Permafrost thawing puts the frozen carbon at risk over the Tibetan Plateau.

abstract：:Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive disease progression such as fibrosis and cancer. Besides growth factor signaling, the local extracellular matrix (ECM) and its mechanical properties are central regulators of these processes. It remains unknown whether transfo...

journal_title：Science advances

authors： Kollmannsberger P,Bidan CM,Dunlop JWC,Fratzl P,Vogel V

更新日期：2018-01-17 00:00:00

abstract：:Tropical forest fragmentation results in habitat and biodiversity loss and increased carbon emissions. Here, we link an increased likelihood of tropical forest loss to decreasing fragment size, particularly in primary forests. The relationship holds for protected areas, albeit with half the rate of loss compared with ...

journal_title：Science advances

authors： Hansen MC,Wang L,Song XP,Tyukavina A,Turubanova S,Potapov PV,Stehman SV

更新日期：2020-03-11 00:00:00

abstract：:It has been proposed that Mars' moons formed from a disk produced by a large impact with the planet. However, whether such an event could produce tiny Phobos and Deimos remains unclear. Using a hybrid N-body model of moon accumulation that includes a full treatment of moon-moon dynamical interactions, we first identif...

journal_title：Science advances

authors： Canup R,Salmon J

更新日期：2018-04-18 00:00:00

abstract：:Carbon deposits are well-known inhibitors of transition metal catalysts. In contrast to this undesirable behavior, here we show that epitaxial graphene grown on Ru(0001) promotes the reversible formation of a C-C bond between -CH2CN and 7,7,8,8-tetracyano-p-quinodimethane (TCNQ). The catalytic role of graphene is mult...

journal_title：Science advances

authors： Navarro JJ,Pisarra M,Nieto-Ortega B,Villalva J,Ayani CG,Díaz C,Calleja F,Miranda R,Martín F,Pérez EM,Vázquez de Parga AL

更新日期：2018-12-14 00:00:00

abstract：:The transcriptional repressors Polycomb repressive complex 1 (PRC1) and PRC2 are required to maintain cell fate during embryonic development. PRC1 and PRC2 catalyze distinct histone modifications, establishing repressive chromatin at shared targets. How PRC1, which consists of canonical PRC1 (cPRC1) and variant PRC1 (...

journal_title：Science advances

authors： Zepeda-Martinez JA,Pribitzer C,Wang J,Bsteh D,Golumbeanu S,Zhao Q,Burkard TR,Reichholf B,Rhie SK,Jude J,Moussa HF,Zuber J,Bell O

更新日期：2020-04-01 00:00:00

abstract：:Recently, the complexity behind manipulations of reflected fields by metasurfaces has been addressed, showing that, even in the simplest scenarios, nonlocal response and excitation of auxiliary evanescent fields are required for perfect field control. In this work, we introduce purely local reflective metasurfaces for...

journal_title：Science advances

authors： Díaz-Rubio A,Li J,Shen C,Cummer SA,Tretyakov SA

更新日期：2019-02-15 00:00:00

abstract：:We present an ab initio computational approach for the calculation of resonant Raman intensities, including both excitonic and nonadiabatic effects. Our diagrammatic approach, which we apply to two prototype, semiconducting layered materials, allows a detailed analysis of the impact of phonon-mediated exciton-exciton ...

journal_title：Science advances

authors： Reichardt S,Wirtz L

更新日期：2020-08-07 00:00:00

abstract：:SN2-type halide substitution and hydrolysis are two of the most ubiquitous reactions in chemistry. The interplay between these processes is fundamental in atmospheric chemistry through reactions of N2O5 and seawater. N2O5 plays a major role in regulating levels of O3, OH, NO x ...

journal_title：Science advances

authors： McCaslin LM,Johnson MA,Gerber RB

更新日期：2019-06-05 00:00:00

abstract：:Many applications in modern technology, such as self-cleaning surfaces and digital microfluidics, require control over individual fluid droplets on flat surfaces. Existing techniques may suffer from side effects resulting from high electric fields and high temperatures. Here, we introduce a markedly different method, ...

journal_title：Science advances

authors： De Jong E,Wang Y,Den Toonder JMJ,Onck PR

更新日期：2019-06-14 00:00:00

abstract：:Metabolic reprogramming is widely considered a hallmark of cancer, and understanding metabolic dynamics described by the conversion rates or "fluxes" of metabolites can shed light onto biological processes of tumorigenesis and response to therapy. For real-time analysis of metabolic flux in intact cells or organisms, ...

journal_title：Science advances

authors： Jeong S,Eskandari R,Park SM,Alvarez J,Tee SS,Weissleder R,Kharas MG,Lee H,Keshari KR

更新日期：2017-06-16 00:00:00

abstract：:Self-propelling micromotors are emerging as a promising micro- and nanoscale tool for single-cell analysis. We have recently shown that the field gradients necessary to manipulate matter via dielectrophoresis can be induced at the surface of a polarizable active ("self-propelling") metallodielectric Janus particle (JP...

journal_title：Science advances

authors： Wu Y,Fu A,Yossifon G

更新日期：2020-01-29 00:00:00

abstract：:Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family of master regulator...

journal_title：Science advances

authors： Ghari F,Quirke AM,Munro S,Kawalkowska J,Picaud S,McGouran J,Subramanian V,Muth A,Williams R,Kessler B,Thompson PR,Fillipakopoulos P,Knapp S,Venables PJ,La Thangue NB

更新日期：2016-02-05 00:00:00

abstract：:We tested how sediment trapping by hydroelectric dams affects tropical estuaries by comparing two dammed and two undammed rivers on Mexico's Pacific coast. We found that dams demonstrably affected the stability and productivity of the estuaries. The two rivers dammed for hydroelectricity had a rapid coastal recession ...

journal_title：Science advances

authors： Ezcurra E,Barrios E,Ezcurra P,Ezcurra A,Vanderplank S,Vidal O,Villanueva-Almanza L,Aburto-Oropeza O

更新日期：2019-03-13 00:00:00

abstract：:Variations in Earth's orbit pace the glacial-interglacial cycles of the Quaternary, but the mechanisms that transform regional and seasonal variations in solar insolation into glacial-interglacial cycles are still elusive. Here, we present transient simulations of coevolution of climate, ice sheets, and carbon cycle o...

journal_title：Science advances

authors： Willeit M,Ganopolski A,Calov R,Brovkin V

更新日期：2019-04-03 00:00:00

abstract：:Starvation is probably the most common stressful situation in nature. In vertebrates, elevation of the biogenic amine norepinephrine levels is common during starvation. However, the precise role of norepinephrine in nutrient deprivation remains largely unknown. We report that in the free-living nematode Caenorhabditis...

journal_title：Science advances

authors： Tao J,Ma YC,Yang ZS,Zou CG,Zhang KQ

更新日期：2016-05-06 00:00:00

abstract：:In retinal detachment (RD), photoreceptor death and permanent vision loss are caused by neurosensory retina separating from the retinal pigment epithelium because of subretinal fluid (SRF), and successful surgical reattachment is not predictive of total visual recovery. As retinal iron overload exacerbates cell death ...

journal_title：Science advances

authors： Daruich A,Le Rouzic Q,Jonet L,Naud MC,Kowalczuk L,Pournaras JA,Boatright JH,Thomas A,Turck N,Moulin A,Behar-Cohen F,Picard E

更新日期：2019-01-09 00:00:00

abstract：:Bacterial chemotaxis-a fundamental example of directional navigation in the living world-is key to many biological processes, including the spreading of bacterial infections. Many bacterial species were recently reported to exhibit several distinct swimming modes-the flagella may, for example, push the cell body or wr...

journal_title：Science advances

authors： Alirezaeizanjani Z,Großmann R,Pfeifer V,Hintsche M,Beta C

更新日期：2020-05-27 00:00:00

abstract：:Analog machine learning hardware platforms promise to be faster and more energy efficient than their digital counterparts. Wave physics, as found in acoustics and optics, is a natural candidate for building analog processors for time-varying signals. Here, we identify a mapping between the dynamics of wave physics and...

journal_title：Science advances

authors： Hughes TW,Williamson IAD,Minkov M,Fan S

更新日期：2019-12-20 00:00:00

abstract：:The Tulare Basin in Central California is a site of intensive agricultural activity and extraction of groundwater, with pronounced ground subsidence and degradation of water resources over the past century. Spatially extensive observations of ground displacements from satellite-based remote sensing allow us to infer t...

journal_title：Science advances

authors： Murray KD,Lohman RB

更新日期：2018-08-29 00:00:00

abstract：:Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS-targeting IgG antibody, inRas37, which directly targets the intracellularly activated form of various...

journal_title：Science advances

authors： Shin SM,Kim JS,Park SW,Jun SY,Kweon HJ,Choi DK,Lee D,Cho YB,Kim YS

更新日期：2020-01-15 00:00:00

abstract：:Nanomaterials often surprise us with unexpected phenomena. Here, we report a discovery of the anti-twinning deformation, previously thought impossible, in nanoscale body-centered cubic (BCC) tungsten crystals. By conducting in situ transmission electron microscopy nanomechanical testing, we observed the nucleation and...

journal_title：Science advances

authors： Wang J,Zeng Z,Wen M,Wang Q,Chen D,Zhang Y,Wang P,Wang H,Zhang Z,Mao SX,Zhu T

更新日期：2020-06-03 00:00:00

abstract：:Low-dimensional materials usually exhibit mechanical properties from those of their bulk counterparts. Here, we show in two-dimensional (2D) rhenium disulfide (ReS2) that the fracture processes are dominated by a variety of previously unidentified phenomena, which are not present in bulk materials. Through direct tran...

journal_title：Science advances

authors： Huang L,Zheng F,Deng Q,Thi QH,Wong LW,Cai Y,Wang N,Lee CS,Lau SP,Ly TH,Zhao J

更新日期：2020-11-18 00:00:00

abstract：:LmrA is a bacterial ATP-binding cassette (ABC) multidrug exporter that uses metabolic energy to transport ions, cytotoxic drugs, and lipids. Voltage clamping in a Port-a-Patch was used to monitor electrical currents associated with the transport of monovalent cationic HEPES+ by single-LmrA transporters and ensembles o...

journal_title：Science advances

authors： Agboh K,Lau CHF,Khoo YSK,Singh H,Raturi S,Nair AV,Howard J,Chiapello M,Feret R,Deery MJ,Murakami S,van Veen HW

更新日期：2018-09-19 00:00:00

abstract：:Complex behaviors demand temporal coordination among functionally distinct brain regions. The basal forebrain's afferent and efferent structure suggests a capacity for mediating this coordination at a large scale. During performance of a spatial orientation task, synaptic activity in this region was dominated by four ...

journal_title：Science advances

authors： Tingley D,Alexander AS,Quinn LK,Chiba AA,Nitz D

更新日期：2018-08-01 00:00:00

abstract：:Viscosity of fluids is strongly system dependent, varies across many orders of magnitude, and depends on molecular interactions and structure in a complex way not amenable to first-principles theories. Despite the variations and theoretical difficulties, we find a new quantity setting the minimal kinematic viscosity o...

journal_title：Science advances

authors： Trachenko K,Brazhkin VV

更新日期：2020-04-24 00:00:00

abstract：:Using a cell-based assay monitoring differential protein transport in the secretory pathway coupled to high-content screening, we have identified three molecules that specifically reduce the delivery of the major co-receptor for HIV-1, CCR5, to the plasma membrane. They have no effect on the closely related receptors ...

journal_title：Science advances

authors： Boncompain G,Herit F,Tessier S,Lescure A,Del Nery E,Gestraud P,Staropoli I,Fukata Y,Fukata M,Brelot A,Niedergang F,Perez F

更新日期：2019-10-16 00:00:00

abstract：:The transcription factor p63 is a key mediator of epidermal development. Point mutations in p63 in patients lead to developmental defects, including orofacial clefting. To date, knowledge on how pivotal the role of p63 is in human craniofacial development is limited. Using an inducible transdifferentiation model, comb...

journal_title：Science advances

authors： Lin-Shiao E,Lan Y,Welzenbach J,Alexander KA,Zhang Z,Knapp M,Mangold E,Sammons M,Ludwig KU,Berger SL

更新日期：2019-05-01 00:00:00

abstract：:Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that causes genome reprogramming through remodeling of enhancers. Here, we describe an unexpected function of RING1B, which is highly expressed in EwS. ...

journal_title：Science advances

authors： Sánchez-Molina S,Figuerola-Bou E,Blanco E,Sánchez-Jiménez M,Táboas P,Gómez S,Ballaré C,García-Domínguez DJ,Prada E,Hontecillas-Prieto L,M Carcaboso Á,Tirado ÓM,Hernández-Muñoz I,de Álava E,Lavarino C,Di Croce L,Mora J

更新日期：2020-10-23 00:00:00

abstract：:Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...

journal_title：Science advances

authors： Chen H,Lin J,Kang J,Kong Q,Lu D,Kang J,Lai M,Quan LN,Lin Z,Jin J,Wang LW,Toney MF,Yang P

更新日期：2020-01-24 00:00:00

abstract：:Exploration for superconductivity is one of the research frontiers in condensed matter physics. In strongly correlated electron systems, the emergence of superconductivity is often inhibited by the formation of a thermodynamically more stable magnetic/charge order. Thus, to develop the superconductivity as the thermod...

journal_title：Science advances

authors： Oike H,Kamitani M,Tokura Y,Kagawa F

更新日期：2018-10-05 00:00:00