abstract：:Cyclosporine A (CsA) is a powerful immunosuppressant, but it is an ineffective stand-alone treatment for systemic lupus erythematosus (SLE) due to poor target tissue distribution and renal toxicity. We hypothesized that CD71 (transferrin receptor 1)-directed delivery of CsA to the lymphatic system would improve SLE ou...

journal_title：Science advances

authors： Ganugula R,Arora M,Zou D,Agarwal SK,Mohan C,Kumar MNVR

更新日期：2020-06-12 00:00:00

abstract：:The structure of many real-world systems is best captured by networks consisting of several interaction layers. Understanding how a multilayered structure of connections affects the synchronization properties of dynamical systems evolving on top of it is a highly relevant endeavor in mathematics and physics and has po...

journal_title：Science advances

authors： Del Genio CI,Gómez-Gardeñes J,Bonamassa I,Boccaletti S

更新日期：2016-11-16 00:00:00

abstract：:Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography-based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and re...

journal_title：Science advances

authors： Javaheri B,Razi H,Gohin S,Wylie S,Chang YM,Salmon P,Lee PD,Pitsillides AA

更新日期：2020-03-06 00:00:00

abstract：:The advent of two-dimensional (2D) materials has led to extensive studies of heterostructures for novel applications. 2D lateral multiheterojunctions and superlattices have been recently demonstrated, but the available growth methods can only produce features with widths in the micrometer or, at best, 100-nm scale and...

journal_title：Science advances

authors： Zhou W,Zhang YY,Chen J,Li D,Zhou J,Liu Z,Chisholm MF,Pantelides ST,Loh KP

更新日期：2018-03-23 00:00:00

abstract：:The mid-infrared (MIR) spectral range, pertaining to important applications, such as molecular "fingerprint" imaging, remote sensing, free space telecommunication, and optical radar, is of particular scientific interest and technological importance. However, state-of-the-art materials for MIR detection are limited by ...

journal_title：Science advances

authors： Long M,Gao A,Wang P,Xia H,Ott C,Pan C,Fu Y,Liu E,Chen X,Lu W,Nilges T,Xu J,Wang X,Hu W,Miao F

更新日期：2017-06-30 00:00:00

abstract：:We present an ab initio computational approach for the calculation of resonant Raman intensities, including both excitonic and nonadiabatic effects. Our diagrammatic approach, which we apply to two prototype, semiconducting layered materials, allows a detailed analysis of the impact of phonon-mediated exciton-exciton ...

journal_title：Science advances

authors： Reichardt S,Wirtz L

更新日期：2020-08-07 00:00:00

abstract：:Many animals understand numbers at a basic level for use in essential tasks such as foraging, shoaling, and resource management. However, complex arithmetic operations, such as addition and subtraction, using symbols and/or labeling have only been demonstrated in a limited number of nonhuman vertebrates. We show that ...

journal_title：Science advances

authors： Howard SR,Avarguès-Weber A,Garcia JE,Greentree AD,Dyer AG

更新日期：2019-02-06 00:00:00

abstract：:Charge order is universal among high-Tc cuprates, but its relation to superconductivity is unclear. While static order competes with superconductivity, dynamic order may be favorable and even contribute to Cooper pairing. Using time-resolved resonant soft x-ray scattering at a free-electron laser, we show that the cha...

journal_title：Science advances

authors： Mitrano M,Lee S,Husain AA,Delacretaz L,Zhu M,de la Peña Munoz G,Sun SX,Joe YI,Reid AH,Wandel SF,Coslovich G,Schlotter W,van Driel T,Schneeloch J,Gu GD,Hartnoll S,Goldenfeld N,Abbamonte P

更新日期：2019-08-16 00:00:00

abstract：:The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic ...

journal_title：Science advances

authors： Zhang M,Lin R,Wang X,Xue J,Deng C,Feng C,Zhuang H,Ma J,Qin C,Wan L,Chang J,Wu C

更新日期：2020-03-20 00:00:00

abstract：:Sedimentary hydrocarbon remnants of eukaryotic C26-C30 sterols can be used to reconstruct early algal evolution. Enhanced C29 sterol abundances provide algal cell membranes a density advantage in large temperature fluctuations. Here, we combined a literature review with new analyses to generate a comprehensive invento...

journal_title：Science advances

authors： Hoshino Y,Poshibaeva A,Meredith W,Snape C,Poshibaev V,Versteegh GJM,Kuznetsov N,Leider A,van Maldegem L,Neumann M,Naeher S,Moczydłowska M,Brocks JJ,Jarrett AJM,Tang Q,Xiao S,McKirdy D,Das SK,Alvaro JJ,Sansjofre P,

更新日期：2017-09-20 00:00:00

abstract：:Previous studies have extensively investigated the impact of Arctic sea ice anomalies on the midlatitude circulation and associated surface climate in winter. However, there is an ongoing scientific debate regarding whether and how sea ice retreat results in the observed cold anomaly over the adjacent continents. We p...

journal_title：Science advances

authors： Zhang P,Wu Y,Simpson IR,Smith KL,Zhang X,De B,Callaghan P

更新日期：2018-07-25 00:00:00

abstract：:The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel a...

journal_title：Science advances

authors： Altwegg K,Balsiger H,Bar-Nun A,Berthelier JJ,Bieler A,Bochsler P,Briois C,Calmonte U,Combi MR,Cottin H,De Keyser J,Dhooghe F,Fiethe B,Fuselier SA,Gasc S,Gombosi TI,Hansen KC,Haessig M,Jäckel A,Kopp E,Korth A,Le

更新日期：2016-05-27 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis or management despite global efforts to find biomarkers of disease. We considered the possibility...

journal_title：Science advances

authors： Hornig M,Montoya JG,Klimas NG,Levine S,Felsenstein D,Bateman L,Peterson DL,Gottschalk CG,Schultz AF,Che X,Eddy ML,Komaroff AL,Lipkin WI

更新日期：2015-02-01 00:00:00

abstract：:Black phosphorus quantum dots (BPQDs) are proposed as effective seed-like sites to modulate the nucleation and growth of CsPbI2Br perovskite crystalline thin layers, allowing an enhanced crystallization and remarkable morphological improvement. We reveal that the lone-pair electrons of BPQDs can induce strong binding ...

journal_title：Science advances

authors： Gong X,Guan L,Li Q,Li Y,Zhang T,Pan H,Sun Q,Shen Y,Grätzel C,Zakeeruddin SM,Grätzel M,Wang M

更新日期：2020-04-10 00:00:00

abstract：:In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the...

journal_title：Science advances

authors： Perianez-Rodriguez J,Rodriguez M,Marconi M,Bustillo-Avendaño E,Wachsman G,Sanchez-Corrionero A,De Gernier H,Cabrera J,Perez-Garcia P,Gude I,Saez A,Serrano-Ron L,Beeckman T,Benfey PN,Rodríguez-Patón A,Del Pozo JC,Wabnik K

更新日期：2021-01-01 00:00:00

abstract：:Superomniphobic textures are at the frontier of surface design for vast arrays of applications. Despite recent substantial advances in fabrication methods for reentrant and doubly reentrant microstructures, design optimization remains a major challenge. We overcome this in two stages. First, we develop readily general...

journal_title：Science advances

authors： Panter JR,Gizaw Y,Kusumaatmaja H

更新日期：2019-06-21 00:00:00

abstract：:A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...

journal_title：Science advances

authors： Bratman GN,Anderson CB,Berman MG,Cochran B,de Vries S,Flanders J,Folke C,Frumkin H,Gross JJ,Hartig T,Kahn PH Jr,Kuo M,Lawler JJ,Levin PS,Lindahl T,Meyer-Lindenberg A,Mitchell R,Ouyang Z,Roe J,Scarlett L,Smith JR,

更新日期：2019-07-24 00:00:00

abstract：:In retinal detachment (RD), photoreceptor death and permanent vision loss are caused by neurosensory retina separating from the retinal pigment epithelium because of subretinal fluid (SRF), and successful surgical reattachment is not predictive of total visual recovery. As retinal iron overload exacerbates cell death ...

journal_title：Science advances

authors： Daruich A,Le Rouzic Q,Jonet L,Naud MC,Kowalczuk L,Pournaras JA,Boatright JH,Thomas A,Turck N,Moulin A,Behar-Cohen F,Picard E

更新日期：2019-01-09 00:00:00

abstract：:The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote...

journal_title：Science advances

authors： Hu S,Li Z,Lutz H,Huang K,Su T,Cores J,Dinh PC,Cheng K

更新日期：2020-07-24 00:00:00

abstract：:Like most homeostatic systems, adiposity in mammals is defended between upper and lower boundary conditions. While leptin and melanocortin-4 receptor (MC4R) signaling are required for defending energy set point, mechanisms controlling upper and lower homeostatic boundaries are less well understood. In contrast to the ...

journal_title：Science advances

authors： Ghamari-Langroudi M,Cakir I,Lippert RN,Sweeney P,Litt MJ,Ellacott KLJ,Cone RD

更新日期：2018-08-22 00:00:00

abstract：:Analog machine learning hardware platforms promise to be faster and more energy efficient than their digital counterparts. Wave physics, as found in acoustics and optics, is a natural candidate for building analog processors for time-varying signals. Here, we identify a mapping between the dynamics of wave physics and...

journal_title：Science advances

authors： Hughes TW,Williamson IAD,Minkov M,Fan S

更新日期：2019-12-20 00:00:00

abstract：:Fundamental understanding of the charge transport physics of hybrid lead halide perovskite semiconductors is important for advancing their use in high-performance optoelectronics. We use field-effect transistors (FETs) to probe the charge transport mechanism in thin films of methylammonium lead iodide (MAPbI3). We sho...

journal_title：Science advances

authors： Senanayak SP,Yang B,Thomas TH,Giesbrecht N,Huang W,Gann E,Nair B,Goedel K,Guha S,Moya X,McNeill CR,Docampo P,Sadhanala A,Friend RH,Sirringhaus H

更新日期：2017-01-27 00:00:00

abstract：:Materials with a stochastic microstructure, like foams, typically exhibit low mechanical stiffness, whereas lattices with a designed microarchitecture often show notably improved stiffness. These periodic architected materials have previously been designed by rule, using the Maxwell criterion to ensure that their defo...

journal_title：Science advances

authors： Chen W,Watts S,Jackson JA,Smith WL,Tortorelli DA,Spadaccini CM

更新日期：2019-09-27 00:00:00