C4a: An Anaphylatoxin in Name Only.

abstract：:To protect against viral infection, the immune response is critically dependent on innate sensing mechanisms to provide rapid detection of pathogens and allow for the development of an appropriate adaptive immune response. Mounting evidence suggests that mechanistic differences in the sensing of viruses by the innate ...

journal_title：Journal of innate immunity

authors： Richer MJ,Horwitz MS

更新日期：2009-01-01 00:00:00

abstract：:The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has been implicated that the translocation of myeloperoxidase (MPO) from neutrophilic granules to the nucleus is crucial to this process. Under di...

journal_title：Journal of innate immunity

authors： Neumann A,Papareddy P,Westman J,Hyldegaard O,Snäll J,Norrby-Teglund A,Herwald H

更新日期：2018-01-01 00:00:00

abstract：:We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...

journal_title：Journal of innate immunity

authors： Kakani P,Kajla M,Choudhury TP,Gupta L,Kumar S

更新日期：2019-01-01 00:00:00

abstract：:Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of T...

journal_title：Journal of innate immunity

authors： Fang LL,Yu HQ,Wu RJ,He C,Li M,Yan H,Li JJ,Wang S,Liu ZG,Liu ZJ,Yang PC

更新日期：2015-01-01 00:00:00

abstract：:There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental d...

journal_title：Journal of innate immunity

authors： Mavroudis PD,Scheff JD,Calvano SE,Androulakis IP

更新日期：2013-01-01 00:00:00

abstract：:L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during vi...

journal_title：Journal of innate immunity

authors： Pan Q,Chen H,Wang F,Jeza VT,Hou W,Zhao Y,Xiang T,Zhu Y,Endo Y,Fujita T,Zhang XL

更新日期：2012-01-01 00:00:00

abstract：:Hemolytic uremic syndrome (HUS), a vascular disease characterized by hemolytic anemia, thrombocytopenia, and acute renal failure, is caused by enterohemorrhagic Shiga toxin (Stx)-producing bacteria, which mainly affect children. Besides Stx, the inflammatory response mediated by neutrophils (PMN) is essential to HUS e...

journal_title：Journal of innate immunity

authors： Ramos MV,Mejias MP,Sabbione F,Fernandez-Brando RJ,Santiago AP,Amaral MM,Exeni R,Trevani AS,Palermo MS

更新日期：2016-01-01 00:00:00

abstract：:There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as ne...

journal_title：Journal of innate immunity

authors： Stockfelt M,Christenson K,Andersson A,Björkman L,Padra M,Brundin B,Ganguly K,Asgeirsdottir H,Lindén S,Qvarfordt I,Bylund J,Lindén A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa (PS) infection results in severe morbidity and mortality, especially in immune-deficient populations. Aerobic exercise (AE) modulates the immune system, but its effects on the outcomes of pulmonary PS infection in elderly mice are unknown. METHODS:BALB/c mice (24 weeks old) were rando...

journal_title：Journal of innate immunity

authors： Stravinskas Durigon T,MacKenzie B,Carneiro Oliveira-Junior M,Santos-Dias A,De Angelis K,Malfitano C,Kelly da Palma R,Moreno Guerra J,Damaceno-Rodrigues NR,Garcia Caldini E,de Almeida FM,Aquino-Santos HC,Rigonato-Oliveira NC,Lea

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of ...

journal_title：Journal of innate immunity

authors： Chowdhury IH,Koo SJ,Gupta S,Liang LY,Bahar B,Silla L,Nuñez-Burgos J,Barrientos N,Zago MP,Garg NJ

更新日期：2017-01-01 00:00:00

abstract：:A family of phosphoinositide-3 kinase (PI3K) isoenzymes catalyzes the production of second messengers that recruit critical regulators of cell growth, survival, proliferation and motility. Conversely, 3'-(phosphatase and tensin homolog) and 5'-inositol polyphosphatases (SH2-containing inositol phosphatases 1/2, SHIP1/...

journal_title：Journal of innate immunity

authors： Kerr WG,Colucci F

更新日期：2011-01-01 00:00:00

abstract：:Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart fro...

journal_title：Journal of innate immunity

authors： Oehmcke S,Mörgelin M,Herwald H

更新日期：2009-01-01 00:00:00

abstract：:Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the...

journal_title：Journal of innate immunity

authors： Batalla EI,Pino Martínez AM,Poncini CV,Duffy T,Schijman AG,González Cappa SM,Alba Soto CD

更新日期：2013-01-01 00:00:00

abstract：:Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...

journal_title：Journal of innate immunity

authors： Hertzén E,Johansson L,Wallin R,Schmidt H,Kroll M,Rehn AP,Kotb M,Mörgelin M,Norrby-Teglund A

更新日期：2010-01-01 00:00:00

abstract：:Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...

journal_title：Journal of innate immunity

authors： García-Laorden MI,Stroo I,Blok DC,Florquin S,Medema JP,de Vos AF,van der Poll T

更新日期：2016-01-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclerosis can perturb normal immune function. Natural killer T (NKT) cells are a spec...

journal_title：Journal of innate immunity

authors： Braun NA,Covarrubias R,Major AS

更新日期：2010-01-01 00:00:00

abstract：:The concept that macrophages play an active role in inflammatory responses began its development in the late 1800s with the now iconic studies by Elie Metchnikoff using starfish larvae and Daphnia [reviewed in Kaufmann SHE: Nat Immunol 2008;9:705-712 and Cavaillon JM: J Leukoc Biol 2011;90:413-424]. Based on his obser...

journal_title：Journal of innate immunity

authors： Dasgupta P,Keegan AD

更新日期：2012-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an im...

journal_title：Journal of innate immunity

authors： Blazusiak E,Florczyk D,Jura J,Potempa J,Koziel J

更新日期：2013-01-01 00:00:00

abstract：:In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...

journal_title：Journal of innate immunity

authors： Bobryshev YV,Orekhov AN,Killingsworth MC,Lu J

更新日期：2011-01-01 00:00:00

abstract：:Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted by goblet cells. In addition, mucosal epithelial cells express cell-bound...

journal_title：Journal of innate immunity

authors： van Putten JPM,Strijbis K

更新日期：2017-01-01 00:00:00

abstract：:Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug relea...

journal_title：Journal of innate immunity

authors： Moghimi SM,Parhamifar L,Ahmadvand D,Wibroe PP,Andresen TL,Farhangrazi ZS,Hunter AC

更新日期：2012-01-01 00:00:00

abstract：:Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 min. This observation sugg...

journal_title：Journal of innate immunity

authors： Carlisle MD,Srikantha RN,Brogden KA

更新日期：2009-01-01 00:00:00

abstract：:Calcium-independent phospholipase A2 (iPLA2) has been suggested to play an important role in the activation of caspase-1 induced by lipopolysaccharides (LPS). Here, we used pharmacological and genetic approaches to study the role of iPLA 2 in the activation of caspase-1. Bromoenol lactone (BEL), an inhibitor that was ...

journal_title：Journal of innate immunity

authors： Franchi L,Chen G,Marina-Garcia N,Abe A,Qu Y,Bao S,Shayman JA,Turk J,Dubyak GR,Núñez G

更新日期：2009-01-01 00:00:00

abstract：:Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...

journal_title：Journal of innate immunity

authors： Friesenhagen J,Viemann D,Börgeling Y,Schmolke M,Spiekermann C,Kirschnek S,Ludwig S,Roth J

更新日期：2013-01-01 00:00:00

abstract：:After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-t...

journal_title：Journal of innate immunity

authors： Koziel J,Chmiest D,Bryzek D,Kmiecik K,Mizgalska D,Maciag-Gudowska A,Shaw LN,Potempa J

更新日期：2015-01-01 00:00:00

abstract：:The phagocyte NADPH oxidase, crucial for innate immunity, is dormant in resting cells, but becomes activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. In activation of the oxidase, the multidomain protein p67(phox)plays a central role: it translocates to the membrane as a ternary...

journal_title：Journal of innate immunity

authors： Yuzawa S,Miyano K,Honbou K,Inagaki F,Sumimoto H

更新日期：2009-01-01 00:00:00

abstract：:Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known ...

journal_title：Journal of innate immunity

authors： Tobin AM,Lynch L,Kirby B,O'Farrelly C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of "hub genes" and upstream regulators during...

journal_title：Journal of innate immunity

authors： Francis A,Bosio E,Stone SF,Fatovich DM,Arendts G,MacDonald SPJ,Burrows S,Brown SGA

更新日期：2019-01-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) recognize class I major histocompatibility complex molecules and participate in the calibration of activation thresholds during human natural killer (NK) cell development. The stochastic expression pattern of the KIR repertoire follows the product rule, meaning that the prob...

journal_title：Journal of innate immunity

authors： Cichocki F,Miller JS,Anderson SK

更新日期：2011-01-01 00:00:00

abstract：:Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...

journal_title：Journal of innate immunity

authors： Takashima K,Oshiumi H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00