TNFα Augments Cytokine-Induced NK Cell IFNγ Production through TNFR2.

abstract：:Hemolytic uremic syndrome (HUS), a vascular disease characterized by hemolytic anemia, thrombocytopenia, and acute renal failure, is caused by enterohemorrhagic Shiga toxin (Stx)-producing bacteria, which mainly affect children. Besides Stx, the inflammatory response mediated by neutrophils (PMN) is essential to HUS e...

journal_title：Journal of innate immunity

authors： Ramos MV,Mejias MP,Sabbione F,Fernandez-Brando RJ,Santiago AP,Amaral MM,Exeni R,Trevani AS,Palermo MS

更新日期：2016-01-01 00:00:00

abstract：:Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. We were able to show that MGHs also differ...

journal_title：Journal of innate immunity

authors： Cinege G,Lerner Z,Magyar LB,Soós B,Tóth R,Kristó I,Vilmos P,Juhász G,Kovács AL,Hegedűs Z,Sensen CW,Kurucz É,Andó I

更新日期：2020-01-01 00:00:00

abstract：:Different liver cell types are endowed with immunological properties, including cell-intrinsic innate immune functions that are important to initially control pathogen infections. However, a full landscape of expression and functionality of the innate immune signaling pathways in the major human liver cells is still m...

journal_title：Journal of innate immunity

authors： Faure-Dupuy S,Vegna S,Aillot L,Dimier L,Esser K,Broxtermann M,Bonnin M,Bendriss-Vermare N,Rivoire M,Passot G,Lesurtel M,Mabrut JY,Ducerf C,Salvetti A,Protzer U,Zoulim F,Durantel D,Lucifora J

更新日期：2018-01-01 00:00:00

abstract：:In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...

journal_title：Journal of innate immunity

authors： Bobryshev YV,Orekhov AN,Killingsworth MC,Lu J

更新日期：2011-01-01 00:00:00

abstract：:The concept that macrophages play an active role in inflammatory responses began its development in the late 1800s with the now iconic studies by Elie Metchnikoff using starfish larvae and Daphnia [reviewed in Kaufmann SHE: Nat Immunol 2008;9:705-712 and Cavaillon JM: J Leukoc Biol 2011;90:413-424]. Based on his obser...

journal_title：Journal of innate immunity

authors： Dasgupta P,Keegan AD

更新日期：2012-01-01 00:00:00

abstract：:As a key molecule in the antiviral innate immune response, the activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation. Knockdown of PLA1A expression suppressed the innate imm...

journal_title：Journal of innate immunity

authors： Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

更新日期：2018-01-01 00:00:00

abstract：:Urinary tract infection (UTI) is a prominent global health care burden. Although UTI is readily treated with antibiotics in healthy adults, complicated cases in immune-compromised individuals and the emerging antibiotic resistance of several uropathogens have accelerated the need for new treatment strategies. Here, we...

journal_title：Journal of innate immunity

authors： Patras KA,Ha AD,Rooholfada E,Olson J,Ramachandra Rao SP,Lin AE,Nizet V

更新日期：2019-01-01 00:00:00

abstract：:The role of the transcription factor nuclear factor of activated T cells (NFAT) was initially identified in T and B cell gene expression, but its role in regulating gene expression in macrophages during sepsis is not known. Our data show that NFATc3 regulates expression of inducible nitric oxide synthase (iNOS) in mac...

journal_title：Journal of innate immunity

authors： Ranjan R,Deng J,Chung S,Lee YG,Park GY,Xiao L,Joo M,Christman JW,Karpurapu M

更新日期：2014-01-01 00:00:00

abstract：:Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known about where eiger is produced. Here, we show that eiger is made in the fly's fat body during a Salmonel...

journal_title：Journal of innate immunity

authors： Mabery EM,Schneider DS

更新日期：2010-01-01 00:00:00

abstract：:Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapid...

journal_title：Journal of innate immunity

authors： Armitage AE,Lim PJ,Frost JN,Pasricha SR,Soilleux EJ,Evans E,Morovat A,Santos A,Diaz R,Biggs D,Davies B,Gileadi U,Robbins PA,Lakhal-Littleton S,Drakesmith H

更新日期：2016-01-01 00:00:00

abstract：:To protect against viral infection, the immune response is critically dependent on innate sensing mechanisms to provide rapid detection of pathogens and allow for the development of an appropriate adaptive immune response. Mounting evidence suggests that mechanistic differences in the sensing of viruses by the innate ...

journal_title：Journal of innate immunity

authors： Richer MJ,Horwitz MS

更新日期：2009-01-01 00:00:00

abstract：:Human immunodeficiency virus-1 (HIV-1) infection and the acquired immune deficiency syndrome (AIDS) pandemic remain global threats in the absence of a protective or a therapeutic vaccine. HIV-1 replication is reportedly inhibited by some cellular factors, including APOBEC3G (A3G) and APOBEC3F (A3F), which are well kno...

journal_title：Journal of innate immunity

authors： Chang MO,Suzuki T,Yamamoto N,Watanabe M,Takaku H

更新日期：2012-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an im...

journal_title：Journal of innate immunity

authors： Blazusiak E,Florczyk D,Jura J,Potempa J,Koziel J

更新日期：2013-01-01 00:00:00

abstract：:γδ T cells function at the interface between innate and adaptive immunity and have well-demonstrated roles in response to infection, autoimmunity and tumors. A common characteristic of these seemingly disparate conditions may be cellular stress or death. However, the conditions under which ligands for γδ T cells are i...

journal_title：Journal of innate immunity

authors： Collins CC,Bashant K,Erikson C,Thwe PM,Fortner KA,Wang H,Morita CT,Budd RC

更新日期：2016-01-01 00:00:00

abstract：:The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src6...

journal_title：Journal of innate immunity

authors： Williams MJ

更新日期：2009-01-01 00:00:00

abstract：:Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...

journal_title：Journal of innate immunity

authors： García-Laorden MI,Stroo I,Blok DC,Florquin S,Medema JP,de Vos AF,van der Poll T

更新日期：2016-01-01 00:00:00

abstract：:Unwarranted overproduction of cytokines, such as interleukin (IL)-1β, can cause moderate to severe pathological complications, and thus elaborate mechanisms are needed to regulate its onset and termination. One such, well-known, mechanism is endotoxin tolerance, generally described as controlling lipopolysaccharide To...

journal_title：Journal of innate immunity

authors： Nahid MA,Satoh M,Chan EK

更新日期：2015-01-01 00:00:00

abstract：:After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-t...

journal_title：Journal of innate immunity

authors： Koziel J,Chmiest D,Bryzek D,Kmiecik K,Mizgalska D,Maciag-Gudowska A,Shaw LN,Potempa J

更新日期：2015-01-01 00:00:00

abstract：:Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the ...

journal_title：Journal of innate immunity

authors： Espinasse MA,Pépin A,Virault-Rocroy P,Szely N,Chollet-Martin S,Pallardy M,Biola-Vidamment A

更新日期：2016-01-01 00:00:00

abstract：:Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...

journal_title：Journal of innate immunity

authors： Takashima K,Oshiumi H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00

abstract：:Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...

journal_title：Journal of innate immunity

authors： Friesenhagen J,Viemann D,Börgeling Y,Schmolke M,Spiekermann C,Kirschnek S,Ludwig S,Roth J

更新日期：2013-01-01 00:00:00

abstract：:Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug relea...

journal_title：Journal of innate immunity

authors： Moghimi SM,Parhamifar L,Ahmadvand D,Wibroe PP,Andresen TL,Farhangrazi ZS,Hunter AC

更新日期：2012-01-01 00:00:00

abstract：:L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during vi...

journal_title：Journal of innate immunity

authors： Pan Q,Chen H,Wang F,Jeza VT,Hou W,Zhao Y,Xiang T,Zhu Y,Endo Y,Fujita T,Zhang XL

更新日期：2012-01-01 00:00:00

abstract：:There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as ne...

journal_title：Journal of innate immunity

authors： Stockfelt M,Christenson K,Andersson A,Björkman L,Padra M,Brundin B,Ganguly K,Asgeirsdottir H,Lindén S,Qvarfordt I,Bylund J,Lindén A

更新日期：2020-01-01 00:00:00

abstract：:We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...

journal_title：Journal of innate immunity

authors： Kakani P,Kajla M,Choudhury TP,Gupta L,Kumar S

更新日期：2019-01-01 00:00:00

abstract：:Elevated inflammation and altered immune responses are features found in atopic asthmatic airways. Recent studies indicate γ-tocopherol (GT) supplementation can suppress airway inflammation in allergic asthma. We studied the effects of in vitro GT supplementation on receptor-mediated phagocytosis and expression of cel...

journal_title：Journal of innate immunity

authors： Geiser M,Lay JC,Bennett WD,Zhou H,Wang X,Peden DB,Alexis NE

更新日期：2013-01-01 00:00:00

abstract：:Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more c...

journal_title：Journal of innate immunity

authors： Portela J,Duval D,Rognon A,Galinier R,Boissier J,Coustau C,Mitta G,Théron A,Gourbal B

更新日期：2013-01-01 00:00:00

abstract：:Despite the extensive efforts that have been made to combat acquired immune deficiency syndrome (AIDS), the number of people infected each year with human immunodeficiency virus type 1 (HIV-1) is still increasing worldwide, and a safe and effective vaccine to control HIV infection is urgently needed. Recently, the nat...

journal_title：Journal of innate immunity

authors： Chang MO,Suzuki T,Suzuki H,Takaku H

更新日期：2012-01-01 00:00:00

abstract：:Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing and regenerative properties among othe...

journal_title：Journal of innate immunity

authors： Barnum SR

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of "hub genes" and upstream regulators during...

journal_title：Journal of innate immunity

authors： Francis A,Bosio E,Stone SF,Fatovich DM,Arendts G,MacDonald SPJ,Burrows S,Brown SGA

更新日期：2019-01-01 00:00:00