Abstract:
:Transplanting beneficial bacteria to the gut microbiome can positively modulate the bacterial composition and remains of great interest in prevention and treatment. However, environmental assaults and rapid transit times in the gastrointestinal (GI) tract result in low oral bioavailability and limited intestinal colonization. Here, we describe a bioinspired strategy of self-coating with biofilms that endows the transplanted gut microbiota with superior resistance and adhesion capacity. Using clinical Bacillus subtilis as a model probiotic bacterium, biofilm-coated probiotics demonstrate substantially improved GI tract tolerance and mucoadhesion in mice and swine. In particular, coated probiotics exhibit a 125-fold higher oral bioavailability and a 17 times greater intestinal colonization than uncoated bacteria in the porcine model. With notable ability to survive and reside in the GI tract, coated bacteria further show a significantly enhanced decolonization effect in mice colonized with Staphylococcus aureus. Self-coating with biofilms suggests a robust platform for oral doses of gut microbiota.
journal_name
Sci Advjournal_title
Science advancesauthors
Wang X,Cao Z,Zhang M,Meng L,Ming Z,Liu Jdoi
10.1126/sciadv.abb1952subject
Has Abstractpub_date
2020-06-24 00:00:00pages
eabb1952issue
26issn
2375-2548pii
abb1952journal_volume
6pub_type
杂志文章相关文献
Science Advances文献大全abstract::We tested how sediment trapping by hydroelectric dams affects tropical estuaries by comparing two dammed and two undammed rivers on Mexico's Pacific coast. We found that dams demonstrably affected the stability and productivity of the estuaries. The two rivers dammed for hydroelectricity had a rapid coastal recession ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9875
更新日期:2019-03-13 00:00:00
abstract::Bacterial chemotaxis-a fundamental example of directional navigation in the living world-is key to many biological processes, including the spreading of bacterial infections. Many bacterial species were recently reported to exhibit several distinct swimming modes-the flagella may, for example, push the cell body or wr...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaz6153
更新日期:2020-05-27 00:00:00
abstract::Multicellular organisms are composed of tissues that have distinct functions requiring specialized proteomes. To define the proteome of a live animal with tissue and subcellular resolution, we adapted a localized proteomics technology for use in the multicellular model organism Caenorhabditis elegans. This approach co...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602426
更新日期:2017-05-10 00:00:00
abstract::Efforts at altering the dismal prognosis of pediatric midline gliomas focus on direct delivery strategies like convection-enhanced delivery (CED), where a cannula is implanted into tumor. Successful CED treatments require confirmation of tumor coverage, dosimetry, and longitudinal in vivo pharmacokinetic monitoring. T...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb4105
更新日期:2020-07-24 00:00:00
abstract::Understanding the precise atomic structure of ice surfaces is critical for revealing the mechanisms of physical and chemical phenomena at the surfaces, such as ice growth, melting, and chemical reactions. Nevertheless, no conclusive structure has been established. In this study, noncontact atomic force microscopy was ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7986
更新日期:2020-09-11 00:00:00
abstract::Despite the important roles that horses have played in human history, particularly in the spread of languages and cultures, and correspondingly intensive research on this topic, the origin of domestic horses remains elusive. Several domestication centers have been hypothesized, but most of these have been invalidated ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb0030
更新日期:2020-09-16 00:00:00
abstract::Rising sea levels will have overwhelmingly negative impacts on coastal communities globally. With previous research focused on how sea-level rise (SLR) affects storm-induced flooding, we show that SLR will also increase both the frequency and the intensity of tsunami-induced flooding, another significant coastal hazar...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat1180
更新日期:2018-08-15 00:00:00
abstract::Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passively (i.e., no killing effect). We screened hundreds of (meth)acrylate polymers in high thro...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aba6574
更新日期:2020-06-05 00:00:00
abstract::Macromolecules tend to respond to applied forces in many different ways. Chemistry at high shear forces can be intriguing, with relatively soft bonds becoming very stiff in specific force-loading geometries. Largely used in bionanotechnology, an important case is the streptavidin (SA)/biotin interaction. Although SA's...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay5999
更新日期:2020-03-25 00:00:00
abstract::Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine triphosphate to adenosine monophosphate (AMP) and AMP to adenosine, respectively. Despite the relevance of CD39/CD73 t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax1387
更新日期:2019-08-21 00:00:00
abstract::By experimentally studying high-order harmonic beams generated in gases, we show how the spatial characteristics of these ultrashort extreme-ultraviolet (XUV) beams can be finely controlled when a single fundamental beam generates harmonics in a thin gas medium. We demonstrate that these XUV beams can be emitted as co...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau7175
更新日期:2019-04-05 00:00:00
abstract::Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desatu...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar6849
更新日期:2018-05-02 00:00:00
abstract::Ice accretion has a negative impact on critical infrastructure, as well as a range of commercial and residential activities. Icephobic surfaces are defined by an ice adhesion strength τice < 100 kPa. However, the passive removal of ice requires much lower values of τice, such as on airplane wings or power lines (τice ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501496
更新日期:2016-03-11 00:00:00
abstract::Here, we demonstrate the use of pump-probe microscopy for high-resolution studies of vermilion degradation. Vermilion (mostly α-HgS), an important red pigment used in historical paintings, blackens over time, and metallic Hg and β-HgS have been implicated as possible degradation products. Conventional analysis techniq...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw3136
更新日期:2019-06-21 00:00:00
abstract::The homotrimeric molecular chaperone Skp of Gram-negative bacteria facilitates the transport of outer membrane proteins across the periplasm. It has been unclear how its activity is modulated during its functional cycle. Here, we report an atomic-resolution characterization of the Escherichia coli Skp monomer-trimer t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abc5822
更新日期:2020-10-21 00:00:00
abstract::Embodied models suggest that moral judgments are strongly intertwined with first-hand somatic experiences, with some pointing to disgust, and others arguing for a role of pain/harm. Both disgust and pain are unpleasant, arousing experiences, with strong relevance for survival, but with distinctive sensory qualities an...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat4390
更新日期:2020-10-16 00:00:00
abstract::Changes in CO2 emissions during the COVID-19 pandemic have been estimated from indicators on activities like transportation and electricity generation. Here, we instead use satellite observations together with bottom-up information to track the daily dynamics of CO2 emissions during the pandemic. Unlike activity data,...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abd4998
更新日期:2020-12-02 00:00:00
abstract::A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aax0903
更新日期:2019-07-24 00:00:00
abstract::Fundamental understanding of the charge transport physics of hybrid lead halide perovskite semiconductors is important for advancing their use in high-performance optoelectronics. We use field-effect transistors (FETs) to probe the charge transport mechanism in thin films of methylammonium lead iodide (MAPbI3). We sho...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601935
更新日期:2017-01-27 00:00:00
abstract::Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb4591
更新日期:2020-08-28 00:00:00
abstract::Cheater viruses, also known as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type upon coinfection. While there is growing interest in using cheaters as antiviral therapeutics, the mechanisms underlying cheating have been rarely explored. During experimental evolution ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.abb7990
更新日期:2020-08-21 00:00:00
abstract::Myofibroblasts orchestrate wound healing processes, and if they remain activated, they drive disease progression such as fibrosis and cancer. Besides growth factor signaling, the local extracellular matrix (ECM) and its mechanical properties are central regulators of these processes. It remains unknown whether transfo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao4881
更新日期:2018-01-17 00:00:00
abstract::Injection-induced earthquakes pose a serious seismic hazard but also offer an opportunity to gain insight into earthquake physics. Currently used models relating the maximum magnitude of injection-induced earthquakes to injection parameters do not incorporate rupture physics. We develop theoretical estimates, validate...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aap7528
更新日期:2017-12-20 00:00:00
abstract::Quantitative three-dimensional (3D) computed tomography (CT) imaging of living single cells enables orientation-independent morphometric analysis of the intricacies of cellular physiology. Since its invention, x-ray CT has become indispensable in the clinic for diagnostic and prognostic purposes due to its quantitativ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1602580
更新日期:2017-12-06 00:00:00
abstract::Weyl semimetals are of great interest because they provide the first realization of the Weyl fermion, exhibit exotic quantum anomalies, and host Fermi arc surface states. The separation between Weyl nodes of opposite chirality gives a measure of the robustness of the Weyl semimetal state. To exploit the novel phenomen...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600295
更新日期:2016-06-24 00:00:00
abstract::Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501164
更新日期:2015-11-27 00:00:00
abstract::We examine the low-temperature states supported by the quasiperiodic host-guest structure of elemental bismuth at high pressure, Bi-III. Our electronic transport and magnetization experiments establish Bi-III as a rare example of type II superconductivity in an element, with a record upper critical field of ~ 2.5 T, u...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao4793
更新日期:2018-04-13 00:00:00
abstract::Many insects use nectar as their principal diet and have mouthparts specialized in nectarivory, whereas most nectar-feeding vertebrates are opportunistic users of floral resources and only a few species show distinct morphological specializations. Specialized nectar-feeding bats extract nectar from flowers using elong...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500525
更新日期:2015-09-25 00:00:00
abstract::Exploration for superconductivity is one of the research frontiers in condensed matter physics. In strongly correlated electron systems, the emergence of superconductivity is often inhibited by the formation of a thermodynamically more stable magnetic/charge order. Thus, to develop the superconductivity as the thermod...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau3489
更新日期:2018-10-05 00:00:00
abstract::Monolithic strong magnetic induction at the mtesla to tesla level provides essential functionalities to physical, chemical, and medical systems. Current design options are constrained by existing capabilities in three-dimensional (3D) structure construction, current handling, and magnetic material integration. We repo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aay4508
更新日期:2020-01-17 00:00:00