A highly shape-adaptive, stretchable design based on conductive liquid for energy harvesting and self-powered biomechanical monitoring.

abstract：:Ants (Hymenoptera: Formicidae) are diverse and ubiquitous, and their ability to sting is familiar to many of us. However, their venoms remain largely unstudied. We provide the first comprehensive characterization of a polypeptidic ant venom, that of the giant red bull ant, Myrmecia gulosa. We reveal a suite of novel p...

journal_title：Science advances

authors： Robinson SD,Mueller A,Clayton D,Starobova H,Hamilton BR,Payne RJ,Vetter I,King GF,Undheim EAB

更新日期：2018-09-12 00:00:00

abstract：:Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here, we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) pers...

journal_title：Science advances

authors： Vaziri A,Khabiri M,Genaw BT,May CE,Freddolino PL,Dus M

更新日期：2020-11-11 00:00:00

abstract：:Transplanting beneficial bacteria to the gut microbiome can positively modulate the bacterial composition and remains of great interest in prevention and treatment. However, environmental assaults and rapid transit times in the gastrointestinal (GI) tract result in low oral bioavailability and limited intestinal colon...

journal_title：Science advances

authors： Wang X,Cao Z,Zhang M,Meng L,Ming Z,Liu J

更新日期：2020-06-24 00:00:00

abstract：:A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...

journal_title：Science advances

authors： Bratman GN,Anderson CB,Berman MG,Cochran B,de Vries S,Flanders J,Folke C,Frumkin H,Gross JJ,Hartig T,Kahn PH Jr,Kuo M,Lawler JJ,Levin PS,Lindahl T,Meyer-Lindenberg A,Mitchell R,Ouyang Z,Roe J,Scarlett L,Smith JR,

更新日期：2019-07-24 00:00:00

abstract：:A sulfide-oxidizing microorganism, Desulfurivibrio alkaliphilus (DA), generates a consistent enrichment of sulfur-34 (34S) in the produced sulfate of +12.5 per mil or greater. This observation challenges the general consensus that the microbial oxidation of sulfide does not result in large 34S enrichments and suggests...

journal_title：Science advances

authors： Pellerin A,Antler G,Holm SA,Findlay AJ,Crockford PW,Turchyn AV,Jørgensen BB,Finster K

更新日期：2019-07-24 00:00:00

abstract：:The key to the development of advanced materials is to understand their electronic structure-property relationship. Utilization of this understanding to design new electronic materials with desired properties led to modern epitaxial growth approaches for synthesizing artificial lattices, which for almost half a centur...

journal_title：Science advances

authors： Mascarenhas A,Fluegel B,Bhusal L

更新日期：2017-06-07 00:00:00

abstract：:The ability of a material to adopt multiple structures, known as polymorphism, is a fascinating natural phenomenon. Various polymorphs with unusual properties are routinely synthesized by compression under positive pressure. However, changing a material's structure by applying tension under negative pressure is much m...

journal_title：Science advances

authors： Siol S,Holder A,Steffes J,Schelhas LT,Stone KH,Garten L,Perkins JD,Parilla PA,Toney MF,Huey BD,Tumas W,Lany S,Zakutayev A

更新日期：2018-04-20 00:00:00

abstract：:Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens for mitotherapeutics using neurons have not been reported. We developed a multiplexed and high-content screening assay using primary neurons and identified 67 small-molecule modulators of neuro...

journal_title：Science advances

authors： Varkuti BH,Kepiro M,Liu Z,Vick K,Avchalumov Y,Pacifico R,MacMullen CM,Kamenecka TM,Puthanveettil SV,Davis RL

更新日期：2020-01-08 00:00:00

abstract：:Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher...

journal_title：Science advances

authors： Huang J,van Zijl PCM,Han X,Dong CM,Cheng GWY,Tse KH,Knutsson L,Chen L,Lai JHC,Wu EX,Xu J,Chan KWY

更新日期：2020-05-13 00:00:00

abstract：:Understanding the remarkable excitonic effects and controlling the exciton binding energies in two-dimensional (2D) semiconductors are crucial in unlocking their full potential for use in future photonic and optoelectronic devices. Here, we demonstrate large excitonic effects and gate-tunable exciton binding energies ...

journal_title：Science advances

authors： Qiu Z,Trushin M,Fang H,Verzhbitskiy I,Gao S,Laksono E,Yang M,Lyu P,Li J,Su J,Telychko M,Watanabe K,Taniguchi T,Wu J,Neto AHC,Yang L,Eda G,Adam S,Lu J

更新日期：2019-07-19 00:00:00

abstract：:RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)-assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacti...

journal_title：Science advances

authors： Liu J,Zhang Y,Zeng Q,Zeng H,Liu X,Wu P,Xie H,He L,Long Z,Lu X,Xiao M,Zhu Y,Bo H,Cao K

更新日期：2019-09-25 00:00:00

abstract：:Synthetic aperture radar is a well-known technique for improving resolution in radio imaging. Extending these synthetic aperture techniques to the visible light domain is not straightforward because optical receivers cannot measure phase information. We propose to use macroscopic Fourier ptychography (FP) as a practic...

journal_title：Science advances

authors： Holloway J,Wu Y,Sharma MK,Cossairt O,Veeraraghavan A

更新日期：2017-04-14 00:00:00

abstract：:Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...

journal_title：Science advances

authors： Brydegaard M,Jansson S,Malmqvist E,Mlacha YP,Gebru A,Okumu F,Killeen GF,Kirkeby C

更新日期：2020-05-13 00:00:00

abstract：:Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4-Å cryo-EM structure of the h...

journal_title：Science advances

authors： Qi C,Di Minin G,Vercellino I,Wutz A,Korkhov VM

更新日期：2019-09-18 00:00:00

abstract：:Advanced molecular materials that combine two or more physical properties are typically constructed by combining different molecules, each being responsible for one of the properties required. Ideally, single molecules could take care of this combined functionality, provided they are self-assembled correctly and endow...

journal_title：Science advances

authors： Gorbunov AV,Garcia Iglesias M,Guilleme J,Cornelissen TD,Roelofs WSC,Torres T,González-Rodríguez D,Meijer EW,Kemerink M

更新日期：2017-09-29 00:00:00

abstract：:Bioengineered three-dimensional (3D) matrices expand our experimental repertoire to study tumor growth and progression in a biologically relevant, yet controlled, manner. Here, we used peptide amphiphiles (PAs) to coassemble with and organize extracellular matrix (ECM) proteins producing tunable 3D models of the tumor...

journal_title：Science advances

authors： Hedegaard CL,Redondo-Gómez C,Tan BY,Ng KW,Loessner D,Mata A

更新日期：2020-10-02 00:00:00

abstract：:Fluid commonly flows in response to an external pressure gradient. However, when a tunnel-containing hydrogel is immersed in water, spontaneous flow occurs through the tunnel without any pressure gradient. We confirmed this flow in a wide range of plant- and animal-derived hydrogels. The flow appears to be driven by a...

journal_title：Science advances

authors： Li Z,Pollack GH

更新日期：2020-05-08 00:00:00

abstract：:Adaptation is a fundamental property of sensory systems that can change subjective experiences in the context of recent information. Adaptation has been postulated to arise from recurrent circuit mechanisms or as a consequence of neuronally intrinsic suppression. However, it is unclear whether intrinsic suppression by...

journal_title：Science advances

authors： Vinken K,Boix X,Kreiman G

更新日期：2020-10-14 00:00:00

abstract：:We investigate the emergence of global alignment in colonies of dividing rod-shaped cells under confinement. Using molecular dynamics simulations and continuous modeling, we demonstrate that geometrical anisotropies in the confining environment give rise to an imbalance in the normal stresses, which, in turn, drives a...

journal_title：Science advances

authors： You Z,Pearce DJG,Giomi L

更新日期：2021-01-22 00:00:00

abstract：:Telomerase is a ribonucleoprotein complex that catalyzes addition of telomeric DNA repeats to maintain telomeres in replicating cells. Here, we demonstrate that the telomerase protein hTERT performs an additional role at telomeres that is independent of telomerase catalytic activity yet essential for telomere integrit...

journal_title：Science advances

authors： Perera ON,Sobinoff AP,Teber ET,Harman A,Maritz MF,Yang SF,Pickett HA,Cesare AJ,Arthur JW,MacKenzie KL,Bryan TM

更新日期：2019-10-02 00:00:00

abstract：:Cheater viruses, also known as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type upon coinfection. While there is growing interest in using cheaters as antiviral therapeutics, the mechanisms underlying cheating have been rarely explored. During experimental evolution ...

journal_title：Science advances

authors： Meir M,Harel N,Miller D,Gelbart M,Eldar A,Gophna U,Stern A

更新日期：2020-08-21 00:00:00

abstract：:Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis coupled with the absence of plasmids makes genetic engineering cumbersome, especially for essen...

journal_title：Science advances

authors： Vyas VK,Barrasa MI,Fink GR

更新日期：2015-01-01 00:00:00

abstract：:The formation of the biophotonic gyroid material in butterfly wing scales is an exceptional feat of evolutionary engineering of functional nanostructures. It is hypothesized that this nanostructure forms by chitin polymerization inside a convoluted membrane of corresponding shape in the endoplasmic reticulum. However,...

journal_title：Science advances

authors： Wilts BD,Apeleo Zubiri B,Klatt MA,Butz B,Fischer MG,Kelly ST,Spiecker E,Steiner U,Schröder-Turk GE

更新日期：2017-04-26 00:00:00

abstract：:During the Last Glacial Maximum, expansive continental ice sheets lowered globally averaged sea level ~130 m, exposing a land bridge at the Bering Strait. During the subsequent deglaciation, sea level rose rapidly and ultimately flooded the Bering Strait, linking the Arctic and Pacific Oceans. Observational records of...

journal_title：Science advances

authors： Pico T,Mitrovica JX,Mix AC

更新日期：2020-02-26 00:00:00

abstract：:Ice-templating holds promise to become a powerful technique to construct high-performance bioinspired materials. Both ice nucleation and growth during the freezing process are crucial for the final architecture of the ice-templated material. However, effective ways to control these two very important factors are still...

journal_title：Science advances

authors： Zhao N,Li M,Gong H,Bai H

更新日期：2020-07-31 00:00:00

abstract：:Ornithine transcarbamylase (OTC) deficiency is an X-linked urea cycle disorder associated with high mortality. Although a promising treatment for late-onset OTC deficiency, adeno-associated virus (AAV) neonatal gene therapy would only provide short-term therapeutic effects as the non-integrated genome gets lost during...

journal_title：Science advances

authors： Wang L,Yang Y,Breton C,Bell P,Li M,Zhang J,Che Y,Saveliev A,He Z,White J,Latshaw C,Xu C,McMenamin D,Yu H,Morizono H,Batshaw ML,Wilson JM

更新日期：2020-02-12 00:00:00

abstract：:The development of advanced chemical-to-electrical energy conversions requires fast and efficient electrocatalysis of multielectron/multiproton reactions, such as the oxygen reduction reaction (ORR). Using molecular catalysts, correlations between the reaction rate and energy efficiency have recently been identified. ...

journal_title：Science advances

authors： Martin DJ,Mercado BQ,Mayer JM

更新日期：2020-03-13 00:00:00

abstract：:Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we intro...

journal_title：Science advances

authors： Kim Y,Yoo YK,Kim HY,Roh JH,Kim J,Baek S,Lee JC,Kim HJ,Chae MS,Jeong D,Park D,Lee S,Jang H,Kim K,Lee JH,Byun BH,Park SY,Ha JH,Lee KC,Cho WW,Kim JS,Koh JY,Lim SM,Hwang KS

更新日期：2019-04-17 00:00:00

abstract：:Many animals understand numbers at a basic level for use in essential tasks such as foraging, shoaling, and resource management. However, complex arithmetic operations, such as addition and subtraction, using symbols and/or labeling have only been demonstrated in a limited number of nonhuman vertebrates. We show that ...

journal_title：Science advances

authors： Howard SR,Avarguès-Weber A,Garcia JE,Greentree AD,Dyer AG

更新日期：2019-02-06 00:00:00

abstract：:B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...

journal_title：Science advances

authors： Zhao X,Xie H,Zhao M,Ahsan A,Li X,Wang F,Yi J,Yang Z,Wu C,Raman I,Li QZ,Kim TJ,Liu W

更新日期：2019-07-17 00:00:00