Octopamine connects nutrient cues to lipid metabolism upon nutrient deprivation.

abstract：:Super-resolution nanoscopy based on wide-field microscopic imaging provided high efficiency but limited resolution. Here, we demonstrate a general strategy to push its resolution down to ~50 nm, which is close to the range of single molecular localization microscopy, without sacrificing the wide-field imaging advantag...

journal_title：Science advances

authors： Liu C,Liu W,Wang S,Li H,Lv Z,Zhang F,Zhang D,Teng J,Zheng T,Li D,Zhang M,Xu P,Gong Q

更新日期：2020-04-17 00:00:00

abstract：:Although electromagnetic brain stimulation is a promising treatment in neurology and psychiatry, clinical outcomes are variable, and underlying mechanisms are ill-defined, which impedes the development of new effective stimulation protocols. Here, we show, in vivo and ex vivo, that repetitive transcranial magnetic sti...

journal_title：Science advances

authors： Dufor T,Grehl S,Tang AD,Doulazmi M,Traoré M,Debray N,Dubacq C,Deng ZD,Mariani J,Lohof AM,Sherrard RM

更新日期：2019-10-30 00:00:00

abstract：:Human sleep is highly regulated by temperature. Might climate change-through increases in nighttime heat-disrupt sleep in the future? We conduct the inaugural investigation of the relationship between climatic anomalies, reports of insufficient sleep, and projected climate change. Using data from 765,000 U.S. survey r...

journal_title：Science advances

authors： Obradovich N,Migliorini R,Mednick SC,Fowler JH

更新日期：2017-05-26 00:00:00

abstract：:Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes. However, the effect of physical stressors on the behavior of adipocytes and their cross-talk with tumor cells remain elusive. Here, we demonstrate that compression of cells, resulting f...

journal_title：Science advances

authors： Li Y,Mao AS,Seo BR,Zhao X,Gupta SK,Chen M,Han YL,Shih TY,Mooney DJ,Guo M

更新日期：2020-01-22 00:00:00

abstract：:Species interactions have long been predicted to increase in intensity toward the tropics and low elevations because of gradients in climate, productivity, or biodiversity. Despite their importance for understanding global ecological and evolutionary processes, plant-animal interaction gradients are particularly diffi...

journal_title：Science advances

authors： Hargreaves AL,Suárez E,Mehltreter K,Myers-Smith I,Vanderplank SE,Slinn HL,Vargas-Rodriguez YL,Haeussler S,David S,Muñoz J,Carlos Almazán-Núñez R,Loughnan D,Benning JW,Moeller DA,Brodie JF,Thomas HJD,Morales M PA

更新日期：2019-02-20 00:00:00

abstract：:Understanding the precise atomic structure of ice surfaces is critical for revealing the mechanisms of physical and chemical phenomena at the surfaces, such as ice growth, melting, and chemical reactions. Nevertheless, no conclusive structure has been established. In this study, noncontact atomic force microscopy was ...

journal_title：Science advances

authors： Kawakami N,Iwata K,Shiotari A,Sugimoto Y

更新日期：2020-09-11 00:00:00

abstract：:Superomniphobic textures are at the frontier of surface design for vast arrays of applications. Despite recent substantial advances in fabrication methods for reentrant and doubly reentrant microstructures, design optimization remains a major challenge. We overcome this in two stages. First, we develop readily general...

journal_title：Science advances

authors： Panter JR,Gizaw Y,Kusumaatmaja H

更新日期：2019-06-21 00:00:00

abstract：:Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all eight major CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors. Streptolysin O, vaginolysin...

journal_title：Science advances

authors： Shewell LK,Day CJ,Jen FE,Haselhorst T,Atack JM,Reijneveld JF,Everest-Dass A,James DBA,Boguslawski KM,Brouwer S,Gillen CM,Luo Z,Kobe B,Nizet V,von Itzstein M,Walker MJ,Paton AW,Paton JC,Torres VJ,Jennings MP

更新日期：2020-05-22 00:00:00

abstract：:Infants' remarkable learning abilities allow them to rapidly acquire many complex skills. It has been suggested that infants achieve this learning by optimally allocating their attention to relevant stimuli in the environment, but the underlying mechanisms remain poorly understood. Here, we modeled infants' looking be...

journal_title：Science advances

authors： Poli F,Serino G,Mars RB,Hunnius S

更新日期：2020-09-23 00:00:00

abstract：:In the healthy kidney, specialized cells called podocytes form a sophisticated blood filtration apparatus that allows excretion of wastes and excess fluid from the blood while preventing loss of proteins such as albumin. To operate effectively, this filter is under substantial hydrostatic mechanical pressure. Given th...

journal_title：Science advances

authors： Haley KE,Kronenberg NM,Liehm P,Elshani M,Bell C,Harrison DJ,Gather MC,Reynolds PA

更新日期：2018-06-27 00:00:00

abstract：:Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific recognition signals that allowed them to be matured, modified, aminoacylated, and processed by the ribo...

journal_title：Science advances

authors： Saint-Léger A,Bello C,Dans PD,Torres AG,Novoa EM,Camacho N,Orozco M,Kondrashov FA,Ribas de Pouplana L

更新日期：2016-04-29 00:00:00

abstract：:Strong coupling between a cavity and transition dipole moments in emitters leads to vacuum Rabi splitting. Researchers have not reported strong coupling between a single emitter and a dielectric cavity at room temperature until now. In this study, we investigated the photoluminescence (PL) spectra of colloidal quantum...

journal_title：Science advances

authors： Xu X,Jin S

更新日期：2020-11-20 00:00:00

abstract：:Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the deve...

journal_title：Science advances

authors： Liang Z,Zhang S,Li X,Wang T,Huang Y,Hang W,Yang Z,Li J,Tian Z

更新日期：2017-12-08 00:00:00

abstract：:Over millions of years, the oxidation of organic carbon contained within sedimentary rocks is one of the main sources of carbon dioxide to the atmosphere, yet the controls on this emission remain poorly constrained. We use rhenium to track the oxidation of rock-bound organic carbon in the mountain watersheds of New Ze...

journal_title：Science advances

authors： Horan K,Hilton RG,Selby D,Ottley CJ,Gröcke DR,Hicks M,Burton KW

更新日期：2017-10-04 00:00:00

abstract：:Spatial patterns of gene expression in living organisms orchestrate cell decisions in development, homeostasis, and disease. However, most methods for reconstructing gene patterning in 3D cell culture and artificial tissues are restricted by patterning depth and scale. We introduce a depth- and scale-flexible method t...

journal_title：Science advances

authors： Corbett DC,Fabyan WB,Grigoryan B,O'Connor CE,Johansson F,Batalov I,Regier MC,DeForest CA,Miller JS,Stevens KR

更新日期：2020-09-30 00:00:00

abstract：:LmrA is a bacterial ATP-binding cassette (ABC) multidrug exporter that uses metabolic energy to transport ions, cytotoxic drugs, and lipids. Voltage clamping in a Port-a-Patch was used to monitor electrical currents associated with the transport of monovalent cationic HEPES+ by single-LmrA transporters and ensembles o...

journal_title：Science advances

authors： Agboh K,Lau CHF,Khoo YSK,Singh H,Raturi S,Nair AV,Howard J,Chiapello M,Feret R,Deery MJ,Murakami S,van Veen HW

更新日期：2018-09-19 00:00:00

abstract：:Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report me...

journal_title：Science advances

authors： Zhang H,Hou J,Hu Y,Wang P,Ou R,Jiang L,Liu JZ,Freeman BD,Hill AJ,Wang H

更新日期：2018-02-09 00:00:00

abstract：:Advanced molecular materials that combine two or more physical properties are typically constructed by combining different molecules, each being responsible for one of the properties required. Ideally, single molecules could take care of this combined functionality, provided they are self-assembled correctly and endow...

journal_title：Science advances

authors： Gorbunov AV,Garcia Iglesias M,Guilleme J,Cornelissen TD,Roelofs WSC,Torres T,González-Rodríguez D,Meijer EW,Kemerink M

更新日期：2017-09-29 00:00:00

abstract：:Key issues for Na-ion batteries are the development of promising electrode materials with favorable sites for Na+ ion intercalation/deintercalation and an understanding of the reaction mechanisms due to its high activation energy and poor electrochemical reversibility. We first report a layered H0.43Ti0.93Nb1.07O5 as ...

journal_title：Science advances

authors： Park H,Kwon J,Choi H,Song T,Paik U

更新日期：2017-10-06 00:00:00

abstract：:The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is frequently mutated or dysregulated in multiple human cancers, and loss of TET2 is associated with changes in DNA methylation patterns. Here, using newly developed TE...

journal_title：Science advances

authors： Wang L,Ozark PA,Smith ER,Zhao Z,Marshall SA,Rendleman EJ,Piunti A,Ryan C,Whelan AL,Helmin KA,Morgan MA,Zou L,Singer BD,Shilatifard A

更新日期：2018-11-07 00:00:00

abstract：:Fluctuations in biodiversity, large and small, pervade the fossil record, yet we do not understand the processes generating them. Here, we extend theory from nonequilibrium statistical physics to describe the fat-tailed form of fluctuations in Phanerozoic marine invertebrate richness. Using this theory, known as super...

journal_title：Science advances

authors： Rominger AJ,Fuentes MA,Marquet PA

更新日期：2019-06-26 00:00:00

abstract：:Lake evaporation can influence basin-wide hydrological cycles and is an important factor in loss of water resources in endorheic lakes of the Tibetan Plateau. Because of the scarcity of data, published lake evaporation values are inconsistent, and their spatial distribution has never been reported. Presenting a plausi...

journal_title：Science advances

authors： Wang B,Ma Y,Su Z,Wang Y,Ma W

更新日期：2020-06-26 00:00:00

abstract：:Quantum phenomena have the potential to speed up the solution of hard optimization problems. For example, quantum annealing, based on the quantum tunneling effect, has recently been shown to scale exponentially better with system size than classical simulated annealing. However, current realizations of quantum anneale...

journal_title：Science advances

authors： Nigg SE,Lörch N,Tiwari RP

更新日期：2017-04-07 00:00:00

abstract：:Precise protein folding is essential for the survival of all cells, and protein misfolding causes a number of diseases that lack effective therapies, yet the general principles governing protein folding in the cell remain poorly understood. In vivo, folding can begin cotranslationally and protein quality control at th...

journal_title：Science advances

authors： Samelson AJ,Bolin E,Costello SM,Sharma AK,O'Brien EP,Marqusee S

更新日期：2018-05-30 00:00:00

abstract：:Ontogenetic studies provide clues for understanding important paleobiological aspects of extinct species. When compared to that of modern humans, the adult Neanderthal thorax was shorter, deeper, and wider. This is related to the wide Neanderthal body and is consistent with their hypothetical large requirements for en...

journal_title：Science advances

authors： García-Martínez D,Bastir M,Gómez-Olivencia A,Maureille B,Golovanova L,Doronichev V,Akazawa T,Kondo O,Ishida H,Gascho D,Zollikofer CPE,de León MP,Heuzé Y

更新日期：2020-10-07 00:00:00

abstract：:Here, we demonstrate the use of pump-probe microscopy for high-resolution studies of vermilion degradation. Vermilion (mostly α-HgS), an important red pigment used in historical paintings, blackens over time, and metallic Hg and β-HgS have been implicated as possible degradation products. Conventional analysis techniq...

journal_title：Science advances

authors： Yu J,Warren WS,Fischer MC

更新日期：2019-06-21 00:00:00

abstract：:High-entropy alloys exhibit exceptional mechanical properties at cryogenic temperatures, due to the activation of twinning in addition to dislocation slip. The coexistence of multiple deformation pathways raises an important question regarding how individual deformation mechanisms compete or synergize during plastic d...

journal_title：Science advances

authors： Naeem M,He H,Zhang F,Huang H,Harjo S,Kawasaki T,Wang B,Lan S,Wu Z,Wang F,Wu Y,Lu Z,Zhang Z,Liu CT,Wang XL

更新日期：2020-03-27 00:00:00

abstract：:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...

journal_title：Science advances

authors： Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

更新日期：2019-06-26 00:00:00

abstract：:The lipid bilayer membrane, which is the foundation of life on Earth, is not viable outside of biology based on liquid water. This fact has caused astronomers who seek conditions suitable for life to search for exoplanets within the "habitable zone," the narrow band in which liquid water can exist. However, can cell m...

journal_title：Science advances

authors： Stevenson J,Lunine J,Clancy P

更新日期：2015-02-27 00:00:00

abstract：:Direct residential and transportation energy consumption (RTC) contributes significantly to ambient fine particulate matter with a diameter smaller than 2.5 μm (PM2.5) in China. During massive rural-urban migration, population and pollutant emissions from RTC have evolved in terms of magnitude and geographic distribut...

journal_title：Science advances

authors： Shen H,Tao S,Chen Y,Ciais P,Güneralp B,Ru M,Zhong Q,Yun X,Zhu X,Huang T,Tao W,Chen Y,Li B,Wang X,Liu W,Liu J,Zhao S

更新日期：2017-07-19 00:00:00