Sequence-encoded colloidal origami and microbot assemblies from patchy magnetic cubes.

abstract：:Stimulation of Escherichia coli by exponential ramps of chemoattractants generates step changes in the concentration of the response regulator, CheY-P. Because flagellar motors are ultrasensitive, this should change the fraction of time that motors spin clockwise, the CWbias. However, early work failed to show changes...

journal_title：Science advances

authors： Lele PP,Shrivastava A,Roland T,Berg HC

更新日期：2015-10-16 00:00:00

abstract：:In mammals, the daily rhythms of physiological functions are timed by the central circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Although the importance of the SCN for the regulation of sleep/wakefulness has been suggested, little is known about the neuronal projections from the SCN,...

journal_title：Science advances

authors： Ono D,Mukai Y,Hung CJ,Chowdhury S,Sugiyama T,Yamanaka A

更新日期：2020-11-06 00:00:00

abstract：:Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. The immunoproteasome is an inducible form of the proteasome that is intimately involved in inflammatory diseases. Here, we found that the expression and activity of immunoproteasome catalytic subunit β5i were significantly u...

journal_title：Science advances

authors： Xie X,Bi HL,Lai S,Zhang YL,Li N,Cao HJ,Han L,Wang HX,Li HH

更新日期：2019-05-08 00:00:00

abstract：:Early identification of pathogens is essential for limiting development of therapy-resistant pathogens and mitigating infectious disease outbreaks. Most bacterial detection schemes use target-specific probes to differentiate pathogen species, creating time and cost inefficiencies in identifying newly discovered organi...

journal_title：Science advances

authors： Aghazadeh A,Lin AY,Sheikh MA,Chen AL,Atkins LM,Johnson CL,Petrosino JF,Drezek RA,Baraniuk RG

更新日期：2016-09-28 00:00:00

abstract：:Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens for mitotherapeutics using neurons have not been reported. We developed a multiplexed and high-content screening assay using primary neurons and identified 67 small-molecule modulators of neuro...

journal_title：Science advances

authors： Varkuti BH,Kepiro M,Liu Z,Vick K,Avchalumov Y,Pacifico R,MacMullen CM,Kamenecka TM,Puthanveettil SV,Davis RL

更新日期：2020-01-08 00:00:00

abstract：:The Rashba physics has been intensively studied in the field of spin orbitronics for the purpose of searching novel physical properties and the ferromagnetic (FM) magnetization switching for technological applications. We report our observation of the inverse Edelstein effect up to room temperature in the Rashba-split...

journal_title：Science advances

authors： Song Q,Zhang H,Su T,Yuan W,Chen Y,Xing W,Shi J,Sun J,Han W

更新日期：2017-03-17 00:00:00

abstract：:Forest loss is one of the most pervasive land surface transformations on Earth, with drastic effects on global climate, ecosystems, and human well-being. As part of biodiversity conservation and climate change mitigation efforts, many countries, including China, have been implementing large-scale policies to conserve ...

journal_title：Science advances

authors： Viña A,McConnell WJ,Yang H,Xu Z,Liu J

更新日期：2016-03-18 00:00:00

abstract：:Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits the development of effective treatments for CNS disorders. We present the facile synthesis of a novel neuroinflammation-targeting polyethylene glycol-based dendrimer (PEGOL-60) using an efficient click chemistry approach. PEGOL-6...

journal_title：Science advances

authors： Sharma A,Sharma R,Zhang Z,Liaw K,Kambhampati SP,Porterfield JE,Lin KC,DeRidder LB,Kannan S,Kannan RM

更新日期：2020-01-22 00:00:00

abstract：:In traditional models of heteroepitaxy, the substrate serves mainly as a crystalline template for the thin-film lattice, dictating the initial roughness of the film and the degree of coherent strain. Here, performing in situ surface x-ray diffraction during the heteroepitaxial growth of LaTiO3 on SrTiO3 (001), we find...

journal_title：Science advances

authors： Cook S,Letchworth-Weaver K,Tung IC,Andersen TK,Hong H,Marks LD,Fong DD

更新日期：2019-04-12 00:00:00

abstract：:Neurochemical dysregulation underlies many pathologies and can be monitored by measuring the composition of brain interstitial fluid (ISF). Existing in vivo tools for sampling ISF do not enable measuring large rare molecules, such as proteins and neuropeptides, and thus cannot generate a complete picture of the neuroc...

journal_title：Science advances

authors： Raman R,Rousseau EB,Wade M,Tong A,Cotler MJ,Kuang J,Lugo AA,Zhang E,Graybiel AM,White FM,Langer R,Cima MJ

更新日期：2020-09-25 00:00:00

abstract：:Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...

journal_title：Science advances

authors： Lee SH,Albright ER,Lee JH,Jacobs D,Kalejta RF

更新日期：2015-11-27 00:00:00

abstract：:Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol ...

journal_title：Science advances

authors： Khom S,Steinkellner T,Hnasko TS,Roberto M

更新日期：2020-03-18 00:00:00

abstract：:The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...

journal_title：Science advances

authors： Pappa AM,Ohayon D,Giovannitti A,Maria IP,Savva A,Uguz I,Rivnay J,McCulloch I,Owens RM,Inal S

更新日期：2018-06-22 00:00:00

abstract：:The ongoing conservation treatment program of the Ghent Altarpiece by Hubert and Jan Van Eyck, one of the iconic paintings of the west, has revealed that the designs of the paintings were changed several times, first by the original artists, and then during later restorations. The central motif, The Lamb of God, repre...

journal_title：Science advances

authors： Van der Snickt G,Dooley KA,Sanyova J,Dubois H,Delaney JK,Gifford EM,Legrand S,Laquiere N,Janssens K

更新日期：2020-07-29 00:00:00

abstract：:Fluctuations in biodiversity, large and small, pervade the fossil record, yet we do not understand the processes generating them. Here, we extend theory from nonequilibrium statistical physics to describe the fat-tailed form of fluctuations in Phanerozoic marine invertebrate richness. Using this theory, known as super...

journal_title：Science advances

authors： Rominger AJ,Fuentes MA,Marquet PA

更新日期：2019-06-26 00:00:00

abstract：:Honeybees use the waggle dance to share information about food-site locations with nestmates. However, the importance of this behavior in colony foraging success remains unclear. We tested whether spatial dance information affects colony foraging success in a human-modified temperate environment by comparing colonies ...

journal_title：Science advances

authors： I'Anson Price R,Dulex N,Vial N,Vincent C,Grüter C

更新日期：2019-02-13 00:00:00

abstract：:Protected areas (PAs) are essential to biodiversity conservation, but their static boundaries may undermine their potential for protecting species under climate change. We assessed how the climatic conditions within global terrestrial PAs may change over time. By 2070, protection is expected to decline in cold and war...

journal_title：Science advances

authors： Elsen PR,Monahan WB,Dougherty ER,Merenlender AM

更新日期：2020-06-17 00:00:00

abstract：:Quantum walks, in virtue of the coherent superposition and quantum interference, have exponential superiority over their classical counterpart in applications of quantum searching and quantum simulation. The quantum-enhanced power is highly related to the state space of quantum walks, which can be expanded by enlargin...

journal_title：Science advances

authors： Tang H,Lin XF,Feng Z,Chen JY,Gao J,Sun K,Wang CY,Lai PC,Xu XY,Wang Y,Qiao LF,Yang AL,Jin XM

更新日期：2018-05-11 00:00:00

abstract：:The catalytic activity of alloy nanoparticles depends on the particle size and composition ratio of different metals. Alloy nanoparticles composed of Pd, Pt, and Au are widely used as catalysts for oxidation reactions. The catalytic activities of Pt and Au nanoparticles in oxidation reactions are known to increase as ...

journal_title：Science advances

authors： Takahashi M,Koizumi H,Chun WJ,Kori M,Imaoka T,Yamamoto K

更新日期：2017-07-26 00:00:00

abstract：:The picture of how a gap closes in a semiconductor has been radically transformed by topological concepts. Instead of the gap closing and immediately reopening, topological arguments predict that, in the absence of inversion symmetry, a metallic phase protected by Weyl nodes persists over a finite interval of the tuni...

journal_title：Science advances

authors： Liang T,Kushwaha S,Kim J,Gibson Q,Lin J,Kioussis N,Cava RJ,Ong NP

更新日期：2017-05-31 00:00:00

abstract：:Homologous recombination is exquisitely activated only during specific cell phases. In the G1 phase, homologous recombination activity is completely suppressed. According to previous reports, the activation of homologous recombination during specific cell phases depends on the kinase activity of cyclin-dependent kinas...

journal_title：Science advances

authors： Lim G,Chang Y,Huh WK

更新日期：2020-02-07 00:00:00

abstract：:Meteorite impact craters are one of the most common geological features in the solar system. An impact event is a near-instantaneous process that releases a huge amount of energy over a very small region on a planetary surface. This results in characteristic changes in the target rocks, from vaporization and melting t...

journal_title：Science advances

authors： Osinski GR,Ferrière L

更新日期：2016-08-05 00:00:00

abstract：:Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we intro...

journal_title：Science advances

authors： Kim Y,Yoo YK,Kim HY,Roh JH,Kim J,Baek S,Lee JC,Kim HJ,Chae MS,Jeong D,Park D,Lee S,Jang H,Kim K,Lee JH,Byun BH,Park SY,Ha JH,Lee KC,Cho WW,Kim JS,Koh JY,Lim SM,Hwang KS

更新日期：2019-04-17 00:00:00

abstract：:Multicellular organisms are composed of tissues that have distinct functions requiring specialized proteomes. To define the proteome of a live animal with tissue and subcellular resolution, we adapted a localized proteomics technology for use in the multicellular model organism Caenorhabditis elegans. This approach co...

journal_title：Science advances

authors： Reinke AW,Mak R,Troemel ER,Bennett EJ

更新日期：2017-05-10 00:00:00

abstract：:Capabilities for assembly of three-dimensional (3D) micro/nanostructures in advanced materials have important implications across a broad range of application areas, reaching nearly every class of microsystem technology. Approaches that rely on the controlled, compressive buckling of 2D precursors are promising becaus...

journal_title：Science advances

authors： Yan Z,Zhang F,Liu F,Han M,Ou D,Liu Y,Lin Q,Guo X,Fu H,Xie Z,Gao M,Huang Y,Kim J,Qiu Y,Nan K,Kim J,Gutruf P,Luo H,Zhao A,Hwang KC,Huang Y,Zhang Y,Rogers JA

更新日期：2016-09-23 00:00:00

abstract：:The tetrapod neuronal protein ARC and its Drosophila melanogaster homolog, dARC1, have important but differing roles in neuronal development. Both are thought to originate through exaptation of ancient Ty3/Gypsy retrotransposon Gag, with their novel function relying on an original capacity for self-assembly and encaps...

journal_title：Science advances

authors： Cottee MA,Letham SC,Young GR,Stoye JP,Taylor IA

更新日期：2020-01-01 00:00:00

abstract：:Neural organoids provide a powerful tool for investigating neural development, modeling neural diseases, screening drugs, and developing cell-based therapies. Somatic cells have previously been reprogrammed by transcription factors (TFs) into sensory ganglion (SG) neurons but not SG organoids. We identify a combinatio...

journal_title：Science advances

authors： Xiao D,Deng Q,Guo Y,Huang X,Zou M,Zhong J,Rao P,Xu Z,Liu Y,Hu Y,Shen Y,Jin K,Xiang M

更新日期：2020-05-29 00:00:00

abstract：:Passive radiative cooling functions by reflecting the solar spectrum and emitting infrared waves in broadband or selectively. However, cooling enclosed spaces that trap heat by greenhouse effect remains a challenge. We present a Janus emitter (JET) consisting of an Ag-polydimethylsiloxane layer on micropatterned quart...

journal_title：Science advances

authors： Heo SY,Lee GJ,Kim DH,Kim YJ,Ishii S,Kim MS,Seok TJ,Lee BJ,Lee H,Song YM

更新日期：2020-09-04 00:00:00

abstract：:Immotile cilia sense extracellular signals such as fluid flow, but whether Ca2+ plays a role in flow sensing has been unclear. Here, we examined the role of ciliary Ca2+ in the flow sensing that initiates the breaking of left-right (L-R) symmetry in the mouse embryo. Intraciliary and cytoplasmic Ca2+ transients were d...

journal_title：Science advances

authors： Mizuno K,Shiozawa K,Katoh TA,Minegishi K,Ide T,Ikawa Y,Nishimura H,Takaoka K,Itabashi T,Iwane AH,Nakai J,Shiratori H,Hamada H

更新日期：2020-07-22 00:00:00

abstract：:The spin Hall effect allows the generation of spin current when charge current is passed along materials with large spin-orbit coupling. It has been recently predicted that heat current in a nonmagnetic metal can be converted into spin current via a process referred to as the spin Nernst effect. We report the observat...

journal_title：Science advances

authors： Sheng P,Sakuraba Y,Lau YC,Takahashi S,Mitani S,Hayashi M

更新日期：2017-11-03 00:00:00