Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals.

Abstract:

:Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desaturases. ωx desaturases have also been described in a small number of invertebrate animals, but their precise distribution has not been systematically explored. This study identifies 121 ωx desaturase sequences from 80 species within the Cnidaria, Rotifera, Mollusca, Annelida, and Arthropoda. Horizontal gene transfer has contributed to this hitherto unknown widespread distribution. Functional characterization of animal ωx desaturases provides evidence that multiple invertebrates have the ability to produce ω3 PUFA de novo and further biosynthesize ω3 long-chain PUFA. This finding represents a fundamental revision in our understanding of ω3 long-chain PUFA production in global food webs, by revealing that numerous widespread and abundant invertebrates have the endogenous capacity to make significant contributions beyond that coming from marine microbes.

journal_name

Sci Adv

journal_title

Science advances

authors

Kabeya N,Fonseca MM,Ferrier DEK,Navarro JC,Bay LK,Francis DS,Tocher DR,Castro LFC,Monroig Ó

doi

10.1126/sciadv.aar6849

subject

Has Abstract

pub_date

2018-05-02 00:00:00

pages

eaar6849

issue

5

issn

2375-2548

pii

aar6849

journal_volume

4

pub_type

杂志文章
  • Single-cell peripheral immunoprofiling of Alzheimer's and Parkinson's diseases.

    abstract::Peripheral blood mononuclear cells (PBMCs) may provide insight into the pathogenesis of Alzheimer's disease (AD) or Parkinson's disease (PD). We investigated PBMC samples from 132 well-characterized research participants using seven canonical immune stimulants, mass cytometric identification of 35 PBMC subsets, and si...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abd5575

    authors: Phongpreecha T,Fernandez R,Mrdjen D,Culos A,Gajera CR,Wawro AM,Stanley N,Gaudilliere B,Poston KL,Aghaeepour N,Montine TJ

    更新日期:2020-11-25 00:00:00

  • The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.

    abstract::Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. The immunoproteasome is an inducible form of the proteasome that is intimately involved in inflammatory diseases. Here, we found that the expression and activity of immunoproteasome catalytic subunit β5i were significantly u...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aau0495

    authors: Xie X,Bi HL,Lai S,Zhang YL,Li N,Cao HJ,Han L,Wang HX,Li HH

    更新日期:2019-05-08 00:00:00

  • Butterfly gyroid nanostructures as a time-frozen glimpse of intracellular membrane development.

    abstract::The formation of the biophotonic gyroid material in butterfly wing scales is an exceptional feat of evolutionary engineering of functional nanostructures. It is hypothesized that this nanostructure forms by chitin polymerization inside a convoluted membrane of corresponding shape in the endoplasmic reticulum. However,...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1603119

    authors: Wilts BD,Apeleo Zubiri B,Klatt MA,Butz B,Fischer MG,Kelly ST,Spiecker E,Steiner U,Schröder-Turk GE

    更新日期:2017-04-26 00:00:00

  • In silico discovery of metal-organic frameworks for precombustion CO2 capture using a genetic algorithm.

    abstract::Discovery of new adsorbent materials with a high CO2 working capacity could help reduce CO2 emissions from newly commissioned power plants using precombustion carbon capture. High-throughput computational screening efforts can accelerate the discovery of new adsorbents but sometimes require significant computational r...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1600909

    authors: Chung YG,Gómez-Gualdrón DA,Li P,Leperi KT,Deria P,Zhang H,Vermeulen NA,Stoddart JF,You F,Hupp JT,Farha OK,Snurr RQ

    更新日期:2016-10-14 00:00:00

  • Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer.

    abstract::Metabolic reprogramming is widely considered a hallmark of cancer, and understanding metabolic dynamics described by the conversion rates or "fluxes" of metabolites can shed light onto biological processes of tumorigenesis and response to therapy. For real-time analysis of metabolic flux in intact cells or organisms, ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1700341

    authors: Jeong S,Eskandari R,Park SM,Alvarez J,Tee SS,Weissleder R,Kharas MG,Lee H,Keshari KR

    更新日期:2017-06-16 00:00:00

  • Combining scaling relationships overcomes rate versus overpotential trade-offs in O2 molecular electrocatalysis.

    abstract::The development of advanced chemical-to-electrical energy conversions requires fast and efficient electrocatalysis of multielectron/multiproton reactions, such as the oxygen reduction reaction (ORR). Using molecular catalysts, correlations between the reaction rate and energy efficiency have recently been identified. ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaz3318

    authors: Martin DJ,Mercado BQ,Mayer JM

    更新日期:2020-03-13 00:00:00

  • Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes.

    abstract::Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-γ (IFN-γ), in offspring's brains play a central role. IFN-γ activates an antiviral cellular state, limiting viral entry and replication. Moreover, IFN-γ is implicated in brain development. We tested th...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aay9506

    authors: Warre-Cornish K,Perfect L,Nagy R,Duarte RRR,Reid MJ,Raval P,Mueller A,Evans AL,Couch A,Ghevaert C,McAlonan G,Loth E,Murphy D,Powell TR,Vernon AC,Srivastava DP,Price J

    更新日期:2020-08-19 00:00:00

  • Attenuated diphtheria toxin mediates siRNA delivery.

    abstract::Toxins efficiently deliver cargo to cells by binding to cell surface ligands, initiating endocytosis, and escaping the endolysosomal pathway into the cytoplasm. We took advantage of this delivery pathway by conjugating an attenuated diphtheria toxin to siRNA, thereby achieving gene downregulation in patient-derived gl...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaz4848

    authors: Arnold AE,Smith LJ,Beilhartz GL,Bahlmann LC,Jameson E,Melnyk RA,Shoichet MS

    更新日期:2020-05-01 00:00:00

  • Metastable asymmetrical structure of a shaftless V1 motor.

    abstract::V1-ATPase is an ATP-driven rotary motor that is composed of a ring-shaped A3B3 complex and a central DF shaft. The nucleotide-free A3B3 complex of Enterococcus hirae, composed of three identical A1B1 heterodimers, showed a unique asymmetrical structure, probably due to the strong binding of the N-terminal barrel domai...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aau8149

    authors: Maruyama S,Suzuki K,Imamura M,Sasaki H,Matsunami H,Mizutani K,Saito Y,Imai FL,Ishizuka-Katsura Y,Kimura-Someya T,Shirouzu M,Uchihashi T,Ando T,Yamato I,Murata T

    更新日期:2019-01-30 00:00:00

  • Voltage control of unidirectional anisotropy in ferromagnet-multiferroic system.

    abstract::Demonstration of ultralow energy switching mechanisms is imperative for continued improvements in computing devices. Ferroelectric (FE) and multiferroic (MF) order and their manipulation promise an ideal combination of state variables to reach attojoule range for logic and memory (i.e., ~30× lower switching energy tha...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aat4229

    authors: Manipatruni S,Nikonov DE,Lin CC,Prasad B,Huang YL,Damodaran AR,Chen Z,Ramesh R,Young IA

    更新日期:2018-11-23 00:00:00

  • Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function.

    abstract::B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaw0315

    authors: Zhao X,Xie H,Zhao M,Ahsan A,Li X,Wang F,Yi J,Yang Z,Wu C,Raman I,Li QZ,Kim TJ,Liu W

    更新日期:2019-07-17 00:00:00

  • Are coral reefs victims of their own past success?

    abstract::As one of the most prolific and widespread reef builders, the staghorn coral Acropora holds a disproportionately large role in how coral reefs will respond to accelerating anthropogenic change. We show that although Acropora has a diverse history extended over the past 50 million years, it was not a dominant reef buil...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1500850

    authors: Renema W,Pandolfi JM,Kiessling W,Bosellini FR,Klaus JS,Korpanty C,Rosen BR,Santodomingo N,Wallace CC,Webster JM,Johnson KG

    更新日期:2016-04-22 00:00:00

  • Climbing droplets driven by mechanowetting on transverse waves.

    abstract::Many applications in modern technology, such as self-cleaning surfaces and digital microfluidics, require control over individual fluid droplets on flat surfaces. Existing techniques may suffer from side effects resulting from high electric fields and high temperatures. Here, we introduce a markedly different method, ...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaw0914

    authors: De Jong E,Wang Y,Den Toonder JMJ,Onck PR

    更新日期:2019-06-14 00:00:00

  • Decoupling of microbial carbon, nitrogen, and phosphorus cycling in response to extreme temperature events.

    abstract::Predicted changes in the intensity and frequency of climate extremes urge a better mechanistic understanding of the stress response of microbially mediated carbon (C) and nutrient cycling processes. We analyzed the resistance and resilience of microbial C, nitrogen (N), and phosphorus (P) cycling processes and microbi...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1602781

    authors: Mooshammer M,Hofhansl F,Frank AH,Wanek W,Hämmerle I,Leitner S,Schnecker J,Wild B,Watzka M,Keiblinger KM,Zechmeister-Boltenstern S,Richter A

    更新日期:2017-05-03 00:00:00

  • Osteoblastic lysosome plays a central role in mineralization.

    abstract::Mineralization is the most fundamental process in vertebrates. It is predominantly mediated by osteoblasts, which secrete mineral precursors, most likely through matrix vesicles (MVs). These vesicular structures are calcium and phosphate rich and contain organic material such as acidic proteins. However, it remains la...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aax0672

    authors: Iwayama T,Okada T,Ueda T,Tomita K,Matsumoto S,Takedachi M,Wakisaka S,Noda T,Ogura T,Okano T,Fratzl P,Ogura T,Murakami S

    更新日期:2019-07-03 00:00:00

  • Reconstructed storm tracks reveal three centuries of changing moisture delivery to North America.

    abstract::Moisture delivery to western North America is closely linked to variability in the westerly storm tracks of midlatitude cyclones, which are, in turn, modified by larger-scale features such as the El Niño-Southern Oscillation system. Instrumental and modeling data suggest that extratropical storm tracks may be intensif...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1602263

    authors: Wise EK,Dannenberg MP

    更新日期:2017-06-07 00:00:00

  • Dual mode standoff imaging spectroscopy documents the painting process of the Lamb of God in the Ghent Altarpiece by J. and H. Van Eyck.

    abstract::The ongoing conservation treatment program of the Ghent Altarpiece by Hubert and Jan Van Eyck, one of the iconic paintings of the west, has revealed that the designs of the paintings were changed several times, first by the original artists, and then during later restorations. The central motif, The Lamb of God, repre...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abb3379

    authors: Van der Snickt G,Dooley KA,Sanyova J,Dubois H,Delaney JK,Gifford EM,Legrand S,Laquiere N,Janssens K

    更新日期:2020-07-29 00:00:00

  • High-capacity poly(2-oxazoline) formulation of TLR 7/8 agonist extends survival in a chemo-insensitive, metastatic model of lung adenocarcinoma.

    abstract::About 40% of patients with non-small cell lung cancer (NSCLC) have stage IV cancer at the time of diagnosis. The only viable treatment options for metastatic disease are systemic chemotherapy and immunotherapy. Nonetheless, chemoresistance remains a major cause of chemotherapy failure. New immunotherapeutic modalities...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aba5542

    authors: Vinod N,Hwang D,Azam SH,Van Swearingen AED,Wayne E,Fussell SC,Sokolsky-Papkov M,Pecot CV,Kabanov AV

    更新日期:2020-06-17 00:00:00

  • Silver(I) as a widely applicable, homogeneous catalyst for aerobic oxidation of aldehydes toward carboxylic acids in water-"silver mirror": From stoichiometric to catalytic.

    abstract::The first example of a homogeneous silver(I)-catalyzed aerobic oxidation of aldehydes in water is reported. More than 50 examples of different aliphatic and aromatic aldehydes, including natural products, were tested, and all of them successfully underwent aerobic oxidation to give the corresponding carboxylic acids i...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1500020

    authors: Liu M,Wang H,Zeng H,Li CJ

    更新日期:2015-03-27 00:00:00

  • Nanobubble-controlled nanofluidic transport.

    abstract::Nanofluidic platforms offering tunable material transport are applicable in biosensing, chemical detection, and filtration. Prior studies have achieved selective and controllable ion transport through electrical, optical, or chemical gating of complex nanostructures. Here, we mechanically control nanofluidic transport...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abd0126

    authors: Rabinowitz J,Whittier E,Liu Z,Jayant K,Frank J,Shepard K

    更新日期:2020-11-13 00:00:00

  • A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules.

    abstract::Sister chromatid cohesion requires cohesin to act as a protein linker to hold chromatids together. How cohesin tethers chromatids remains poorly understood. We have used optical tweezers to visualize cohesin as it holds DNA molecules. We show that cohesin complexes tether DNAs in the presence of Scc2/Scc4 and ATP demo...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aay6804

    authors: Gutierrez-Escribano P,Newton MD,Llauró A,Huber J,Tanasie L,Davy J,Aly I,Aramayo R,Montoya A,Kramer H,Stigler J,Rueda DS,Aragon L

    更新日期:2019-11-27 00:00:00

  • A highly stretchable, transparent, and conductive polymer.

    abstract::Previous breakthroughs in stretchable electronics stem from strain engineering and nanocomposite approaches. Routes toward intrinsically stretchable molecular materials remain scarce but, if successful, will enable simpler fabrication processes, such as direct printing and coating, mechanically robust devices, and mor...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1602076

    authors: Wang Y,Zhu C,Pfattner R,Yan H,Jin L,Chen S,Molina-Lopez F,Lissel F,Liu J,Rabiah NI,Chen Z,Chung JW,Linder C,Toney MF,Murmann B,Bao Z

    更新日期:2017-03-10 00:00:00

  • The politics of zero-sum thinking: The relationship between political ideology and the belief that life is a zero-sum game.

    abstract::The tendency to see life as zero-sum exacerbates political conflicts. Six studies (N = 3223) examine the relationship between political ideology and zero-sum thinking: the belief that one party's gains can only be obtained at the expense of another party's losses. We find that both liberals and conservatives view life...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aay3761

    authors: Davidai S,Ongis M

    更新日期:2019-12-18 00:00:00

  • Deterministic quantum teleportation through fiber channels.

    abstract::Quantum teleportation, which is the transfer of an unknown quantum state from one station to another over a certain distance with the help of nonlocal entanglement shared by a sender and a receiver, has been widely used as a fundamental element in quantum communication and quantum computation. Optical fibers are cruci...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aas9401

    authors: Huo M,Qin J,Cheng J,Yan Z,Qin Z,Su X,Jia X,Xie C,Peng K

    更新日期:2018-10-19 00:00:00

  • Ultrafast selective transport of alkali metal ions in metal organic frameworks with subnanometer pores.

    abstract::Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation, water purification, and energy conversion, but it is still a huge challenge to efficiently separate monatomic ions of the same valence and similar sizes using synthetic membranes. We report me...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaq0066

    authors: Zhang H,Hou J,Hu Y,Wang P,Ou R,Jiang L,Liu JZ,Freeman BD,Hill AJ,Wang H

    更新日期:2018-02-09 00:00:00

  • Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes.

    abstract::Dendritic cells (DCs) are adept at cross-presentation and initiation of antigen-specific immunity. Clinically, however, DCs produced by in vitro differentiation of monocytes in the presence of exogenous cytokines have been met with limited success. We hypothesized that DCs produced in a physiological manner may be mor...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.aaz1580

    authors: Han P,Hanlon D,Arshad N,Lee JS,Tatsuno K,Robinson E,Filler R,Sobolev O,Cote C,Rivera-Molina F,Toomre D,Fahmy T,Edelson R

    更新日期:2020-03-11 00:00:00

  • Sequence-encoded colloidal origami and microbot assemblies from patchy magnetic cubes.

    abstract::Colloidal-scale assemblies that reconfigure on demand may serve as the next generation of soft "microbots," artificial muscles, and other biomimetic devices. This requires the precise arrangement of particles into structures that are preprogrammed to reversibly change shape when actuated by external fields. The design...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1701108

    authors: Han K,Shields CW 4th,Diwakar NM,Bharti B,López GP,Velev OD

    更新日期:2017-08-04 00:00:00

  • Strong coupling of single quantum dots with low-refractive-index/high-refractive-index materials at room temperature.

    abstract::Strong coupling between a cavity and transition dipole moments in emitters leads to vacuum Rabi splitting. Researchers have not reported strong coupling between a single emitter and a dielectric cavity at room temperature until now. In this study, we investigated the photoluminescence (PL) spectra of colloidal quantum...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.abb3095

    authors: Xu X,Jin S

    更新日期:2020-11-20 00:00:00

  • The prevalence of kilometer-scale heterogeneity in the source region of MORB upper mantle.

    abstract::The source regions of mid-ocean ridge basalts (MORB) are heterogeneous, consisting of chemically and lithologically distinct domains of variable size. Partial melting of such heterogeneous mantle sources gives rise to diverse isotopic compositions of MORB and abyssal peridotites. Variations in radiogenic isotope ratio...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1701872

    authors: Liu B,Liang Y

    更新日期:2017-11-22 00:00:00

  • Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation.

    abstract::Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that a...

    journal_title:Science advances

    pub_type: 杂志文章

    doi:10.1126/sciadv.1601556

    authors: Schneider CS,Xu Q,Boylan NJ,Chisholm J,Tang BC,Schuster BS,Henning A,Ensign LM,Lee E,Adstamongkonkul P,Simons BW,Wang SS,Gong X,Yu T,Boyle MP,Suk JS,Hanes J

    更新日期:2017-04-05 00:00:00