Metastable asymmetrical structure of a shaftless V1 motor.

abstract：:Lymphatic filariasis and onchocerciasis are two important neglected tropical diseases (NTDs) that cause severe disability. Control efforts are hindered by the lack of a safe macrofilaricidal drug. Targeting the Wolbachia bacterial endosymbionts in these parasites with doxycycline leads to a macrofilaricidal outcome, b...

journal_title：Science advances

authors： Johnston KL,Cook DAN,Berry NG,David Hong W,Clare RH,Goddard M,Ford L,Nixon GL,O'Neill PM,Ward SA,Taylor MJ

更新日期：2017-09-27 00:00:00

abstract：:The urea channel of Helicobacterpylori (HpUreI) is an ideal drug target for preventing gastric cancer but incomplete understanding of its gating mechanism has hampered development of inhibitors for the eradication of H. pylori. Here, we present the cryo-EM structures of HpUreI in closed and open conformations, both at...

journal_title：Science advances

authors： Cui Y,Zhou K,Strugatsky D,Wen Y,Sachs G,Zhou ZH,Munson K

更新日期：2019-03-20 00:00:00

abstract：:Chiral fermions in solid state feature "Fermi arc" states, connecting the surface projections of the bulk chiral nodes. The surface Fermi arc is a signature of nontrivial bulk topology. Unconventional chiral fermions with an extensive Fermi arc traversing the whole Brillouin zone have been theoretically proposed in Co...

journal_title：Science advances

authors： Yuan QQ,Zhou L,Rao ZC,Tian S,Zhao WM,Xue CL,Liu Y,Zhang T,Tang CY,Shi ZQ,Jia ZY,Weng H,Ding H,Sun YJ,Lei H,Li SC

更新日期：2019-12-20 00:00:00

abstract：:Focal adjustment and zooming are universal features of cameras and advanced optical systems. Such tuning is usually performed longitudinally along the optical axis by mechanical or electrical control of focal length. However, the recent advent of ultrathin planar lenses based on metasurfaces (metalenses), which opens ...

journal_title：Science advances

authors： She A,Zhang S,Shian S,Clarke DR,Capasso F

更新日期：2018-02-23 00:00:00

abstract：:The development of advanced chemical-to-electrical energy conversions requires fast and efficient electrocatalysis of multielectron/multiproton reactions, such as the oxygen reduction reaction (ORR). Using molecular catalysts, correlations between the reaction rate and energy efficiency have recently been identified. ...

journal_title：Science advances

authors： Martin DJ,Mercado BQ,Mayer JM

更新日期：2020-03-13 00:00:00

abstract：:The Paris Agreement aims to mitigate the potential impacts of climate change on ecological and social systems. Using an ensemble of climate-marine ecosystem and economic models, we explore the effects of implementing the Agreement on fish, fishers, and seafood consumers worldwide. We find that implementing the Agreeme...

journal_title：Science advances

authors： Sumaila UR,Tai TC,Lam VWY,Cheung WWL,Bailey M,Cisneros-Montemayor AM,Chen OL,Gulati SS

更新日期：2019-02-27 00:00:00

abstract：:Large-scale modes of climate variability can force widespread crop yield anomalies and are therefore often presented as a risk to food security. We quantify how modes of climate variability contribute to crop production variance. We find that the El Niño Southern Oscillation (ENSO), the Indian Ocean Dipole (IOD), trop...

journal_title：Science advances

authors： Anderson WB,Seager R,Baethgen W,Cane M,You L

更新日期：2019-07-03 00:00:00

abstract：:Tumor angiogenesis provides critical nutrients for cancer progression and may also facilitate pathways for dissemination during the process of metastasis. It is well established that cells that metastasize display characteristics of stem cells; however, the prevailing paradigm points to these stem-like cells residing ...

journal_title：Science advances

authors： Lee J,Abdeen AA,Hedhli J,Wycislo KL,Dobrucka IT,Fan TM,Dobrucki LW,Kilian KA

更新日期：2017-10-25 00:00:00

abstract：:There have been increasing attempts to reverse habitat degradation through active restoration, but few large-scale successes are reported to guide these efforts. Here, we report outcomes from a unique and very successful seagrass restoration project: Since 1999, over 70 million seeds of a marine angiosperm, eelgrass (...

journal_title：Science advances

authors： Orth RJ,Lefcheck JS,McGlathery KS,Aoki L,Luckenbach MW,Moore KA,Oreska MPJ,Snyder R,Wilcox DJ,Lusk B

更新日期：2020-10-07 00:00:00

abstract：:The spin-polarized surface states of topological insulators (TIs) are attractive for applications in spintronics and quantum computing. A central challenge with these materials is to reliably tune the chemical potential of their electrons with respect to the Dirac point and the bulk bands. We demonstrate persistent, b...

journal_title：Science advances

authors： Yeats AL,Pan Y,Richardella A,Mintun PJ,Samarth N,Awschalom DD

更新日期：2015-10-09 00:00:00

abstract：:A key problem in the study of the senses is to describe how sense organs extract perceptual information from the physics of the environment. We previously observed that dynamic touch elicits mechanical waves that propagate throughout the hand. Here, we show that these waves produce an efficient encoding of tactile inf...

journal_title：Science advances

authors： Shao Y,Hayward V,Visell Y

更新日期：2020-04-15 00:00:00

abstract：:Improved constraints on lower-mantle composition are fundamental to understand the accretion, differentiation, and thermochemical evolution of our planet. Cosmochemical arguments indicate that lower-mantle rocks may be enriched in Si relative to upper-mantle pyrolite, whereas seismic tomography images suggest whole-ma...

journal_title：Science advances

authors： Ballmer MD,Schmerr NC,Nakagawa T,Ritsema J

更新日期：2015-12-10 00:00:00

abstract：:Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new histones at the promoters of genes. The role of these histone exchange events in transcription remains unclear. In particular, the causal relationship between histone exchange and activator...

journal_title：Science advances

authors： Kassem S,Ferrari P,Hughes AL,Soudet J,Rando OJ,Strubin M

更新日期：2020-09-02 00:00:00

abstract：:The natural selection and the evolutionary optimization of complex shapes in nature are closely related to their functions. Mechanostabilization of shape of biological structure via morphogenesis has several beautiful examples. With the help of simple mechanics-based modeling and experiments, we show an important caus...

journal_title：Science advances

authors： Tiwary CS,Kishore S,Sarkar S,Mahapatra DR,Ajayan PM,Chattopadhyay K

更新日期：2015-05-15 00:00:00

abstract：:Wearable textile electronics are highly desirable for realizing personalized health management. However, most reported textile electronics can either periodically target a single physiological signal or miss the explicit details of the signals, leading to a partial health assessment. Furthermore, textiles with excelle...

journal_title：Science advances

authors： Fan W,He Q,Meng K,Tan X,Zhou Z,Zhang G,Yang J,Wang ZL

更新日期：2020-03-13 00:00:00

abstract：:Adaptation is a fundamental property of sensory systems that can change subjective experiences in the context of recent information. Adaptation has been postulated to arise from recurrent circuit mechanisms or as a consequence of neuronally intrinsic suppression. However, it is unclear whether intrinsic suppression by...

journal_title：Science advances

authors： Vinken K,Boix X,Kreiman G

更新日期：2020-10-14 00:00:00

abstract：:Continental rifting and seafloor spreading play a fundamental role in the generation of new crust. However, the distribution of magma and its relationship with tectonics and volcanism remain poorly understood, particularly in back-arc settings. We show evidence for a large, long-lived, off-axis magmatic intrusion loca...

journal_title：Science advances

authors： Hamling IJ,Hreinsdóttir S,Bannister S,Palmer N

更新日期：2016-06-03 00:00:00

abstract：:Protected areas (PAs) are essential to biodiversity conservation, but their static boundaries may undermine their potential for protecting species under climate change. We assessed how the climatic conditions within global terrestrial PAs may change over time. By 2070, protection is expected to decline in cold and war...

journal_title：Science advances

authors： Elsen PR,Monahan WB,Dougherty ER,Merenlender AM

更新日期：2020-06-17 00:00:00

abstract：:The process of sheep and goat (caprine) domestication began by 9000 to 8000 BCE in Southwest Asia. The early Neolithic site at Aşıklı Höyük in central Turkey preserves early archaeological evidence of this transformation, such as culling by age and sex and use of enclosures inside the settlement. People's strategies f...

journal_title：Science advances

authors： Abell JT,Quade J,Duru G,Mentzer SM,Stiner MC,Uzdurum M,Özbaşaran M

更新日期：2019-04-17 00:00:00

abstract：:The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...

journal_title：Science advances

authors： Wang L,Ozark PA,Smith ER,Zhao Z,Marshall SA,Rendleman EJ,Piunti A,Ryan C,Whelan AL,Helmin KA,Morgan MA,Zou L,Singer BD,Shilatifard A

更新日期：2018-11-07 00:00:00

abstract：:A withdrawal-associated impairment in β-endorphin neurotransmission in the arcuate nucleus (ARC) of the hypothalamus is associated with alcohol dependence characterized by a chronic relapsing disorder. Although acupuncture activates β-endorphin neurons in the ARC projecting to the nucleus accumbens (NAc), a role for A...

journal_title：Science advances

authors： Chang S,Kim DH,Jang EY,Yoon SS,Gwak YS,Yi YJ,Lee JY,Ahn SH,Kim JM,Ryu YH,Kim SN,Roh HS,Lee MY,Kim SC,Lee BH,Kim HY,Yang CH

更新日期：2019-09-04 00:00:00

abstract：:The basic physics of earthquakes is such that strong ground motion cannot be expected from an earthquake unless the earthquake itself is very close or has grown to be very large. We use simple seismological relationships to calculate the minimum time that must elapse before such ground motion can be expected at a dist...

journal_title：Science advances

authors： Minson SE,Meier MA,Baltay AS,Hanks TC,Cochran ES

更新日期：2018-03-21 00:00:00

abstract：:Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...

journal_title：Science advances

authors： Naffouti M,Backofen R,Salvalaglio M,Bottein T,Lodari M,Voigt A,David T,Benkouider A,Fraj I,Favre L,Ronda A,Berbezier I,Grosso D,Abbarchi M,Bollani M

更新日期：2017-11-10 00:00:00

abstract：:The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...

journal_title：Science advances

authors： Pappa AM,Ohayon D,Giovannitti A,Maria IP,Savva A,Uguz I,Rivnay J,McCulloch I,Owens RM,Inal S

更新日期：2018-06-22 00:00:00

abstract：:In the post-Moore era, an electrically driven monolithic optoelectronic integrated circuit (OEIC) fabricated from a single material is pursued globally to enable the construction of wafer-scale compact computing systems with powerful processing capabilities and low-power consumption. We report a monolithic plasmonic i...

journal_title：Science advances

authors： Liu Y,Zhang J,Liu H,Wang S,Peng LM

更新日期：2017-10-20 00:00:00

abstract：:The catalytic activity of alloy nanoparticles depends on the particle size and composition ratio of different metals. Alloy nanoparticles composed of Pd, Pt, and Au are widely used as catalysts for oxidation reactions. The catalytic activities of Pt and Au nanoparticles in oxidation reactions are known to increase as ...

journal_title：Science advances

authors： Takahashi M,Koizumi H,Chun WJ,Kori M,Imaoka T,Yamamoto K

更新日期：2017-07-26 00:00:00

abstract：:Fluid catalytic cracking (FCC) particles account for 40 to 45% of worldwide gasoline production. The hierarchical complex particle pore structure allows access of long-chain feedstock molecules into active catalyst domains where they are cracked into smaller, more valuable hydrocarbon products (for example, gasoline)....

journal_title：Science advances

authors： Meirer F,Kalirai S,Morris D,Soparawalla S,Liu Y,Mesu G,Andrews JC,Weckhuysen BM

更新日期：2015-04-03 00:00:00

abstract：:Organic matter burial in mangrove forests results in the removal and long-term storage of atmospheric CO2, so-called "blue carbon." However, some of this organic matter is metabolized and returned to the atmosphere as CH4. Because CH4 has a higher global warming potential than the CO2 fixed in the organic matter, it c...

journal_title：Science advances

authors： Rosentreter JA,Maher DT,Erler DV,Murray RH,Eyre BD

更新日期：2018-06-13 00:00:00

abstract：:In a recent paper, Lechner, Hauke, and Zoller (LHZ) described a means to translate a Hamiltonian of N spin-1/2 particles with "all-to-all" interactions into a larger physical lattice with only on-site energies and local parity constraints. LHZ used this mapping to propose a novel form of quantum annealing. We provide ...

journal_title：Science advances

authors： Rocchetto A,Benjamin SC,Li Y

更新日期：2016-10-21 00:00:00

abstract：:Correlating spatial chemical information with the morphology of closely packed nanostructures remains a challenge for the scientific community. For example, supramolecular self-assembly, which provides a powerful and low-cost way to create nanoscale patterns and engineered nanostructures, is not easily interrogated in...

journal_title：Science advances

authors： Nowak D,Morrison W,Wickramasinghe HK,Jahng J,Potma E,Wan L,Ruiz R,Albrecht TR,Schmidt K,Frommer J,Sanders DP,Park S

更新日期：2016-03-25 00:00:00