History of the solar nebula from meteorite paleomagnetism.

abstract：:Injection-induced earthquakes pose a serious seismic hazard but also offer an opportunity to gain insight into earthquake physics. Currently used models relating the maximum magnitude of injection-induced earthquakes to injection parameters do not incorporate rupture physics. We develop theoretical estimates, validate...

journal_title：Science advances

authors： Galis M,Ampuero JP,Mai PM,Cappa F

更新日期：2017-12-20 00:00:00

abstract：:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...

journal_title：Science advances

authors： Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

更新日期：2019-06-26 00:00:00

abstract：:Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscie...

journal_title：Science advances

authors： Mejias JF,Murray JD,Kennedy H,Wang XJ

更新日期：2016-11-16 00:00:00

abstract：:Multicellular organisms are composed of tissues that have distinct functions requiring specialized proteomes. To define the proteome of a live animal with tissue and subcellular resolution, we adapted a localized proteomics technology for use in the multicellular model organism Caenorhabditis elegans. This approach co...

journal_title：Science advances

authors： Reinke AW,Mak R,Troemel ER,Bennett EJ

更新日期：2017-05-10 00:00:00

abstract：:Under rapid high-temperature, high-pressure loading, lattices exhibit complex elastic-inelastic responses. The dynamics of these responses are challenging to measure experimentally because of high sample density and extremely small relevant spatial and temporal scales. Here, we use an x-ray free-electron laser providi...

journal_title：Science advances

authors： Brown SB,Gleason AE,Galtier E,Higginbotham A,Arnold B,Fry A,Granados E,Hashim A,Schroer CG,Schropp A,Seiboth F,Tavella F,Xing Z,Mao W,Lee HJ,Nagler B

更新日期：2019-03-08 00:00:00

abstract：:Oxygen activation is a critical step in ubiquitous heterogeneous oxidative processes, most prominently in catalysis, electrolysis, and pharmaceutical applications. We present here our findings on metal-free O2 activation on covalent triazine frameworks (CTFs) as an important class of N-rich materials. The O2 activatio...

journal_title：Science advances

authors： Abednatanzi S,Gohari Derakhshandeh P,Leus K,Vrielinck H,Callens F,Schmidt J,Savateev A,Van Der Voort P

更新日期：2020-04-03 00:00:00

abstract：:In 2015, more than 200,000 saiga antelopes died in 3 weeks in central Kazakhstan. The proximate cause of death is confirmed as hemorrhagic septicemia caused by the bacterium Pasteurella multocida type B, based on multiple strands of evidence. Statistical modeling suggests that there was unusually high relative humidit...

journal_title：Science advances

authors： Kock RA,Orynbayev M,Robinson S,Zuther S,Singh NJ,Beauvais W,Morgan ER,Kerimbayev A,Khomenko S,Martineau HM,Rystaeva R,Omarova Z,Wolfs S,Hawotte F,Radoux J,Milner-Gulland EJ

更新日期：2018-01-17 00:00:00

abstract：:The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids i...

journal_title：Science advances

authors： Liu M,Wang H,Zeng H,Li CJ

更新日期：2015-03-27 00:00:00

abstract：:The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo-electron tomography to directly visualize ER dynamics in several secretory cell types including pancreatic β-cells and neurons under near-native conditions. Using these imaging approaches, w...

journal_title：Science advances

authors： Carter SD,Hampton CM,Langlois R,Melero R,Farino ZJ,Calderon MJ,Li W,Wallace CT,Tran NH,Grassucci RA,Siegmund SE,Pemberton J,Morgenstern TJ,Eisenman L,Aguilar JI,Greenberg NL,Levy ES,Yi E,Mitchell WG,Rice WJ,Wigge

更新日期：2020-04-01 00:00:00

abstract：:Glutathione (GSH), the most abundant nonprotein thiol functioning as an antioxidant, plays critical roles in maintaining the core functions of mesenchymal stem cells (MSCs), which are used as a cellular immunotherapy for graft-versus-host disease (GVHD). However, the role of GSH dynamics in MSCs remains elusive. Genom...

journal_title：Science advances

authors： Lim J,Heo J,Ju H,Shin JW,Kim Y,Lee S,Yu HY,Ryu CM,Yun H,Song S,Hong KS,Chung HM,Kim HR,Roe JS,Choi K,Kim IG,Jeong EM,Shin DM

更新日期：2020-04-15 00:00:00

abstract：:Proinflammatory activation and accumulation of adipose tissue macrophages (ATMs) are associated with increased risk of insulin resistance in obesity. Here, we described the previously unidentified role of selenocysteine insertion sequence-binding protein 2 (SBP2) in maintaining insulin sensitivity in obesity. SBP2 was...

journal_title：Science advances

authors： Wang N,Tan HY,Li S,Wang D,Xu Y,Zhang C,Xia W,Che CM,Feng Y

更新日期：2019-08-14 00:00:00

abstract：:Planarians exhibit traits of cephalization but are unique among bilaterians in that they ingest food by means of goal-directed movements of a trunk-positioned pharynx, following protrusion of the pharynx out of the body, raising the question of how planarians control such a complex set of body movements for achieving ...

journal_title：Science advances

authors： Miyamoto M,Hattori M,Hosoda K,Sawamoto M,Motoishi M,Hayashi T,Inoue T,Umesono Y

更新日期：2020-04-08 00:00:00

abstract：:Neurodegenerative disorders are caused by progressive neuronal loss, and there is no complete treatment available yet. Neuroinflammation is a common feature across neurodegenerative disorders and implicated in the progression of neurodegeneration. Dysregulated activation of microglia causes neuroinflammation and has b...

journal_title：Science advances

authors： Nakano-Kobayashi A,Fukumoto A,Morizane A,Nguyen DT,Le TM,Hashida K,Hosoya T,Takahashi R,Takahashi J,Hori O,Hagiwara M

更新日期：2020-11-13 00:00:00

abstract：:Fluid commonly flows in response to an external pressure gradient. However, when a tunnel-containing hydrogel is immersed in water, spontaneous flow occurs through the tunnel without any pressure gradient. We confirmed this flow in a wide range of plant- and animal-derived hydrogels. The flow appears to be driven by a...

journal_title：Science advances

authors： Li Z,Pollack GH

更新日期：2020-05-08 00:00:00

abstract：:The Mott transition-a metal-insulator transition caused by repulsive Coulomb interactions between electrons-is a central issue in condensed matter physics because it is the mother earth of various attractive phenomena. Outstanding examples are high-Tc (critical temperature) cuprates and manganites exhibiting colossal ...

journal_title：Science advances

authors： Itou T,Watanabe E,Maegawa S,Tajima A,Tajima N,Kubo K,Kato R,Kanoda K

更新日期：2017-08-11 00:00:00

abstract：:Using a national longitudinal survey data set from the Higher Education Research Institute, this study tested whether students who identified as a sexual minority (for example, lesbian, gay, bisexual, or queer) were more or less likely to persist after 4 years in science, technology, engineering, and mathematics (STEM...

journal_title：Science advances

authors： Hughes BE

更新日期：2018-03-14 00:00:00

abstract：:Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and basolateral amygdala (BLA), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. Here, we report that acid-sensing ion channel 1a (ASIC1a) is a c...

journal_title：Science advances

authors： Wang Q,Wang Q,Song XL,Jiang Q,Wu YJ,Li Y,Yuan TF,Zhang S,Xu NJ,Zhu MX,Li WG,Xu TL

更新日期：2018-10-24 00:00:00

abstract：:To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional su...

journal_title：Science advances

authors： Turner TC,Sok MCP,Hymel LA,Pittman FS,York WY,Mac QD,Vyshnya S,Lim HS,Kwong GA,Qiu P,Botchwey EA

更新日期：2020-10-30 00:00:00

abstract：:SWI/SNF (switch/sucrose nonfermenting) complexes regulate transcription through chromatin remodeling and opposing gene silencing by Polycomb group (PcG) proteins. Genes encoding SWI/SNF components are critical for normal development and frequently mutated in human cancer. We characterized the in vivo contributions of ...

journal_title：Science advances

authors： van der Vaart A,Godfrey M,Portegijs V,van den Heuvel S

更新日期：2020-05-20 00:00:00

abstract：:Rising temperatures in the Arctic Ocean region are responsible for changes such as reduced ice cover, permafrost thawing, and increased river discharge, which, together, alter nutrient and carbon cycles over the vast Arctic continental shelf. We show that the concentration of radium-228, sourced to seawater through se...

journal_title：Science advances

authors： Kipp LE,Charette MA,Moore WS,Henderson PB,Rigor IG

更新日期：2018-01-03 00:00:00

abstract：:Cellular cross-talk between ubiquitination and other posttranslational modifications contributes to the regulation of numerous processes. One example is ADP-ribosylation of the carboxyl terminus of ubiquitin by the E3 DTX3L/ADP-ribosyltransferase PARP9 heterodimer, but the mechanism remains elusive. Here, we show that...

journal_title：Science advances

authors： Chatrin C,Gabrielsen M,Buetow L,Nakasone MA,Ahmed SF,Sumpton D,Sibbet GJ,Smith BO,Huang DT

更新日期：2020-09-18 00:00:00

abstract：:Nitrogen oxides (NO x ) emitted from human activities are believed to regulate the atmospheric oxidation capacity of the troposphere. However, observational evidence is limited for the low-to-median NO x concentrations prevalen...

journal_title：Science advances

authors： Liu Y,Seco R,Kim S,Guenther AB,Goldstein AH,Keutsch FN,Springston SR,Watson TB,Artaxo P,Souza RAF,McKinney KA,Martin ST

更新日期：2018-04-11 00:00:00

abstract：:Toxins efficiently deliver cargo to cells by binding to cell surface ligands, initiating endocytosis, and escaping the endolysosomal pathway into the cytoplasm. We took advantage of this delivery pathway by conjugating an attenuated diphtheria toxin to siRNA, thereby achieving gene downregulation in patient-derived gl...

journal_title：Science advances

authors： Arnold AE,Smith LJ,Beilhartz GL,Bahlmann LC,Jameson E,Melnyk RA,Shoichet MS

更新日期：2020-05-01 00:00:00

abstract：:Human sleep is highly regulated by temperature. Might climate change-through increases in nighttime heat-disrupt sleep in the future? We conduct the inaugural investigation of the relationship between climatic anomalies, reports of insufficient sleep, and projected climate change. Using data from 765,000 U.S. survey r...

journal_title：Science advances

authors： Obradovich N,Migliorini R,Mednick SC,Fowler JH

更新日期：2017-05-26 00:00:00

abstract：:Two-dimensional (2D) layered hybrid organic-inorganic halide perovskite semiconductors form natural "multiple quantum wells" that have strong spin-orbit coupling due to the heavy elements in their building blocks. This may lead to "Rashba splitting" close to the extrema in the electron bands. We have used a plethora o...

journal_title：Science advances

authors： Zhai Y,Baniya S,Zhang C,Li J,Haney P,Sheng CX,Ehrenfreund E,Vardeny ZV

更新日期：2017-07-28 00:00:00

abstract：:Discovery of new adsorbent materials with a high CO2 working capacity could help reduce CO2 emissions from newly commissioned power plants using precombustion carbon capture. High-throughput computational screening efforts can accelerate the discovery of new adsorbents but sometimes require significant computational r...

journal_title：Science advances

authors： Chung YG,Gómez-Gualdrón DA,Li P,Leperi KT,Deria P,Zhang H,Vermeulen NA,Stoddart JF,You F,Hupp JT,Farha OK,Snurr RQ

更新日期：2016-10-14 00:00:00

abstract：:The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a...

journal_title：Science advances

authors： Park HH,Kim HN,Kim H,Yoo Y,Shin H,Choi EY,Bae JS,Lee W

更新日期：2020-07-31 00:00:00

abstract：:Fifty years after its discovery, the ovonic threshold switching (OTS) phenomenon, a unique nonlinear conductivity behavior observed in some chalcogenide glasses, has been recently the source of a real technological breakthrough in the field of data storage memories. This breakthrough was achieved because of the succes...

journal_title：Science advances

authors： Noé P,Verdy A,d'Acapito F,Dory JB,Bernard M,Navarro G,Jager JB,Gaudin J,Raty JY

更新日期：2020-02-28 00:00:00

abstract：:Arthropod herbivores cause substantial economic costs that drive an increasing need to develop environmentally sustainable approaches to herbivore control. Increasing plant diversity is expected to limit herbivory by altering plant-herbivore and predator-herbivore interactions, but the simultaneous influence of these ...

journal_title：Science advances

authors： Barnes AD,Scherber C,Brose U,Borer ET,Ebeling A,Gauzens B,Giling DP,Hines J,Isbell F,Ristok C,Tilman D,Weisser WW,Eisenhauer N

更新日期：2020-11-06 00:00:00

abstract：:Spatial patterns of gene expression in living organisms orchestrate cell decisions in development, homeostasis, and disease. However, most methods for reconstructing gene patterning in 3D cell culture and artificial tissues are restricted by patterning depth and scale. We introduce a depth- and scale-flexible method t...

journal_title：Science advances

authors： Corbett DC,Fabyan WB,Grigoryan B,O'Connor CE,Johansson F,Batalov I,Regier MC,DeForest CA,Miller JS,Stevens KR

更新日期：2020-09-30 00:00:00