Abstract:
:The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids in extremely high yields. The reaction conditions are very mild and greener, requiring only a very low silver(I) catalyst loading, using atmospheric oxygen as the oxidant and water as the solvent, and allowing gram-scale oxidation with only 2 mg of our catalyst. Chromatography is completely unnecessary for purification in most cases.
journal_name
Sci Advjournal_title
Science advancesauthors
Liu M,Wang H,Zeng H,Li CJdoi
10.1126/sciadv.1500020subject
Has Abstractpub_date
2015-03-27 00:00:00pages
e1500020issue
2issn
2375-2548pii
1500020journal_volume
1pub_type
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