Abstract:
:We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria, and tumors in the mouse body and brain. We developed machine learning-based software for commercial imaging systems for temporal unmixed OA imaging, enabling its routine use in life sciences.
journal_name
Sci Advjournal_title
Science advancesauthors
Mishra K,Stankevych M,Fuenzalida-Werner JP,Grassmann S,Gujrati V,Huang Y,Klemm U,Buchholz VR,Ntziachristos V,Stiel ACdoi
10.1126/sciadv.aaz6293subject
Has Abstractpub_date
2020-06-12 00:00:00pages
eaaz6293issue
24issn
2375-2548pii
aaz6293journal_volume
6pub_type
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