Bioactive polyamine production by a novel hybrid system comprising multiple indigenous gut bacterial strategies.

abstract：:Cancer cells often encounter oxidative stress. However, it is unclear whether normal and cancer cells differentially respond to oxidative stress. Here, we demonstrated that under oxidative stress, hepatocellular carcinoma (HCC) cells exhibit increased antioxidative response and survival rates compared to normal hepato...

journal_title：Science advances

authors： Xu D,Li X,Shao F,Lv G,Lv H,Lee JH,Qian X,Wang Z,Xia Y,Du L,Zheng Y,Wang H,Lyu J,Lu Z

更新日期：2019-04-24 00:00:00

abstract：:About 40% of patients with non-small cell lung cancer (NSCLC) have stage IV cancer at the time of diagnosis. The only viable treatment options for metastatic disease are systemic chemotherapy and immunotherapy. Nonetheless, chemoresistance remains a major cause of chemotherapy failure. New immunotherapeutic modalities...

journal_title：Science advances

authors： Vinod N,Hwang D,Azam SH,Van Swearingen AED,Wayne E,Fussell SC,Sokolsky-Papkov M,Pecot CV,Kabanov AV

更新日期：2020-06-17 00:00:00

abstract：:Genetically modified pigs for biomedical applications have been mainly generated using the somatic cell nuclear transfer technique; however, this approach requires complex micromanipulation techniques and sometimes increases the risks of both prenatal and postnatal death by faulty epigenetic reprogramming of a donor s...

journal_title：Science advances

authors： Tanihara F,Takemoto T,Kitagawa E,Rao S,Do LT,Onishi A,Yamashita Y,Kosugi C,Suzuki H,Sembon S,Suzuki S,Nakai M,Hashimoto M,Yasue A,Matsuhisa M,Noji S,Fujimura T,Fuchimoto D,Otoi T

更新日期：2016-09-14 00:00:00

abstract：:The control of product distribution in a multistep catalytic selective hydrogenation reaction is challenging. For instance, the deep hydrogenation of dimethyl oxalate (DMO) is inclined to proceed over Cu/SiO2 catalysts because of inevitable coexistence of Cu+ and Cu0, leading to hard acquisition of the preliminary hyd...

journal_title：Science advances

authors： Sun J,Yu J,Ma Q,Meng F,Wei X,Sun Y,Tsubaki N

更新日期：2018-12-21 00:00:00

abstract：:Wogonin and baicalein are bioactive flavones in the popular Chinese herbal remedy Huang-Qin (Scutellaria baicalensis Georgi). These specialized flavones lack a 4'-hydroxyl group on the B ring (4'-deoxyflavones) and induce apoptosis in a wide spectrum of human tumor cells in vitro and inhibit tumor growth in vivo in di...

journal_title：Science advances

authors： Zhao Q,Zhang Y,Wang G,Hill L,Weng JK,Chen XY,Xue H,Martin C

更新日期：2016-04-08 00:00:00

abstract：:Complex behaviors demand temporal coordination among functionally distinct brain regions. The basal forebrain's afferent and efferent structure suggests a capacity for mediating this coordination at a large scale. During performance of a spatial orientation task, synaptic activity in this region was dominated by four ...

journal_title：Science advances

authors： Tingley D,Alexander AS,Quinn LK,Chiba AA,Nitz D

更新日期：2018-08-01 00:00:00

abstract：:Polyphosphate, an energy-rich polymer conserved in all kingdoms of life, is integral to many cellular stress responses, including nutrient deprivation, and yet, the mechanisms that underlie its biological roles are not well understood. In this work, we elucidate the physiological function of this polymer in the acclim...

journal_title：Science advances

authors： Sanz-Luque E,Saroussi S,Huang W,Akkawi N,Grossman AR

更新日期：2020-09-30 00:00:00

abstract：:Copper-containing nitrite reductases (CuNiRs), encoded by nirK gene, are found in all kingdoms of life with only 5% of CuNiR denitrifiers having two or more copies of nirK Recently, we have identified two copies of nirK genes in several α-proteobacteria of the order Rhizobiales including Bradyrhizobium sp. ORS 375, en...

journal_title：Science advances

authors： Rose SL,Antonyuk SV,Sasaki D,Yamashita K,Hirata K,Ueno G,Ago H,Eady RR,Tosha T,Yamamoto M,Hasnain SS

更新日期：2021-01-01 00:00:00

abstract：:Can a diverse crowd of individuals whose interests focus on distinct issues related to racial identity, class, gender, and sexuality mobilize around a shared issue? If so, how does this process work in practice? To date, limited research has explored intersectionality as a mobilization tool for social movements. This ...

journal_title：Science advances

authors： Fisher DR,Dow DM,Ray R

更新日期：2017-09-20 00:00:00

abstract：:Fibulin-4 is a matricellular protein required for extracellular matrix (ECM) assembly. Mice deficient in fibulin-4 (Fbln4-/- ) have disrupted collagen and elastin fibers and die shortly after birth from aortic and diaphragmatic rupture. The function of fibulin-4 in ECM assembly, however, remains elusive. Here, we show...

journal_title：Science advances

authors： Noda K,Kitagawa K,Miki T,Horiguchi M,Akama TO,Taniguchi T,Taniguchi H,Takahashi K,Ogra Y,Mecham RP,Terajima M,Yamauchi M,Nakamura T

更新日期：2020-11-25 00:00:00

abstract：:In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the...

journal_title：Science advances

authors： Perianez-Rodriguez J,Rodriguez M,Marconi M,Bustillo-Avendaño E,Wachsman G,Sanchez-Corrionero A,De Gernier H,Cabrera J,Perez-Garcia P,Gude I,Saez A,Serrano-Ron L,Beeckman T,Benfey PN,Rodríguez-Patón A,Del Pozo JC,Wabnik K

更新日期：2021-01-01 00:00:00

abstract：:Compound climate extremes are receiving increasing attention because of their disproportionate impacts on humans and ecosystems. However, risks assessments generally focus on univariate statistics. We analyze the co-occurrence of hot and dry summers and show that these are correlated, inducing a much higher frequency ...

journal_title：Science advances

authors： Zscheischler J,Seneviratne SI

更新日期：2017-06-28 00:00:00

abstract：:Ice accretion has a negative impact on critical infrastructure, as well as a range of commercial and residential activities. Icephobic surfaces are defined by an ice adhesion strength τice < 100 kPa. However, the passive removal of ice requires much lower values of τice, such as on airplane wings or power lines (τice ...

journal_title：Science advances

authors： Golovin K,Kobaku SP,Lee DH,DiLoreto ET,Mabry JM,Tuteja A

更新日期：2016-03-11 00:00:00

abstract：:Meteorite impact craters are one of the most common geological features in the solar system. An impact event is a near-instantaneous process that releases a huge amount of energy over a very small region on a planetary surface. This results in characteristic changes in the target rocks, from vaporization and melting t...

journal_title：Science advances

authors： Osinski GR,Ferrière L

更新日期：2016-08-05 00:00:00

abstract：:The key to the development of advanced materials is to understand their electronic structure-property relationship. Utilization of this understanding to design new electronic materials with desired properties led to modern epitaxial growth approaches for synthesizing artificial lattices, which for almost half a centur...

journal_title：Science advances

authors： Mascarenhas A,Fluegel B,Bhusal L

更新日期：2017-06-07 00:00:00

abstract：:In a recent paper, Lechner, Hauke, and Zoller (LHZ) described a means to translate a Hamiltonian of N spin-1/2 particles with "all-to-all" interactions into a larger physical lattice with only on-site energies and local parity constraints. LHZ used this mapping to propose a novel form of quantum annealing. We provide ...

journal_title：Science advances

authors： Rocchetto A,Benjamin SC,Li Y

更新日期：2016-10-21 00:00:00

abstract：:The formation of the biophotonic gyroid material in butterfly wing scales is an exceptional feat of evolutionary engineering of functional nanostructures. It is hypothesized that this nanostructure forms by chitin polymerization inside a convoluted membrane of corresponding shape in the endoplasmic reticulum. However,...

journal_title：Science advances

authors： Wilts BD,Apeleo Zubiri B,Klatt MA,Butz B,Fischer MG,Kelly ST,Spiecker E,Steiner U,Schröder-Turk GE

更新日期：2017-04-26 00:00:00

abstract：:The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chemistry, can be used in a radical chain reaction ...

journal_title：Science advances

authors： Povie G,Suravarapu SR,Bircher MP,Mojzes MM,Rieder S,Renaud P

更新日期：2018-07-20 00:00:00

abstract：:The ongoing conservation treatment program of the Ghent Altarpiece by Hubert and Jan Van Eyck, one of the iconic paintings of the west, has revealed that the designs of the paintings were changed several times, first by the original artists, and then during later restorations. The central motif, The Lamb of God, repre...

journal_title：Science advances

authors： Van der Snickt G,Dooley KA,Sanyova J,Dubois H,Delaney JK,Gifford EM,Legrand S,Laquiere N,Janssens K

更新日期：2020-07-29 00:00:00

abstract：:Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric mucosa using its outer membrane protein BabA. Structural information for BabA has been elusive, and thus, it...

journal_title：Science advances

authors： Hage N,Howard T,Phillips C,Brassington C,Overman R,Debreczeni J,Gellert P,Stolnik S,Winkler GS,Falcone FH

更新日期：2015-08-14 00:00:00

abstract：:Fluid catalytic cracking (FCC) particles account for 40 to 45% of worldwide gasoline production. The hierarchical complex particle pore structure allows access of long-chain feedstock molecules into active catalyst domains where they are cracked into smaller, more valuable hydrocarbon products (for example, gasoline)....

journal_title：Science advances

authors： Meirer F,Kalirai S,Morris D,Soparawalla S,Liu Y,Mesu G,Andrews JC,Weckhuysen BM

更新日期：2015-04-03 00:00:00

abstract：:In retinal detachment (RD), photoreceptor death and permanent vision loss are caused by neurosensory retina separating from the retinal pigment epithelium because of subretinal fluid (SRF), and successful surgical reattachment is not predictive of total visual recovery. As retinal iron overload exacerbates cell death ...

journal_title：Science advances

authors： Daruich A,Le Rouzic Q,Jonet L,Naud MC,Kowalczuk L,Pournaras JA,Boatright JH,Thomas A,Turck N,Moulin A,Behar-Cohen F,Picard E

更新日期：2019-01-09 00:00:00

abstract：:Despite the important roles that horses have played in human history, particularly in the spread of languages and cultures, and correspondingly intensive research on this topic, the origin of domestic horses remains elusive. Several domestication centers have been hypothesized, but most of these have been invalidated ...

journal_title：Science advances

authors： Guimaraes S,Arbuckle BS,Peters J,Adcock SE,Buitenhuis H,Chazin H,Manaseryan N,Uerpmann HP,Grange T,Geigl EM

更新日期：2020-09-16 00:00:00

abstract：:The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids i...

journal_title：Science advances

authors： Liu M,Wang H,Zeng H,Li CJ

更新日期：2015-03-27 00:00:00

abstract：:Forecasting fields of oceanic phenomena has long been dependent on physical equation-based numerical models. The challenge is that many natural processes need to be considered for understanding complicated phenomena. In contrast, rules of the processes are already embedded in the time-series observation itself. Thus, ...

journal_title：Science advances

authors： Zheng G,Li X,Zhang RH,Liu B

更新日期：2020-07-15 00:00:00

abstract：:Exploration for superconductivity is one of the research frontiers in condensed matter physics. In strongly correlated electron systems, the emergence of superconductivity is often inhibited by the formation of a thermodynamically more stable magnetic/charge order. Thus, to develop the superconductivity as the thermod...

journal_title：Science advances

authors： Oike H,Kamitani M,Tokura Y,Kagawa F

更新日期：2018-10-05 00:00:00

abstract：:Characterizing and understanding the emergence of multiple macroscopically ordered electronic phases through subtle tuning of temperature, pressure, and chemical doping has been a long-standing central issue for complex materials research. We report the first comprehensive studies of optical doping-induced emergence o...

journal_title：Science advances

authors： Han TR,Zhou F,Malliakas CD,Duxbury PM,Mahanti SD,Kanatzidis MG,Ruan CY

更新日期：2015-06-26 00:00:00

abstract：:Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of microglia. Mechani...

journal_title：Science advances

authors： Li X,Xia Q,Mao M,Zhou H,Zheng L,Wang Y,Zeng Z,Yan L,Zhao Y,Shi J

更新日期：2021-01-20 00:00:00

abstract：:Revealing physical interactions in complex systems from observed collective dynamics constitutes a fundamental inverse problem in science. Current reconstruction methods require access to a system's model or dynamical data at a level of detail often not available. We exploit changes in invariant measures, in particula...

journal_title：Science advances

authors： Nitzan M,Casadiego J,Timme M

更新日期：2017-02-10 00:00:00

abstract：:Holoprosencephaly (HPE) is a congenital forebrain defect often associated with embryonic lethality and lifelong disabilities. Currently, therapeutic and diagnostic options are limited by lack of knowledge of potential disease-causing mutations. We have identified a new mutation in the PRDM15 gene (C844Y) associated wi...

journal_title：Science advances

authors： Mzoughi S,Di Tullio F,Low DHP,Motofeanu CM,Ong SLM,Wollmann H,Wun CM,Kruszka P,Muenke M,Hildebrandt F,Dunn NR,Messerschmidt DM,Guccione E

更新日期：2020-01-10 00:00:00