Multiplexed oscillations and phase rate coding in the basal forebrain.

abstract：:Low seismic velocity regions in the mantle and crust are commonly attributed to the presence of silicate melts. Determining melt volume and geometric distribution is fundamental to understanding planetary dynamics. We present a new model for seismic velocity reductions that accounts for the anomalous compressibility o...

journal_title：Science advances

authors： Clark AN,Lesher CE

更新日期：2017-12-13 00:00:00

abstract：:The Mott transition-a metal-insulator transition caused by repulsive Coulomb interactions between electrons-is a central issue in condensed matter physics because it is the mother earth of various attractive phenomena. Outstanding examples are high-Tc (critical temperature) cuprates and manganites exhibiting colossal ...

journal_title：Science advances

authors： Itou T,Watanabe E,Maegawa S,Tajima A,Tajima N,Kubo K,Kato R,Kanoda K

更新日期：2017-08-11 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is life-threatening because of limited therapies and lack of effective therapeutic targets. Here, we found that moesin (MSN) was significantly overexpressed in TNBC compared with other subtypes of breast cancer and was positively correlated with poor overall survival. However, litt...

journal_title：Science advances

authors： Qin Y,Chen W,Jiang G,Zhou L,Yang X,Li H,He X,Wang HL,Zhou YB,Huang S,Liu S

更新日期：2020-02-19 00:00:00

abstract：:Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4-Å cryo-EM structure of the h...

journal_title：Science advances

authors： Qi C,Di Minin G,Vercellino I,Wutz A,Korkhov VM

更新日期：2019-09-18 00:00:00

abstract：:Quantum teleportation, which is the transfer of an unknown quantum state from one station to another over a certain distance with the help of nonlocal entanglement shared by a sender and a receiver, has been widely used as a fundamental element in quantum communication and quantum computation. Optical fibers are cruci...

journal_title：Science advances

authors： Huo M,Qin J,Cheng J,Yan Z,Qin Z,Su X,Jia X,Xie C,Peng K

更新日期：2018-10-19 00:00:00

abstract：:Active materials are capable of converting free energy into directional motion, giving rise to notable dynamical phenomena. Developing a general understanding of their structure in relation to the underlying nonequilibrium physics would provide a route toward control of their dynamic behavior and pave the way for pote...

journal_title：Science advances

authors： Kumar N,Zhang R,de Pablo JJ,Gardel ML

更新日期：2018-10-12 00:00:00

abstract：:The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...

journal_title：Science advances

authors： Movaghar A,Page D,Brilliant M,Baker MW,Greenberg J,Hong J,DaWalt LS,Saha K,Kuusisto F,Stewart R,Berry-Kravis E,Mailick MR

更新日期：2019-08-21 00:00:00

abstract：:Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities that can alter their function in response to environmental cues. In the present study, we report an engineered p...

journal_title：Science advances

authors： Shields CW 4th,Evans MA,Wang LL,Baugh N,Iyer S,Wu D,Zhao Z,Pusuluri A,Ukidve A,Pan DC,Mitragotri S

更新日期：2020-04-29 00:00:00

abstract：:Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. While spraying in the field, farmworkers get exposed to pesticides through the dermal route. Internalized pesticide inhibits AChE, which leads to neurotoxicity, cardiotoxicity, cognitive dysfunct...

journal_title：Science advances

authors： Thorat K,Pandey S,Chandrashekharappa S,Vavilthota N,Hiwale AA,Shah P,Sreekumar S,Upadhyay S,Phuntsok T,Mahato M,Mudnakudu-Nagaraju KK,Sunnapu O,Vemula PK

更新日期：2018-10-17 00:00:00

abstract：:Intrachain charge transport is unique to conjugated polymers distinct from inorganic and small molecular semiconductors and is key to achieving high-performance organic electronics. Polymer backbone planarity and thin film morphology sensitively modulate intrachain charge transport. However, simple, generic nonsynthet...

journal_title：Science advances

authors： Park KS,Kwok JJ,Dilmurat R,Qu G,Kafle P,Luo X,Jung SH,Olivier Y,Lee JK,Mei J,Beljonne D,Diao Y

更新日期：2019-08-09 00:00:00

abstract：:Cell chirality is a newly discovered intrinsic property of the cell, reflecting the bias of the cell to polarize in the left-right axis. Despite increasing evidence on its substantial role in the asymmetric development of embryos, little is known about implications of cell chirality in physiology and disease. We demon...

journal_title：Science advances

authors： Fan J,Ray P,Lu YW,Kaur G,Schwarz JJ,Wan LQ

更新日期：2018-10-24 00:00:00

abstract：:Although electromagnetic brain stimulation is a promising treatment in neurology and psychiatry, clinical outcomes are variable, and underlying mechanisms are ill-defined, which impedes the development of new effective stimulation protocols. Here, we show, in vivo and ex vivo, that repetitive transcranial magnetic sti...

journal_title：Science advances

authors： Dufor T,Grehl S,Tang AD,Doulazmi M,Traoré M,Debray N,Dubacq C,Deng ZD,Mariani J,Lohof AM,Sherrard RM

更新日期：2019-10-30 00:00:00

abstract：:The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...

journal_title：Science advances

authors： Pappa AM,Ohayon D,Giovannitti A,Maria IP,Savva A,Uguz I,Rivnay J,McCulloch I,Owens RM,Inal S

更新日期：2018-06-22 00:00:00

abstract：:We present a physically inspired model and an efficient algorithm to infer hierarchical rankings of nodes in directed networks. It assigns real-valued ranks to nodes rather than simply ordinal ranks, and it formalizes the assumption that interactions are more likely to occur between individuals with similar ranks. It ...

journal_title：Science advances

authors： De Bacco C,Larremore DB,Moore C

更新日期：2018-07-20 00:00:00

abstract：:Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...

journal_title：Science advances

authors： Naffouti M,Backofen R,Salvalaglio M,Bottein T,Lodari M,Voigt A,David T,Benkouider A,Fraj I,Favre L,Ronda A,Berbezier I,Grosso D,Abbarchi M,Bollani M

更新日期：2017-11-10 00:00:00

abstract：:A major challenge in modern physics is to accurately describe strongly interacting quantum many-body systems. One-dimensional systems provide fundamental insights because they are often amenable to exact methods. However, no exact solution is known for the experimentally relevant case of external confinement. We propo...

journal_title：Science advances

authors： Levinsen J,Massignan P,Bruun GM,Parish MM

更新日期：2015-07-24 00:00:00

abstract：:Bioacoustic networks could vastly expand the coverage of wildlife monitoring to complement satellite observations of climate and vegetation. This approach would enable global-scale understanding of how climate change influences phenomena such as migratory timing of avian species. The enormous data sets that autonomous...

journal_title：Science advances

authors： Oliver RY,Ellis DPW,Chmura HE,Krause JS,Pérez JH,Sweet SK,Gough L,Wingfield JC,Boelman NT

更新日期：2018-06-20 00:00:00

abstract：:Interaction of swimming bacteria with flows controls their ability to explore complex environments, crucial to many societal and environmental challenges and relevant for microfluidic applications such as cell sorting. Combining experimental, numerical, and theoretical analysis, we present a comprehensive study of the...

journal_title：Science advances

authors： Jing G,Zöttl A,Clément É,Lindner A

更新日期：2020-07-10 00:00:00

abstract：:V1-ATPase is an ATP-driven rotary motor that is composed of a ring-shaped A3B3 complex and a central DF shaft. The nucleotide-free A3B3 complex of Enterococcus hirae, composed of three identical A1B1 heterodimers, showed a unique asymmetrical structure, probably due to the strong binding of the N-terminal barrel domai...

journal_title：Science advances

authors： Maruyama S,Suzuki K,Imamura M,Sasaki H,Matsunami H,Mizutani K,Saito Y,Imai FL,Ishizuka-Katsura Y,Kimura-Someya T,Shirouzu M,Uchihashi T,Ando T,Yamato I,Murata T

更新日期：2019-01-30 00:00:00

abstract：:Nanometer-scale skyrmions are prospective candidates for information bits in low-power consumption devices owing to their topological nature and controllability with low current density. Studies on skyrmion dynamics in different classes of materials have exploited the topological Hall effect and current-driven fast mo...

journal_title：Science advances

authors： Yu XZ,Morikawa D,Nakajima K,Shibata K,Kanazawa N,Arima T,Nagaosa N,Tokura Y

更新日期：2020-06-17 00:00:00

abstract：:Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive disease progression such as fibrosis and cancer. Besides growth factor signaling, the local extracellular matrix (ECM) and its mechanical properties are central regulators of these processes. It remains unknown whether transfo...

journal_title：Science advances

authors： Kollmannsberger P,Bidan CM,Dunlop JWC,Fratzl P,Vogel V

更新日期：2018-01-17 00:00:00

abstract：:The process of sheep and goat (caprine) domestication began by 9000 to 8000 BCE in Southwest Asia. The early Neolithic site at Aşıklı Höyük in central Turkey preserves early archaeological evidence of this transformation, such as culling by age and sex and use of enclosures inside the settlement. People's strategies f...

journal_title：Science advances

authors： Abell JT,Quade J,Duru G,Mentzer SM,Stiner MC,Uzdurum M,Özbaşaran M

更新日期：2019-04-17 00:00:00

abstract：:Exploration for superconductivity is one of the research frontiers in condensed matter physics. In strongly correlated electron systems, the emergence of superconductivity is often inhibited by the formation of a thermodynamically more stable magnetic/charge order. Thus, to develop the superconductivity as the thermod...

journal_title：Science advances

authors： Oike H,Kamitani M,Tokura Y,Kagawa F

更新日期：2018-10-05 00:00:00

abstract：:SN2-type halide substitution and hydrolysis are two of the most ubiquitous reactions in chemistry. The interplay between these processes is fundamental in atmospheric chemistry through reactions of N2O5 and seawater. N2O5 plays a major role in regulating levels of O3, OH, NO x ...

journal_title：Science advances

authors： McCaslin LM,Johnson MA,Gerber RB

更新日期：2019-06-05 00:00:00

abstract：:Confined to a two-dimensional plane, electrons in a strong magnetic field travel along the edge in one-dimensional quantum Hall channels that are protected against backscattering. These channels can be used as solid-state analogs of monochromatic beams of light, providing a unique platform for studying electron interf...

journal_title：Science advances

authors： Wei DS,van der Sar T,Sanchez-Yamagishi JD,Watanabe K,Taniguchi T,Jarillo-Herrero P,Halperin BI,Yacoby A

更新日期：2017-08-18 00:00:00

abstract：:Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol ...

journal_title：Science advances

authors： Khom S,Steinkellner T,Hnasko TS,Roberto M

更新日期：2020-03-18 00:00:00

abstract：:Two-dimensional (2D) semiconductors have shown great potential for electronic and optoelectronic applications. However, their development is limited by a large Schottky barrier (SB) at the metal-semiconductor junction (MSJ), which is difficult to tune by using conventional metals because of the effect of strong Fermi ...

journal_title：Science advances

authors： Liu Y,Stradins P,Wei SH

更新日期：2016-04-22 00:00:00

abstract：:By developing new computational models, we examine how enzymatic reactions on an underlying surface can be harnessed to direct the motion and organization of reagent-laden microcapsules in a fluid-filled microchannel. In the presence of appropriate reagents, surface-bound enzymes can act as pumps, which drive large-sc...

journal_title：Science advances

authors： Shklyaev OE,Shum H,Sen A,Balazs AC

更新日期：2016-03-18 00:00:00

abstract：:Solar-thermal desalination (STD) is a potentially low-cost, sustainable approach for providing high-quality fresh water in the absence of water and energy infrastructures. Despite recent efforts to advance STD by improving heat-absorbing materials and system designs, the best strategies for maximizing STD performance ...

journal_title：Science advances

authors： Wang Z,Horseman T,Straub AP,Yip NY,Li D,Elimelech M,Lin S

更新日期：2019-07-26 00:00:00

abstract：:Many animals understand numbers at a basic level for use in essential tasks such as foraging, shoaling, and resource management. However, complex arithmetic operations, such as addition and subtraction, using symbols and/or labeling have only been demonstrated in a limited number of nonhuman vertebrates. We show that ...

journal_title：Science advances

authors： Howard SR,Avarguès-Weber A,Garcia JE,Greentree AD,Dyer AG

更新日期：2019-02-06 00:00:00