Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).

abstract：:Ficolins are a group of oligomeric lectins with subunits consisting of both collagen-like and fibrinogen-like domains. The majority of ficolins identified in vertebrates and invertebrates to date recognize N-acetylglucosamine (GlcNAc). X-ray crystallographic analysis of human ficolins has shown that the fibrinogen-lik...

journal_title：Journal of innate immunity

authors： Matsushita M

更新日期：2010-01-01 00:00:00

abstract：:The concept that macrophages play an active role in inflammatory responses began its development in the late 1800s with the now iconic studies by Elie Metchnikoff using starfish larvae and Daphnia [reviewed in Kaufmann SHE: Nat Immunol 2008;9:705-712 and Cavaillon JM: J Leukoc Biol 2011;90:413-424]. Based on his obser...

journal_title：Journal of innate immunity

authors： Dasgupta P,Keegan AD

更新日期：2012-01-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclerosis can perturb normal immune function. Natural killer T (NKT) cells are a spec...

journal_title：Journal of innate immunity

authors： Braun NA,Covarrubias R,Major AS

更新日期：2010-01-01 00:00:00

abstract：:The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src6...

journal_title：Journal of innate immunity

authors： Williams MJ

更新日期：2009-01-01 00:00:00

abstract：:A family of phosphoinositide-3 kinase (PI3K) isoenzymes catalyzes the production of second messengers that recruit critical regulators of cell growth, survival, proliferation and motility. Conversely, 3'-(phosphatase and tensin homolog) and 5'-inositol polyphosphatases (SH2-containing inositol phosphatases 1/2, SHIP1/...

journal_title：Journal of innate immunity

authors： Kerr WG,Colucci F

更新日期：2011-01-01 00:00:00

abstract：:To protect against viral infection, the immune response is critically dependent on innate sensing mechanisms to provide rapid detection of pathogens and allow for the development of an appropriate adaptive immune response. Mounting evidence suggests that mechanistic differences in the sensing of viruses by the innate ...

journal_title：Journal of innate immunity

authors： Richer MJ,Horwitz MS

更新日期：2009-01-01 00:00:00

abstract：:Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart fro...

journal_title：Journal of innate immunity

authors： Oehmcke S,Mörgelin M,Herwald H

更新日期：2009-01-01 00:00:00

abstract：:Neutrophil-derived antimicrobial peptides and proteins (AMPs) play an important role in the defense against microbes. Absence of defense is illustrated by neutropenic patients with frequent bacterial and fungal infections. However, the specificity of the antimicrobial effects has not been adequately described. We set ...

journal_title：Journal of innate immunity

authors： Cederlund A,Agerberth B,Bergman P

更新日期：2010-01-01 00:00:00

abstract：:L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during vi...

journal_title：Journal of innate immunity

authors： Pan Q,Chen H,Wang F,Jeza VT,Hou W,Zhao Y,Xiang T,Zhu Y,Endo Y,Fujita T,Zhang XL

更新日期：2012-01-01 00:00:00

abstract：:Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...

journal_title：Journal of innate immunity

authors： Hertzén E,Johansson L,Wallin R,Schmidt H,Kroll M,Rehn AP,Kotb M,Mörgelin M,Norrby-Teglund A

更新日期：2010-01-01 00:00:00

abstract：:Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of T...

journal_title：Journal of innate immunity

authors： Fang LL,Yu HQ,Wu RJ,He C,Li M,Yan H,Li JJ,Wang S,Liu ZG,Liu ZJ,Yang PC

更新日期：2015-01-01 00:00:00

abstract：:As a key molecule in the antiviral innate immune response, the activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation. Knockdown of PLA1A expression suppressed the innate imm...

journal_title：Journal of innate immunity

authors： Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

更新日期：2018-01-01 00:00:00

abstract：:Unwarranted overproduction of cytokines, such as interleukin (IL)-1β, can cause moderate to severe pathological complications, and thus elaborate mechanisms are needed to regulate its onset and termination. One such, well-known, mechanism is endotoxin tolerance, generally described as controlling lipopolysaccharide To...

journal_title：Journal of innate immunity

authors： Nahid MA,Satoh M,Chan EK

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of "hub genes" and upstream regulators during...

journal_title：Journal of innate immunity

authors： Francis A,Bosio E,Stone SF,Fatovich DM,Arendts G,MacDonald SPJ,Burrows S,Brown SGA

更新日期：2019-01-01 00:00:00

abstract：:Different liver cell types are endowed with immunological properties, including cell-intrinsic innate immune functions that are important to initially control pathogen infections. However, a full landscape of expression and functionality of the innate immune signaling pathways in the major human liver cells is still m...

journal_title：Journal of innate immunity

authors： Faure-Dupuy S,Vegna S,Aillot L,Dimier L,Esser K,Broxtermann M,Bonnin M,Bendriss-Vermare N,Rivoire M,Passot G,Lesurtel M,Mabrut JY,Ducerf C,Salvetti A,Protzer U,Zoulim F,Durantel D,Lucifora J

更新日期：2018-01-01 00:00:00

abstract：:Histones are small basic proteins and highly conserved among eukaryotes. Their main function is binding, packaging and organizing of DNA in the nucleus, but extracellular histones are also potent antimicrobial proteins. Here we found that Streptococcus pyogenes - an important human pathogen - protects itself from hist...

journal_title：Journal of innate immunity

authors： Nitzsche R,Köhler J,Kreikemeyer B,Oehmcke-Hecht S

更新日期：2016-01-01 00:00:00

abstract：:Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. We were able to show that MGHs also differ...

journal_title：Journal of innate immunity

authors： Cinege G,Lerner Z,Magyar LB,Soós B,Tóth R,Kristó I,Vilmos P,Juhász G,Kovács AL,Hegedűs Z,Sensen CW,Kurucz É,Andó I

更新日期：2020-01-01 00:00:00

abstract：:The role of the transcription factor nuclear factor of activated T cells (NFAT) was initially identified in T and B cell gene expression, but its role in regulating gene expression in macrophages during sepsis is not known. Our data show that NFATc3 regulates expression of inducible nitric oxide synthase (iNOS) in mac...

journal_title：Journal of innate immunity

authors： Ranjan R,Deng J,Chung S,Lee YG,Park GY,Xiao L,Joo M,Christman JW,Karpurapu M

更新日期：2014-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an im...

journal_title：Journal of innate immunity

authors： Blazusiak E,Florczyk D,Jura J,Potempa J,Koziel J

更新日期：2013-01-01 00:00:00

abstract：:Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known about where eiger is produced. Here, we show that eiger is made in the fly's fat body during a Salmonel...

journal_title：Journal of innate immunity

authors： Mabery EM,Schneider DS

更新日期：2010-01-01 00:00:00

abstract：:There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental d...

journal_title：Journal of innate immunity

authors： Mavroudis PD,Scheff JD,Calvano SE,Androulakis IP

更新日期：2013-01-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL deficiency due to MBL2 polymorphisms, which potentially increases susceptibility t...

journal_title：Journal of innate immunity

authors： Eisen DP

更新日期：2010-01-01 00:00:00

abstract：:Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...

journal_title：Journal of innate immunity

authors： García-Laorden MI,Stroo I,Blok DC,Florquin S,Medema JP,de Vos AF,van der Poll T

更新日期：2016-01-01 00:00:00

abstract：:In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...

journal_title：Journal of innate immunity

authors： Bobryshev YV,Orekhov AN,Killingsworth MC,Lu J

更新日期：2011-01-01 00:00:00

abstract：:Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 min. This observation sugg...

journal_title：Journal of innate immunity

authors： Carlisle MD,Srikantha RN,Brogden KA

更新日期：2009-01-01 00:00:00

abstract：:Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the...

journal_title：Journal of innate immunity

authors： Batalla EI,Pino Martínez AM,Poncini CV,Duffy T,Schijman AG,González Cappa SM,Alba Soto CD

更新日期：2013-01-01 00:00:00

abstract：:Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing and regenerative properties among othe...

journal_title：Journal of innate immunity

authors： Barnum SR

更新日期：2015-01-01 00:00:00

abstract：:NK cells play a central role in innate immunity, acting directly through cell-mediated cytotoxicity and by secreting cytokines. TNFα activation of TNFR2 enhances NK cell cytotoxicity, but its effects on the other essential function of NK cells - cytokine production, for which IFNγ is paramount - are poorly defined. We...

journal_title：Journal of innate immunity

authors： Almishri W,Santodomingo-Garzon T,Le T,Stack D,Mody CH,Swain MG

更新日期：2016-01-01 00:00:00

abstract：:Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more c...

journal_title：Journal of innate immunity

authors： Portela J,Duval D,Rognon A,Galinier R,Boissier J,Coustau C,Mitta G,Théron A,Gourbal B

更新日期：2013-01-01 00:00:00

abstract：:Calcium-independent phospholipase A2 (iPLA2) has been suggested to play an important role in the activation of caspase-1 induced by lipopolysaccharides (LPS). Here, we used pharmacological and genetic approaches to study the role of iPLA 2 in the activation of caspase-1. Bromoenol lactone (BEL), an inhibitor that was ...

journal_title：Journal of innate immunity

authors： Franchi L,Chen G,Marina-Garcia N,Abe A,Qu Y,Bao S,Shayman JA,Turk J,Dubyak GR,Núñez G

更新日期：2009-01-01 00:00:00