Abstract:
:Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more complex and specific than previously thought. Mounting evidence has shown that at least some invertebrates (mainly Ecdysozoa) show high levels of specificity in their immune responses to different pathogens, and that subsequent reexposure may result in enhanced protection (recently called 'immune priming'). Here, we investigated immune priming in the Lophotrochozoan snail species Biomphalaria glabrata, following infection by the trematode pathogen Schistosoma mansoni. We confirmed that snails were protected against a secondary homologous infection whatever the host strain. We then investigated how immune priming occurs and the level of specificity of B. glabrata immune priming. In this report we confirmed that immune priming exists and we identified a genotype-dependent immune priming in the fresh-water snail B. glabrata.
journal_name
J Innate Immunjournal_title
Journal of innate immunityauthors
Portela J,Duval D,Rognon A,Galinier R,Boissier J,Coustau C,Mitta G,Théron A,Gourbal Bdoi
10.1159/000345909subject
Has Abstractpub_date
2013-01-01 00:00:00pages
261-76issue
3eissn
1662-811Xissn
1662-8128pii
000345909journal_volume
5pub_type
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