In situ repair abilities of human umbilical cord-derived mesenchymal stem cells and autocrosslinked hyaluronic acid gel complex in rhesus monkeys with intrauterine adhesion.

abstract：:Multicellular organisms are composed of tissues that have distinct functions requiring specialized proteomes. To define the proteome of a live animal with tissue and subcellular resolution, we adapted a localized proteomics technology for use in the multicellular model organism Caenorhabditis elegans. This approach co...

journal_title：Science advances

authors： Reinke AW,Mak R,Troemel ER,Bennett EJ

更新日期：2017-05-10 00:00:00

abstract：:Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. Gene expression and DNA methylation ...

journal_title：Science advances

authors： Salvadores M,Fuster-Tormo F,Supek F

更新日期：2020-07-01 00:00:00

abstract：:The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of the PML-RAR oncogene. AP...

journal_title：Science advances

authors： Ravasio R,Ceccacci E,Nicosia L,Hosseini A,Rossi PL,Barozzi I,Fornasari L,Zuffo RD,Valente S,Fioravanti R,Mercurio C,Varasi M,Mattevi A,Mai A,Pavesi G,Bonaldi T,Minucci S

更新日期：2020-04-08 00:00:00

abstract：:Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we intro...

journal_title：Science advances

authors： Kim Y,Yoo YK,Kim HY,Roh JH,Kim J,Baek S,Lee JC,Kim HJ,Chae MS,Jeong D,Park D,Lee S,Jang H,Kim K,Lee JH,Byun BH,Park SY,Ha JH,Lee KC,Cho WW,Kim JS,Koh JY,Lim SM,Hwang KS

更新日期：2019-04-17 00:00:00

abstract：:Many animals understand numbers at a basic level for use in essential tasks such as foraging, shoaling, and resource management. However, complex arithmetic operations, such as addition and subtraction, using symbols and/or labeling have only been demonstrated in a limited number of nonhuman vertebrates. We show that ...

journal_title：Science advances

authors： Howard SR,Avarguès-Weber A,Garcia JE,Greentree AD,Dyer AG

更新日期：2019-02-06 00:00:00

abstract：:Energy band engineering is of fundamental importance in nanoelectronics. Compared to chemical approaches such as doping and surface functionalization, electrical and optical methods provide greater flexibility that enables continuous, reversible, and in situ band tuning on electronic devices of various kinds. In this ...

journal_title：Science advances

authors： Wu E,Xie Y,Zhang J,Zhang H,Hu X,Liu J,Zhou C,Zhang D

更新日期：2019-05-03 00:00:00

abstract：:Resistances that exceed the Mott-Ioffe-Regel limit (known as bad metal behavior) and non-Fermi liquid behavior are ubiquitous features of the normal state of many strongly correlated materials. We establish the conditions that lead to bad metal and non-Fermi liquid phases in NdNiO3, which exhibits a prototype bandwidt...

journal_title：Science advances

authors： Mikheev E,Hauser AJ,Himmetoglu B,Moreno NE,Janotti A,Van de Walle CG,Stemmer S

更新日期：2015-11-06 00:00:00

abstract：:Wearable textile electronics are highly desirable for realizing personalized health management. However, most reported textile electronics can either periodically target a single physiological signal or miss the explicit details of the signals, leading to a partial health assessment. Furthermore, textiles with excelle...

journal_title：Science advances

authors： Fan W,He Q,Meng K,Tan X,Zhou Z,Zhang G,Yang J,Wang ZL

更新日期：2020-03-13 00:00:00

abstract：:Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochondrial membrane requi...

journal_title：Science advances

authors： Parey K,Haapanen O,Sharma V,Köfeler H,Züllig T,Prinz S,Siegmund K,Wittig I,Mills DJ,Vonck J,Kühlbrandt W,Zickermann V

更新日期：2019-12-11 00:00:00

abstract：:Ocean circulation redistributes Earth's energy and water masses and influences global climate. Under historical greenhouse warming, regional ocean currents show diverse tendencies, but whether there is an emerging trend of the global mean ocean circulation system is not yet clear. Here, we show a statistically signifi...

journal_title：Science advances

authors： Hu S,Sprintall J,Guan C,McPhaden MJ,Wang F,Hu D,Cai W

更新日期：2020-02-05 00:00:00

abstract：:Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits the development of effective treatments for CNS disorders. We present the facile synthesis of a novel neuroinflammation-targeting polyethylene glycol-based dendrimer (PEGOL-60) using an efficient click chemistry approach. PEGOL-6...

journal_title：Science advances

authors： Sharma A,Sharma R,Zhang Z,Liaw K,Kambhampati SP,Porterfield JE,Lin KC,DeRidder LB,Kannan S,Kannan RM

更新日期：2020-01-22 00:00:00

abstract：:Coordinatively unsaturated (CUS) iron sites are highly active in catalytic oxidation reactions; however, maintaining the CUS structure of iron during heterogeneous catalytic reactions is a great challenge. Here, we report a strategy to stabilize single-atom CUS iron sites by embedding highly dispersed FeN4 centers in ...

journal_title：Science advances

authors： Deng D,Chen X,Yu L,Wu X,Liu Q,Liu Y,Yang H,Tian H,Hu Y,Du P,Si R,Wang J,Cui X,Li H,Xiao J,Xu T,Deng J,Yang F,Duchesne PN,Zhang P,Zhou J,Sun L,Li J,Pan X,Bao X

更新日期：2015-12-04 00:00:00

abstract：:Exploration of phase transitions and construction of associated phase diagrams are of fundamental importance for condensed matter physics and materials science alike, and remain the focus of extensive research for both theoretical and experimental studies. For the latter, comprehensive studies involving scattering, th...

journal_title：Science advances

authors： Li L,Yang Y,Zhang D,Ye ZG,Jesse S,Kalinin SV,Vasudevan RK

更新日期：2018-03-30 00:00:00

abstract：:Two-dimensional (2D) semiconductors have shown great potential for electronic and optoelectronic applications. However, their development is limited by a large Schottky barrier (SB) at the metal-semiconductor junction (MSJ), which is difficult to tune by using conventional metals because of the effect of strong Fermi ...

journal_title：Science advances

authors： Liu Y,Stradins P,Wei SH

更新日期：2016-04-22 00:00:00

abstract：:Fractures and faults riddle the Earth's crust on all scales, and the deformation associated with them is presumed to have had significant effects on its petrological and structural evolution. However, despite the abundance of directly observable earthquake activity, unequivocal evidence for seismic slip rates along an...

journal_title：Science advances

authors： Austrheim H,Dunkel KG,Plümper O,Ildefonse B,Liu Y,Jamtveit B

更新日期：2017-02-22 00:00:00

abstract：:Donkeys and horses share a common ancestor dating back to about 4 million years ago. Although a high-quality genome assembly at the chromosomal level is available for the horse, current assemblies available for the donkey are limited to moderately sized scaffolds. The absence of a better-quality assembly for the donke...

journal_title：Science advances

authors： Renaud G,Petersen B,Seguin-Orlando A,Bertelsen MF,Waller A,Newton R,Paillot R,Bryant N,Vaudin M,Librado P,Orlando L

更新日期：2018-04-04 00:00:00

abstract：:Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was mediated through TOR s...

journal_title：Science advances

authors： Yu R,Sun L,Sun Y,Han X,Qin L,Dang W

更新日期：2019-07-10 00:00:00

abstract：:Cost-benefit trade-offs for individuals participating in social behaviors are the basis for current theories on the evolution of social behaviors and societies. However, research on social strategies has largely ignored solitary animals, in which we assume that rare interactions are explained by courtship or territori...

journal_title：Science advances

authors： Elbroch LM,Levy M,Lubell M,Quigley H,Caragiulo A

更新日期：2017-10-11 00:00:00

abstract：:The past few years have witnessed rapid advances in the synthesis of high-quality perovskite nanocrystals (PNCs). However, despite the impressive developments, the stability of PNCs remains a substantial challenge. The ability to reliably improve stability of PNCs while retaining their individual nanometer size repres...

journal_title：Science advances

authors： He Y,Yoon YJ,Harn YW,Biesold-McGee GV,Liang S,Lin CH,Tsukruk VV,Thadhani N,Kang Z,Lin Z

更新日期：2019-11-29 00:00:00

abstract：:One of the most elusive scientific challenges for over 150 years has been to explain why cooperation survives despite being a seemingly inferior strategy from an evolutionary point of view. Over the years, various theoretical scenarios aimed at solving the evolutionary puzzle of cooperation have been proposed, eventua...

journal_title：Science advances

authors： Wang Z,Jusup M,Wang RW,Shi L,Iwasa Y,Moreno Y,Kurths J

更新日期：2017-03-29 00:00:00

abstract：:Meteorite impact craters are one of the most common geological features in the solar system. An impact event is a near-instantaneous process that releases a huge amount of energy over a very small region on a planetary surface. This results in characteristic changes in the target rocks, from vaporization and melting t...

journal_title：Science advances

authors： Osinski GR,Ferrière L

更新日期：2016-08-05 00:00:00

abstract：:Black phosphorus (BP) offers considerable promise for infrared and visible photonics. Efficient tuning of the bandgap and higher subbands in BP by modulation of the Fermi level or application of vertical electric fields has been previously demonstrated, allowing electrical control of its above-bandgap optical properti...

journal_title：Science advances

authors： Biswas S,Whitney WS,Grajower MY,Watanabe K,Taniguchi T,Bechtel HA,Rossman GR,Atwater HA

更新日期：2021-01-08 00:00:00

abstract：:Asymmetric interactions such as entropic (e.g., encoded by nonspherical shapes) or surface forces (e.g., encoded by patterned surface chemistry or DNA hybridization) provide access to functional states of colloidal matter, but versatile approaches for engineering asymmetric van der Waals interactions have the potentia...

journal_title：Science advances

authors： Fuster HA,Wang X,Wang X,Bukusoglu E,Spagnolie SE,Abbott NL

更新日期：2020-06-19 00:00:00

abstract：:Capabilities for assembly of three-dimensional (3D) micro/nanostructures in advanced materials have important implications across a broad range of application areas, reaching nearly every class of microsystem technology. Approaches that rely on the controlled, compressive buckling of 2D precursors are promising becaus...

journal_title：Science advances

authors： Yan Z,Zhang F,Liu F,Han M,Ou D,Liu Y,Lin Q,Guo X,Fu H,Xie Z,Gao M,Huang Y,Kim J,Qiu Y,Nan K,Kim J,Gutruf P,Luo H,Zhao A,Hwang KC,Huang Y,Zhang Y,Rogers JA

更新日期：2016-09-23 00:00:00

abstract：:Dendritic actin networks develop from a first actin filament through branching by the Arp2/3 complex. At the surface of endosomes, the WASH complex activates the Arp2/3 complex and interacts with the capping protein for unclear reasons. Here, we show that the WASH complex interacts with dynactin and uncaps it through ...

journal_title：Science advances

authors： Fokin AI,David V,Oguievetskaia K,Derivery E,Stone CE,Cao L,Rocques N,Molinie N,Henriot V,Aumont-Nicaise M,Hinckelmann MV,Saudou F,Le Clainche C,Carter AP,Romet-Lemonne G,Gautreau AM

更新日期：2021-01-13 00:00:00

abstract：:Superomniphobic textures are at the frontier of surface design for vast arrays of applications. Despite recent substantial advances in fabrication methods for reentrant and doubly reentrant microstructures, design optimization remains a major challenge. We overcome this in two stages. First, we develop readily general...

journal_title：Science advances

authors： Panter JR,Gizaw Y,Kusumaatmaja H

更新日期：2019-06-21 00:00:00

abstract：:Revealing physical interactions in complex systems from observed collective dynamics constitutes a fundamental inverse problem in science. Current reconstruction methods require access to a system's model or dynamical data at a level of detail often not available. We exploit changes in invariant measures, in particula...

journal_title：Science advances

authors： Nitzan M,Casadiego J,Timme M

更新日期：2017-02-10 00:00:00

abstract：:Silicic volcanic activity has long been framed as either violently explosive or gently effusive. However, recent observations demonstrate that explosive and effusive behavior can occur simultaneously. Here, we propose that rhyolitic magma feeding subaerial eruptions generally fragments during ascent through the upper ...

journal_title：Science advances

authors： Wadsworth FB,Llewellin EW,Vasseur J,Gardner JE,Tuffen H

更新日期：2020-09-23 00:00:00

abstract：:Photoresponsive liquid crystalline elastomers (LCEs) constitute ideal actuators for soft robots because their light-induced macroscopic shape changes can be harnessed to perform specific articulated motions. Conventional LCEs, however, do not typically exhibit complex modes of bending and twisting necessary to perform...

journal_title：Science advances

authors： Waters JT,Li S,Yao Y,Lerch MM,Aizenberg M,Aizenberg J,Balazs AC

更新日期：2020-03-27 00:00:00

abstract：:We present a framework for quantifying the spatial and temporal co-occurrence of climate stresses in a nonstationary climate. We find that, globally, anthropogenic climate forcing has doubled the joint probability of years that are both warm and dry in the same location (relative to the 1961-1990 baseline). In additio...

journal_title：Science advances

authors： Sarhadi A,Ausín MC,Wiper MP,Touma D,Diffenbaugh NS

更新日期：2018-11-28 00:00:00