Molecular behavior of zero-dimensional perovskites.

abstract：:Predator-prey interactions revealed by vertebrate trace fossils are extremely rare. We present footprint evidence from White Sands National Monument in New Mexico for the association of sloth and human trackways. Geologically, the sloth and human trackways were made contemporaneously, and the sloth trackways show evid...

journal_title：Science advances

authors： Bustos D,Jakeway J,Urban TM,Holliday VT,Fenerty B,Raichlen DA,Budka M,Reynolds SC,Allen BD,Love DW,Santucci VL,Odess D,Willey P,McDonald HG,Bennett MR

更新日期：2018-04-25 00:00:00

abstract：:Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, particles that a...

journal_title：Science advances

authors： Schneider CS,Xu Q,Boylan NJ,Chisholm J,Tang BC,Schuster BS,Henning A,Ensign LM,Lee E,Adstamongkonkul P,Simons BW,Wang SS,Gong X,Yu T,Boyle MP,Suk JS,Hanes J

更新日期：2017-04-05 00:00:00

abstract：:Cancer cells often encounter oxidative stress. However, it is unclear whether normal and cancer cells differentially respond to oxidative stress. Here, we demonstrated that under oxidative stress, hepatocellular carcinoma (HCC) cells exhibit increased antioxidative response and survival rates compared to normal hepato...

journal_title：Science advances

authors： Xu D,Li X,Shao F,Lv G,Lv H,Lee JH,Qian X,Wang Z,Xia Y,Du L,Zheng Y,Wang H,Lyu J,Lu Z

更新日期：2019-04-24 00:00:00

abstract：:Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and basolateral amygdala (BLA), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. Here, we report that acid-sensing ion channel 1a (ASIC1a) is a c...

journal_title：Science advances

authors： Wang Q,Wang Q,Song XL,Jiang Q,Wu YJ,Li Y,Yuan TF,Zhang S,Xu NJ,Zhu MX,Li WG,Xu TL

更新日期：2018-10-24 00:00:00

abstract：:Large earthquakes occur in rocks undergoing high-pressure/low-temperature metamorphism during subduction. Rhythmic major-element zoning in garnet is a common product of such metamorphism, and one that must record a fundamental subduction process. We argue that rhythmic major-element zoning in subduction zone garnets f...

journal_title：Science advances

authors： Viete DR,Hacker BR,Allen MB,Seward GGE,Tobin MJ,Kelley CS,Cinque G,Duckworth AR

更新日期：2018-03-21 00:00:00

abstract：:The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of the PML-RAR oncogene. AP...

journal_title：Science advances

authors： Ravasio R,Ceccacci E,Nicosia L,Hosseini A,Rossi PL,Barozzi I,Fornasari L,Zuffo RD,Valente S,Fioravanti R,Mercurio C,Varasi M,Mattevi A,Mai A,Pavesi G,Bonaldi T,Minucci S

更新日期：2020-04-08 00:00:00

abstract：:Optical investigation and manipulation constitute the core of biological experiments. Here, we introduce a new borosilicate glass material that contains the rare-earth ion terbium(III) (Tb3+), which emits green fluorescence upon blue light excitation, similar to green fluorescent protein (GFP), and thus is widely comp...

journal_title：Science advances

authors： Okamoto K,Ebina T,Fujii N,Konishi K,Sato Y,Kashima T,Nakano R,Hioki H,Takeuchi H,Yumoto J,Matsuzaki M,Ikegaya Y

更新日期：2021-01-06 00:00:00

abstract：:E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...

journal_title：Science advances

authors： Roworth AP,Carr SM,Liu G,Barczak W,Miller RL,Munro S,Kanapin A,Samsonova A,La Thangue NB

更新日期：2019-06-26 00:00:00

abstract：:Starvation is probably the most common stressful situation in nature. In vertebrates, elevation of the biogenic amine norepinephrine levels is common during starvation. However, the precise role of norepinephrine in nutrient deprivation remains largely unknown. We report that in the free-living nematode Caenorhabditis...

journal_title：Science advances

authors： Tao J,Ma YC,Yang ZS,Zou CG,Zhang KQ

更新日期：2016-05-06 00:00:00

abstract：:Fundamental understanding of the charge transport physics of hybrid lead halide perovskite semiconductors is important for advancing their use in high-performance optoelectronics. We use field-effect transistors (FETs) to probe the charge transport mechanism in thin films of methylammonium lead iodide (MAPbI3). We sho...

journal_title：Science advances

authors： Senanayak SP,Yang B,Thomas TH,Giesbrecht N,Huang W,Gann E,Nair B,Goedel K,Guha S,Moya X,McNeill CR,Docampo P,Sadhanala A,Friend RH,Sirringhaus H

更新日期：2017-01-27 00:00:00

abstract：:The prenatal origins of heart disease in offspring have been established. However, research in species with developmental milestones comparable to humans is lacking, preventing translation of this knowledge to clinical contexts. Using sheep and chickens, two species with similar cardiovascular developmental milestones...

journal_title：Science advances

authors： Botting KJ,Skeffington KL,Niu Y,Allison BJ,Brain KL,Itani N,Beck C,Logan A,Murray AJ,Murphy MP,Giussani DA

更新日期：2020-08-19 00:00:00

abstract：:We examine the low-temperature states supported by the quasiperiodic host-guest structure of elemental bismuth at high pressure, Bi-III. Our electronic transport and magnetization experiments establish Bi-III as a rare example of type II superconductivity in an element, with a record upper critical field of ~ 2.5 T, u...

journal_title：Science advances

authors： Brown P,Semeniuk K,Wang D,Monserrat B,Pickard CJ,Grosche FM

更新日期：2018-04-13 00:00:00

abstract：:The social bond between parents and offspring is characterized by coadaptation and balance between altruistic and selfish tendencies. However, its underlying genetic mechanism remains poorly understood. Using transcriptomic screens in the subsocial European earwig, Forficula auricularia, we found the expression of mor...

journal_title：Science advances

authors： Wu M,Walser JC,Sun L,Kölliker M

更新日期：2020-01-03 00:00:00

abstract：:Large-scale modes of climate variability can force widespread crop yield anomalies and are therefore often presented as a risk to food security. We quantify how modes of climate variability contribute to crop production variance. We find that the El Niño Southern Oscillation (ENSO), the Indian Ocean Dipole (IOD), trop...

journal_title：Science advances

authors： Anderson WB,Seager R,Baethgen W,Cane M,You L

更新日期：2019-07-03 00:00:00

abstract：:The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11-dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about the regulatory role of various metabolic pathways in the control of caspase-11 activation. Here, we demon...

journal_title：Science advances

authors： Chen R,Zeng L,Zhu S,Liu J,Zeh HJ,Kroemer G,Wang H,Billiar TR,Jiang J,Tang D,Kang R

更新日期：2019-05-22 00:00:00

abstract：:The control and use of light polarization in optical sciences and engineering are widespread. Despite remarkable developments in polarization-resolved imaging for life sciences, their transposition to strongly scattering media is currently not possible, because of the inherent depolarization effects arising from multi...

journal_title：Science advances

authors： de Aguiar HB,Gigan S,Brasselet S

更新日期：2017-09-01 00:00:00

abstract：:The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instability. While the majority of cGAS is cytoplasmic, a fraction of cGA...

journal_title：Science advances

authors： Chen H,Chen H,Zhang J,Wang Y,Simoneau A,Yang H,Levine AS,Zou L,Chen Z,Lan L

更新日期：2020-10-14 00:00:00

abstract：:Gender inequality in contemporary U.S. society is a well-documented, widespread phenomenon. However, little is known about gender disparities in product markets. This study is the first to use actual market data to study the behavior of women and men as sellers and buyers and differences in market outcomes. We analyze...

journal_title：Science advances

authors： Kricheli-Katz T,Regev T

更新日期：2016-02-19 00:00:00

abstract：:Fractures and faults riddle the Earth's crust on all scales, and the deformation associated with them is presumed to have had significant effects on its petrological and structural evolution. However, despite the abundance of directly observable earthquake activity, unequivocal evidence for seismic slip rates along an...

journal_title：Science advances

authors： Austrheim H,Dunkel KG,Plümper O,Ildefonse B,Liu Y,Jamtveit B

更新日期：2017-02-22 00:00:00

abstract：:Moisture delivery to western North America is closely linked to variability in the westerly storm tracks of midlatitude cyclones, which are, in turn, modified by larger-scale features such as the El Niño-Southern Oscillation system. Instrumental and modeling data suggest that extratropical storm tracks may be intensif...

journal_title：Science advances

authors： Wise EK,Dannenberg MP

更新日期：2017-06-07 00:00:00

abstract：:Demyelinating diseases involve loss of myelin sheaths and eventually lead to neurological problems. Unfortunately, the precise mechanisms remain unknown, and there are no effective therapies. To overcome these limitations, a reliable and physiologically relevant in vitro model is required. Here, we present a three-dim...

journal_title：Science advances

authors： Hyung S,Lee SR,Kim J,Kim Y,Kim S,Kim HN,Jeon NL

更新日期：2021-01-29 00:00:00

abstract：:Embodied models suggest that moral judgments are strongly intertwined with first-hand somatic experiences, with some pointing to disgust, and others arguing for a role of pain/harm. Both disgust and pain are unpleasant, arousing experiences, with strong relevance for survival, but with distinctive sensory qualities an...

journal_title：Science advances

authors： Sharvit G,Lin E,Vuilleumier P,Corradi-Dell'Acqua C

更新日期：2020-10-16 00:00:00

abstract：:Dysregulated physical stresses are generated during tumorigenesis that affect the surrounding compliant tissues including adipocytes. However, the effect of physical stressors on the behavior of adipocytes and their cross-talk with tumor cells remain elusive. Here, we demonstrate that compression of cells, resulting f...

journal_title：Science advances

authors： Li Y,Mao AS,Seo BR,Zhao X,Gupta SK,Chen M,Han YL,Shih TY,Mooney DJ,Guo M

更新日期：2020-01-22 00:00:00

abstract：:Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function within multicomponent assemblies remain elusive. By combining thermodynamic and structural data, we have discovered an allostery-based mechanism regulating the so...

journal_title：Science advances

authors： Blus BJ,Koh J,Krolak A,Seo HS,Coutavas E,Blobel G

更新日期：2019-11-27 00:00:00

abstract：:Proinflammatory activation and accumulation of adipose tissue macrophages (ATMs) are associated with increased risk of insulin resistance in obesity. Here, we described the previously unidentified role of selenocysteine insertion sequence-binding protein 2 (SBP2) in maintaining insulin sensitivity in obesity. SBP2 was...

journal_title：Science advances

authors： Wang N,Tan HY,Li S,Wang D,Xu Y,Zhang C,Xia W,Che CM,Feng Y

更新日期：2019-08-14 00:00:00

abstract：:Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all eight major CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors. Streptolysin O, vaginolysin...

journal_title：Science advances

authors： Shewell LK,Day CJ,Jen FE,Haselhorst T,Atack JM,Reijneveld JF,Everest-Dass A,James DBA,Boguslawski KM,Brouwer S,Gillen CM,Luo Z,Kobe B,Nizet V,von Itzstein M,Walker MJ,Paton AW,Paton JC,Torres VJ,Jennings MP

更新日期：2020-05-22 00:00:00

abstract：:The rapid growth of deformable and stretchable electronics calls for a deformable and stretchable power source. We report a scalable approach for energy harvesters and self-powered sensors that can be highly deformable and stretchable. With conductive liquid contained in a polymer cover, a shape-adaptive triboelectric...

journal_title：Science advances

authors： Yi F,Wang X,Niu S,Li S,Yin Y,Dai K,Zhang G,Lin L,Wen Z,Guo H,Wang J,Yeh MH,Zi Y,Liao Q,You Z,Zhang Y,Wang ZL

更新日期：2016-06-17 00:00:00

abstract：:The degradation of cadmium sulfide (CdS)-based oil paints is a phenomenon potentially threatening the iconic painting The Scream (ca. 1910) by Edvard Munch (Munch Museum, Oslo) that is still poorly understood. Here, we provide evidence for the presence of cadmium sulfate and sulfites as alteration products of the orig...

journal_title：Science advances

authors： Monico L,Cartechini L,Rosi F,Chieli A,Grazia C,De Meyer S,Nuyts G,Vanmeert F,Janssens K,Cotte M,De Nolf W,Falkenberg G,Sandu ICA,Tveit ES,Mass J,de Freitas RP,Romani A,Miliani C

更新日期：2020-05-15 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aao6652.]. ...

journal_title：Science advances

authors：

更新日期：2018-07-13 00:00:00

abstract：:Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS-targeting IgG antibody, inRas37, which directly targets the intracellularly activated form of various...

journal_title：Science advances

authors： Shin SM,Kim JS,Park SW,Jun SY,Kweon HJ,Choi DK,Lee D,Cho YB,Kim YS

更新日期：2020-01-15 00:00:00