Structural basis of Lewis(b) antigen binding by the Helicobacter pylori adhesin BabA.

abstract：:Calcium homeostasis modulator 1 (CALHM1) is a voltage-gated ATP release channel that plays an important role in neural gustatory signaling and the pathogenesis of Alzheimer's disease. Here, we present a cryo-electron microscopy structure of full-length Ca2+-free CALHM1 from Danio rerio at an overall resolution of 3.1 ...

journal_title：Science advances

authors： Ren Y,Wen T,Xi Z,Li S,Lu J,Zhang X,Yang X,Shen Y

更新日期：2020-07-17 00:00:00

abstract：:Bioacoustic networks could vastly expand the coverage of wildlife monitoring to complement satellite observations of climate and vegetation. This approach would enable global-scale understanding of how climate change influences phenomena such as migratory timing of avian species. The enormous data sets that autonomous...

journal_title：Science advances

authors： Oliver RY,Ellis DPW,Chmura HE,Krause JS,Pérez JH,Sweet SK,Gough L,Wingfield JC,Boelman NT

更新日期：2018-06-20 00:00:00

abstract：:Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with uniqu...

journal_title：Science advances

authors： Lee J,Liu Z,Suzuki PH,Ahrens JF,Lai S,Lu X,Guan S,St-Pierre F

更新日期：2020-10-23 00:00:00

abstract：:Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits the development of effective treatments for CNS disorders. We present the facile synthesis of a novel neuroinflammation-targeting polyethylene glycol-based dendrimer (PEGOL-60) using an efficient click chemistry approach. PEGOL-6...

journal_title：Science advances

authors： Sharma A,Sharma R,Zhang Z,Liaw K,Kambhampati SP,Porterfield JE,Lin KC,DeRidder LB,Kannan S,Kannan RM

更新日期：2020-01-22 00:00:00

abstract：:We review recent advances in our understanding of magnetism in the solar nebula and protoplanetary disks (PPDs). We discuss the implications of theory, meteorite measurements, and astronomical observations for planetary formation and nebular evolution. Paleomagnetic measurements indicate the presence of fields of 0.54...

journal_title：Science advances

authors： Weiss BP,Bai XN,Fu RR

更新日期：2021-01-01 00:00:00

abstract：:Recently, the complexity behind manipulations of reflected fields by metasurfaces has been addressed, showing that, even in the simplest scenarios, nonlocal response and excitation of auxiliary evanescent fields are required for perfect field control. In this work, we introduce purely local reflective metasurfaces for...

journal_title：Science advances

authors： Díaz-Rubio A,Li J,Shen C,Cummer SA,Tretyakov SA

更新日期：2019-02-15 00:00:00

abstract：:The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend against environmental insults. While studies have shown that smoking alters bronchial epithelial function and morphology, its precise effects on specific cell types and overall tissue composition are unclear. We used si...

journal_title：Science advances

authors： Duclos GE,Teixeira VH,Autissier P,Gesthalter YB,Reinders-Luinge MA,Terrano R,Dumas YM,Liu G,Mazzilli SA,Brandsma CA,van den Berge M,Janes SM,Timens W,Lenburg ME,Spira A,Campbell JD,Beane J

更新日期：2019-12-11 00:00:00

abstract：:High-entropy alloys exhibit exceptional mechanical properties at cryogenic temperatures, due to the activation of twinning in addition to dislocation slip. The coexistence of multiple deformation pathways raises an important question regarding how individual deformation mechanisms compete or synergize during plastic d...

journal_title：Science advances

authors： Naeem M,He H,Zhang F,Huang H,Harjo S,Kawasaki T,Wang B,Lan S,Wu Z,Wang F,Wu Y,Lu Z,Zhang Z,Liu CT,Wang XL

更新日期：2020-03-27 00:00:00

abstract：:Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...

journal_title：Science advances

authors： Chen H,Lin J,Kang J,Kong Q,Lu D,Kang J,Lai M,Quan LN,Lin Z,Jin J,Wang LW,Toney MF,Yang P

更新日期：2020-01-24 00:00:00

abstract：:Many applications in modern technology, such as self-cleaning surfaces and digital microfluidics, require control over individual fluid droplets on flat surfaces. Existing techniques may suffer from side effects resulting from high electric fields and high temperatures. Here, we introduce a markedly different method, ...

journal_title：Science advances

authors： De Jong E,Wang Y,Den Toonder JMJ,Onck PR

更新日期：2019-06-14 00:00:00

abstract：:We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug deli...

journal_title：Science advances

authors： Magdanz V,Khalil ISM,Simmchen J,Furtado GP,Mohanty S,Gebauer J,Xu H,Klingner A,Aziz A,Medina-Sánchez M,Schmidt OG,Misra S

更新日期：2020-07-08 00:00:00

abstract：:Perovskite oxides with poor conductivity call for three-dimensional (3D) conductive scaffolds to demonstrate their superb reactivities for oxygen evolution reaction (OER). However, perovskite formation usually requires high-temperature annealing at 600° to 900°C in air, under which most of the used conductive framewor...

journal_title：Science advances

authors： Li BQ,Tang C,Wang HF,Zhu XL,Zhang Q

更新日期：2016-10-21 00:00:00

abstract：:Mineral exploitation has spread from land to shallow coastal waters and is now planned for the offshore, deep seabed. Large seafloor areas are being approved for exploration for seafloor mineral deposits, creating an urgent need for regional environmental management plans. Networks of areas where mining and mining imp...

journal_title：Science advances

authors： Dunn DC,Van Dover CL,Etter RJ,Smith CR,Levin LA,Morato T,Colaço A,Dale AC,Gebruk AV,Gjerde KM,Halpin PN,Howell KL,Johnson D,Perez JAA,Ribeiro MC,Stuckas H,Weaver P,SEMPIA Workshop Participants.

更新日期：2018-07-04 00:00:00

abstract：:We studied a bilayer system hosting two-dimensional electron systems (2DESs) in close proximity but isolated from one another by a thin barrier. One 2DES has low electron density and forms a Wigner solid (WS) at high magnetic fields. The other has much higher density and, in the same field, exhibits fractional quantum...

journal_title：Science advances

authors： Hatke AT,Deng H,Liu Y,Engel LW,Pfeiffer LN,West KW,Baldwin KW,Shayegan M

更新日期：2019-03-15 00:00:00

abstract：:Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previ...

journal_title：Science advances

authors： Brödel AK,Rodrigues R,Jaramillo A,Isalan M

更新日期：2020-06-10 00:00:00

abstract：:Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex. At the surface of endosomes, the WASH complex activates the Arp2/3 complex and interacts with the capping protein for unclear reasons. Here, we show that the WASH complex interacts with dynactin and uncaps it through ...

journal_title：Science advances

authors： Fokin AI,David V,Oguievetskaia K,Derivery E,Stone CE,Cao L,Rocques N,Molinie N,Henriot V,Aumont-Nicaise M,Hinckelmann MV,Saudou F,Le Clainche C,Carter AP,Romet-Lemonne G,Gautreau AM

更新日期：2021-01-13 00:00:00

abstract：:Human sleep is highly regulated by temperature. Might climate change-through increases in nighttime heat-disrupt sleep in the future? We conduct the inaugural investigation of the relationship between climatic anomalies, reports of insufficient sleep, and projected climate change. Using data from 765,000 U.S. survey r...

journal_title：Science advances

authors： Obradovich N,Migliorini R,Mednick SC,Fowler JH

更新日期：2017-05-26 00:00:00

abstract：:Metal-organic frameworks (MOFs) have been attracting intensive attention because of their commendable potential in many applications. Postsynthetic modification for redesigning chemical characteristics and pore structures can greatly improve performance and expand functionality of MOF materials. Here, we develop a ver...

journal_title：Science advances

authors： Wu W,Su J,Jia M,Li Z,Liu G,Li W

更新日期：2020-05-01 00:00:00

abstract：:Declines in commercial landings and increases in fishing fleet power have raised concerns over the continued provisioning of nutritional and economic services by tropical wild fisheries. Yet, because tropical fisheries are often data-poor, mechanisms that might buffer fishers to declines are not understood. This data ...

journal_title：Science advances

authors： Robinson JPW,Robinson J,Gerry C,Govinden R,Freshwater C,Graham NAJ

更新日期：2020-02-21 00:00:00

abstract：:Reef-building corals form their calcium carbonate skeletons within an extracellular calcifying medium (ECM). Despite the critical role of the ECM in coral calcification, ECM carbonate chemistry is poorly constrained in vivo, and full ECM carbonate chemistry has never been characterized based solely on direct in vivo m...

journal_title：Science advances

authors： Sevilgen DS,Venn AA,Hu MY,Tambutté E,de Beer D,Planas-Bielsa V,Tambutté S

更新日期：2019-01-16 00:00:00

abstract：:Two-dimensional (2D) polymers hold great promise in the rational materials design tailored for next-generation applications. However, little is known about the grain boundaries in 2D polymers, not to mention their formation mechanisms and potential influences on the material's functionalities. Using aberration-correct...

journal_title：Science advances

authors： Qi H,Sahabudeen H,Liang B,Položij M,Addicoat MA,Gorelik TE,Hambsch M,Mundszinger M,Park S,Lotsch BV,Mannsfeld SCB,Zheng Z,Dong R,Heine T,Feng X,Kaiser U

更新日期：2020-08-14 00:00:00

abstract：:Honeybees use the waggle dance to share information about food-site locations with nestmates. However, the importance of this behavior in colony foraging success remains unclear. We tested whether spatial dance information affects colony foraging success in a human-modified temperate environment by comparing colonies ...

journal_title：Science advances

authors： I'Anson Price R,Dulex N,Vial N,Vincent C,Grüter C

更新日期：2019-02-13 00:00:00

abstract：:Vertical stacking is widely viewed as a promising approach for designing advanced functionalities using two-dimensional (2D) materials. Combining crystallographically commensurate materials in these 2D stacks has been shown to result in rich new electronic structure, magnetotransport, and optical properties. In this c...

journal_title：Science advances

authors： Vargas A,Liu F,Lane C,Rubin D,Bilgin I,Hennighausen Z,DeCapua M,Bansil A,Kar S

更新日期：2017-07-14 00:00:00

abstract：:Transplantation with donor corneas is the mainstay for treating corneal blindness, but a severe worldwide shortage necessitates the development of other treatment options. Corneal perforation from infection or inflammation is sealed with cyanoacrylate glue. However, the resulting cytotoxicity requires transplantation....

journal_title：Science advances

authors： McTiernan CD,Simpson FC,Haagdorens M,Samarawickrama C,Hunter D,Buznyk O,Fagerholm P,Ljunggren MK,Lewis P,Pintelon I,Olsen D,Edin E,Groleau M,Allan BD,Griffith M

更新日期：2020-06-17 00:00:00

abstract：:Cancer cells often encounter oxidative stress. However, it is unclear whether normal and cancer cells differentially respond to oxidative stress. Here, we demonstrated that under oxidative stress, hepatocellular carcinoma (HCC) cells exhibit increased antioxidative response and survival rates compared to normal hepato...

journal_title：Science advances

authors： Xu D,Li X,Shao F,Lv G,Lv H,Lee JH,Qian X,Wang Z,Xia Y,Du L,Zheng Y,Wang H,Lyu J,Lu Z

更新日期：2019-04-24 00:00:00

abstract：:Coherent interactions between electromagnetic and matter waves lie at the heart of quantum science and technology. However, the diffraction nature of light has limited the scalability of many atom-light-based quantum systems. We use the optical fields in a hollow-core photonic crystal fiber to spatially split, reflect...

journal_title：Science advances

authors： Xin M,Leong WS,Chen Z,Lan SY

更新日期：2018-01-19 00:00:00

abstract：:The rapid growth of deformable and stretchable electronics calls for a deformable and stretchable power source. We report a scalable approach for energy harvesters and self-powered sensors that can be highly deformable and stretchable. With conductive liquid contained in a polymer cover, a shape-adaptive triboelectric...

journal_title：Science advances

authors： Yi F,Wang X,Niu S,Li S,Yin Y,Dai K,Zhang G,Lin L,Wen Z,Guo H,Wang J,Yeh MH,Zi Y,Liao Q,You Z,Zhang Y,Wang ZL

更新日期：2016-06-17 00:00:00

abstract：:Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscie...

journal_title：Science advances

authors： Mejias JF,Murray JD,Kennedy H,Wang XJ

更新日期：2016-11-16 00:00:00

abstract：:Wächtershäuser's proposal of the autotrophic origin of life theory and subsequent laboratory demonstrations of relevant organic reactions have opened a new gate for the exploration of the origin of life. However, this scenario remains controversial because, at present, it requires a high pressure of CO as a source of ...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Li Y,Yamaguchi A,Gilbert A,Ueno Y,Yoshida N,Oono Y

更新日期：2018-04-04 00:00:00

abstract：:The catalytic activity of alloy nanoparticles depends on the particle size and composition ratio of different metals. Alloy nanoparticles composed of Pd, Pt, and Au are widely used as catalysts for oxidation reactions. The catalytic activities of Pt and Au nanoparticles in oxidation reactions are known to increase as ...

journal_title：Science advances

authors： Takahashi M,Koizumi H,Chun WJ,Kori M,Imaoka T,Yamamoto K

更新日期：2017-07-26 00:00:00