Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system.

abstract：:Cyclosporine A (CsA) is a powerful immunosuppressant, but it is an ineffective stand-alone treatment for systemic lupus erythematosus (SLE) due to poor target tissue distribution and renal toxicity. We hypothesized that CD71 (transferrin receptor 1)-directed delivery of CsA to the lymphatic system would improve SLE ou...

journal_title：Science advances

authors： Ganugula R,Arora M,Zou D,Agarwal SK,Mohan C,Kumar MNVR

更新日期：2020-06-12 00:00:00

abstract：:Exploration for superconductivity is one of the research frontiers in condensed matter physics. In strongly correlated electron systems, the emergence of superconductivity is often inhibited by the formation of a thermodynamically more stable magnetic/charge order. Thus, to develop the superconductivity as the thermod...

journal_title：Science advances

authors： Oike H,Kamitani M,Tokura Y,Kagawa F

更新日期：2018-10-05 00:00:00

abstract：:Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. Gene expression and DNA methylation ...

journal_title：Science advances

authors： Salvadores M,Fuster-Tormo F,Supek F

更新日期：2020-07-01 00:00:00

abstract：:Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that causes genome reprogramming through remodeling of enhancers. Here, we describe an unexpected function of RING1B, which is highly expressed in EwS. ...

journal_title：Science advances

authors： Sánchez-Molina S,Figuerola-Bou E,Blanco E,Sánchez-Jiménez M,Táboas P,Gómez S,Ballaré C,García-Domínguez DJ,Prada E,Hontecillas-Prieto L,M Carcaboso Á,Tirado ÓM,Hernández-Muñoz I,de Álava E,Lavarino C,Di Croce L,Mora J

更新日期：2020-10-23 00:00:00

abstract：:A large body of previous neuroimaging studies suggests that multiple languages are processed and organized in a single neuroanatomical system in the bilingual brain, although differential activation may be seen in some studies because of different proficiency levels and/or age of acquisition of the two languages. Howe...

journal_title：Science advances

authors： Xu M,Baldauf D,Chang CQ,Desimone R,Tan LH

更新日期：2017-07-12 00:00:00

abstract：:Micrometer-scale acoustic waves are highly useful for refined optomechanical and acoustofluidic manipulation, where these fields are spatially localized along the transducer aperture but not along the acoustic propagation direction. In the case of acoustic tweezers, such a conventional acoustic standing wave results i...

journal_title：Science advances

authors： Collins DJ,Devendran C,Ma Z,Ng JW,Neild A,Ai Y

更新日期：2016-07-13 00:00:00

abstract：:Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography-based, four-dimensional imaging methods and computational analysis to monitor acute and chronic whole-bone shape adaptation and re...

journal_title：Science advances

authors： Javaheri B,Razi H,Gohin S,Wylie S,Chang YM,Salmon P,Lee PD,Pitsillides AA

更新日期：2020-03-06 00:00:00

abstract：:One of the most plausible scenarios of the origin of life assumes the preceding prebiotic autotrophic metabolism in sulfide-rich hydrothermal vent environments. However, geochemical mechanisms to harness the reductive power provided by hydrothermal systems remain to be elucidated. Here, we show that, under a geoelectr...

journal_title：Science advances

authors： Kitadai N,Nakamura R,Yamamoto M,Takai K,Yoshida N,Oono Y

更新日期：2019-06-19 00:00:00

abstract：:To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host receptors. Many nAbs bin...

journal_title：Science advances

authors： Tzarum N,Giang E,Kadam RU,Chen F,Nagy K,Augestad EH,Velázquez-Moctezuma R,Keck ZY,Hua Y,Stanfield RL,Dreux M,Prentoe J,Foung SKH,Bukh J,Wilson IA,Law M

更新日期：2020-07-24 00:00:00

abstract：:The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the brain. Glymphatic system activity increases during sleep or ketamine/xylazine (K/X) anesthesia, yet the mechanism(s) facilitating CSF in...

journal_title：Science advances

authors： Hablitz LM,Vinitsky HS,Sun Q,Stæger FF,Sigurdsson B,Mortensen KN,Lilius TO,Nedergaard M

更新日期：2019-02-27 00:00:00

abstract：:Many animals understand numbers at a basic level for use in essential tasks such as foraging, shoaling, and resource management. However, complex arithmetic operations, such as addition and subtraction, using symbols and/or labeling have only been demonstrated in a limited number of nonhuman vertebrates. We show that ...

journal_title：Science advances

authors： Howard SR,Avarguès-Weber A,Garcia JE,Greentree AD,Dyer AG

更新日期：2019-02-06 00:00:00

abstract：:G protein-coupled receptors (GPCRs) play a fundamental role in the modulation of synaptic transmission. A pivotal example is provided by the metabotropic glutamate receptor type 4 (mGluR4), which inhibits glutamate release at presynaptic active zones (AZs). However, how GPCRs are organized within AZs to regulate neuro...

journal_title：Science advances

authors： Siddig S,Aufmkolk S,Doose S,Jobin ML,Werner C,Sauer M,Calebiro D

更新日期：2020-04-15 00:00:00

abstract：:We describe an approach to print composite polymers in high-resolution three-dimensional (3D) architectures that can be rapidly transformed to a new permanent configuration directly by heating. The permanent shape of a component results from the programmed time evolution of the printed shape upon heating via the desig...

journal_title：Science advances

authors： Ding Z,Yuan C,Peng X,Wang T,Qi HJ,Dunn ML

更新日期：2017-04-12 00:00:00

abstract：:In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the...

journal_title：Science advances

authors： Perianez-Rodriguez J,Rodriguez M,Marconi M,Bustillo-Avendaño E,Wachsman G,Sanchez-Corrionero A,De Gernier H,Cabrera J,Perez-Garcia P,Gude I,Saez A,Serrano-Ron L,Beeckman T,Benfey PN,Rodríguez-Patón A,Del Pozo JC,Wabnik K

更新日期：2021-01-01 00:00:00

abstract：:We report a negative resistance, namely, a voltage drop along the opposite direction of a current flow, in the superconducting gap of NbSe2 thin films under the irradiation of surface acoustic waves (SAWs). The amplitude of the negative resistance becomes larger by increasing the SAW power and decreasing temperature. ...

journal_title：Science advances

authors： Yokoi M,Fujiwara S,Kawamura T,Arakawa T,Aoyama K,Fukuyama H,Kobayashi K,Niimi Y

更新日期：2020-08-21 00:00:00

abstract：:Fluid commonly flows in response to an external pressure gradient. However, when a tunnel-containing hydrogel is immersed in water, spontaneous flow occurs through the tunnel without any pressure gradient. We confirmed this flow in a wide range of plant- and animal-derived hydrogels. The flow appears to be driven by a...

journal_title：Science advances

authors： Li Z,Pollack GH

更新日期：2020-05-08 00:00:00

abstract：:The prenatal origins of heart disease in offspring have been established. However, research in species with developmental milestones comparable to humans is lacking, preventing translation of this knowledge to clinical contexts. Using sheep and chickens, two species with similar cardiovascular developmental milestones...

journal_title：Science advances

authors： Botting KJ,Skeffington KL,Niu Y,Allison BJ,Brain KL,Itani N,Beck C,Logan A,Murray AJ,Murphy MP,Giussani DA

更新日期：2020-08-19 00:00:00

abstract：:Silicic volcanic activity has long been framed as either violently explosive or gently effusive. However, recent observations demonstrate that explosive and effusive behavior can occur simultaneously. Here, we propose that rhyolitic magma feeding subaerial eruptions generally fragments during ascent through the upper ...

journal_title：Science advances

authors： Wadsworth FB,Llewellin EW,Vasseur J,Gardner JE,Tuffen H

更新日期：2020-09-23 00:00:00

abstract：:Yearly, a quarter billion people are infected and a half a million killed by the mosquito-borne disease malaria. Lack of real-time observational tools for continuously assessing the unperturbed mosquito flight activity in situ limits progress toward improved vector control. We deployed a high-resolution entomological ...

journal_title：Science advances

authors： Brydegaard M,Jansson S,Malmqvist E,Mlacha YP,Gebru A,Okumu F,Killeen GF,Kirkeby C

更新日期：2020-05-13 00:00:00

abstract：:This study introduces new methods of screening for and tuning chiral space and in so doing identifies a promising set of chiral ligands for asymmetric synthesis. The carbafructopyranosyl-1,2-diamine(s) and salens constructed therefrom are particularly compelling. It is shown that by removing the native anomeric effect...

journal_title：Science advances

authors： Karukurichi KR,Fei X,Swyka RA,Broussy S,Shen W,Dey S,Roy SK,Berkowitz DB

更新日期：2015-07-01 00:00:00

abstract：:The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chemistry, can be used in a radical chain reaction ...

journal_title：Science advances

authors： Povie G,Suravarapu SR,Bircher MP,Mojzes MM,Rieder S,Renaud P

更新日期：2018-07-20 00:00:00

abstract：:Ultraviolet (UV) reception is useful for such basic behaviors as mate choice, foraging, predator avoidance, communication, and navigation, whereas violet reception improves visual resolution and subtle contrast detection. UV and violet reception are mediated by the short wavelength-sensitive (SWS1) pigments that absor...

journal_title：Science advances

authors： Yokoyama S,Altun A,Jia H,Yang H,Koyama T,Faggionato D,Liu Y,Starmer WT

更新日期：2015-09-18 00:00:00

abstract：:Achieving perovskite-based high-color purity blue-emitting light-emitting diodes (LEDs) is still challenging. Here, we report successful synthesis of a series of blue-emissive two-dimensional Ruddlesden-Popper phase single crystals and their high-color purity blue-emitting LED demonstrations. Although this approach su...

journal_title：Science advances

authors： Chen H,Lin J,Kang J,Kong Q,Lu D,Kang J,Lai M,Quan LN,Lin Z,Jin J,Wang LW,Toney MF,Yang P

更新日期：2020-01-24 00:00:00

abstract：:The ability of a material to adopt multiple structures, known as polymorphism, is a fascinating natural phenomenon. Various polymorphs with unusual properties are routinely synthesized by compression under positive pressure. However, changing a material's structure by applying tension under negative pressure is much m...

journal_title：Science advances

authors： Siol S,Holder A,Steffes J,Schelhas LT,Stone KH,Garten L,Perkins JD,Parilla PA,Toney MF,Huey BD,Tumas W,Lany S,Zakutayev A

更新日期：2018-04-20 00:00:00

abstract：:There have been increasing attempts to reverse habitat degradation through active restoration, but few large-scale successes are reported to guide these efforts. Here, we report outcomes from a unique and very successful seagrass restoration project: Since 1999, over 70 million seeds of a marine angiosperm, eelgrass (...

journal_title：Science advances

authors： Orth RJ,Lefcheck JS,McGlathery KS,Aoki L,Luckenbach MW,Moore KA,Oreska MPJ,Snyder R,Wilcox DJ,Lusk B

更新日期：2020-10-07 00:00:00

abstract：:Polyphosphate, an energy-rich polymer conserved in all kingdoms of life, is integral to many cellular stress responses, including nutrient deprivation, and yet, the mechanisms that underlie its biological roles are not well understood. In this work, we elucidate the physiological function of this polymer in the acclim...

journal_title：Science advances

authors： Sanz-Luque E,Saroussi S,Huang W,Akkawi N,Grossman AR

更新日期：2020-09-30 00:00:00

abstract：:Demonstration of ultralow energy switching mechanisms is imperative for continued improvements in computing devices. Ferroelectric (FE) and multiferroic (MF) order and their manipulation promise an ideal combination of state variables to reach attojoule range for logic and memory (i.e., ~30× lower switching energy tha...

journal_title：Science advances

authors： Manipatruni S,Nikonov DE,Lin CC,Prasad B,Huang YL,Damodaran AR,Chen Z,Ramesh R,Young IA

更新日期：2018-11-23 00:00:00

abstract：:Slow slip events have been suggested to trigger subduction earthquakes. However, examples to date have been poorly recorded, occurring offshore, where data are sparse. Better understanding of slow slip events and their influence on subsequent earthquakes is critical for hazard forecasts. We analyze a well-recorded eve...

journal_title：Science advances

authors： Voss N,Dixon TH,Liu Z,Malservisi R,Protti M,Schwartz S

更新日期：2018-10-31 00:00:00

abstract：:Local thermal magnetization fluctuations in Li-doped MnTe are found to increase its thermopower α strongly at temperatures up to 900 K. Below the Néel temperature (TN ~ 307 K), MnTe is antiferromagnetic, and magnon drag contributes αmd to the thermopower, which scales as ~T3. Magnon drag persists into the paramagnetic...

journal_title：Science advances

authors： Zheng Y,Lu T,Polash MMH,Rasoulianboroujeni M,Liu N,Manley ME,Deng Y,Sun PJ,Chen XL,Hermann RP,Vashaee D,Heremans JP,Zhao H

更新日期：2019-09-13 00:00:00

abstract：:Ornithine transcarbamylase (OTC) deficiency is an X-linked urea cycle disorder associated with high mortality. Although a promising treatment for late-onset OTC deficiency, adeno-associated virus (AAV) neonatal gene therapy would only provide short-term therapeutic effects as the non-integrated genome gets lost during...

journal_title：Science advances

authors： Wang L,Yang Y,Breton C,Bell P,Li M,Zhang J,Che Y,Saveliev A,He Z,White J,Latshaw C,Xu C,McMenamin D,Yu H,Morizono H,Batshaw ML,Wilson JM

更新日期：2020-02-12 00:00:00