Abstract:
:Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface that allows the binding and activation of the contact system. In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs.
journal_name
J Innate Immunjournal_title
Journal of innate immunityauthors
Oehmcke S,Mörgelin M,Herwald Hdoi
10.1159/000203700subject
Has Abstractpub_date
2009-01-01 00:00:00pages
225-30issue
3eissn
1662-811Xissn
1662-8128pii
000203700journal_volume
1pub_type
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journal_title:Journal of innate immunity
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1159/000226247
更新日期:2009-01-01 00:00:00
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abstract::Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of T...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000398799
更新日期:2015-01-01 00:00:00
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doi:10.1159/000443401
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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更新日期:2016-01-01 00:00:00