Abstract:
:The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chemistry, can be used in a radical chain reaction to enable notoriously intractable transformations. By overcoming the radical chain inhibitor properties of substituted alkenes, the radical-mediated hydroalkylation of mono-, di-, tri-, and even tetrasubstituted unactivated olefins could be performed under mild conditions. With a remarkable functional group tolerance, this reaction provides a general coupling method for the derivatization of olefin-containing natural products.
journal_name
Sci Advjournal_title
Science advancesauthors
Povie G,Suravarapu SR,Bircher MP,Mojzes MM,Rieder S,Renaud Pdoi
10.1126/sciadv.aat6031subject
Has Abstractpub_date
2018-07-20 00:00:00pages
eaat6031issue
7issn
2375-2548pii
aat6031journal_volume
4pub_type
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