Abstract:
:Functionally graded materials (FGMs) enable applications in fields such as biomedicine and architecture, but their fabrication suffers from shortcomings in gradient continuity, interfacial bonding, and directional freedom. In addition, most commercial design software fail to incorporate property gradient data, hindering explorations of the design space of FGMs. Here, we leveraged a combined approach of materials engineering and digital processing to enable extrusion-based multimaterial additive manufacturing of cellulose-based tunable viscoelastic materials with continuous, high-contrast, and multidirectional stiffness gradients. A method to engineer sets of cellulose-based materials with similar compositions, yet distinct mechanical and rheological properties, was established. In parallel, a digital workflow was developed to embed gradient information into design models with integrated fabrication path planning. The payoff of integrating these physical and digital tools is the ability to achieve the same stiffness gradient in multiple ways, opening design possibilities previously limited by the rigid coupling of material and geometry.
journal_name
Sci Advjournal_title
Science advancesauthors
Giachini PAGS,Gupta SS,Wang W,Wood D,Yunusa M,Baharlou E,Sitti M,Menges Adoi
10.1126/sciadv.aay0929subject
Has Abstractpub_date
2020-02-21 00:00:00pages
eaay0929issue
8issn
2375-2548pii
aay0929journal_volume
6pub_type
杂志文章相关文献
Science Advances文献大全abstract::Slow slip events have been suggested to trigger subduction earthquakes. However, examples to date have been poorly recorded, occurring offshore, where data are sparse. Better understanding of slow slip events and their influence on subsequent earthquakes is critical for hazard forecasts. We analyze a well-recorded eve...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat8472
更新日期:2018-10-31 00:00:00
abstract::A sulfide-oxidizing microorganism, Desulfurivibrio alkaliphilus (DA), generates a consistent enrichment of sulfur-34 (34S) in the produced sulfate of +12.5 per mil or greater. This observation challenges the general consensus that the microbial oxidation of sulfide does not result in large 34S enrichments and suggests...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw1480
更新日期:2019-07-24 00:00:00
abstract::Surface plasmon resonance microscopy (SPRM) with single-direction illumination is a powerful platform for biomedical imaging because of its wide-field, label-free, and high-surface-sensitivity imaging capabilities. However, two disadvantages prevent wider use of SPRM. The first is its poor spatial resolution that can ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5335
更新日期:2019-03-29 00:00:00
abstract::Coordinatively unsaturated (CUS) iron sites are highly active in catalytic oxidation reactions; however, maintaining the CUS structure of iron during heterogeneous catalytic reactions is a great challenge. Here, we report a strategy to stabilize single-atom CUS iron sites by embedding highly dispersed FeN4 centers in ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500462
更新日期:2015-12-04 00:00:00
abstract::Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9859
更新日期:2018-11-14 00:00:00
abstract::We present results from a study in the Democratic Republic of the Congo that uses mobile money networks to run rotating savings and credit associations (ROSCAs), peer-to-peer finance groups ubiquitous across the developing world. We find high rates of contribution and ROSCA success. The unexpected success of such e-RO...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5831
更新日期:2021-01-01 00:00:00
abstract::Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent. However, molecular targets relevant to its therapeutic actions remain enigmatic. Sulfide-quinone oxidoreductase (SQR) irreversibly oxidizes H2S. Therefore, SQR is assumed to inhibit H2S signaling. We now report that SQR-mediated oxidation o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz5752
更新日期:2020-08-26 00:00:00
abstract::The advent of two-dimensional (2D) materials has led to extensive studies of heterostructures for novel applications. 2D lateral multiheterojunctions and superlattices have been recently demonstrated, but the available growth methods can only produce features with widths in the micrometer or, at best, 100-nm scale and...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aap9096
更新日期:2018-03-23 00:00:00
abstract::The high-lying vibrational states of the magnesium dimer (Mg2), which has been recognized as an important system in studies of ultracold and collisional phenomena, have eluded experimental characterization for half a century. Until now, only the first 14 vibrational states of Mg2 have been experimentally resolved, alt...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay4058
更新日期:2020-04-03 00:00:00
abstract::We have developed a way to map brain-wide networks using focal pulsed infrared neural stimulation in ultrahigh-field magnetic resonance imaging (MRI). The patterns of connections revealed are similar to those of connections previously mapped with anatomical tract tracing methods. These include connections between cort...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau7046
更新日期:2019-04-24 00:00:00
abstract::Peripheral blood mononuclear cells (PBMCs) may provide insight into the pathogenesis of Alzheimer's disease (AD) or Parkinson's disease (PD). We investigated PBMC samples from 132 well-characterized research participants using seven canonical immune stimulants, mass cytometric identification of 35 PBMC subsets, and si...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd5575
更新日期:2020-11-25 00:00:00
abstract::Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, increased expression o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay3704
更新日期:2020-03-20 00:00:00
abstract::Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new histones at the promoters of genes. The role of these histone exchange events in transcription remains unclear. In particular, the causal relationship between histone exchange and activator...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0333
更新日期:2020-09-02 00:00:00
abstract::Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay4045
更新日期:2020-01-24 00:00:00
abstract::Nucleosynthetic isotope variability among solar system objects provides insights into the accretion history of terrestrial planets. We report on the nucleosynthetic Fe isotope composition (μ54Fe) of various meteorites and show that the only material matching the terrestrial composition is CI (Ivuna-type) carbonaceous ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay7604
更新日期:2020-02-12 00:00:00
abstract::A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aax0903
更新日期:2019-07-24 00:00:00
abstract::Using a cell-based assay monitoring differential protein transport in the secretory pathway coupled to high-content screening, we have identified three molecules that specifically reduce the delivery of the major co-receptor for HIV-1, CCR5, to the plasma membrane. They have no effect on the closely related receptors ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax0821
更新日期:2019-10-16 00:00:00
abstract::Cellular cross-talk between ubiquitination and other posttranslational modifications contributes to the regulation of numerous processes. One example is ADP-ribosylation of the carboxyl terminus of ubiquitin by the E3 DTX3L/ADP-ribosyltransferase PARP9 heterodimer, but the mechanism remains elusive. Here, we show that...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc0418
更新日期:2020-09-18 00:00:00
abstract::Regulatory T (Treg) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the Treg cell program. We found that mice deficient in Bcl11b TF solely in Treg cells developed fatal autoimmunity, and Bcl11b-deficient...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0480
更新日期:2019-08-07 00:00:00
abstract::Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tu...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz5216
更新日期:2020-05-20 00:00:00
abstract::Identifying key players in coupled individual systems is a fundamental problem in network theory. We investigate synchronizable network-coupled dynamical systems such as high-voltage electric power grids and coupled oscillators on complex networks. We define key players as nodes that, once perturbed, generate the larg...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw8359
更新日期:2019-11-22 00:00:00
abstract::Wogonin and baicalein are bioactive flavones in the popular Chinese herbal remedy Huang-Qin (Scutellaria baicalensis Georgi). These specialized flavones lack a 4'-hydroxyl group on the B ring (4'-deoxyflavones) and induce apoptosis in a wide spectrum of human tumor cells in vitro and inhibit tumor growth in vivo in di...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501780
更新日期:2016-04-08 00:00:00
abstract::Developing cost-effective, active, and durable electrocatalysts is one of the most important issues for the commercialization of fuel cells. Ultrathin Pt-Mo-Ni nanowires (NWs) with a diameter of ~2.5 nm and lengths of up to several micrometers were synthesized via a H2-assisted solution route (HASR). This catalyst was...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1603068
更新日期:2017-08-30 00:00:00
abstract::Eruptive phenomena at all scales, from hydrothermal geysers to flood basalts, can potentially be initiated or modulated by external mechanical perturbations. We present evidence for the triggering of magmatism on a global scale by the Chicxulub meteorite impact at the Cretaceous-Paleogene (K-Pg) boundary, recorded by ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao2994
更新日期:2018-02-07 00:00:00
abstract::Nitrogen oxides (NO x ) emitted from human activities are believed to regulate the atmospheric oxidation capacity of the troposphere. However, observational evidence is limited for the low-to-median NO x concentrations prevalen...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar2547
更新日期:2018-04-11 00:00:00
abstract::Over the past decade, the Arctic has warmed by 0.75°C, far outpacing the global average, while Antarctic temperatures have remained comparatively stable. As Earth approaches 2°C warming, the Arctic and Antarctic may reach 4°C and 2°C mean annual warming, and 7°C and 3°C winter warming, respectively. Expected consequen...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aaw9883
更新日期:2019-12-04 00:00:00
abstract::The biophysical and biochemical properties of live tissues are important in the context of development and disease. Methods for evaluating these properties typically involve destroying the tissue or require specialized technology and complicated analyses. Here, we present a novel, noninvasive methodology for determini...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5546
更新日期:2020-12-04 00:00:00
abstract::Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown. Here, we show that macrophages centripetally migrate toward the lesion epicenter after inf...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5086
更新日期:2019-05-15 00:00:00
abstract::The paramyxovirus RNA-dependent RNA-polymerase (RdRp) complex loads onto the nucleocapsid protein (N)-encapsidated viral N:RNA genome for RNA synthesis. Binding of the RdRp of measles virus (MeV), a paramyxovirus archetype, is mediated through interaction with a molecular recognition element (MoRE) located near the en...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602350
更新日期:2017-02-03 00:00:00
abstract::Estimating minimum ice volume during the last interglacial based on local sea-level indicators requires that these indicators are corrected for processes that alter local sea level relative to the global average. Although glacial isostatic adjustment is generally accounted for, global scale dynamic changes in topograp...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1700457
更新日期:2017-07-07 00:00:00