Altered 3D chromatin structure permits inversional recombination at the IgH locus.

abstract：:Transistors with exfoliated two-dimensional (2D) materials on a SiO2/Si substrate have been applied and have been proven effective in a wide range of applications, such as circuits, memory, photodetectors, gas sensors, optical modulators, valleytronics, and spintronics. However, these devices usually suffer from limit...

journal_title：Science advances

authors： Xu J,Chen L,Dai YW,Cao Q,Sun QQ,Ding SJ,Zhu H,Zhang DW

更新日期：2017-05-19 00:00:00

abstract：:Understanding how surfaces direct nucleation is a complex problem that limits our ability to predict and control crystal formation. We here address this challenge using high-speed imaging to identify and quantify the sites at which ice nucleates in water droplets on the two natural cleavage faces of macroscopic feldsp...

journal_title：Science advances

authors： Holden MA,Whale TF,Tarn MD,O'Sullivan D,Walshaw RD,Murray BJ,Meldrum FC,Christenson HK

更新日期：2019-02-01 00:00:00

abstract：:We studied a bilayer system hosting two-dimensional electron systems (2DESs) in close proximity but isolated from one another by a thin barrier. One 2DES has low electron density and forms a Wigner solid (WS) at high magnetic fields. The other has much higher density and, in the same field, exhibits fractional quantum...

journal_title：Science advances

authors： Hatke AT,Deng H,Liu Y,Engel LW,Pfeiffer LN,West KW,Baldwin KW,Shayegan M

更新日期：2019-03-15 00:00:00

abstract：:We reveal an intriguing manifestation of topology, which appears in the depletion rate of topological states of matter in response to an external drive. This phenomenon is presented by analyzing the response of a generic two-dimensional (2D) Chern insulator subjected to a circular time-periodic perturbation. Because o...

journal_title：Science advances

authors： Tran DT,Dauphin A,Grushin AG,Zoller P,Goldman N

更新日期：2017-08-18 00:00:00

abstract：:Coastal vertical land motion affects projections of sea-level rise, and subsidence exacerbates flooding hazards. Along the ~1350-km California coastline, records of high-resolution vertical land motion rates are scarce due to sparse instrumentation, and hazards to coastal communities are underestimated. Here, we consi...

journal_title：Science advances

authors： Blackwell E,Shirzaei M,Ojha C,Werth S

更新日期：2020-07-31 00:00:00

abstract：:The mammalian retina system consists of a complicated photoreceptor structure, which exhibits extensive random synaptic connections. To study retinal development and degeneration, various experimental models have been used previously, but these models are often uncontrollable, are difficult to manipulate, and do not p...

journal_title：Science advances

authors： Ma Y,Han X,de Castro RB,Zhang P,Zhang K,Hu Z,Qin L

更新日期：2018-05-09 00:00:00

abstract：:The Paris Agreement aims to mitigate the potential impacts of climate change on ecological and social systems. Using an ensemble of climate-marine ecosystem and economic models, we explore the effects of implementing the Agreement on fish, fishers, and seafood consumers worldwide. We find that implementing the Agreeme...

journal_title：Science advances

authors： Sumaila UR,Tai TC,Lam VWY,Cheung WWL,Bailey M,Cisneros-Montemayor AM,Chen OL,Gulati SS

更新日期：2019-02-27 00:00:00

abstract：:Changes in the Atlantic Meridional Overturning Circulation (AMOC) are moderate in most climate model projections under increasing greenhouse gas forcing. This intermodel consensus may be an artifact of common model biases that favor a stable AMOC. Observationally based freshwater budget analyses suggest that the AMOC ...

journal_title：Science advances

authors： Liu W,Xie SP,Liu Z,Zhu J

更新日期：2017-01-04 00:00:00

abstract：:The control of product distribution in a multistep catalytic selective hydrogenation reaction is challenging. For instance, the deep hydrogenation of dimethyl oxalate (DMO) is inclined to proceed over Cu/SiO2 catalysts because of inevitable coexistence of Cu+ and Cu0, leading to hard acquisition of the preliminary hyd...

journal_title：Science advances

authors： Sun J,Yu J,Ma Q,Meng F,Wei X,Sun Y,Tsubaki N

更新日期：2018-12-21 00:00:00

abstract：:Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities that can alter their function in response to environmental cues. In the present study, we report an engineered p...

journal_title：Science advances

authors： Shields CW 4th,Evans MA,Wang LL,Baugh N,Iyer S,Wu D,Zhao Z,Pusuluri A,Ukidve A,Pan DC,Mitragotri S

更新日期：2020-04-29 00:00:00

abstract：:By experimentally studying high-order harmonic beams generated in gases, we show how the spatial characteristics of these ultrashort extreme-ultraviolet (XUV) beams can be finely controlled when a single fundamental beam generates harmonics in a thin gas medium. We demonstrate that these XUV beams can be emitted as co...

journal_title：Science advances

authors： Quintard L,Strelkov V,Vabek J,Hort O,Dubrouil A,Descamps D,Burgy F,Péjot C,Mével E,Catoire F,Constant E

更新日期：2019-04-05 00:00:00

abstract：:Mass loss from the West Antarctic ice shelves and glaciers has been linked to basal melt by ocean heat flux. The Totten Ice Shelf in East Antarctica, which buttresses a marine-based ice sheet with a volume equivalent to at least 3.5 m of global sea-level rise, also experiences rapid basal melt, but the role of ocean f...

journal_title：Science advances

authors： Rintoul SR,Silvano A,Pena-Molino B,van Wijk E,Rosenberg M,Greenbaum JS,Blankenship DD

更新日期：2016-12-16 00:00:00

abstract：:Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine triphosphate to adenosine monophosphate (AMP) and AMP to adenosine, respectively. Despite the relevance of CD39/CD73 t...

journal_title：Science advances

authors： Shih YV,Liu M,Kwon SK,Iida M,Gong Y,Sangaj N,Varghese S

更新日期：2019-08-21 00:00:00

abstract：:Exploration of phase transitions and construction of associated phase diagrams are of fundamental importance for condensed matter physics and materials science alike, and remain the focus of extensive research for both theoretical and experimental studies. For the latter, comprehensive studies involving scattering, th...

journal_title：Science advances

authors： Li L,Yang Y,Zhang D,Ye ZG,Jesse S,Kalinin SV,Vasudevan RK

更新日期：2018-03-30 00:00:00

abstract：:Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility,...

journal_title：Science advances

authors： Luan L,Wei X,Zhao Z,Siegel JJ,Potnis O,Tuppen CA,Lin S,Kazmi S,Fowler RA,Holloway S,Dunn AK,Chitwood RA,Xie C

更新日期：2017-02-15 00:00:00

abstract：:Homologous recombination is exquisitely activated only during specific cell phases. In the G1 phase, homologous recombination activity is completely suppressed. According to previous reports, the activation of homologous recombination during specific cell phases depends on the kinase activity of cyclin-dependent kinas...

journal_title：Science advances

authors： Lim G,Chang Y,Huh WK

更新日期：2020-02-07 00:00:00

abstract：:The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...

journal_title：Science advances

authors： Movaghar A,Page D,Brilliant M,Baker MW,Greenberg J,Hong J,DaWalt LS,Saha K,Kuusisto F,Stewart R,Berry-Kravis E,Mailick MR

更新日期：2019-08-21 00:00:00

abstract：:Eruptive phenomena at all scales, from hydrothermal geysers to flood basalts, can potentially be initiated or modulated by external mechanical perturbations. We present evidence for the triggering of magmatism on a global scale by the Chicxulub meteorite impact at the Cretaceous-Paleogene (K-Pg) boundary, recorded by ...

journal_title：Science advances

authors： Byrnes JS,Karlstrom L

更新日期：2018-02-07 00:00:00

abstract：:Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS-targeting IgG antibody, inRas37, which directly targets the intracellularly activated form of various...

journal_title：Science advances

authors： Shin SM,Kim JS,Park SW,Jun SY,Kweon HJ,Choi DK,Lee D,Cho YB,Kim YS

更新日期：2020-01-15 00:00:00

abstract：:Concern on the impacts of ocean acidification on calcifiers, such as bivalves, sea urchins, and foraminifers, has led to efforts to understand the controls on pH in their habitats, which include kelp forests and seagrass meadows. The metabolism of these habitats can lead to diel fluctuation in pH with increases during...

journal_title：Science advances

authors： Krause-Jensen D,Marbà N,Sanz-Martin M,Hendriks IE,Thyrring J,Carstensen J,Sejr MK,Duarte CM

更新日期：2016-12-14 00:00:00

abstract：:Grippers are widely used for the gripping, manipulation, and assembly of objects with a wide range of scales, shapes, and quantities in research, industry, and our daily lives. A simple yet universal solution is very challenging. Here, we manage to address this challenge utilizing a simple shape memory polymer (SMP) b...

journal_title：Science advances

authors： Linghu C,Zhang S,Wang C,Yu K,Li C,Zeng Y,Zhu H,Jin X,You Z,Song J

更新日期：2020-02-14 00:00:00

abstract：:Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. Gene expression and DNA methylation ...

journal_title：Science advances

authors： Salvadores M,Fuster-Tormo F,Supek F

更新日期：2020-07-01 00:00:00

abstract：:Confined to a two-dimensional plane, electrons in a strong magnetic field travel along the edge in one-dimensional quantum Hall channels that are protected against backscattering. These channels can be used as solid-state analogs of monochromatic beams of light, providing a unique platform for studying electron interf...

journal_title：Science advances

authors： Wei DS,van der Sar T,Sanchez-Yamagishi JD,Watanabe K,Taniguchi T,Jarillo-Herrero P,Halperin BI,Yacoby A

更新日期：2017-08-18 00:00:00

abstract：:Moisture delivery to western North America is closely linked to variability in the westerly storm tracks of midlatitude cyclones, which are, in turn, modified by larger-scale features such as the El Niño-Southern Oscillation system. Instrumental and modeling data suggest that extratropical storm tracks may be intensif...

journal_title：Science advances

authors： Wise EK,Dannenberg MP

更新日期：2017-06-07 00:00:00

abstract：:Topological superconductors are exotic phases of matter featuring robust surface states that could be leveraged for topological quantum computation. A useful guiding principle for the search of topological superconductors is to relate the topological invariants with the behavior of the pairing order parameter on the n...

journal_title：Science advances

authors： Ono S,Po HC,Watanabe H

更新日期：2020-05-01 00:00:00

abstract：:The rapid growth of deformable and stretchable electronics calls for a deformable and stretchable power source. We report a scalable approach for energy harvesters and self-powered sensors that can be highly deformable and stretchable. With conductive liquid contained in a polymer cover, a shape-adaptive triboelectric...

journal_title：Science advances

authors： Yi F,Wang X,Niu S,Li S,Yin Y,Dai K,Zhang G,Lin L,Wen Z,Guo H,Wang J,Yeh MH,Zi Y,Liao Q,You Z,Zhang Y,Wang ZL

更新日期：2016-06-17 00:00:00

abstract：:In graphene superlattices, bulk topological currents can lead to long-range charge-neutral flow and nonlocal resistance near Dirac points. A ballistic version of these phenomena has never been explored. We report transport properties of ballistic graphene superlattices. This allows us to study and exploit giant nonloc...

journal_title：Science advances

authors： Komatsu K,Morita Y,Watanabe E,Tsuya D,Watanabe K,Taniguchi T,Moriyama S

更新日期：2018-05-18 00:00:00

abstract：:Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscie...

journal_title：Science advances

authors： Mejias JF,Murray JD,Kennedy H,Wang XJ

更新日期：2016-11-16 00:00:00

abstract：:Neurodegeneration in mitochondrial disorders is considered irreversible because of limited metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial dysfunction for neuronal metabolism in vivo are poorly understood. Here, we profiled the cell-specific proteome of Purkinje neurons undergoin...

journal_title：Science advances

authors： Motori E,Atanassov I,Kochan SMV,Folz-Donahue K,Sakthivelu V,Giavalisco P,Toni N,Puyal J,Larsson NG

更新日期：2020-08-28 00:00:00

abstract：:To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...

journal_title：Science advances

authors： Turner TC,Sok MCP,Hymel LA,Pittman FS,York WY,Mac QD,Vyshnya S,Lim HS,Kwong GA,Qiu P,Botchwey EA

更新日期：2020-10-30 00:00:00