Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy.

abstract：:Honeybees use the waggle dance to share information about food-site locations with nestmates. However, the importance of this behavior in colony foraging success remains unclear. We tested whether spatial dance information affects colony foraging success in a human-modified temperate environment by comparing colonies ...

journal_title：Science advances

authors： I'Anson Price R,Dulex N,Vial N,Vincent C,Grüter C

更新日期：2019-02-13 00:00:00

abstract：:Spatial patterns of gene expression in living organisms orchestrate cell decisions in development, homeostasis, and disease. However, most methods for reconstructing gene patterning in 3D cell culture and artificial tissues are restricted by patterning depth and scale. We introduce a depth- and scale-flexible method t...

journal_title：Science advances

authors： Corbett DC,Fabyan WB,Grigoryan B,O'Connor CE,Johansson F,Batalov I,Regier MC,DeForest CA,Miller JS,Stevens KR

更新日期：2020-09-30 00:00:00

abstract：:Iron deficiency and anemia are prominent contributors to the preventable disease burden worldwide. A substantial proportion of people with inadequate dietary iron rely on rice as a staple food, but fortification efforts are limited by low iron bioavailability. Furthermore, using high iron fortification dosages may not...

journal_title：Science advances

authors： Hackl LS,Abizari AR,Speich C,Zungbey-Garti H,Cercamondi CI,Zeder C,Zimmermann MB,Moretti D

更新日期：2019-03-27 00:00:00

abstract：:Dirac materials such as graphene and topological insulators (TIs) are known to have unique electronic and spintronic properties. We combine graphene with TIs in van der Waals heterostructures to demonstrate the emergence of a strong proximity-induced spin-orbit coupling in graphene. By performing spin transport and pr...

journal_title：Science advances

authors： Khokhriakov D,Cummings AW,Song K,Vila M,Karpiak B,Dankert A,Roche S,Dash SP

更新日期：2018-09-21 00:00:00

abstract：:The role of sialyloligosaccharides on the surface of secreted glycoproteins is still unclear because of the difficulty in the preparation of sialylglycoproteins in a homogeneous form. We selected erythropoietin (EPO) as a target molecule and designed an efficient synthetic strategy for the chemical synthesis of a homo...

journal_title：Science advances

authors： Murakami M,Kiuchi T,Nishihara M,Tezuka K,Okamoto R,Izumi M,Kajihara Y

更新日期：2016-01-15 00:00:00

abstract：:Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS-targeting IgG antibody, inRas37, which directly targets the intracellularly activated form of various...

journal_title：Science advances

authors： Shin SM,Kim JS,Park SW,Jun SY,Kweon HJ,Choi DK,Lee D,Cho YB,Kim YS

更新日期：2020-01-15 00:00:00

abstract：:We reveal an intriguing manifestation of topology, which appears in the depletion rate of topological states of matter in response to an external drive. This phenomenon is presented by analyzing the response of a generic two-dimensional (2D) Chern insulator subjected to a circular time-periodic perturbation. Because o...

journal_title：Science advances

authors： Tran DT,Dauphin A,Grushin AG,Zoller P,Goldman N

更新日期：2017-08-18 00:00:00

abstract：:Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passively (i.e., no killing effect). We screened hundreds of (meth)acrylate polymers in high thro...

journal_title：Science advances

authors： Vallieres C,Hook AL,He Y,Crucitti VC,Figueredo G,Davies CR,Burroughs L,Winkler DA,Wildman RD,Irvine DJ,Alexander MR,Avery SV

更新日期：2020-06-05 00:00:00

abstract：:Sedimentary hydrocarbon remnants of eukaryotic C26-C30 sterols can be used to reconstruct early algal evolution. Enhanced C29 sterol abundances provide algal cell membranes a density advantage in large temperature fluctuations. Here, we combined a literature review with new analyses to generate a comprehensive invento...

journal_title：Science advances

authors： Hoshino Y,Poshibaeva A,Meredith W,Snape C,Poshibaev V,Versteegh GJM,Kuznetsov N,Leider A,van Maldegem L,Neumann M,Naeher S,Moczydłowska M,Brocks JJ,Jarrett AJM,Tang Q,Xiao S,McKirdy D,Das SK,Alvaro JJ,Sansjofre P,

更新日期：2017-09-20 00:00:00

abstract：:After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorde...

journal_title：Science advances

authors： Wright JL,Wasef S,Heupink TH,Westaway MC,Rasmussen S,Pardoe C,Fourmile GG,Young M,Johnson T,Slade J,Kennedy R,Winch P,Pappin M Sr,Wales T,Bates WB,Hamilton S,Whyman N,van Holst Pellekaan S,McAllister PJ,Taçon PSC,

更新日期：2018-12-19 00:00:00

abstract：:Amorphous solids, such as glasses, have complex responses to deformations, with substantial consequences in material design and applications. In this respect, two intertwined aspects are important: stability and reversibility. It is crucial to understand, on the one hand, how a glass may become unstable due to increas...

journal_title：Science advances

authors： Jin Y,Urbani P,Zamponi F,Yoshino H

更新日期：2018-12-07 00:00:00

abstract：:The exceptionally long quantum coherence times of phosphorus donor nuclear spin qubits in silicon, coupled with the proven scalability of silicon-based nano-electronics, make them attractive candidates for large-scale quantum computing. However, the high threshold of topological quantum error correction can only be ca...

journal_title：Science advances

authors： Hill CD,Peretz E,Hile SJ,House MG,Fuechsle M,Rogge S,Simmons MY,Hollenberg LC

更新日期：2015-10-30 00:00:00

abstract：:To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host receptors. Many nAbs bin...

journal_title：Science advances

authors： Tzarum N,Giang E,Kadam RU,Chen F,Nagy K,Augestad EH,Velázquez-Moctezuma R,Keck ZY,Hua Y,Stanfield RL,Dreux M,Prentoe J,Foung SKH,Bukh J,Wilson IA,Law M

更新日期：2020-07-24 00:00:00

abstract：:Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lact...

journal_title：Science advances

authors： Lee H,Song C,Hong YS,Kim MS,Cho HR,Kang T,Shin K,Choi SH,Hyeon T,Kim DH

更新日期：2017-03-08 00:00:00

abstract：:Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by elect...

journal_title：Science advances

authors： Wang J,Yu J,Zhang Y,Zhang X,Kahkoska AR,Chen G,Wang Z,Sun W,Cai L,Chen Z,Qian C,Shen Q,Khademhosseini A,Buse JB,Gu Z

更新日期：2019-07-10 00:00:00

abstract：:In 2018-2019, New York City experienced the largest measles outbreak in the United States in nearly three decades. To identify key contributing factors, we modeled the transmission dynamics of this outbreak. Results indicate that delayed vaccination of 1- to 4-year-olds enabled the initial spread and that increased in...

journal_title：Science advances

authors： Yang W

更新日期：2020-05-27 00:00:00

abstract：:The natural selection and the evolutionary optimization of complex shapes in nature are closely related to their functions. Mechanostabilization of shape of biological structure via morphogenesis has several beautiful examples. With the help of simple mechanics-based modeling and experiments, we show an important caus...

journal_title：Science advances

authors： Tiwary CS,Kishore S,Sarkar S,Mahapatra DR,Ajayan PM,Chattopadhyay K

更新日期：2015-05-15 00:00:00

abstract：:The structural hierarchy exhibited by materials on more than one length scale can play a major part in determining bulk material properties. Understanding the hierarchical structure can lead to new materials with physical properties tailored for specific applications. We have used a combined experimental and phase-fie...

journal_title：Science advances

authors： Meher S,Aagesen LK,Carroll MC,Pollock TM,Carroll LJ

更新日期：2018-11-16 00:00:00

abstract：:Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report me...

journal_title：Science advances

authors： Zhang H,Hou J,Hu Y,Wang P,Ou R,Jiang L,Liu JZ,Freeman BD,Hill AJ,Wang H

更新日期：2018-02-09 00:00:00

abstract：:Two-dimensional (2D) layered hybrid organic-inorganic halide perovskite semiconductors form natural "multiple quantum wells" that have strong spin-orbit coupling due to the heavy elements in their building blocks. This may lead to "Rashba splitting" close to the extrema in the electron bands. We have used a plethora o...

journal_title：Science advances

authors： Zhai Y,Baniya S,Zhang C,Li J,Haney P,Sheng CX,Ehrenfreund E,Vardeny ZV

更新日期：2017-07-28 00:00:00

abstract：:Injection-induced earthquakes pose a serious seismic hazard but also offer an opportunity to gain insight into earthquake physics. Currently used models relating the maximum magnitude of injection-induced earthquakes to injection parameters do not incorporate rupture physics. We develop theoretical estimates, validate...

journal_title：Science advances

authors： Galis M,Ampuero JP,Mai PM,Cappa F

更新日期：2017-12-20 00:00:00

abstract：:A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such a motif represents current repertoire of viral fusion inhibitors. Here, we report that triterpenoids, a class of natural products, antagonize this trimer-of-hairpins via its ...

journal_title：Science advances

authors： Si L,Meng K,Tian Z,Sun J,Li H,Zhang Z,Soloveva V,Li H,Fu G,Xia Q,Xiao S,Zhang L,Zhou D

更新日期：2018-11-21 00:00:00

abstract：:To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...

journal_title：Science advances

authors： Turner TC,Sok MCP,Hymel LA,Pittman FS,York WY,Mac QD,Vyshnya S,Lim HS,Kwong GA,Qiu P,Botchwey EA

更新日期：2020-10-30 00:00:00

abstract：:Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that a...

journal_title：Science advances

authors： Schneider CS,Xu Q,Boylan NJ,Chisholm J,Tang BC,Schuster BS,Henning A,Ensign LM,Lee E,Adstamongkonkul P,Simons BW,Wang SS,Gong X,Yu T,Boyle MP,Suk JS,Hanes J

更新日期：2017-04-05 00:00:00

abstract：:Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography-based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and re...

journal_title：Science advances

authors： Javaheri B,Razi H,Gohin S,Wylie S,Chang YM,Salmon P,Lee PD,Pitsillides AA

更新日期：2020-03-06 00:00:00

abstract：:Changes in the Atlantic Meridional Overturning Circulation (AMOC) are moderate in most climate model projections under increasing greenhouse gas forcing. This intermodel consensus may be an artifact of common model biases that favor a stable AMOC. Observationally based freshwater budget analyses suggest that the AMOC ...

journal_title：Science advances

authors： Liu W,Xie SP,Liu Z,Zhu J

更新日期：2017-01-04 00:00:00

abstract：:Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard...

journal_title：Science advances

authors： Castle MJ,Cheng Y,Asokan A,Tuszynski MH

更新日期：2018-11-14 00:00:00

abstract：:The response to programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) blockade in cancer immunotherapy is limited because of multiple immune evasion mechanisms. Here, a previously unknown strategy is proposed to synergize the nuclear factor κB (NF-κB) inhibition and PD-1 blockade for antitumor immun...

journal_title：Science advances

authors： Xiao Z,Su Z,Han S,Huang J,Lin L,Shuai X

更新日期：2020-02-05 00:00:00

abstract：:The human gut microbiota established during infancy has persistent effects on health. In vitro studies have suggested that human milk oligosaccharides (HMOs) in breast milk promote the formation of a bifidobacteria-rich microbiota in infant guts; however, the underlying molecular mechanism remains elusive. Here, we ch...

journal_title：Science advances

authors： Sakanaka M,Hansen ME,Gotoh A,Katoh T,Yoshida K,Odamaki T,Yachi H,Sugiyama Y,Kurihara S,Hirose J,Urashima T,Xiao JZ,Kitaoka M,Fukiya S,Yokota A,Lo Leggio L,Abou Hachem M,Katayama T

更新日期：2019-08-28 00:00:00

abstract：:Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown. Here, we show that macrophages centripetally migrate toward the lesion epicenter after inf...

journal_title：Science advances

authors： Kobayakawa K,Ohkawa Y,Yoshizaki S,Tamaru T,Saito T,Kijima K,Yokota K,Hara M,Kubota K,Matsumoto Y,Harimaya K,Ozato K,Masuda T,Tsuda M,Tamura T,Inoue K,Edgerton VR,Iwamoto Y,Nakashima Y,Okada S

更新日期：2019-05-15 00:00:00