Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration.

abstract：:NSF (N-ethylmaleimide-sensitive factor) and α-SNAP (α-soluble NSF attachment protein) bind to the SNARE (soluble NSF attachment protein receptor) complex, the minimum machinery to mediate membrane fusion, to form a 20S complex, which disassembles the SNARE complex for reuse. We report the cryo-EM structures of the α-S...

journal_title：Science advances

authors： Huang X,Sun S,Wang X,Fan F,Zhou Q,Lu S,Cao Y,Wang QW,Dong MQ,Yao J,Sui SF

更新日期：2019-04-10 00:00:00

abstract：:Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric mucosa using its outer membrane protein BabA. Structural information for BabA has been elusive, and thus, it...

journal_title：Science advances

authors： Hage N,Howard T,Phillips C,Brassington C,Overman R,Debreczeni J,Gellert P,Stolnik S,Winkler GS,Falcone FH

更新日期：2015-08-14 00:00:00

abstract：:Understanding the precise atomic structure of ice surfaces is critical for revealing the mechanisms of physical and chemical phenomena at the surfaces, such as ice growth, melting, and chemical reactions. Nevertheless, no conclusive structure has been established. In this study, noncontact atomic force microscopy was ...

journal_title：Science advances

authors： Kawakami N,Iwata K,Shiotari A,Sugimoto Y

更新日期：2020-09-11 00:00:00

abstract：:Resistances that exceed the Mott-Ioffe-Regel limit (known as bad metal behavior) and non-Fermi liquid behavior are ubiquitous features of the normal state of many strongly correlated materials. We establish the conditions that lead to bad metal and non-Fermi liquid phases in NdNiO3, which exhibits a prototype bandwidt...

journal_title：Science advances

authors： Mikheev E,Hauser AJ,Himmetoglu B,Moreno NE,Janotti A,Van de Walle CG,Stemmer S

更新日期：2015-11-06 00:00:00

abstract：:Rising sea levels will have overwhelmingly negative impacts on coastal communities globally. With previous research focused on how sea-level rise (SLR) affects storm-induced flooding, we show that SLR will also increase both the frequency and the intensity of tsunami-induced flooding, another significant coastal hazar...

journal_title：Science advances

authors： Li L,Switzer AD,Wang Y,Chan CH,Qiu Q,Weiss R

更新日期：2018-08-15 00:00:00

abstract：:Rising temperatures in the Arctic Ocean region are responsible for changes such as reduced ice cover, permafrost thawing, and increased river discharge, which, together, alter nutrient and carbon cycles over the vast Arctic continental shelf. We show that the concentration of radium-228, sourced to seawater through se...

journal_title：Science advances

authors： Kipp LE,Charette MA,Moore WS,Henderson PB,Rigor IG

更新日期：2018-01-03 00:00:00

abstract：:The mammalian retina system consists of a complicated photoreceptor structure, which exhibits extensive random synaptic connections. To study retinal development and degeneration, various experimental models have been used previously, but these models are often uncontrollable, are difficult to manipulate, and do not p...

journal_title：Science advances

authors： Ma Y,Han X,de Castro RB,Zhang P,Zhang K,Hu Z,Qin L

更新日期：2018-05-09 00:00:00

abstract：:Forest loss is one of the most pervasive land surface transformations on Earth, with drastic effects on global climate, ecosystems, and human well-being. As part of biodiversity conservation and climate change mitigation efforts, many countries, including China, have been implementing large-scale policies to conserve ...

journal_title：Science advances

authors： Viña A,McConnell WJ,Yang H,Xu Z,Liu J

更新日期：2016-03-18 00:00:00

abstract：:Demyelinating diseases involve loss of myelin sheaths and eventually lead to neurological problems. Unfortunately, the precise mechanisms remain unknown, and there are no effective therapies. To overcome these limitations, a reliable and physiologically relevant in vitro model is required. Here, we present a three-dim...

journal_title：Science advances

authors： Hyung S,Lee SR,Kim J,Kim Y,Kim S,Kim HN,Jeon NL

更新日期：2021-01-29 00:00:00

abstract：:Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities that can alter their function in response to environmental cues. In the present study, we report an engineered p...

journal_title：Science advances

authors： Shields CW 4th,Evans MA,Wang LL,Baugh N,Iyer S,Wu D,Zhao Z,Pusuluri A,Ukidve A,Pan DC,Mitragotri S

更新日期：2020-04-29 00:00:00

abstract：:We report a negative resistance, namely, a voltage drop along the opposite direction of a current flow, in the superconducting gap of NbSe2 thin films under the irradiation of surface acoustic waves (SAWs). The amplitude of the negative resistance becomes larger by increasing the SAW power and decreasing temperature. ...

journal_title：Science advances

authors： Yokoi M,Fujiwara S,Kawamura T,Arakawa T,Aoyama K,Fukuyama H,Kobayashi K,Niimi Y

更新日期：2020-08-21 00:00:00

abstract：:Protected areas (PAs) are essential to biodiversity conservation, but their static boundaries may undermine their potential for protecting species under climate change. We assessed how the climatic conditions within global terrestrial PAs may change over time. By 2070, protection is expected to decline in cold and war...

journal_title：Science advances

authors： Elsen PR,Monahan WB,Dougherty ER,Merenlender AM

更新日期：2020-06-17 00:00:00

abstract：:Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...

journal_title：Science advances

authors： Wang L,Yu C,Chang T,Zhang M,Song S,Xiong C,Su P,Xiang W

更新日期：2020-05-22 00:00:00

abstract：:Mobile genetic elements, such as human endogenous retroviruses (HERVs), produce proteins that regulate brain cell functions and synaptic transmission and have been implicated in the etiology of neurological and neurodevelopmental psychiatric disorders. However, the mechanisms by which these proteins of retroviral orig...

journal_title：Science advances

authors： Johansson EM,Bouchet D,Tamouza R,Ellul P,Morr AS,Avignone E,Germi R,Leboyer M,Perron H,Groc L

更新日期：2020-07-17 00:00:00

abstract：:The human transfer RNA methyltransferase 9-like gene (TRM9L, also known as KIAA1456) encodes a negative regulator of tumor growth that is frequently silenced in many forms of cancer. While TRM9L can inhibit tumor cell growth in vivo, the molecular mechanisms underlying the tumor inhibition activity of TRM9L are unknow...

journal_title：Science advances

authors： Gu C,Ramos J,Begley U,Dedon PC,Fu D,Begley TJ

更新日期：2018-07-11 00:00:00

abstract：:In a recent paper, Lechner, Hauke, and Zoller (LHZ) described a means to translate a Hamiltonian of N spin-1/2 particles with "all-to-all" interactions into a larger physical lattice with only on-site energies and local parity constraints. LHZ used this mapping to propose a novel form of quantum annealing. We provide ...

journal_title：Science advances

authors： Rocchetto A,Benjamin SC,Li Y

更新日期：2016-10-21 00:00:00

abstract：:Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. Gene expression and DNA methylation ...

journal_title：Science advances

authors： Salvadores M,Fuster-Tormo F,Supek F

更新日期：2020-07-01 00:00:00

abstract：:Association of peripheral proteins with lipid bilayers regulates membrane signaling and dynamics. Pleckstrin homology (PH) domains bind to phosphatidylinositol phosphate (PIP) molecules in membranes. The effects of local PIP enrichment on the interaction of PH domains with membranes is unclear. Molecular dynamics simu...

journal_title：Science advances

authors： Yamamoto E,Domański J,Naughton FB,Best RB,Kalli AC,Stansfeld PJ,Sansom MSP

更新日期：2020-02-19 00:00:00

abstract：:The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote...

journal_title：Science advances

authors： Hu S,Li Z,Lutz H,Huang K,Su T,Cores J,Dinh PC,Cheng K

更新日期：2020-07-24 00:00:00

abstract：:Superomniphobic textures are at the frontier of surface design for vast arrays of applications. Despite recent substantial advances in fabrication methods for reentrant and doubly reentrant microstructures, design optimization remains a major challenge. We overcome this in two stages. First, we develop readily general...

journal_title：Science advances

authors： Panter JR,Gizaw Y,Kusumaatmaja H

更新日期：2019-06-21 00:00:00

abstract：:Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn-[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable of transforming...

journal_title：Science advances

authors： Liu Y,Cheng Y,Zhang H,Zhou M,Yu Y,Lin S,Jiang B,Zhao X,Miao L,Wei CW,Liu Q,Lin YW,Du Y,Butch CJ,Wei H

更新日期：2020-07-17 00:00:00

abstract：:Fibrosis, characterized by aberrant tissue scarring from activated myofibroblasts, is often untreatable. Although the extracellular matrix becomes increasingly stiff and fibrous during disease progression, how these physical cues affect myofibroblast differentiation in 3D is poorly understood. Here, we describe a mult...

journal_title：Science advances

authors： Matera DL,DiLillo KM,Smith MR,Davidson CD,Parikh R,Said M,Wilke CA,Lombaert IM,Arnold KB,Moore BB,Baker BM

更新日期：2020-09-09 00:00:00

abstract：:Ornithine transcarbamylase (OTC) deficiency is an X-linked urea cycle disorder associated with high mortality. Although a promising treatment for late-onset OTC deficiency, adeno-associated virus (AAV) neonatal gene therapy would only provide short-term therapeutic effects as the non-integrated genome gets lost during...

journal_title：Science advances

authors： Wang L,Yang Y,Breton C,Bell P,Li M,Zhang J,Che Y,Saveliev A,He Z,White J,Latshaw C,Xu C,McMenamin D,Yu H,Morizono H,Batshaw ML,Wilson JM

更新日期：2020-02-12 00:00:00

abstract：:Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transcriptomes of Drosophila melanogaster (w1118 ) and 141 Drosophila...

journal_title：Science advances

authors： Litovchenko M,Meireles-Filho ACA,Frochaux MV,Bevers RPJ,Prunotto A,Anduaga AM,Hollis B,Gardeux V,Braman VS,Russeil JMC,Kadener S,Dal Peraro M,Deplancke B

更新日期：2021-01-29 00:00:00

abstract：:Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that causes genome reprogramming through remodeling of enhancers. Here, we describe an unexpected function of RING1B, which is highly expressed in EwS. ...

journal_title：Science advances

authors： Sánchez-Molina S,Figuerola-Bou E,Blanco E,Sánchez-Jiménez M,Táboas P,Gómez S,Ballaré C,García-Domínguez DJ,Prada E,Hontecillas-Prieto L,M Carcaboso Á,Tirado ÓM,Hernández-Muñoz I,de Álava E,Lavarino C,Di Croce L,Mora J

更新日期：2020-10-23 00:00:00

abstract：:Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desatu...

journal_title：Science advances

authors： Kabeya N,Fonseca MM,Ferrier DEK,Navarro JC,Bay LK,Francis DS,Tocher DR,Castro LFC,Monroig Ó

更新日期：2018-05-02 00:00:00

abstract：:The essence of turbulent flow is the conveyance of energy through the formation, interaction, and destruction of eddies over a wide range of spatial scales-from the largest scales where energy is injected down to the smallest scales where it is dissipated through viscosity. Currently, there is no mechanistic framework...

journal_title：Science advances

authors： McKeown R,Ostilla-Mónico R,Pumir A,Brenner MP,Rubinstein SM

更新日期：2020-02-28 00:00:00

abstract：:Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the deve...

journal_title：Science advances

authors： Liang Z,Zhang S,Li X,Wang T,Huang Y,Hang W,Yang Z,Li J,Tian Z

更新日期：2017-12-08 00:00:00

abstract：:Efforts at altering the dismal prognosis of pediatric midline gliomas focus on direct delivery strategies like convection-enhanced delivery (CED), where a cannula is implanted into tumor. Successful CED treatments require confirmation of tumor coverage, dosimetry, and longitudinal in vivo pharmacokinetic monitoring. T...

journal_title：Science advances

authors： Tosi U,Kommidi H,Adeuyan O,Guo H,Maachani UB,Chen N,Su T,Zhang G,Pisapia DJ,Dahmane N,Ting R,Souweidane MM

更新日期：2020-07-24 00:00:00

abstract：:Changes in the Atlantic Meridional Overturning Circulation (AMOC) are moderate in most climate model projections under increasing greenhouse gas forcing. This intermodel consensus may be an artifact of common model biases that favor a stable AMOC. Observationally based freshwater budget analyses suggest that the AMOC ...

journal_title：Science advances

authors： Liu W,Xie SP,Liu Z,Zhu J

更新日期：2017-01-04 00:00:00