Oriented assembly of anisotropic nanoparticles into frame-like superstructures.

abstract：:Mimicking subcellular compartments containing enzymes in organisms is considered a promising approach to substitute for missing or lost cellular functions. Inspired by the multicompartment structures of cellular architectures, we present a novel multienzyme system based on hollow hydrogel microcapsules with flexible e...

journal_title：Science advances

authors： Wang H,Zhao Z,Liu Y,Shao C,Bian F,Zhao Y

更新日期：2018-06-15 00:00:00

abstract：:The urea channel of Helicobacterpylori (HpUreI) is an ideal drug target for preventing gastric cancer but incomplete understanding of its gating mechanism has hampered development of inhibitors for the eradication of H. pylori. Here, we present the cryo-EM structures of HpUreI in closed and open conformations, both at...

journal_title：Science advances

authors： Cui Y,Zhou K,Strugatsky D,Wen Y,Sachs G,Zhou ZH,Munson K

更新日期：2019-03-20 00:00:00

abstract：:Regulatory T (Treg) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the Treg cell program. We found that mice deficient in Bcl11b TF solely in Treg cells developed fatal autoimmunity, and Bcl11b-deficient...

journal_title：Science advances

authors： Drashansky TT,Helm E,Huo Z,Curkovic N,Kumar P,Luo X,Parthasarathy U,Zuniga A,Cho JJ,Lorentsen KJ,Xu Z,Uddin M,Moshkani S,Zhou L,Avram D

更新日期：2019-08-07 00:00:00

abstract：:Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive disease progression such as fibrosis and cancer. Besides growth factor signaling, the local extracellular matrix (ECM) and its mechanical properties are central regulators of these processes. It remains unknown whether transfo...

journal_title：Science advances

authors： Kollmannsberger P,Bidan CM,Dunlop JWC,Fratzl P,Vogel V

更新日期：2018-01-17 00:00:00

abstract：:Prosocial behavior is paradoxical because it often entails a cost to one's own welfare to benefit others. Theoretical models suggest that prosociality is driven by several forms of reciprocity. Although we know a great deal about how each of these forms operates in isolation, they are rarely isolated in the real world...

journal_title：Science advances

authors： Melamed D,Simpson B,Abernathy J

更新日期：2020-06-03 00:00:00

abstract：:Low seismic velocity regions in the mantle and crust are commonly attributed to the presence of silicate melts. Determining melt volume and geometric distribution is fundamental to understanding planetary dynamics. We present a new model for seismic velocity reductions that accounts for the anomalous compressibility o...

journal_title：Science advances

authors： Clark AN,Lesher CE

更新日期：2017-12-13 00:00:00

abstract：:Starvation is probably the most common stressful situation in nature. In vertebrates, elevation of the biogenic amine norepinephrine levels is common during starvation. However, the precise role of norepinephrine in nutrient deprivation remains largely unknown. We report that in the free-living nematode Caenorhabditis...

journal_title：Science advances

authors： Tao J,Ma YC,Yang ZS,Zou CG,Zhang KQ

更新日期：2016-05-06 00:00:00

abstract：:Deep CO2 emissions characterize many nonvolcanic, seismically active regions worldwide, and the involvement of deep CO2 in the earthquake cycle is now generally recognized. However, no long-time records of such emissions have been published, and the temporal relations between earthquake occurrence and tectonic CO2 rel...

journal_title：Science advances

authors： Chiodini G,Cardellini C,Di Luccio F,Selva J,Frondini F,Caliro S,Rosiello A,Beddini G,Ventura G

更新日期：2020-08-26 00:00:00

abstract：:Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA) against various cancer cells was reported. This study was aimed at assessing the translational value of n-HA both as a bone-regenerating material ...

journal_title：Science advances

authors： Zhang K,Zhou Y,Xiao C,Zhao W,Wu H,Tang J,Li Z,Yu S,Li X,Min L,Yu Z,Wang G,Wang L,Zhang K,Yang X,Zhu X,Tu C,Zhang X

更新日期：2019-08-02 00:00:00

abstract：:The Mott metal-insulator transition, a paradigm of strong electron-electron correlations, has been considered as a source of intriguing phenomena. Despite its importance for a wide range of materials, fundamental aspects of the transition, such as its universal properties, are still under debate. We report detailed me...

journal_title：Science advances

authors： Gati E,Garst M,Manna RS,Tutsch U,Wolf B,Bartosch L,Schubert H,Sasaki T,Schlueter JA,Lang M

更新日期：2016-12-07 00:00:00

abstract：:Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previ...

journal_title：Science advances

authors： Brödel AK,Rodrigues R,Jaramillo A,Isalan M

更新日期：2020-06-10 00:00:00

abstract：:Interaction of swimming bacteria with flows controls their ability to explore complex environments, crucial to many societal and environmental challenges and relevant for microfluidic applications such as cell sorting. Combining experimental, numerical, and theoretical analysis, we present a comprehensive study of the...

journal_title：Science advances

authors： Jing G,Zöttl A,Clément É,Lindner A

更新日期：2020-07-10 00:00:00

abstract：:Kv2.1 channels mediate cell death-enabling loss of cytosolic potassium in neurons following plasma membrane insertion at somatodendritic clusters. Overexpression of the carboxyl terminus (CT) of the cognate channel Kv2.2 is neuroprotective by disrupting Kv2.1 surface clusters. Here, we define a seven-amino acid declus...

journal_title：Science advances

authors： Schulien AJ,Yeh CY,Orange BN,Pav OJ,Hopkins MP,Moutal A,Khanna R,Sun D,Justice JA,Aizenman E

更新日期：2020-07-01 00:00:00

abstract：:The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...

journal_title：Science advances

authors： Wang L,Ozark PA,Smith ER,Zhao Z,Marshall SA,Rendleman EJ,Piunti A,Ryan C,Whelan AL,Helmin KA,Morgan MA,Zou L,Singer BD,Shilatifard A

更新日期：2018-11-07 00:00:00

abstract：:Key issues for Na-ion batteries are the development of promising electrode materials with favorable sites for Na+ ion intercalation/deintercalation and an understanding of the reaction mechanisms due to its high activation energy and poor electrochemical reversibility. We first report a layered H0.43Ti0.93Nb1.07O5 as ...

journal_title：Science advances

authors： Park H,Kwon J,Choi H,Song T,Paik U

更新日期：2017-10-06 00:00:00

abstract：:The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a...

journal_title：Science advances

authors： Park HH,Kim HN,Kim H,Yoo Y,Shin H,Choi EY,Bae JS,Lee W

更新日期：2020-07-31 00:00:00

abstract：:B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...

journal_title：Science advances

authors： Zhao X,Xie H,Zhao M,Ahsan A,Li X,Wang F,Yi J,Yang Z,Wu C,Raman I,Li QZ,Kim TJ,Liu W

更新日期：2019-07-17 00:00:00

abstract：:Metabolic reprogramming is widely considered a hallmark of cancer, and understanding metabolic dynamics described by the conversion rates or "fluxes" of metabolites can shed light onto biological processes of tumorigenesis and response to therapy. For real-time analysis of metabolic flux in intact cells or organisms, ...

journal_title：Science advances

authors： Jeong S,Eskandari R,Park SM,Alvarez J,Tee SS,Weissleder R,Kharas MG,Lee H,Keshari KR

更新日期：2017-06-16 00:00:00

abstract：:Selective nerve transfers surgically rewire motor neurons and are used in extremity reconstruction to restore muscle function or to facilitate intuitive prosthetic control. We investigated the neurophysiological effects of rewiring motor axons originating from spinal motor neuron pools into target muscles with lower i...

journal_title：Science advances

authors： Bergmeister KD,Aman M,Muceli S,Vujaklija I,Manzano-Szalai K,Unger E,Byrne RA,Scheinecker C,Riedl O,Salminger S,Frommlet F,Borschel GH,Farina D,Aszmann OC

更新日期：2019-01-02 00:00:00

abstract：:Dewetting is a ubiquitous phenomenon in nature; many different thin films of organic and inorganic substances (such as liquids, polymers, metals, and semiconductors) share this shape instability driven by surface tension and mass transport. Via templated solid-state dewetting, we frame complex nanoarchitectures of mon...

journal_title：Science advances

authors： Naffouti M,Backofen R,Salvalaglio M,Bottein T,Lodari M,Voigt A,David T,Benkouider A,Fraj I,Favre L,Ronda A,Berbezier I,Grosso D,Abbarchi M,Bollani M

更新日期：2017-11-10 00:00:00

abstract：:Over the past decade, the Arctic has warmed by 0.75°C, far outpacing the global average, while Antarctic temperatures have remained comparatively stable. As Earth approaches 2°C warming, the Arctic and Antarctic may reach 4°C and 2°C mean annual warming, and 7°C and 3°C winter warming, respectively. Expected consequen...

journal_title：Science advances

authors： Post E,Alley RB,Christensen TR,Macias-Fauria M,Forbes BC,Gooseff MN,Iler A,Kerby JT,Laidre KL,Mann ME,Olofsson J,Stroeve JC,Ulmer F,Virginia RA,Wang M

更新日期：2019-12-04 00:00:00

abstract：:Iron deficiency and anemia are prominent contributors to the preventable disease burden worldwide. A substantial proportion of people with inadequate dietary iron rely on rice as a staple food, but fortification efforts are limited by low iron bioavailability. Furthermore, using high iron fortification dosages may not...

journal_title：Science advances

authors： Hackl LS,Abizari AR,Speich C,Zungbey-Garti H,Cercamondi CI,Zeder C,Zimmermann MB,Moretti D

更新日期：2019-03-27 00:00:00

abstract：:Unraveling the genetic and epigenetic determinants of phenotypes is critical for understanding and re-engineering biology and would benefit from improved methods to separate cells based on phenotypes. Here, we report SPOTlight, a versatile high-throughput technique to isolate individual yeast or human cells with uniqu...

journal_title：Science advances

authors： Lee J,Liu Z,Suzuki PH,Ahrens JF,Lai S,Lu X,Guan S,St-Pierre F

更新日期：2020-10-23 00:00:00

abstract：:Perovskite oxides with poor conductivity call for three-dimensional (3D) conductive scaffolds to demonstrate their superb reactivities for oxygen evolution reaction (OER). However, perovskite formation usually requires high-temperature annealing at 600° to 900°C in air, under which most of the used conductive framewor...

journal_title：Science advances

authors： Li BQ,Tang C,Wang HF,Zhu XL,Zhang Q

更新日期：2016-10-21 00:00:00

abstract：:Characterizing and understanding the emergence of multiple macroscopically ordered electronic phases through subtle tuning of temperature, pressure, and chemical doping has been a long-standing central issue for complex materials research. We report the first comprehensive studies of optical doping-induced emergence o...

journal_title：Science advances

authors： Han TR,Zhou F,Malliakas CD,Duxbury PM,Mahanti SD,Kanatzidis MG,Ruan CY

更新日期：2015-06-26 00:00:00

abstract：:Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinke...

journal_title：Science advances

authors： Wang L,Yu C,Chang T,Zhang M,Song S,Xiong C,Su P,Xiang W

更新日期：2020-05-22 00:00:00

abstract：:The homotrimeric molecular chaperone Skp of Gram-negative bacteria facilitates the transport of outer membrane proteins across the periplasm. It has been unclear how its activity is modulated during its functional cycle. Here, we report an atomic-resolution characterization of the Escherichia coli Skp monomer-trimer t...

journal_title：Science advances

authors： Mas G,Burmann BM,Sharpe T,Claudi B,Bumann D,Hiller S

更新日期：2020-10-21 00:00:00

abstract：:Honeybees use the waggle dance to share information about food-site locations with nestmates. However, the importance of this behavior in colony foraging success remains unclear. We tested whether spatial dance information affects colony foraging success in a human-modified temperate environment by comparing colonies ...

journal_title：Science advances

authors： I'Anson Price R,Dulex N,Vial N,Vincent C,Grüter C

更新日期：2019-02-13 00:00:00

abstract：:Changes in extreme weather, such as tropical cyclones, are one of the most serious ways society experiences the impact of climate change. Advance forecasted conditional attribution statements, using a numerical model, were made about the anthropogenic climate change influence on an individual tropical cyclone, Hurrica...

journal_title：Science advances

authors： Reed KA,Stansfield AM,Wehner MF,Zarzycki CM

更新日期：2020-01-01 00:00:00

abstract：:The transcriptional repressors Polycomb repressive complex 1 (PRC1) and PRC2 are required to maintain cell fate during embryonic development. PRC1 and PRC2 catalyze distinct histone modifications, establishing repressive chromatin at shared targets. How PRC1, which consists of canonical PRC1 (cPRC1) and variant PRC1 (...

journal_title：Science advances

authors： Zepeda-Martinez JA,Pribitzer C,Wang J,Bsteh D,Golumbeanu S,Zhao Q,Burkard TR,Reichholf B,Rhie SK,Jude J,Moussa HF,Zuber J,Bell O

更新日期：2020-04-01 00:00:00