Elastic properties of silicate melts: Implications for low velocity zones at the lithosphere-asthenosphere boundary.

abstract：:Quantitative three-dimensional (3D) computed tomography (CT) imaging of living single cells enables orientation-independent morphometric analysis of the intricacies of cellular physiology. Since its invention, x-ray CT has become indispensable in the clinic for diagnostic and prognostic purposes due to its quantitativ...

journal_title：Science advances

authors： Kelbauskas L,Shetty R,Cao B,Wang KC,Smith D,Wang H,Chao SH,Gangaraju S,Ashcroft B,Kritzer M,Glenn H,Johnson RH,Meldrum DR

更新日期：2017-12-06 00:00:00

abstract：:Ammonia synthesis consumes 3 to 5% of the world's natural gas, making it a significant contributor to greenhouse gas emissions. Strategies for synthesizing ammonia that are not dependent on the energy-intensive and methane-based Haber-Bosch process are critically important for reducing global energy consumption and mi...

journal_title：Science advances

authors： Song Y,Johnson D,Peng R,Hensley DK,Bonnesen PV,Liang L,Huang J,Yang F,Zhang F,Qiao R,Baddorf AP,Tschaplinski TJ,Engle NL,Hatzell MC,Wu Z,Cullen DA,Meyer HM 3rd,Sumpter BG,Rondinone AJ

更新日期：2018-04-27 00:00:00

abstract：:Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all eight major CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors. Streptolysin O, vaginolysin...

journal_title：Science advances

authors： Shewell LK,Day CJ,Jen FE,Haselhorst T,Atack JM,Reijneveld JF,Everest-Dass A,James DBA,Boguslawski KM,Brouwer S,Gillen CM,Luo Z,Kobe B,Nizet V,von Itzstein M,Walker MJ,Paton AW,Paton JC,Torres VJ,Jennings MP

更新日期：2020-05-22 00:00:00

abstract：:Precise protein folding is essential for the survival of all cells, and protein misfolding causes a number of diseases that lack effective therapies, yet the general principles governing protein folding in the cell remain poorly understood. In vivo, folding can begin cotranslationally and protein quality control at th...

journal_title：Science advances

authors： Samelson AJ,Bolin E,Costello SM,Sharma AK,O'Brien EP,Marqusee S

更新日期：2018-05-30 00:00:00

abstract：:Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by elect...

journal_title：Science advances

authors： Wang J,Yu J,Zhang Y,Zhang X,Kahkoska AR,Chen G,Wang Z,Sun W,Cai L,Chen Z,Qian C,Shen Q,Khademhosseini A,Buse JB,Gu Z

更新日期：2019-07-10 00:00:00

abstract：:Grippers are widely used for the gripping, manipulation, and assembly of objects with a wide range of scales, shapes, and quantities in research, industry, and our daily lives. A simple yet universal solution is very challenging. Here, we manage to address this challenge utilizing a simple shape memory polymer (SMP) b...

journal_title：Science advances

authors： Linghu C,Zhang S,Wang C,Yu K,Li C,Zeng Y,Zhu H,Jin X,You Z,Song J

更新日期：2020-02-14 00:00:00

abstract：:Soft robotics may enable many new technologies in which humans and robots physically interact, yet the necessary high-performance soft actuators still do not exist. The optimal soft actuators need to be fast and forceful and have programmable shape changes. Furthermore, they should be energy efficient for untethered a...

journal_title：Science advances

authors： Davidson ZS,Shahsavan H,Aghakhani A,Guo Y,Hines L,Xia Y,Yang S,Sitti M

更新日期：2019-11-22 00:00:00

abstract：:Natively paired sequencing (NPS) of B cell receptors [variable heavy (VH) and light (VL)] and T cell receptors (TCRb and TCRa) is essential for the understanding of adaptive immunity in health and disease. Despite many recent technical advances, determining the VH:VL or TCRb:a repertoire with high accuracy and through...

journal_title：Science advances

authors： Tanno H,McDaniel JR,Stevens CA,Voss WN,Li J,Durrett R,Lee J,Gollihar J,Tanno Y,Delidakis G,Pothukuchy A,Ellefson JW,Goronzy JJ,Maynard JA,Ellington AD,Ippolito GC,Georgiou G

更新日期：2020-04-22 00:00:00

abstract：:The transcription factor p63 is a key mediator of epidermal development. Point mutations in p63 in patients lead to developmental defects, including orofacial clefting. To date, knowledge on how pivotal the role of p63 is in human craniofacial development is limited. Using an inducible transdifferentiation model, comb...

journal_title：Science advances

authors： Lin-Shiao E,Lan Y,Welzenbach J,Alexander KA,Zhang Z,Knapp M,Mangold E,Sammons M,Ludwig KU,Berger SL

更新日期：2019-05-01 00:00:00

abstract：:Early identification of pathogens is essential for limiting development of therapy-resistant pathogens and mitigating infectious disease outbreaks. Most bacterial detection schemes use target-specific probes to differentiate pathogen species, creating time and cost inefficiencies in identifying newly discovered organi...

journal_title：Science advances

authors： Aghazadeh A,Lin AY,Sheikh MA,Chen AL,Atkins LM,Johnson CL,Petrosino JF,Drezek RA,Baraniuk RG

更新日期：2016-09-28 00:00:00

abstract：:Toxins efficiently deliver cargo to cells by binding to cell surface ligands, initiating endocytosis, and escaping the endolysosomal pathway into the cytoplasm. We took advantage of this delivery pathway by conjugating an attenuated diphtheria toxin to siRNA, thereby achieving gene downregulation in patient-derived gl...

journal_title：Science advances

authors： Arnold AE,Smith LJ,Beilhartz GL,Bahlmann LC,Jameson E,Melnyk RA,Shoichet MS

更新日期：2020-05-01 00:00:00

abstract：:Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we intro...

journal_title：Science advances

authors： Kim Y,Yoo YK,Kim HY,Roh JH,Kim J,Baek S,Lee JC,Kim HJ,Chae MS,Jeong D,Park D,Lee S,Jang H,Kim K,Lee JH,Byun BH,Park SY,Ha JH,Lee KC,Cho WW,Kim JS,Koh JY,Lim SM,Hwang KS

更新日期：2019-04-17 00:00:00

abstract：:Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...

journal_title：Science advances

authors： Wang L,Yu C,Chang T,Zhang M,Song S,Xiong C,Su P,Xiang W

更新日期：2020-05-22 00:00:00

abstract：:By developing new computational models, we examine how enzymatic reactions on an underlying surface can be harnessed to direct the motion and organization of reagent-laden microcapsules in a fluid-filled microchannel. In the presence of appropriate reagents, surface-bound enzymes can act as pumps, which drive large-sc...

journal_title：Science advances

authors： Shklyaev OE,Shum H,Sen A,Balazs AC

更新日期：2016-03-18 00:00:00

abstract：:Hybrid organic-inorganic halide perovskites have shown remarkable optoelectronic properties, exhibiting an impressive tolerance to defects believed to originate from correlated motion of charge carriers and the polar lattice forming large polarons. Few experimental techniques are capable of directly probing these corr...

journal_title：Science advances

authors： Lan Y,Dringoli BJ,Valverde-Chávez DA,Ponseca CS Jr,Sutton M,He Y,Kanatzidis MG,Cooke DG

更新日期：2019-05-31 00:00:00

abstract：:Metal-organic frameworks (MOFs) have been attracting intensive attention because of their commendable potential in many applications. Postsynthetic modification for redesigning chemical characteristics and pore structures can greatly improve performance and expand functionality of MOF materials. Here, we develop a ver...

journal_title：Science advances

authors： Wu W,Su J,Jia M,Li Z,Liu G,Li W

更新日期：2020-05-01 00:00:00

abstract：:Six percent of Americans, including 3 million high schoolers, use e-cigarettes, which contain potentially toxic substances, volatile organic compounds, and metals. We present the first human study on the effects of e-cigarette exposure in the oral cavity. By interrogating both immunoinflammatory responses and microbia...

journal_title：Science advances

authors： Ganesan SM,Dabdoub SM,Nagaraja HN,Scott ML,Pamulapati S,Berman ML,Shields PG,Wewers ME,Kumar PS

更新日期：2020-05-27 00:00:00

abstract：:Tumor angiogenesis provides critical nutrients for cancer progression and may also facilitate pathways for dissemination during the process of metastasis. It is well established that cells that metastasize display characteristics of stem cells; however, the prevailing paradigm points to these stem-like cells residing ...

journal_title：Science advances

authors： Lee J,Abdeen AA,Hedhli J,Wycislo KL,Dobrucka IT,Fan TM,Dobrucki LW,Kilian KA

更新日期：2017-10-25 00:00:00

abstract：:Cell chirality is a newly discovered intrinsic property of the cell, reflecting the bias of the cell to polarize in the left-right axis. Despite increasing evidence on its substantial role in the asymmetric development of embryos, little is known about implications of cell chirality in physiology and disease. We demon...

journal_title：Science advances

authors： Fan J,Ray P,Lu YW,Kaur G,Schwarz JJ,Wan LQ

更新日期：2018-10-24 00:00:00

abstract：:Deep CO2 emissions characterize many nonvolcanic, seismically active regions worldwide, and the involvement of deep CO2 in the earthquake cycle is now generally recognized. However, no long-time records of such emissions have been published, and the temporal relations between earthquake occurrence and tectonic CO2 rel...

journal_title：Science advances

authors： Chiodini G,Cardellini C,Di Luccio F,Selva J,Frondini F,Caliro S,Rosiello A,Beddini G,Ventura G

更新日期：2020-08-26 00:00:00

abstract：:Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol ...

journal_title：Science advances

authors： Khom S,Steinkellner T,Hnasko TS,Roberto M

更新日期：2020-03-18 00:00:00

abstract：:The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...

journal_title：Science advances

authors： Movaghar A,Page D,Brilliant M,Baker MW,Greenberg J,Hong J,DaWalt LS,Saha K,Kuusisto F,Stewart R,Berry-Kravis E,Mailick MR

更新日期：2019-08-21 00:00:00

abstract：:The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored. Here, we established an integrated screening strategy to discover lncRNAs implicated in neurotransmitter and synaptic vesicle release. With this approach, we ...

journal_title：Science advances

authors： Keihani S,Kluever V,Mandad S,Bansal V,Rahman R,Fritsch E,Gomes LC,Gärtner A,Kügler S,Urlaub H,Wren JD,Bonn S,Rizzoli SO,Fornasiero EF

更新日期：2019-12-18 00:00:00

abstract：:Granular dynamics govern earthquakes, avalanches, and landslides and are of fundamental importance in a variety of industries ranging from energy to pharmaceuticals to agriculture. Nonetheless, our understanding of the underlying physics is poor because we lack spatially and temporally resolved experimental measuremen...

journal_title：Science advances

authors： Penn A,Tsuji T,Brunner DO,Boyce CM,Pruessmann KP,Müller CR

更新日期：2017-09-15 00:00:00

abstract：:Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...

journal_title：Science advances

authors： Lee SH,Albright ER,Lee JH,Jacobs D,Kalejta RF

更新日期：2015-11-27 00:00:00

abstract：:The essence of turbulent flow is the conveyance of energy through the formation, interaction, and destruction of eddies over a wide range of spatial scales-from the largest scales where energy is injected down to the smallest scales where it is dissipated through viscosity. Currently, there is no mechanistic framework...

journal_title：Science advances

authors： McKeown R,Ostilla-Mónico R,Pumir A,Brenner MP,Rubinstein SM

更新日期：2020-02-28 00:00:00

abstract：:Two-dimensional (2D) layered hybrid organic-inorganic halide perovskite semiconductors form natural "multiple quantum wells" that have strong spin-orbit coupling due to the heavy elements in their building blocks. This may lead to "Rashba splitting" close to the extrema in the electron bands. We have used a plethora o...

journal_title：Science advances

authors： Zhai Y,Baniya S,Zhang C,Li J,Haney P,Sheng CX,Ehrenfreund E,Vardeny ZV

更新日期：2017-07-28 00:00:00

abstract：:Rising sea levels will have overwhelmingly negative impacts on coastal communities globally. With previous research focused on how sea-level rise (SLR) affects storm-induced flooding, we show that SLR will also increase both the frequency and the intensity of tsunami-induced flooding, another significant coastal hazar...

journal_title：Science advances

authors： Li L,Switzer AD,Wang Y,Chan CH,Qiu Q,Weiss R

更新日期：2018-08-15 00:00:00

abstract：:Vertical stacking is widely viewed as a promising approach for designing advanced functionalities using two-dimensional (2D) materials. Combining crystallographically commensurate materials in these 2D stacks has been shown to result in rich new electronic structure, magnetotransport, and optical properties. In this c...

journal_title：Science advances

authors： Vargas A,Liu F,Lane C,Rubin D,Bilgin I,Hennighausen Z,DeCapua M,Bansil A,Kar S

更新日期：2017-07-14 00:00:00

abstract：:Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard...

journal_title：Science advances

authors： Castle MJ,Cheng Y,Asokan A,Tuszynski MH

更新日期：2018-11-14 00:00:00