Multifaceted design optimization for superomniphobic surfaces.

abstract：:Smart materials that are capable of memorizing a temporary shape, and morph in response to a stimulus, have the potential to revolutionize medicine and robotics. Here, we introduce an innovative method to program protein hydrogels and to induce shape changes in aqueous solutions at room temperature. We demonstrate our...

journal_title：Science advances

authors： Khoury LR,Slawinski M,Collison DR,Popa I

更新日期：2020-04-29 00:00:00

abstract：:Changes in the Atlantic Meridional Overturning Circulation (AMOC) are moderate in most climate model projections under increasing greenhouse gas forcing. This intermodel consensus may be an artifact of common model biases that favor a stable AMOC. Observationally based freshwater budget analyses suggest that the AMOC ...

journal_title：Science advances

authors： Liu W,Xie SP,Liu Z,Zhu J

更新日期：2017-01-04 00:00:00

abstract：:Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...

journal_title：Science advances

authors： Lee SH,Albright ER,Lee JH,Jacobs D,Kalejta RF

更新日期：2015-11-27 00:00:00

abstract：:Chaotic itinerancy is a frequently observed phenomenon in high-dimensional nonlinear dynamical systems and is characterized by itinerant transitions among multiple quasi-attractors. Several studies have pointed out that high-dimensional activity in animal brains can be observed to exhibit chaotic itinerancy, which is ...

journal_title：Science advances

authors： Inoue K,Nakajima K,Kuniyoshi Y

更新日期：2020-11-11 00:00:00

abstract：:Despite the potential of photodynamic therapy (PDT), its comprehensive use in cancer treatment has not been achieved because of the nondegradable risks of photosensitizing drugs and limits of light penetration and instrumentation. Here, we present bioluminescence (BL)-induced proteinaceous PDT (BLiP-PDT), through the ...

journal_title：Science advances

authors： Kim EH,Park S,Kim YK,Moon M,Park J,Lee KJ,Lee S,Kim YP

更新日期：2020-09-11 00:00:00

abstract：:Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits the development of effective treatments for CNS disorders. We present the facile synthesis of a novel neuroinflammation-targeting polyethylene glycol-based dendrimer (PEGOL-60) using an efficient click chemistry approach. PEGOL-6...

journal_title：Science advances

authors： Sharma A,Sharma R,Zhang Z,Liaw K,Kambhampati SP,Porterfield JE,Lin KC,DeRidder LB,Kannan S,Kannan RM

更新日期：2020-01-22 00:00:00

abstract：:Measuring motor skill proficiency is critical for the certification of highly skilled individuals in numerous fields. However, conventional measures use subjective metrics that often cannot distinguish between expertise levels. We present an advanced optical neuroimaging methodology that can objectively and successful...

journal_title：Science advances

authors： Nemani A,Yücel MA,Kruger U,Gee DW,Cooper C,Schwaitzberg SD,De S,Intes X

更新日期：2018-10-03 00:00:00

abstract：:Preventing the degradation of metal perovskite solar cells (PSCs) by humid air poses a substantial challenge for their future deployment. We introduce here a two-dimensional (2D) A2PbI4 perovskite layer using pentafluorophenylethylammonium (FEA) as a fluoroarene cation inserted between the 3D light-harvesting perovski...

journal_title：Science advances

authors： Liu Y,Akin S,Pan L,Uchida R,Arora N,Milić JV,Hinderhofer A,Schreiber F,Uhl AR,Zakeeruddin SM,Hagfeldt A,Dar MI,Grätzel M

更新日期：2019-06-07 00:00:00

abstract：:One of the most plausible scenarios of the origin of life assumes the preceding prebiotic autotrophic metabolism in sulfide-rich hydrothermal vent environments. However, geochemical mechanisms to harness the reductive power provided by hydrothermal systems remain to be elucidated. Here, we show that, under a geoelectr...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Yoshida N,Oono Y

更新日期：2019-06-19 00:00:00

abstract：:Ice-templating holds promise to become a powerful technique to construct high-performance bioinspired materials. Both ice nucleation and growth during the freezing process are crucial for the final architecture of the ice-templated material. However, effective ways to control these two very important factors are still...

journal_title：Science advances

authors： Zhao N,Li M,Gong H,Bai H

更新日期：2020-07-31 00:00:00

abstract：:Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties. Whereas several fusion proteins induce leukemogenesis by activating Hox gene expression (Hox-activating fusions), others impinge on different pathways that do not...

journal_title：Science advances

authors： Rossi A,Ferrari KJ,Piunti A,Jammula S,Chiacchiera F,Mazzarella L,Scelfo A,Pelicci PG,Pasini D

更新日期：2016-10-07 00:00:00

abstract：:Dust condensation and coagulation in the early solar system are the first steps toward forming the terrestrial planets, but the time scales of these processes remain poorly constrained. Through isotopic analysis of small Ca-Al-rich inclusions (CAIs) (30 to 100 μm in size) found in one of the most pristine chondrites, ...

journal_title：Science advances

authors： Liu MC,Han J,Brearley AJ,Hertwig AT

更新日期：2019-09-11 00:00:00

abstract：:Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...

journal_title：Science advances

authors： Tsatskis Y,Rosenfeld R,Pearson JD,Boswell C,Qu Y,Kim K,Fabian L,Mohammad A,Wang X,Robson MI,Krchma K,Wu J,Gonçalves J,Hodzic D,Wu S,Potter D,Pelletier L,Dunham WH,Gingras AC,Sun Y,Meng J,Godt D,Schedl T,Ciru

更新日期：2020-08-28 00:00:00

abstract：:Computer vision (CV) has the potential to change medicine fundamentally. Expert knowledge provided by CV can enhance diagnosis. Unfortunately, existing algorithms often remain below expectations, as databases used for training are usually too small, incomplete, and heterogeneous in quality. Moreover, data protection i...

journal_title：Science advances

authors： Han T,Nebelung S,Haarburger C,Horst N,Reinartz S,Merhof D,Kiessling F,Schulz V,Truhn D

更新日期：2020-12-02 00:00:00

abstract：:One of the most elusive scientific challenges for over 150 years has been to explain why cooperation survives despite being a seemingly inferior strategy from an evolutionary point of view. Over the years, various theoretical scenarios aimed at solving the evolutionary puzzle of cooperation have been proposed, eventua...

journal_title：Science advances

authors： Wang Z,Jusup M,Wang RW,Shi L,Iwasa Y,Moreno Y,Kurths J

更新日期：2017-03-29 00:00:00

abstract：:The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored. Here, we established an integrated screening strategy to discover lncRNAs implicated in neurotransmitter and synaptic vesicle release. With this approach, we ...

journal_title：Science advances

authors： Keihani S,Kluever V,Mandad S,Bansal V,Rahman R,Fritsch E,Gomes LC,Gärtner A,Kügler S,Urlaub H,Wren JD,Bonn S,Rizzoli SO,Fornasiero EF

更新日期：2019-12-18 00:00:00

abstract：:The locally accumulated damage by tropical cyclones (TCs) can intensify substantially when these cyclones move more slowly. While some observational evidence suggests that TC motion might have slowed significantly since the mid-20th century (1), the robustness of the observed trend and its relation to anthropogenic wa...

journal_title：Science advances

authors： Zhang G,Murakami H,Knutson TR,Mizuta R,Yoshida K

更新日期：2020-04-22 00:00:00

abstract：:Plants produce a myriad of taxonomically restricted specialized metabolites. This diversity-and our ability to correlate genotype with phenotype-makes the evolution of these ecologically and medicinally important compounds interesting and experimentally tractable. Trichomes of tomato and other nightshade family plants...

journal_title：Science advances

authors： Leong BJ,Lybrand DB,Lou YR,Fan P,Schilmiller AL,Last RL

更新日期：2019-04-24 00:00:00

abstract：:Continental rifting and seafloor spreading play a fundamental role in the generation of new crust. However, the distribution of magma and its relationship with tectonics and volcanism remain poorly understood, particularly in back-arc settings. We show evidence for a large, long-lived, off-axis magmatic intrusion loca...

journal_title：Science advances

authors： Hamling IJ,Hreinsdóttir S,Bannister S,Palmer N

更新日期：2016-06-03 00:00:00

abstract：:Lake evaporation can influence basin-wide hydrological cycles and is an important factor in loss of water resources in endorheic lakes of the Tibetan Plateau. Because of the scarcity of data, published lake evaporation values are inconsistent, and their spatial distribution has never been reported. Presenting a plausi...

journal_title：Science advances

authors： Wang B,Ma Y,Su Z,Wang Y,Ma W

更新日期：2020-06-26 00:00:00

abstract：:Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochondrial membrane requi...

journal_title：Science advances

authors： Parey K,Haapanen O,Sharma V,Köfeler H,Züllig T,Prinz S,Siegmund K,Wittig I,Mills DJ,Vonck J,Kühlbrandt W,Zickermann V

更新日期：2019-12-11 00:00:00

abstract：:Functionally graded materials (FGMs) enable applications in fields such as biomedicine and architecture, but their fabrication suffers from shortcomings in gradient continuity, interfacial bonding, and directional freedom. In addition, most commercial design software fail to incorporate property gradient data, hinderi...

journal_title：Science advances

authors： Giachini PAGS,Gupta SS,Wang W,Wood D,Yunusa M,Baharlou E,Sitti M,Menges A

更新日期：2020-02-21 00:00:00

abstract：:The advent of two-dimensional (2D) materials has led to extensive studies of heterostructures for novel applications. 2D lateral multiheterojunctions and superlattices have been recently demonstrated, but the available growth methods can only produce features with widths in the micrometer or, at best, 100-nm scale and...

journal_title：Science advances

authors： Zhou W,Zhang YY,Chen J,Li D,Zhou J,Liu Z,Chisholm MF,Pantelides ST,Loh KP

更新日期：2018-03-23 00:00:00

abstract：:Over millions of years, the oxidation of organic carbon contained within sedimentary rocks is one of the main sources of carbon dioxide to the atmosphere, yet the controls on this emission remain poorly constrained. We use rhenium to track the oxidation of rock-bound organic carbon in the mountain watersheds of New Ze...

journal_title：Science advances

authors： Horan K,Hilton RG,Selby D,Ottley CJ,Gröcke DR,Hicks M,Burton KW

更新日期：2017-10-04 00:00:00

abstract：:Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility,...

journal_title：Science advances

authors： Luan L,Wei X,Zhao Z,Siegel JJ,Potnis O,Tuppen CA,Lin S,Kazmi S,Fowler RA,Holloway S,Dunn AK,Chitwood RA,Xie C

更新日期：2017-02-15 00:00:00

abstract：:In 2015, more than 200,000 saiga antelopes died in 3 weeks in central Kazakhstan. The proximate cause of death is confirmed as hemorrhagic septicemia caused by the bacterium Pasteurella multocida type B, based on multiple strands of evidence. Statistical modeling suggests that there was unusually high relative humidit...

journal_title：Science advances

authors： Kock RA,Orynbayev M,Robinson S,Zuther S,Singh NJ,Beauvais W,Morgan ER,Kerimbayev A,Khomenko S,Martineau HM,Rystaeva R,Omarova Z,Wolfs S,Hawotte F,Radoux J,Milner-Gulland EJ

更新日期：2018-01-17 00:00:00

abstract：:Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing has been unclear. Here, we examined the role of ciliary Ca2+ in the flow sensing that initiates the breaking of left-right (L-R) symmetry in the mouse embryo. Intraciliary and cytoplasmic Ca2+ transients were d...

journal_title：Science advances

authors： Mizuno K,Shiozawa K,Katoh TA,Minegishi K,Ide T,Ikawa Y,Nishimura H,Takaoka K,Itabashi T,Iwane AH,Nakai J,Shiratori H,Hamada H

更新日期：2020-07-22 00:00:00

abstract：:Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...

journal_title：Science advances

authors： Qi H,Sahabudeen H,Liang B,Položij M,Addicoat MA,Gorelik TE,Hambsch M,Mundszinger M,Park S,Lotsch BV,Mannsfeld SCB,Zheng Z,Dong R,Heine T,Feng X,Kaiser U

更新日期：2020-08-14 00:00:00

abstract：:Electron interferometry via phase-contrast microscopy, holography, or picodiffraction can provide a direct visualization of the static electric and magnetic fields inside or around a material at subatomic precision, but understanding the electromagnetic origin of light-matter interaction requires time resolution as we...

journal_title：Science advances

authors： Mohler KJ,Ehberger D,Gronwald I,Lange C,Huber R,Baum P

更新日期：2020-11-20 00:00:00

abstract：:Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family of master regulator...

journal_title：Science advances

authors： Ghari F,Quirke AM,Munro S,Kawalkowska J,Picaud S,McGouran J,Subramanian V,Muth A,Williams R,Kessler B,Thompson PR,Fillipakopoulos P,Knapp S,Venables PJ,La Thangue NB

更新日期：2016-02-05 00:00:00