Abstract:
:Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new histones at the promoters of genes. The role of these histone exchange events in transcription remains unclear. In particular, the causal relationship between histone exchange and activator binding, preinitiation complex (PIC) assembly, and/or subsequent transcription remains unclear. Here, we provide evidence that histone exchange at gene promoters is not simply a consequence of PIC assembly or transcription but instead is mediated by activators. We further show that not all activators up-regulate gene expression by inducing histone turnover. Thus, histone exchange does not simply correlate with transcriptional activity, but instead reflects the mode of action of the activator. Last, we show that histone turnover is not only associated with activator function but also plays a role in transcriptional repression at the histone loci.
journal_name
Sci Advjournal_title
Science advancesauthors
Kassem S,Ferrari P,Hughes AL,Soudet J,Rando OJ,Strubin Mdoi
10.1126/sciadv.abb0333subject
Has Abstractpub_date
2020-09-02 00:00:00issue
36issn
2375-2548pii
6/36/eabb0333journal_volume
6pub_type
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