Powering the ABC multidrug exporter LmrA: How nucleotides embrace the ion-motive force.

abstract：:The basic physics of earthquakes is such that strong ground motion cannot be expected from an earthquake unless the earthquake itself is very close or has grown to be very large. We use simple seismological relationships to calculate the minimum time that must elapse before such ground motion can be expected at a dist...

journal_title：Science advances

authors： Minson SE,Meier MA,Baltay AS,Hanks TC,Cochran ES

更新日期：2018-03-21 00:00:00

abstract：:Fundamental understanding of the charge transport physics of hybrid lead halide perovskite semiconductors is important for advancing their use in high-performance optoelectronics. We use field-effect transistors (FETs) to probe the charge transport mechanism in thin films of methylammonium lead iodide (MAPbI3). We sho...

journal_title：Science advances

authors： Senanayak SP,Yang B,Thomas TH,Giesbrecht N,Huang W,Gann E,Nair B,Goedel K,Guha S,Moya X,McNeill CR,Docampo P,Sadhanala A,Friend RH,Sirringhaus H

更新日期：2017-01-27 00:00:00

abstract：:Approaching predators cast expanding shadows (i.e., looming) that elicit innate defensive responses in most animals. Where looming is first detected and how critical parameters of predatory approaches are extracted are unclear. In mice, we identify a retinal interneuron (the VG3 amacrine cell) that responds robustly t...

journal_title：Science advances

authors： Kim T,Shen N,Hsiang JC,Johnson KP,Kerschensteiner D

更新日期：2020-11-18 00:00:00

abstract：:The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend against environmental insults. While studies have shown that smoking alters bronchial epithelial function and morphology, its precise effects on specific cell types and overall tissue composition are unclear. We used si...

journal_title：Science advances

authors： Duclos GE,Teixeira VH,Autissier P,Gesthalter YB,Reinders-Luinge MA,Terrano R,Dumas YM,Liu G,Mazzilli SA,Brandsma CA,van den Berge M,Janes SM,Timens W,Lenburg ME,Spira A,Campbell JD,Beane J

更新日期：2019-12-11 00:00:00

abstract：:Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed wha...

journal_title：Science advances

authors： Lee JH,Lewis KM,Moural TW,Kirilenko B,Borgonovo B,Prange G,Koessl M,Huggenberger S,Kang C,Hiller M

更新日期：2018-09-26 00:00:00

abstract：:RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)-assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacti...

journal_title：Science advances

authors： Liu J,Zhang Y,Zeng Q,Zeng H,Liu X,Wu P,Xie H,He L,Long Z,Lu X,Xiao M,Zhu Y,Bo H,Cao K

更新日期：2019-09-25 00:00:00

abstract：:The Late Paleogene surface height and paleoenvironment for the core area of the Qinghai-Tibetan Plateau (QTP) remain critically unresolved. Here, we report the discovery of the youngest well-preserved fossil palm leaves from Tibet. They were recovered from the Late Paleogene (Chattian), ca. 25.5 ± 0.5 million years, p...

journal_title：Science advances

authors： Su T,Farnsworth A,Spicer RA,Huang J,Wu FX,Liu J,Li SF,Xing YW,Huang YJ,Deng WY,Tang H,Xu CL,Zhao F,Srivastava G,Valdes PJ,Deng T,Zhou ZK

更新日期：2019-03-06 00:00:00

abstract：:The Mott transition-a metal-insulator transition caused by repulsive Coulomb interactions between electrons-is a central issue in condensed matter physics because it is the mother earth of various attractive phenomena. Outstanding examples are high-Tc (critical temperature) cuprates and manganites exhibiting colossal ...

journal_title：Science advances

authors： Itou T,Watanabe E,Maegawa S,Tajima A,Tajima N,Kubo K,Kato R,Kanoda K

更新日期：2017-08-11 00:00:00

abstract：:The past few years have witnessed rapid advances in the synthesis of high-quality perovskite nanocrystals (PNCs). However, despite the impressive developments, the stability of PNCs remains a substantial challenge. The ability to reliably improve stability of PNCs while retaining their individual nanometer size repres...

journal_title：Science advances

authors： He Y,Yoon YJ,Harn YW,Biesold-McGee GV,Liang S,Lin CH,Tsukruk VV,Thadhani N,Kang Z,Lin Z

更新日期：2019-11-29 00:00:00

abstract：:The geothermal heat flux is a critical thermal boundary condition that influences the melting, flow, and mass balance of ice sheets, but measurements of this parameter are difficult to make in ice-covered regions. We report the first direct measurement of geothermal heat flux into the base of the West Antarctic Ice Sh...

journal_title：Science advances

authors： Fisher AT,Mankoff KD,Tulaczyk SM,Tyler SW,Foley N,WISSARD Science Team.

更新日期：2015-07-10 00:00:00

abstract：:Adjacent neurons in visual cortex have overlapping receptive fields within and across area boundaries, an arrangement theorized to minimize wiring cost. This constraint is traditionally thought to create retinotopic maps of opposing field signs (mirror and nonmirror visual field representations) in adjacent areas, a c...

journal_title：Science advances

authors： Yu HH,Rowley DP,Price NSC,Rosa MGP,Zavitz E

更新日期：2020-10-28 00:00:00

abstract：:Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric mucosa using its outer membrane protein BabA. Structural information for BabA has been elusive, and thus, it...

journal_title：Science advances

authors： Hage N,Howard T,Phillips C,Brassington C,Overman R,Debreczeni J,Gellert P,Stolnik S,Winkler GS,Falcone FH

更新日期：2015-08-14 00:00:00

abstract：:Campylobacter coli and Campylobacter jejuni are responsible for 400 million to 500 million cases of enteric disease each year and represent the most common cause of bacterial gastroenteritis worldwide. Despite its global importance, Campylobacter vaccine development has been hampered by the lack of animal models that ...

journal_title：Science advances

authors： Quintel BK,Prongay K,Lewis AD,Raué HP,Hendrickson S,Rhoades NS,Messaoudi I,Gao L,Slifka MK,Amanna IJ

更新日期：2020-06-24 00:00:00

abstract：:Concern on the impacts of ocean acidification on calcifiers, such as bivalves, sea urchins, and foraminifers, has led to efforts to understand the controls on pH in their habitats, which include kelp forests and seagrass meadows. The metabolism of these habitats can lead to diel fluctuation in pH with increases during...

journal_title：Science advances

authors： Krause-Jensen D,Marbà N,Sanz-Martin M,Hendriks IE,Thyrring J,Carstensen J,Sejr MK,Duarte CM

更新日期：2016-12-14 00:00:00

abstract：:Energy band engineering is of fundamental importance in nanoelectronics. Compared to chemical approaches such as doping and surface functionalization, electrical and optical methods provide greater flexibility that enables continuous, reversible, and in situ band tuning on electronic devices of various kinds. In this ...

journal_title：Science advances

authors： Wu E,Xie Y,Zhang J,Zhang H,Hu X,Liu J,Zhou C,Zhang D

更新日期：2019-05-03 00:00:00

abstract：:Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report me...

journal_title：Science advances

authors： Zhang H,Hou J,Hu Y,Wang P,Ou R,Jiang L,Liu JZ,Freeman BD,Hill AJ,Wang H

更新日期：2018-02-09 00:00:00

abstract：:Metabolites of the intestinal microbiota are thought to be generated through metabolic pathways spanning multiple taxa of intestinal bacteria. We have previously shown that the level of putrescine, a polyamine found abundantly in the human intestinal lumen, is increased in the colonic lumen following administration of...

journal_title：Science advances

authors： Kitada Y,Muramatsu K,Toju H,Kibe R,Benno Y,Kurihara S,Matsumoto M

更新日期：2018-06-27 00:00:00

abstract：:Materials with a stochastic microstructure, like foams, typically exhibit low mechanical stiffness, whereas lattices with a designed microarchitecture often show notably improved stiffness. These periodic architected materials have previously been designed by rule, using the Maxwell criterion to ensure that their defo...

journal_title：Science advances

authors： Chen W,Watts S,Jackson JA,Smith WL,Tortorelli DA,Spadaccini CM

更新日期：2019-09-27 00:00:00

abstract：:We analyze a collection of empirical networks in a wide spectrum of disciplines and show that strong non-normality is ubiquitous in network science. Dynamical processes evolving on non-normal networks exhibit a peculiar behavior, as initial small disturbances may undergo a transient phase and be strongly amplified in ...

journal_title：Science advances

authors： Asllani M,Lambiotte R,Carletti T

更新日期：2018-12-12 00:00:00

abstract：:Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes. However, the effect of physical stressors on the behavior of adipocytes and their cross-talk with tumor cells remain elusive. Here, we demonstrate that compression of cells, resulting f...

journal_title：Science advances

authors： Li Y,Mao AS,Seo BR,Zhao X,Gupta SK,Chen M,Han YL,Shih TY,Mooney DJ,Guo M

更新日期：2020-01-22 00:00:00

abstract：:Difunctionalization of alkenes is a valuable and versatile chemical transformation that could quickly build complex molecules. Extensive efforts have been made, and great achievement, such as Sharpless aminohydroxylation and dihydroxylation, has been reached. However, in marked contrast to the extensive research of am...

journal_title：Science advances

authors： Yuan Y,Chen Y,Tang S,Huang Z,Lei A

更新日期：2018-08-03 00:00:00

abstract：:Rising temperatures in the Arctic Ocean region are responsible for changes such as reduced ice cover, permafrost thawing, and increased river discharge, which, together, alter nutrient and carbon cycles over the vast Arctic continental shelf. We show that the concentration of radium-228, sourced to seawater through se...

journal_title：Science advances

authors： Kipp LE,Charette MA,Moore WS,Henderson PB,Rigor IG

更新日期：2018-01-03 00:00:00

abstract：:Reef-building corals form their calcium carbonate skeletons within an extracellular calcifying medium (ECM). Despite the critical role of the ECM in coral calcification, ECM carbonate chemistry is poorly constrained in vivo, and full ECM carbonate chemistry has never been characterized based solely on direct in vivo m...

journal_title：Science advances

authors： Sevilgen DS,Venn AA,Hu MY,Tambutté E,de Beer D,Planas-Bielsa V,Tambutté S

更新日期：2019-01-16 00:00:00

abstract：:Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...

journal_title：Science advances

authors： Lee SH,Albright ER,Lee JH,Jacobs D,Kalejta RF

更新日期：2015-11-27 00:00:00

abstract：:The natural selection and the evolutionary optimization of complex shapes in nature are closely related to their functions. Mechanostabilization of shape of biological structure via morphogenesis has several beautiful examples. With the help of simple mechanics-based modeling and experiments, we show an important caus...

journal_title：Science advances

authors： Tiwary CS,Kishore S,Sarkar S,Mahapatra DR,Ajayan PM,Chattopadhyay K

更新日期：2015-05-15 00:00:00

abstract：:Grippers are widely used for the gripping, manipulation, and assembly of objects with a wide range of scales, shapes, and quantities in research, industry, and our daily lives. A simple yet universal solution is very challenging. Here, we manage to address this challenge utilizing a simple shape memory polymer (SMP) b...

journal_title：Science advances

authors： Linghu C,Zhang S,Wang C,Yu K,Li C,Zeng Y,Zhu H,Jin X,You Z,Song J

更新日期：2020-02-14 00:00:00

abstract：:Ocean circulation redistributes Earth's energy and water masses and influences global climate. Under historical greenhouse warming, regional ocean currents show diverse tendencies, but whether there is an emerging trend of the global mean ocean circulation system is not yet clear. Here, we show a statistically signifi...

journal_title：Science advances

authors： Hu S,Sprintall J,Guan C,McPhaden MJ,Wang F,Hu D,Cai W

更新日期：2020-02-05 00:00:00

abstract：:Band structure theory plays an essential role in exploring physics in both solid-state systems and photonics. Here, we demonstrate a direct experimental measurement of the dynamic band structure in a synthetic space including the frequency axis of light, realized in a ring resonator under near-resonant dynamic modulat...

journal_title：Science advances

authors： Li G,Zheng Y,Dutt A,Yu D,Shan Q,Liu S,Yuan L,Fan S,Chen X

更新日期：2021-01-08 00:00:00

abstract：:Quantum phenomena have the potential to speed up the solution of hard optimization problems. For example, quantum annealing, based on the quantum tunneling effect, has recently been shown to scale exponentially better with system size than classical simulated annealing. However, current realizations of quantum anneale...

journal_title：Science advances

authors： Nigg SE,Lörch N,Tiwari RP

更新日期：2017-04-07 00:00:00

abstract：:Early identification of pathogens is essential for limiting development of therapy-resistant pathogens and mitigating infectious disease outbreaks. Most bacterial detection schemes use target-specific probes to differentiate pathogen species, creating time and cost inefficiencies in identifying newly discovered organi...

journal_title：Science advances

authors： Aghazadeh A,Lin AY,Sheikh MA,Chen AL,Atkins LM,Johnson CL,Petrosino JF,Drezek RA,Baraniuk RG

更新日期：2016-09-28 00:00:00