Persistent collapse of biomass in Amazonian forest edges following deforestation leads to unaccounted carbon losses.

abstract：:G-quadruplex (G4) is one of the most important secondary structures in nucleic acids. Until recently, G4 RNAs have not been reported in any ribovirus, such as the hepatitis C virus. Our bioinformatics analysis reveals highly conserved guanine-rich consensus sequences within the core gene of hepatitis C despite the hig...

journal_title：Science advances

authors： Wang SR,Min YQ,Wang JQ,Liu CX,Fu BS,Wu F,Wu LY,Qiao ZX,Song YY,Xu GH,Wu ZG,Huang G,Peng NF,Huang R,Mao WX,Peng S,Chen YQ,Zhu Y,Tian T,Zhang XL,Zhou X

更新日期：2016-04-01 00:00:00

abstract：:It is fascinating but challenging for nanoscientists to organize nanoparticles (NPs) into ordered architectures just as it is for chemists to manipulate atoms and molecules to form functional molecules and supramolecules. We explore a strategy to assemble anisotropic NPs into open frame-like superstructures via orient...

journal_title：Science advances

authors： Nai J,Guan BY,Yu L,Lou XWD

更新日期：2017-08-23 00:00:00

abstract：:During the Last Glacial Maximum, expansive continental ice sheets lowered globally averaged sea level ~130 m, exposing a land bridge at the Bering Strait. During the subsequent deglaciation, sea level rose rapidly and ultimately flooded the Bering Strait, linking the Arctic and Pacific Oceans. Observational records of...

journal_title：Science advances

authors： Pico T,Mitrovica JX,Mix AC

更新日期：2020-02-26 00:00:00

abstract：:Despite the potential of photodynamic therapy (PDT), its comprehensive use in cancer treatment has not been achieved because of the nondegradable risks of photosensitizing drugs and limits of light penetration and instrumentation. Here, we present bioluminescence (BL)-induced proteinaceous PDT (BLiP-PDT), through the ...

journal_title：Science advances

authors： Kim EH,Park S,Kim YK,Moon M,Park J,Lee KJ,Lee S,Kim YP

更新日期：2020-09-11 00:00:00

abstract：:Nitrogen oxides (NO x ) emitted from human activities are believed to regulate the atmospheric oxidation capacity of the troposphere. However, observational evidence is limited for the low-to-median NO x concentrations prevalen...

journal_title：Science advances

authors： Liu Y,Seco R,Kim S,Guenther AB,Goldstein AH,Keutsch FN,Springston SR,Watson TB,Artaxo P,Souza RAF,McKinney KA,Martin ST

更新日期：2018-04-11 00:00:00

abstract：:The mid-infrared (MIR) spectral range, pertaining to important applications, such as molecular "fingerprint" imaging, remote sensing, free space telecommunication, and optical radar, is of particular scientific interest and technological importance. However, state-of-the-art materials for MIR detection are limited by ...

journal_title：Science advances

authors： Long M,Gao A,Wang P,Xia H,Ott C,Pan C,Fu Y,Liu E,Chen X,Lu W,Nilges T,Xu J,Wang X,Hu W,Miao F

更新日期：2017-06-30 00:00:00

abstract：:Difunctionalization of alkenes is a valuable and versatile chemical transformation that could quickly build complex molecules. Extensive efforts have been made, and great achievement, such as Sharpless aminohydroxylation and dihydroxylation, has been reached. However, in marked contrast to the extensive research of am...

journal_title：Science advances

authors： Yuan Y,Chen Y,Tang S,Huang Z,Lei A

更新日期：2018-08-03 00:00:00

abstract：:Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients with high-grade serous carcinoma (HGSC) to uncover the metabolomes of these distinct TME compart...

journal_title：Science advances

authors： Kilgour MK,MacPherson S,Zacharias LG,Ellis AE,Sheldon RD,Liu EY,Keyes S,Pauly B,Carleton G,Allard B,Smazynski J,Williams KS,Watson PH,Stagg J,Nelson BH,DeBerardinis RJ,Jones RG,Hamilton PT,Lum JJ

更新日期：2021-01-20 00:00:00

abstract：:Biogenesis in prokaryotes and eukaryotes requires the insertion of α-helical proteins into cellular membranes for which they use universally conserved cellular machineries. In bacterial inner membranes, insertion is facilitated by YidC insertase and SecYEG translocon working individually or cooperatively. How insertas...

journal_title：Science advances

authors： Serdiuk T,Steudle A,Mari SA,Manioglu S,Kaback HR,Kuhn A,Müller DJ

更新日期：2019-01-30 00:00:00

abstract：:Since Darwin's conception of sexual selection theory, scientists have struggled to identify the evolutionary forces underlying the pervasive differences between male and female behavior, morphology, and physiology. The Darwin-Bateman paradigm predicts that anisogamy imposes stronger sexual selection on males, which, i...

journal_title：Science advances

authors： Janicke T,Häderer IK,Lajeunesse MJ,Anthes N

更新日期：2016-02-12 00:00:00

abstract：:The formation of the Isthmus of Panama stands as one of the greatest natural events of the Cenozoic, driving profound biotic transformations on land and in the oceans. Some recent studies suggest that the Isthmus formed many millions of years earlier than the widely recognized age of approximately 3 million years ago ...

journal_title：Science advances

authors： O'Dea A,Lessios HA,Coates AG,Eytan RI,Restrepo-Moreno SA,Cione AL,Collins LS,de Queiroz A,Farris DW,Norris RD,Stallard RF,Woodburne MO,Aguilera O,Aubry MP,Berggren WA,Budd AF,Cozzuol MA,Coppard SE,Duque-Caro H,Finne

更新日期：2016-08-17 00:00:00

abstract：:Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard...

journal_title：Science advances

authors： Castle MJ,Cheng Y,Asokan A,Tuszynski MH

更新日期：2018-11-14 00:00:00

abstract：:Intrachain charge transport is unique to conjugated polymers distinct from inorganic and small molecular semiconductors and is key to achieving high-performance organic electronics. Polymer backbone planarity and thin film morphology sensitively modulate intrachain charge transport. However, simple, generic nonsynthet...

journal_title：Science advances

authors： Park KS,Kwok JJ,Dilmurat R,Qu G,Kafle P,Luo X,Jung SH,Olivier Y,Lee JK,Mei J,Beljonne D,Diao Y

更新日期：2019-08-09 00:00:00

abstract：:Materials with a stochastic microstructure, like foams, typically exhibit low mechanical stiffness, whereas lattices with a designed microarchitecture often show notably improved stiffness. These periodic architected materials have previously been designed by rule, using the Maxwell criterion to ensure that their defo...

journal_title：Science advances

authors： Chen W,Watts S,Jackson JA,Smith WL,Tortorelli DA,Spadaccini CM

更新日期：2019-09-27 00:00:00

abstract：:Pressure is a key parameter in the physics and chemistry of planet formation and evolution. Previous studies have erroneously assumed that internal pressures monotonically increase with the mass of a body. Using smoothed particle hydrodynamics and potential field method calculations, we demonstrate that the hot, rapid...

journal_title：Science advances

authors： Lock SJ,Stewart ST

更新日期：2019-09-04 00:00:00

abstract：:Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis coupled with the absence of plasmids makes genetic engineering cumbersome, especially for essen...

journal_title：Science advances

authors： Vyas VK,Barrasa MI,Fink GR

更新日期：2015-01-01 00:00:00

abstract：:The transcription factor p63 is a key mediator of epidermal development. Point mutations in p63 in patients lead to developmental defects, including orofacial clefting. To date, knowledge on how pivotal the role of p63 is in human craniofacial development is limited. Using an inducible transdifferentiation model, comb...

journal_title：Science advances

authors： Lin-Shiao E,Lan Y,Welzenbach J,Alexander KA,Zhang Z,Knapp M,Mangold E,Sammons M,Ludwig KU,Berger SL

更新日期：2019-05-01 00:00:00

abstract：:Successful rehabilitation of oropharyngeal swallowing disorders (i.e., dysphagia) requires frequent performance of head/neck exercises that primarily rely on expensive biofeedback devices, often only available in large medical centers. This directly affects treatment compliance and outcomes, and highlights the need to...

journal_title：Science advances

authors： Kim MK,Kantarcigil C,Kim B,Baruah RK,Maity S,Park Y,Kim K,Lee S,Malandraki JB,Avlani S,Smith A,Sen S,Alam MA,Malandraki G,Lee CH

更新日期：2019-12-13 00:00:00

abstract：:Microbial communities are self-controlled by repertoires of lethal agents, the antibiotics. In their turn, these antibiotics are regulated by bioscavengers that are selected in the course of evolution. Kinase-mediated phosphorylation represents one of the general strategies for the emergence of antibiotic resistance. ...

journal_title：Science advances

authors： Terekhov SS,Mokrushina YA,Nazarov AS,Zlobin A,Zalevsky A,Bourenkov G,Golovin A,Belogurov A Jr,Osterman IA,Kulikova AA,Mitkevich VA,Lou HJ,Turk BE,Wilmanns M,Smirnov IV,Altman S,Gabibov AG

更新日期：2020-06-24 00:00:00

abstract：:[This corrects the article DOI: 10.1126/sciadv.aar3761.]. ...

journal_title：Science advances

authors：

更新日期：2018-07-06 00:00:00

abstract：:Many applications in modern technology, such as self-cleaning surfaces and digital microfluidics, require control over individual fluid droplets on flat surfaces. Existing techniques may suffer from side effects resulting from high electric fields and high temperatures. Here, we introduce a markedly different method, ...

journal_title：Science advances

authors： De Jong E,Wang Y,Den Toonder JMJ,Onck PR

更新日期：2019-06-14 00:00:00

abstract：:Infants' remarkable learning abilities allow them to rapidly acquire many complex skills. It has been suggested that infants achieve this learning by optimally allocating their attention to relevant stimuli in the environment, but the underlying mechanisms remain poorly understood. Here, we modeled infants' looking be...

journal_title：Science advances

authors： Poli F,Serino G,Mars RB,Hunnius S

更新日期：2020-09-23 00:00:00

abstract：:Using theory and experiments, we study the interface between two immiscible domains in a colloidal membrane composed of rigid rods of different lengths. Geometric considerations of rigid rod packing imply that a domain of sufficiently short rods in a background membrane of long rods is more susceptible to twist than t...

journal_title：Science advances

authors： Miller JM,Hall D,Robaszewski J,Sharma P,Hagan MF,Grason GM,Dogic Z

更新日期：2020-07-29 00:00:00

abstract：:Monolithic strong magnetic induction at the mtesla to tesla level provides essential functionalities to physical, chemical, and medical systems. Current design options are constrained by existing capabilities in three-dimensional (3D) structure construction, current handling, and magnetic material integration. We repo...

journal_title：Science advances

authors： Huang W,Yang Z,Kraman MD,Wang Q,Ou Z,Rojo MM,Yalamarthy AS,Chen V,Lian F,Ni JH,Liu S,Yu H,Sang L,Michaels J,Sievers DJ,Eden JG,Braun PV,Chen Q,Gong S,Senesky DG,Pop E,Li X

更新日期：2020-01-17 00:00:00

abstract：:Driven by advances in materials and computer science, researchers are attempting to design systems where the computer and material are one and the same entity. Using theoretical and computational modeling, we design a hybrid material system that can autonomously transduce chemical, mechanical, and electrical energy to...

journal_title：Science advances

authors： Fang Y,Yashin VV,Levitan SP,Balazs AC

更新日期：2016-09-02 00:00:00

abstract：:A rapid, direct, and low-cost method for detecting bacterial toxins associated with common gastrointestinal diseases remains a great challenge despite numerous studies and clinical assays. Motion-based detection through tracking the emerging micro- and nanorobots has shown great potential in chemo- and biosensing due ...

journal_title：Science advances

authors： Zhang Y,Zhang L,Yang L,Vong CI,Chan KF,Wu WKK,Kwong TNY,Lo NWS,Ip M,Wong SH,Sung JJY,Chiu PWY,Zhang L

更新日期：2019-01-11 00:00:00

abstract：:Vertical stacking is widely viewed as a promising approach for designing advanced functionalities using two-dimensional (2D) materials. Combining crystallographically commensurate materials in these 2D stacks has been shown to result in rich new electronic structure, magnetotransport, and optical properties. In this c...

journal_title：Science advances

authors： Vargas A,Liu F,Lane C,Rubin D,Bilgin I,Hennighausen Z,DeCapua M,Bansil A,Kar S

更新日期：2017-07-14 00:00:00

abstract：:Coastal vertical land motion affects projections of sea-level rise, and subsidence exacerbates flooding hazards. Along the ~1350-km California coastline, records of high-resolution vertical land motion rates are scarce due to sparse instrumentation, and hazards to coastal communities are underestimated. Here, we consi...

journal_title：Science advances

authors： Blackwell E,Shirzaei M,Ojha C,Werth S

更新日期：2020-07-31 00:00:00

abstract：:A major challenge in modern physics is to accurately describe strongly interacting quantum many-body systems. One-dimensional systems provide fundamental insights because they are often amenable to exact methods. However, no exact solution is known for the experimentally relevant case of external confinement. We propo...

journal_title：Science advances

authors： Levinsen J,Massignan P,Bruun GM,Parish MM

更新日期：2015-07-24 00:00:00

abstract：:Inputs of nitrogen into terrestrial ecosystems, mainly via the use of ammonium-based fertilizers in agroecosystems, are enormous, but the fate of this nitrogen under elevated atmospheric carbon dioxide (CO2) is not well understood. We have taken advantage of a 15-year free-air CO2 enrichment study to investigate the i...

journal_title：Science advances

authors： Xu C,Zhang K,Zhu W,Xiao J,Zhu C,Zhang N,Yu F,Li S,Zhu C,Tu Q,Chen X,Zhu J,Hu S,Koide RT,Firestone MK,Cheng L

更新日期：2020-10-16 00:00:00