Abstract:
:Diets rich in sugar, salt, and fat alter taste perception and food preference, contributing to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here, we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) persistently reprograms the sensory neurons of Drosophila melanogaster flies to reduce sweet sensation and promote obesity. In animals fed high sugar, the binding of PRC2.1 to the chromatin of the sweet gustatory neurons is redistributed to repress a developmental transcriptional network that modulates the responsiveness of these cells to sweet stimuli, reducing sweet sensation. Half of these transcriptional changes persist despite returning the animals to a control diet, causing a permanent decrease in sweet taste. Our results uncover a new epigenetic mechanism that, in response to the dietary environment, regulates neural plasticity and feeding behavior to promote obesity.
journal_name
Sci Advjournal_title
Science advancesauthors
Vaziri A,Khabiri M,Genaw BT,May CE,Freddolino PL,Dus Mdoi
10.1126/sciadv.abc8492subject
Has Abstractpub_date
2020-11-11 00:00:00issue
46issn
2375-2548pii
6/46/eabc8492journal_volume
6pub_type
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