Novel technology for storage and distribution of live vaccines and other biological medicines at ambient temperature.

abstract：:Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...

journal_title：Science advances

authors： Lee SH,Albright ER,Lee JH,Jacobs D,Kalejta RF

更新日期：2015-11-27 00:00:00

abstract：:The advent of two-dimensional (2D) materials has led to extensive studies of heterostructures for novel applications. 2D lateral multiheterojunctions and superlattices have been recently demonstrated, but the available growth methods can only produce features with widths in the micrometer or, at best, 100-nm scale and...

journal_title：Science advances

authors： Zhou W,Zhang YY,Chen J,Li D,Zhou J,Liu Z,Chisholm MF,Pantelides ST,Loh KP

更新日期：2018-03-23 00:00:00

abstract：:In Arabidopsis, the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the...

journal_title：Science advances

authors： Perianez-Rodriguez J,Rodriguez M,Marconi M,Bustillo-Avendaño E,Wachsman G,Sanchez-Corrionero A,De Gernier H,Cabrera J,Perez-Garcia P,Gude I,Saez A,Serrano-Ron L,Beeckman T,Benfey PN,Rodríguez-Patón A,Del Pozo JC,Wabnik K

更新日期：2021-01-01 00:00:00

abstract：:Fifty years after its discovery, the ovonic threshold switching (OTS) phenomenon, a unique nonlinear conductivity behavior observed in some chalcogenide glasses, has been recently the source of a real technological breakthrough in the field of data storage memories. This breakthrough was achieved because of the succes...

journal_title：Science advances

authors： Noé P,Verdy A,d'Acapito F,Dory JB,Bernard M,Navarro G,Jager JB,Gaudin J,Raty JY

更新日期：2020-02-28 00:00:00

abstract：:Bacterial chemotaxis-a fundamental example of directional navigation in the living world-is key to many biological processes, including the spreading of bacterial infections. Many bacterial species were recently reported to exhibit several distinct swimming modes-the flagella may, for example, push the cell body or wr...

journal_title：Science advances

authors： Alirezaeizanjani Z,Großmann R,Pfeifer V,Hintsche M,Beta C

更新日期：2020-05-27 00:00:00

abstract：:Soft robotics may enable many new technologies in which humans and robots physically interact, yet the necessary high-performance soft actuators still do not exist. The optimal soft actuators need to be fast and forceful and have programmable shape changes. Furthermore, they should be energy efficient for untethered a...

journal_title：Science advances

authors： Davidson ZS,Shahsavan H,Aghakhani A,Guo Y,Hines L,Xia Y,Yang S,Sitti M

更新日期：2019-11-22 00:00:00

abstract：:In this study, we report the existence of a communication system among human smooth muscle cells that uses mechanical forces to frequency modulate long-range calcium waves. An important consequence of this mechanical signaling is that changes in stiffness of the underlying extracellular matrix can interfere with the f...

journal_title：Science advances

authors： Stasiak SE,Jamieson RR,Bouffard J,Cram EJ,Parameswaran H

更新日期：2020-08-05 00:00:00

abstract：:Regulatory T (Treg) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the Treg cell program. We found that mice deficient in Bcl11b TF solely in Treg cells developed fatal autoimmunity, and Bcl11b-deficient...

journal_title：Science advances

authors： Drashansky TT,Helm E,Huo Z,Curkovic N,Kumar P,Luo X,Parthasarathy U,Zuniga A,Cho JJ,Lorentsen KJ,Xu Z,Uddin M,Moshkani S,Zhou L,Avram D

更新日期：2019-08-07 00:00:00

abstract：:The Mott metal-insulator transition, a paradigm of strong electron-electron correlations, has been considered as a source of intriguing phenomena. Despite its importance for a wide range of materials, fundamental aspects of the transition, such as its universal properties, are still under debate. We report detailed me...

journal_title：Science advances

authors： Gati E,Garst M,Manna RS,Tutsch U,Wolf B,Bartosch L,Schubert H,Sasaki T,Schlueter JA,Lang M

更新日期：2016-12-07 00:00:00

abstract：:Posthemorrhagic hydrocephalus (PHH) in premature infants is a common neurological disorder treated with invasive neurosurgical interventions. Patients with PHH lack effective therapeutic interventions and suffer chronic comorbidities. Here, we report a murine lysophosphatidic acid (LPA)-induced postnatal PHH model tha...

journal_title：Science advances

authors： Lummis NC,Sánchez-Pavón P,Kennedy G,Frantz AJ,Kihara Y,Blaho VA,Chun J

更新日期：2019-10-09 00:00:00

abstract：:The spin-polarized surface states of topological insulators (TIs) are attractive for applications in spintronics and quantum computing. A central challenge with these materials is to reliably tune the chemical potential of their electrons with respect to the Dirac point and the bulk bands. We demonstrate persistent, b...

journal_title：Science advances

authors： Yeats AL,Pan Y,Richardella A,Mintun PJ,Samarth N,Awschalom DD

更新日期：2015-10-09 00:00:00

abstract：:Mesoscale turbulence in the ocean strongly affects the circulation, water mass formation, and transport of tracers. Little is known, however, about how mixing varies on climate timescales. We present the first time-resolved global dataset of lateral mesoscale eddy diffusivities at the ocean surface, obtained by applyi...

journal_title：Science advances

authors： Busecke JJM,Abernathey RP

更新日期：2019-01-23 00:00:00

abstract：:Engineering the thermal conductivity of amorphous materials is highly essential for the thermal management of future electronic devices. Here, we demonstrate the impact of ultrafine nanostructuring on the thermal conductivity reduction of amorphous silicon nitride (a-Si3N4) thin films, in which the thermal transport i...

journal_title：Science advances

authors： Tambo N,Liao Y,Zhou C,Ashley EM,Takahashi K,Nealey PF,Naito Y,Shiomi J

更新日期：2020-09-25 00:00:00

abstract：:Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. W...

journal_title：Science advances

authors： Nakatsuji T,Fenical W,Gallo RL

更新日期：2019-09-11 00:00:00

abstract：:Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility,...

journal_title：Science advances

authors： Luan L,Wei X,Zhao Z,Siegel JJ,Potnis O,Tuppen CA,Lin S,Kazmi S,Fowler RA,Holloway S,Dunn AK,Chitwood RA,Xie C

更新日期：2017-02-15 00:00:00

abstract：:Holoprosencephaly (HPE) is a congenital forebrain defect often associated with embryonic lethality and lifelong disabilities. Currently, therapeutic and diagnostic options are limited by lack of knowledge of potential disease-causing mutations. We have identified a new mutation in the PRDM15 gene (C844Y) associated wi...

journal_title：Science advances

authors： Mzoughi S,Di Tullio F,Low DHP,Motofeanu CM,Ong SLM,Wollmann H,Wun CM,Kruszka P,Muenke M,Hildebrandt F,Dunn NR,Messerschmidt DM,Guccione E

更新日期：2020-01-10 00:00:00

abstract：:Earthquakes in the continental crust commonly occur in the upper 15 to 20 km. Recent studies demonstrate that earthquakes also occur in the lower crust of collision zones and play a key role in metamorphic processes that modify its physical properties. However, details of the failure process and sequence of events tha...

journal_title：Science advances

authors： Petley-Ragan A,Ben-Zion Y,Austrheim H,Ildefonse B,Renard F,Jamtveit B

更新日期：2019-07-31 00:00:00

abstract：:Metabolic engineering uses enzymes to produce small molecules with industrial, pharmaceutical, and energy applications. However, efforts to optimize enzymatic pathways for commercial production are limited by the throughput of assays for quantifying metabolic intermediates and end products. We developed a multiplexed ...

journal_title：Science advances

authors： O'Kane PT,Dudley QM,McMillan AK,Jewett MC,Mrksich M

更新日期：2019-06-05 00:00:00

abstract：:It is fascinating but challenging for nanoscientists to organize nanoparticles (NPs) into ordered architectures just as it is for chemists to manipulate atoms and molecules to form functional molecules and supramolecules. We explore a strategy to assemble anisotropic NPs into open frame-like superstructures via orient...

journal_title：Science advances

authors： Nai J,Guan BY,Yu L,Lou XWD

更新日期：2017-08-23 00:00:00

abstract：:Soil organic carbon (SOC) stored in permafrost across the high-latitude/altitude Northern Hemisphere represents an important potential carbon source under future warming. Here, we provide a comprehensive investigation on the spatiotemporal dynamics of SOC over the high-altitude Tibetan Plateau (TP), which has received...

journal_title：Science advances

authors： Wang T,Yang D,Yang Y,Piao S,Li X,Cheng G,Fu B

更新日期：2020-05-06 00:00:00

abstract：:Mineral exploitation has spread from land to shallow coastal waters and is now planned for the offshore, deep seabed. Large seafloor areas are being approved for exploration for seafloor mineral deposits, creating an urgent need for regional environmental management plans. Networks of areas where mining and mining imp...

journal_title：Science advances

authors： Dunn DC,Van Dover CL,Etter RJ,Smith CR,Levin LA,Morato T,Colaço A,Dale AC,Gebruk AV,Gjerde KM,Halpin PN,Howell KL,Johnson D,Perez JAA,Ribeiro MC,Stuckas H,Weaver P,SEMPIA Workshop Participants.

更新日期：2018-07-04 00:00:00

abstract：:An immense demand in biomedical imaging is to develop efficient photoluminescent probes with high biocompatibility and quantum yield, as well as multiphoton absorption performance to improve penetration depth and spatial resolution. Here, iron selenide (FeSe) quantum dots (QDs) are reported to meet these criteria. The...

journal_title：Science advances

authors： Kwon J,Jun SW,Choi SI,Mao X,Kim J,Koh EK,Kim YH,Kim SK,Hwang DY,Kim CS,Lee J

更新日期：2019-12-06 00:00:00

abstract：:Glutathione (GSH), the most abundant nonprotein thiol functioning as an antioxidant, plays critical roles in maintaining the core functions of mesenchymal stem cells (MSCs), which are used as a cellular immunotherapy for graft-versus-host disease (GVHD). However, the role of GSH dynamics in MSCs remains elusive. Genom...

journal_title：Science advances

authors： Lim J,Heo J,Ju H,Shin JW,Kim Y,Lee S,Yu HY,Ryu CM,Yun H,Song S,Hong KS,Chung HM,Kim HR,Roe JS,Choi K,Kim IG,Jeong EM,Shin DM

更新日期：2020-04-15 00:00:00

abstract：:The repair of DNA double-strand breaks occurs through nonhomologous end joining or homologous recombination in vertebrate cells-a choice that is thought to be decided by a competition between DNA-dependent protein kinase (DNA-PK) and the Mre11/Rad50/Nbs1 (MRN) complex but is not well understood. Using ensemble biochem...

journal_title：Science advances

authors： Deshpande RA,Myler LR,Soniat MM,Makharashvili N,Lee L,Lees-Miller SP,Finkelstein IJ,Paull TT

更新日期：2020-01-08 00:00:00

abstract：:Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by macrophages and other phagocytes, forming pores in their membranes. Loss of perforin-2 renders individual phagocytes and whole organisms significantly more susceptible to bacterial pathogens. Here, we reveal the mechanism of perforin-...

journal_title：Science advances

authors： Ni T,Jiao F,Yu X,Aden S,Ginger L,Williams SI,Bai F,Pražák V,Karia D,Stansfeld P,Zhang P,Munson G,Anderluh G,Scheuring S,Gilbert RJC

更新日期：2020-01-29 00:00:00

abstract：:Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla: Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and Taphrinomycotina (fission yeasts). Despite its importance, we lack a comprehensive genome-scale phylogeny or understanding of the similarities and differenc...

journal_title：Science advances

authors： Shen XX,Steenwyk JL,LaBella AL,Opulente DA,Zhou X,Kominek J,Li Y,Groenewald M,Hittinger CT,Rokas A

更新日期：2020-11-04 00:00:00

abstract：:Pressure is a key parameter in the physics and chemistry of planet formation and evolution. Previous studies have erroneously assumed that internal pressures monotonically increase with the mass of a body. Using smoothed particle hydrodynamics and potential field method calculations, we demonstrate that the hot, rapid...

journal_title：Science advances

authors： Lock SJ,Stewart ST

更新日期：2019-09-04 00:00:00

abstract：:A semiconductor nanowire with strong spin-orbit coupling in proximity to a superconductor is predicted to display Majorana edge states emerging under a properly oriented magnetic field. The experimental investigation of these exotic states requires assessing the one-dimensional (1D) character of the nanowire and under...

journal_title：Science advances

authors： Estrada Saldaña JC,Žitko R,Cleuziou JP,Lee EJH,Zannier V,Ercolani D,Sorba L,Aguado R,De Franceschi S

更新日期：2019-07-05 00:00:00

abstract：:Fractures and faults riddle the Earth's crust on all scales, and the deformation associated with them is presumed to have had significant effects on its petrological and structural evolution. However, despite the abundance of directly observable earthquake activity, unequivocal evidence for seismic slip rates along an...

journal_title：Science advances

authors： Austrheim H,Dunkel KG,Plümper O,Ildefonse B,Liu Y,Jamtveit B

更新日期：2017-02-22 00:00:00

abstract：:The notorious ~60° bend separating the Hawaiian and Emperor chains marked a prominent change in the motion of the Pacific plate at ~47 Ma (million years ago), but the origin of that change remains an outstanding controversy that bears on the nature of major plate reorganizations. Lesser known but equally significant i...

journal_title：Science advances

authors： Domeier M,Shephard GE,Jakob J,Gaina C,Doubrovine PV,Torsvik TH

更新日期：2017-11-08 00:00:00