Off-axis magmatism along a subaerial back-arc rift: Observations from the Taupo Volcanic Zone, New Zealand.

abstract：:Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients with high-grade serous carcinoma (HGSC) to uncover the metabolomes of these distinct TME compart...

journal_title：Science advances

authors： Kilgour MK,MacPherson S,Zacharias LG,Ellis AE,Sheldon RD,Liu EY,Keyes S,Pauly B,Carleton G,Allard B,Smazynski J,Williams KS,Watson PH,Stagg J,Nelson BH,DeBerardinis RJ,Jones RG,Hamilton PT,Lum JJ

更新日期：2021-01-20 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, litt...

journal_title：Science advances

authors： Qin Y,Chen W,Jiang G,Zhou L,Yang X,Li H,He X,Wang HL,Zhou YB,Huang S,Liu S

更新日期：2020-02-19 00:00:00

abstract：:Meta-regressions of around 1000 cases published over the period 1997-2018 suggest that the direction of the relationship between land area and agricultural performance strongly depends on the performance indicator selected. Net value and efficiency indicators show that larger farms tend to be more performant than smal...

journal_title：Science advances

authors： Garzón Delvaux PA,Riesgo L,Gomez Y Paloma S

更新日期：2020-10-09 00:00:00

abstract：:Concern on the impacts of ocean acidification on calcifiers, such as bivalves, sea urchins, and foraminifers, has led to efforts to understand the controls on pH in their habitats, which include kelp forests and seagrass meadows. The metabolism of these habitats can lead to diel fluctuation in pH with increases during...

journal_title：Science advances

authors： Krause-Jensen D,Marbà N,Sanz-Martin M,Hendriks IE,Thyrring J,Carstensen J,Sejr MK,Duarte CM

更新日期：2016-12-14 00:00:00

abstract：:The paramyxovirus RNA-dependent RNA-polymerase (RdRp) complex loads onto the nucleocapsid protein (N)-encapsidated viral N:RNA genome for RNA synthesis. Binding of the RdRp of measles virus (MeV), a paramyxovirus archetype, is mediated through interaction with a molecular recognition element (MoRE) located near the en...

journal_title：Science advances

authors： Cox RM,Krumm SA,Thakkar VD,Sohn M,Plemper RK

更新日期：2017-02-03 00:00:00

abstract：:Weyl semimetals are of great interest because they provide the first realization of the Weyl fermion, exhibit exotic quantum anomalies, and host Fermi arc surface states. The separation between Weyl nodes of opposite chirality gives a measure of the robustness of the Weyl semimetal state. To exploit the novel phenomen...

journal_title：Science advances

authors： Chang G,Xu SY,Sanchez DS,Huang SM,Lee CC,Chang TR,Bian G,Zheng H,Belopolski I,Alidoust N,Jeng HT,Bansil A,Lin H,Hasan MZ

更新日期：2016-06-24 00:00:00

abstract：:To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...

journal_title：Science advances

authors： Turner TC,Sok MCP,Hymel LA,Pittman FS,York WY,Mac QD,Vyshnya S,Lim HS,Kwong GA,Qiu P,Botchwey EA

更新日期：2020-10-30 00:00:00

abstract：:Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we intro...

journal_title：Science advances

authors： Kim Y,Yoo YK,Kim HY,Roh JH,Kim J,Baek S,Lee JC,Kim HJ,Chae MS,Jeong D,Park D,Lee S,Jang H,Kim K,Lee JH,Byun BH,Park SY,Ha JH,Lee KC,Cho WW,Kim JS,Koh JY,Lim SM,Hwang KS

更新日期：2019-04-17 00:00:00

abstract：:The ongoing conservation treatment program of the Ghent Altarpiece by Hubert and Jan Van Eyck, one of the iconic paintings of the west, has revealed that the designs of the paintings were changed several times, first by the original artists, and then during later restorations. The central motif, The Lamb of God, repre...

journal_title：Science advances

authors： Van der Snickt G,Dooley KA,Sanyova J,Dubois H,Delaney JK,Gifford EM,Legrand S,Laquiere N,Janssens K

更新日期：2020-07-29 00:00:00

abstract：:Neurodegenerative disorders are caused by progressive neuronal loss, and there is no complete treatment available yet. Neuroinflammation is a common feature across neurodegenerative disorders and implicated in the progression of neurodegeneration. Dysregulated activation of microglia causes neuroinflammation and has b...

journal_title：Science advances

authors： Nakano-Kobayashi A,Fukumoto A,Morizane A,Nguyen DT,Le TM,Hashida K,Hosoya T,Takahashi R,Takahashi J,Hori O,Hagiwara M

更新日期：2020-11-13 00:00:00

abstract：:Rising sea levels will have overwhelmingly negative impacts on coastal communities globally. With previous research focused on how sea-level rise (SLR) affects storm-induced flooding, we show that SLR will also increase both the frequency and the intensity of tsunami-induced flooding, another significant coastal hazar...

journal_title：Science advances

authors： Li L,Switzer AD,Wang Y,Chan CH,Qiu Q,Weiss R

更新日期：2018-08-15 00:00:00

abstract：:Sodium/potassium-transporting adenosine triphosphatase (Na+/K+-ATPase) is one of the most abundant cell membrane proteins and is essential for eukaryotes. Endogenous negative regulators have long been postulated to play an important role in regulating the activity and stability of Na+/K+-ATPase, but characterization o...

journal_title：Science advances

authors： Chin AC,Gao Z,Riley AM,Furkert D,Wittwer C,Dutta A,Rojas T,Semenza ER,Felder RA,Pluznick JL,Jessen HJ,Fiedler D,Potter BVL,Snyder SH,Fu C

更新日期：2020-10-28 00:00:00

abstract：:Fractures and faults riddle the Earth's crust on all scales, and the deformation associated with them is presumed to have had significant effects on its petrological and structural evolution. However, despite the abundance of directly observable earthquake activity, unequivocal evidence for seismic slip rates along an...

journal_title：Science advances

authors： Austrheim H,Dunkel KG,Plümper O,Ildefonse B,Liu Y,Jamtveit B

更新日期：2017-02-22 00:00:00

abstract：:Wogonin and baicalein are bioactive flavones in the popular Chinese herbal remedy Huang-Qin (Scutellaria baicalensis Georgi). These specialized flavones lack a 4'-hydroxyl group on the B ring (4'-deoxyflavones) and induce apoptosis in a wide spectrum of human tumor cells in vitro and inhibit tumor growth in vivo in di...

journal_title：Science advances

authors： Zhao Q,Zhang Y,Wang G,Hill L,Weng JK,Chen XY,Xue H,Martin C

更新日期：2016-04-08 00:00:00

abstract：:Using a cell-based assay monitoring differential protein transport in the secretory pathway coupled to high-content screening, we have identified three molecules that specifically reduce the delivery of the major co-receptor for HIV-1, CCR5, to the plasma membrane. They have no effect on the closely related receptors ...

journal_title：Science advances

authors： Boncompain G,Herit F,Tessier S,Lescure A,Del Nery E,Gestraud P,Staropoli I,Fukata Y,Fukata M,Brelot A,Niedergang F,Perez F

更新日期：2019-10-16 00:00:00

abstract：:Development of composite indicators for integrated health in populations typically relies on a priori assumptions rather than model-free, data-driven evidence. Traditional variable selection processes tend not to consider relatedness and redundancy among variables, instead considering only individual correlations. In ...

journal_title：Science advances

authors： Servadio JL,Convertino M

更新日期：2018-02-02 00:00:00

abstract：:Previous breakthroughs in stretchable electronics stem from strain engineering and nanocomposite approaches. Routes toward intrinsically stretchable molecular materials remain scarce but, if successful, will enable simpler fabrication processes, such as direct printing and coating, mechanically robust devices, and mor...

journal_title：Science advances

authors： Wang Y,Zhu C,Pfattner R,Yan H,Jin L,Chen S,Molina-Lopez F,Lissel F,Liu J,Rabiah NI,Chen Z,Chung JW,Linder C,Toney MF,Murmann B,Bao Z

更新日期：2017-03-10 00:00:00

abstract：:Climatic conditions shift gradually over millennia, altering the rates at which carbon (C) is fixed from the atmosphere and stored in the soil. However, legacy impacts of past climates on current soil C stocks are poorly understood. We used data from more than 5000 terrestrial sites from three global and regional data...

journal_title：Science advances

authors： Delgado-Baquerizo M,Eldridge DJ,Maestre FT,Karunaratne SB,Trivedi P,Reich PB,Singh BK

更新日期：2017-04-12 00:00:00

abstract：:Cyclosporine A (CsA) is a powerful immunosuppressant, but it is an ineffective stand-alone treatment for systemic lupus erythematosus (SLE) due to poor target tissue distribution and renal toxicity. We hypothesized that CD71 (transferrin receptor 1)-directed delivery of CsA to the lymphatic system would improve SLE ou...

journal_title：Science advances

authors： Ganugula R,Arora M,Zou D,Agarwal SK,Mohan C,Kumar MNVR

更新日期：2020-06-12 00:00:00

abstract：:Glass-forming ability (GFA) is the ability of a liquid to avoid crystallization during cooling. Metal-organic frameworks (MOFs) are a new class of glass formers (1-3), with hitherto unknown dynamic and thermodynamic properties. We report the discovery of a new series of tetrahedral glass systems, zeolitic imidazolate ...

journal_title：Science advances

authors： Qiao A,Bennett TD,Tao H,Krajnc A,Mali G,Doherty CM,Thornton AW,Mauro JC,Greaves GN,Yue Y

更新日期：2018-03-09 00:00:00

abstract：:Energy band engineering is of fundamental importance in nanoelectronics. Compared to chemical approaches such as doping and surface functionalization, electrical and optical methods provide greater flexibility that enables continuous, reversible, and in situ band tuning on electronic devices of various kinds. In this ...

journal_title：Science advances

authors： Wu E,Xie Y,Zhang J,Zhang H,Hu X,Liu J,Zhou C,Zhang D

更新日期：2019-05-03 00:00:00

abstract：:Nanofluidic platforms offering tunable material transport are applicable in biosensing, chemical detection, and filtration. Prior studies have achieved selective and controllable ion transport through electrical, optical, or chemical gating of complex nanostructures. Here, we mechanically control nanofluidic transport...

journal_title：Science advances

authors： Rabinowitz J,Whittier E,Liu Z,Jayant K,Frank J,Shepard K

更新日期：2020-11-13 00:00:00

abstract：:Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes. However, the effect of physical stressors on the behavior of adipocytes and their cross-talk with tumor cells remain elusive. Here, we demonstrate that compression of cells, resulting f...

journal_title：Science advances

authors： Li Y,Mao AS,Seo BR,Zhao X,Gupta SK,Chen M,Han YL,Shih TY,Mooney DJ,Guo M

更新日期：2020-01-22 00:00:00

abstract：:Skin-mountable microelectronics are garnering substantial interest for various promising applications including human-machine interfaces, biointegrated devices, and personalized medicine. However, it remains a critical challenge to develop e-skins to mimic the human somatosensory system in full working range. Here, we...

journal_title：Science advances

authors： Cai Y,Shen J,Yang CW,Wan Y,Tang HL,Aljarb AA,Chen C,Fu JH,Wei X,Huang KW,Han Y,Jonas SJ,Dong X,Tung V

更新日期：2020-11-27 00:00:00

abstract：:[This corrects the article e1602026 in vol. 3, PMID: 28246641.]. ...

journal_title：Science advances

authors：

更新日期：2017-09-29 00:00:00

abstract：:Large earthquakes occur in rocks undergoing high-pressure/low-temperature metamorphism during subduction. Rhythmic major-element zoning in garnet is a common product of such metamorphism, and one that must record a fundamental subduction process. We argue that rhythmic major-element zoning in subduction zone garnets f...

journal_title：Science advances

authors： Viete DR,Hacker BR,Allen MB,Seward GGE,Tobin MJ,Kelley CS,Cinque G,Duckworth AR

更新日期：2018-03-21 00:00:00

abstract：:The structural hierarchy exhibited by materials on more than one length scale can play a major part in determining bulk material properties. Understanding the hierarchical structure can lead to new materials with physical properties tailored for specific applications. We have used a combined experimental and phase-fie...

journal_title：Science advances

authors： Meher S,Aagesen LK,Carroll MC,Pollock TM,Carroll LJ

更新日期：2018-11-16 00:00:00

abstract：:Reef-building corals form their calcium carbonate skeletons within an extracellular calcifying medium (ECM). Despite the critical role of the ECM in coral calcification, ECM carbonate chemistry is poorly constrained in vivo, and full ECM carbonate chemistry has never been characterized based solely on direct in vivo m...

journal_title：Science advances

authors： Sevilgen DS,Venn AA,Hu MY,Tambutté E,de Beer D,Planas-Bielsa V,Tambutté S

更新日期：2019-01-16 00:00:00

abstract：:Dynamic modulation of soft helix in terms of the molecular organization, handedness, and pitch length could result in a sophisticated control over its functions, opening numerous possibilities toward the exploration of previously unidentified applications. Here, we report a dynamic and reversible transformation of a s...

journal_title：Science advances

authors： Yuan CL,Huang W,Zheng ZG,Liu B,Bisoyi HK,Li Y,Shen D,Lu Y,Li Q

更新日期：2019-10-04 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neuro...

journal_title：Science advances

authors： Siddig S,Aufmkolk S,Doose S,Jobin ML,Werner C,Sauer M,Calebiro D

更新日期：2020-04-15 00:00:00