The origin and stability of nanostructural hierarchy in crystalline solids.

abstract：:Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neuroc...

journal_title：Science advances

authors： Raman R,Rousseau EB,Wade M,Tong A,Cotler MJ,Kuang J,Lugo AA,Zhang E,Graybiel AM,White FM,Langer R,Cima MJ

更新日期：2020-09-25 00:00:00

abstract：:Metal-organic frameworks (MOFs) have been attracting intensive attention because of their commendable potential in many applications. Postsynthetic modification for redesigning chemical characteristics and pore structures can greatly improve performance and expand functionality of MOF materials. Here, we develop a ver...

journal_title：Science advances

authors： Wu W,Su J,Jia M,Li Z,Liu G,Li W

更新日期：2020-05-01 00:00:00

abstract：:Perovskite oxides exhibit potential for use as electrocatalysts in the oxygen evolution reaction (OER). However, their low specific surface area is the main obstacle to realizing a high mass-specific activity that is required to be competitive against the state-of-the-art precious metal-based catalysts. We report the ...

journal_title：Science advances

authors： Chen G,Zhou W,Guan D,Sunarso J,Zhu Y,Hu X,Zhang W,Shao Z

更新日期：2017-06-21 00:00:00

abstract：:Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. The immunoproteasome is an inducible form of the proteasome that is intimately involved in inflammatory diseases. Here, we found that the expression and activity of immunoproteasome catalytic subunit β5i were significantly u...

journal_title：Science advances

authors： Xie X,Bi HL,Lai S,Zhang YL,Li N,Cao HJ,Han L,Wang HX,Li HH

更新日期：2019-05-08 00:00:00

abstract：:Animal collective motion arises from the intricate interactions between the natural variability among individuals, and the homogenizing effect of the group, working to generate synchronization and maintain coherence. Here, these interactions were studied using marching locust nymphs under controlled laboratory setting...

journal_title：Science advances

authors： Knebel D,Ayali A,Guershon M,Ariel G

更新日期：2019-01-02 00:00:00

abstract：:Metabolites of the intestinal microbiota are thought to be generated through metabolic pathways spanning multiple taxa of intestinal bacteria. We have previously shown that the level of putrescine, a polyamine found abundantly in the human intestinal lumen, is increased in the colonic lumen following administration of...

journal_title：Science advances

authors： Kitada Y,Muramatsu K,Toju H,Kibe R,Benno Y,Kurihara S,Matsumoto M

更新日期：2018-06-27 00:00:00

abstract：:Cheater viruses, also known as defective interfering viruses, cannot replicate on their own yet replicate faster than the wild type upon coinfection. While there is growing interest in using cheaters as antiviral therapeutics, the mechanisms underlying cheating have been rarely explored. During experimental evolution ...

journal_title：Science advances

authors： Meir M,Harel N,Miller D,Gelbart M,Eldar A,Gophna U,Stern A

更新日期：2020-08-21 00:00:00

abstract：:Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific recognition signals that allowed them to be matured, modified, aminoacylated, and processed by the ribo...

journal_title：Science advances

authors： Saint-Léger A,Bello C,Dans PD,Torres AG,Novoa EM,Camacho N,Orozco M,Kondrashov FA,Ribas de Pouplana L

更新日期：2016-04-29 00:00:00

abstract：:Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities that can alter their function in response to environmental cues. In the present study, we report an engineered p...

journal_title：Science advances

authors： Shields CW 4th,Evans MA,Wang LL,Baugh N,Iyer S,Wu D,Zhao Z,Pusuluri A,Ukidve A,Pan DC,Mitragotri S

更新日期：2020-04-29 00:00:00

abstract：:We tested how sediment trapping by hydroelectric dams affects tropical estuaries by comparing two dammed and two undammed rivers on Mexico's Pacific coast. We found that dams demonstrably affected the stability and productivity of the estuaries. The two rivers dammed for hydroelectricity had a rapid coastal recession ...

journal_title：Science advances

authors： Ezcurra E,Barrios E,Ezcurra P,Ezcurra A,Vanderplank S,Vidal O,Villanueva-Almanza L,Aburto-Oropeza O

更新日期：2019-03-13 00:00:00

abstract：:Cyclosporine A (CsA) is a powerful immunosuppressant, but it is an ineffective stand-alone treatment for systemic lupus erythematosus (SLE) due to poor target tissue distribution and renal toxicity. We hypothesized that CD71 (transferrin receptor 1)-directed delivery of CsA to the lymphatic system would improve SLE ou...

journal_title：Science advances

authors： Ganugula R,Arora M,Zou D,Agarwal SK,Mohan C,Kumar MNVR

更新日期：2020-06-12 00:00:00

abstract：:This study introduces new methods of screening for and tuning chiral space and in so doing identifies a promising set of chiral ligands for asymmetric synthesis. The carbafructopyranosyl-1,2-diamine(s) and salens constructed therefrom are particularly compelling. It is shown that by removing the native anomeric effect...

journal_title：Science advances

authors： Karukurichi KR,Fei X,Swyka RA,Broussy S,Shen W,Dey S,Roy SK,Berkowitz DB

更新日期：2015-07-01 00:00:00

abstract：:Exploration of phase transitions and construction of associated phase diagrams are of fundamental importance for condensed matter physics and materials science alike, and remain the focus of extensive research for both theoretical and experimental studies. For the latter, comprehensive studies involving scattering, th...

journal_title：Science advances

authors： Li L,Yang Y,Zhang D,Ye ZG,Jesse S,Kalinin SV,Vasudevan RK

更新日期：2018-03-30 00:00:00

abstract：:Coherent interactions between electromagnetic and matter waves lie at the heart of quantum science and technology. However, the diffraction nature of light has limited the scalability of many atom-light-based quantum systems. We use the optical fields in a hollow-core photonic crystal fiber to spatially split, reflect...

journal_title：Science advances

authors： Xin M,Leong WS,Chen Z,Lan SY

更新日期：2018-01-19 00:00:00

abstract：:Self-assembly of colloidal nanocrystals into complex superstructures offers notable opportunities to create functional devices and artificial materials with unusual properties. Anisotropic nanoparticles with nonspherical shapes, such as rods, plates, polyhedra, and multipods, enable the formation of a diverse range of...

journal_title：Science advances

authors： Wang Q,Wang Z,Li Z,Xiao J,Shan H,Fang Z,Qi L

更新日期：2017-10-27 00:00:00

abstract：:Induced earthquakes currently pose a significant hazard in the central United States, but there is considerable uncertainty about the severity of their ground motions. We measure stress drops of 39 moderate-magnitude induced and tectonic earthquakes in the central United States and eastern North America. Induced earth...

journal_title：Science advances

authors： Huang Y,Ellsworth WL,Beroza GC

更新日期：2017-08-02 00:00:00

abstract：:Organophosphate-based pesticides inhibit acetylcholinesterase (AChE), which plays a pivotal role in neuromuscular function. While spraying in the field, farmworkers get exposed to pesticides through the dermal route. Internalized pesticide inhibits AChE, which leads to neurotoxicity, cardiotoxicity, cognitive dysfunct...

journal_title：Science advances

authors： Thorat K,Pandey S,Chandrashekharappa S,Vavilthota N,Hiwale AA,Shah P,Sreekumar S,Upadhyay S,Phuntsok T,Mahato M,Mudnakudu-Nagaraju KK,Sunnapu O,Vemula PK

更新日期：2018-10-17 00:00:00

abstract：:Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previ...

journal_title：Science advances

authors： Brödel AK,Rodrigues R,Jaramillo A,Isalan M

更新日期：2020-06-10 00:00:00

abstract：:Cost-benefit trade-offs for individuals participating in social behaviors are the basis for current theories on the evolution of social behaviors and societies. However, research on social strategies has largely ignored solitary animals, in which we assume that rare interactions are explained by courtship or territori...

journal_title：Science advances

authors： Elbroch LM,Levy M,Lubell M,Quigley H,Caragiulo A

更新日期：2017-10-11 00:00:00

abstract：:Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desatu...

journal_title：Science advances

authors： Kabeya N,Fonseca MM,Ferrier DEK,Navarro JC,Bay LK,Francis DS,Tocher DR,Castro LFC,Monroig Ó

更新日期：2018-05-02 00:00:00

abstract：:Many insects use nectar as their principal diet and have mouthparts specialized in nectarivory, whereas most nectar-feeding vertebrates are opportunistic users of floral resources and only a few species show distinct morphological specializations. Specialized nectar-feeding bats extract nectar from flowers using elong...

journal_title：Science advances

authors： Tschapka M,Gonzalez-Terrazas TP,Knörnschild M

更新日期：2015-09-25 00:00:00

abstract：:Conjugated polymer-polyelectrolyte blends combine and couple electronic semiconductor functionality with selective ionic transport, making them attractive as the active material in organic biosensors and bioelectronics, electrochromic displays, neuromorphic computing, and energy conversion and storage. Although extens...

journal_title：Science advances

authors： Tybrandt K,Zozoulenko IV,Berggren M

更新日期：2017-12-15 00:00:00

abstract：:We studied a bilayer system hosting two-dimensional electron systems (2DESs) in close proximity but isolated from one another by a thin barrier. One 2DES has low electron density and forms a Wigner solid (WS) at high magnetic fields. The other has much higher density and, in the same field, exhibits fractional quantum...

journal_title：Science advances

authors： Hatke AT,Deng H,Liu Y,Engel LW,Pfeiffer LN,West KW,Baldwin KW,Shayegan M

更新日期：2019-03-15 00:00:00

abstract：:Predicted changes in the intensity and frequency of climate extremes urge a better mechanistic understanding of the stress response of microbially mediated carbon (C) and nutrient cycling processes. We analyzed the resistance and resilience of microbial C, nitrogen (N), and phosphorus (P) cycling processes and microbi...

journal_title：Science advances

authors： Mooshammer M,Hofhansl F,Frank AH,Wanek W,Hämmerle I,Leitner S,Schnecker J,Wild B,Watzka M,Keiblinger KM,Zechmeister-Boltenstern S,Richter A

更新日期：2017-05-03 00:00:00

abstract：:The Mott transition-a metal-insulator transition caused by repulsive Coulomb interactions between electrons-is a central issue in condensed matter physics because it is the mother earth of various attractive phenomena. Outstanding examples are high-Tc (critical temperature) cuprates and manganites exhibiting colossal ...

journal_title：Science advances

authors： Itou T,Watanabe E,Maegawa S,Tajima A,Tajima N,Kubo K,Kato R,Kanoda K

更新日期：2017-08-11 00:00:00

abstract：:The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel a...

journal_title：Science advances

authors： Altwegg K,Balsiger H,Bar-Nun A,Berthelier JJ,Bieler A,Bochsler P,Briois C,Calmonte U,Combi MR,Cottin H,De Keyser J,Dhooghe F,Fiethe B,Fuselier SA,Gasc S,Gombosi TI,Hansen KC,Haessig M,Jäckel A,Kopp E,Korth A,Le

更新日期：2016-05-27 00:00:00

abstract：:V1-ATPase is an ATP-driven rotary motor that is composed of a ring-shaped A3B3 complex and a central DF shaft. The nucleotide-free A3B3 complex of Enterococcus hirae, composed of three identical A1B1 heterodimers, showed a unique asymmetrical structure, probably due to the strong binding of the N-terminal barrel domai...

journal_title：Science advances

authors： Maruyama S,Suzuki K,Imamura M,Sasaki H,Matsunami H,Mizutani K,Saito Y,Imai FL,Ishizuka-Katsura Y,Kimura-Someya T,Shirouzu M,Uchihashi T,Ando T,Yamato I,Murata T

更新日期：2019-01-30 00:00:00

abstract：:About 40% of patients with non-small cell lung cancer (NSCLC) have stage IV cancer at the time of diagnosis. The only viable treatment options for metastatic disease are systemic chemotherapy and immunotherapy. Nonetheless, chemoresistance remains a major cause of chemotherapy failure. New immunotherapeutic modalities...

journal_title：Science advances

authors： Vinod N,Hwang D,Azam SH,Van Swearingen AED,Wayne E,Fussell SC,Sokolsky-Papkov M,Pecot CV,Kabanov AV

更新日期：2020-06-17 00:00:00

abstract：:Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tu...

journal_title：Science advances

authors： Zheng Z,Wang X,Li M,Li Y,Yang Z,Wang X,Pan X,Gong M,Zhang Y,Guo Y,Wang Y,Liu J,Cai Y,Chen Q,Okpeku M,Colli L,Cai D,Wang K,Huang S,Sonstegard TS,Esmailizadeh A,Zhang W,Zhang T,Xu Y,Xu N,Yang Y,Han J,C

更新日期：2020-05-20 00:00:00

abstract：:An immense demand in biomedical imaging is to develop efficient photoluminescent probes with high biocompatibility and quantum yield, as well as multiphoton absorption performance to improve penetration depth and spatial resolution. Here, iron selenide (FeSe) quantum dots (QDs) are reported to meet these criteria. The...

journal_title：Science advances

authors： Kwon J,Jun SW,Choi SI,Mao X,Kim J,Koh EK,Kim YH,Kim SK,Hwang DY,Kim CS,Lee J

更新日期：2019-12-06 00:00:00