当前位置： SCI文献检索 > Journal of Innate Immunity期刊下所有文献 > HIV-1 Gag-virus-like particles induce natural killer cell immune responses via activation and maturation of dendritic cells.

HIV-1 Gag-virus-like particles induce natural killer cell immune responses via activation and maturation of dendritic cells.

Abstract：

:Despite the extensive efforts that have been made to combat acquired immune deficiency syndrome (AIDS), the number of people infected each year with human immunodeficiency virus type 1 (HIV-1) is still increasing worldwide, and a safe and effective vaccine to control HIV infection is urgently needed. Recently, the natural killer (NK) cell-mediated innate immune response, which represents the first line of defense against infections, has attracted attention for its role in combating HIV infection and disease progression. In the present study, we investigated the immunogenic ability of HIV-1 Gag-virus-like particles (Gag-VLPs) to induce NK cell immune responses in vitro and in vivo. Gag-VLPs efficiently activated human monocyte-derived dendritic cells (MDDCs), eliciting MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II, MDDC proliferation and proinflammatory cytokine production. Gag-VLP-treated MDDCs subsequently activated autologous NK cells, leading to their proliferation and production of interferon-γ and to the upregulation of NK cell cytotoxicity against YAC-1 cells and HIV-1-infected CD4(+) T cells. In addition, we introduced a 2-phase immunization strategy in BALB/c mice to assess the role of DCs in the induction of NK cell immune responses by Gag-VLPs in vivo. Our findings reveal that Gag-VLPs efficiently activate DCs, which in turn induce innate and Gag-specific immune responses in NK cells.

journal_name

J Innate Immun

journal_title

Journal of innate immunity

authors

Chang MO,Suzuki T,Suzuki H,Takaku H

doi

10.1159/000329226

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

187-200

issue

2

eissn

1662-811X

issn

1662-8128

pii

000329226

journal_volume

4

pub_type

杂志文章

相关文献

Journal of Innate Immunity文献大全
  • Streptococcus pyogenes Escapes Killing from Extracellular Histones through Plasminogen Binding and Activation by Streptokinase.

    abstract：:Histones are small basic proteins and highly conserved among eukaryotes. Their main function is binding, packaging and organizing of DNA in the nucleus, but extracellular histones are also potent antimicrobial proteins. Here we found that Streptococcus pyogenes - an important human pathogen - protects itself from hist...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000448039

    authors： Nitzsche R,Köhler J,Kreikemeyer B,Oehmcke-Hecht S

    更新日期：2016-01-01 00:00:00

  • The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response.

    abstract：:Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known about where eiger is produced. Here, we show that eiger is made in the fly's fat body during a Salmonel...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000315050

    authors： Mabery EM,Schneider DS

    更新日期：2010-01-01 00:00:00

  • Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease.

    abstract：BACKGROUND:Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of ...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000451055

    authors： Chowdhury IH,Koo SJ,Gupta S,Liang LY,Bahar B,Silla L,Nuñez-Burgos J,Barrientos N,Zago MP,Garg NJ

    更新日期：2017-01-01 00:00:00

  • Thrombospondin 1 Modulates Monocyte Properties to Suppress Intestinal Mucosal Inflammation.

    abstract：:Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of T...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000398799

    authors： Fang LL,Yu HQ,Wu RJ,He C,Li M,Yan H,Li JJ,Wang S,Liu ZG,Liu ZJ,Yang PC

    更新日期：2015-01-01 00:00:00

  • The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections.

    abstract：:Listeria monocytogenes is a facultative intracellular pathogen which can infect Drosophila melanogaster. Upon infection, Drosophila mounts an immune response including antimicrobial peptide production and autophagy activation. A set of previously published results prompted us to study the role of the deubiquitinating ...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000360293

    authors： Taillebourg E,Schneider DS,Fauvarque MO

    更新日期：2014-01-01 00:00:00

  • A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity.

    abstract：BACKGROUND:Alpha-synuclein (αS) is a nerve cell protein associated with Parkinson disease (PD). Accumulation of αS within the enteric nervous system (ENS) and its traffic from the gut to the brain are implicated in the pathogenesis and progression of PD. αS has no known function in humans and the reason for its accumul...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000477990

    authors： Stolzenberg E,Berry D,Yang,Lee EY,Kroemer A,Kaufman S,Wong GCL,Oppenheim JJ,Sen S,Fishbein T,Bax A,Harris B,Barbut D,Zasloff MA

    更新日期：2017-01-01 00:00:00

  • Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study.

    abstract：BACKGROUND:We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of "hub genes" and upstream regulators during...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000492301

    authors： Francis A,Bosio E,Stone SF,Fatovich DM,Arendts G,MacDonald SPJ,Burrows S,Brown SGA

    更新日期：2019-01-01 00:00:00

  • Impairment in natural killer cells editing of immature dendritic cells by infection with a virulent Trypanosoma cruzi population.

    abstract：:Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000350242

    authors： Batalla EI,Pino Martínez AM,Poncini CV,Duffy T,Schijman AG,González Cappa SM,Alba Soto CD

    更新日期：2013-01-01 00:00:00

  • HIV-1 Gag-virus-like particles inhibit HIV-1 replication in dendritic cells and T cells through IFN-α-dependent upregulation of APOBEC3G and 3F.

    abstract：:Human immunodeficiency virus-1 (HIV-1) infection and the acquired immune deficiency syndrome (AIDS) pandemic remain global threats in the absence of a protective or a therapeutic vaccine. HIV-1 replication is reportedly inhibited by some cellular factors, including APOBEC3G (A3G) and APOBEC3F (A3F), which are well kno...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000339402

    authors： Chang MO,Suzuki T,Yamamoto N,Watanabe M,Takaku H

    更新日期：2012-01-01 00:00:00

  • Ficolins: complement-activating lectins involved in innate immunity.

    abstract：:Ficolins are a group of oligomeric lectins with subunits consisting of both collagen-like and fibrinogen-like domains. The majority of ficolins identified in vertebrates and invertebrates to date recognize N-acetylglucosamine (GlcNAc). X-ray crystallographic analysis of human ficolins has shown that the fibrinogen-lik...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章,评审

    doi：10.1159/000228160

    authors： Matsushita M

    更新日期：2010-01-01 00:00:00

  • Anopheles stephensi Dual Oxidase Silencing Activates the Thioester-Containing Protein 1 Pathway to Suppress Plasmodium Development.

    abstract：:We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000497417

    authors： Kakani P,Kajla M,Choudhury TP,Gupta L,Kumar S

    更新日期：2019-01-01 00:00:00

  • PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.

    abstract：:As a key molecule in the antiviral innate immune response, the activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation. Knockdown of PLA1A expression suppressed the innate imm...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000489832

    authors： Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

    更新日期：2018-01-01 00:00:00

  • Glucocorticoid-Induced Leucine Zipper Is Expressed in Human Neutrophils and Promotes Apoptosis through Mcl-1 Down-Regulation.

    abstract：:Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the ...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000439052

    authors： Espinasse MA,Pépin A,Virault-Rocroy P,Szely N,Chollet-Martin S,Pallardy M,Biola-Vidamment A

    更新日期：2016-01-01 00:00:00

  • C4a: An Anaphylatoxin in Name Only.

    abstract：:Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing and regenerative properties among othe...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章,评审

    doi：10.1159/000371423

    authors： Barnum SR

    更新日期：2015-01-01 00:00:00

  • Highly pathogenic influenza viruses inhibit inflammatory response in monocytes via activation of rar-related orphan receptor RORα.

    abstract：:Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000346706

    authors： Friesenhagen J,Viemann D,Börgeling Y,Schmolke M,Spiekermann C,Kirschnek S,Ludwig S,Roth J

    更新日期：2013-01-01 00:00:00

  • Natural killer cells in psoriasis.

    abstract：:Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known ...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章,评审

    doi：10.1159/000328011

    authors： Tobin AM,Lynch L,Kirby B,O'Farrelly C

    更新日期：2011-01-01 00:00:00

  • Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1.

    abstract：:Fibroblasts are known to eliminate intracellular bacteria, but the lethal hit of the bactericidal mechanism has not been defined. We show that primary embryonic and established fibroblasts can be induced by interferons or by intracellular bacterial infection to express a perforin-like mRNA previously described as macr...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000345249

    authors： McCormack R,de Armas LR,Shiratsuchi M,Ramos JE,Podack ER

    更新日期：2013-01-01 00:00:00

  • M1 protein-dependent intracellular trafficking promotes persistence and replication of Streptococcus pyogenes in macrophages.

    abstract：:Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000317635

    authors： Hertzén E,Johansson L,Wallin R,Schmidt H,Kroll M,Rehn AP,Kotb M,Mörgelin M,Norrby-Teglund A

    更新日期：2010-01-01 00:00:00

  • Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus.

    abstract：:Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. We were able to show that MGHs also differ...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000502646

    authors： Cinege G,Lerner Z,Magyar LB,Soós B,Tóth R,Kristó I,Vilmos P,Juhász G,Kovács AL,Hegedűs Z,Sensen CW,Kurucz É,Andó I

    更新日期：2020-01-01 00:00:00

  • Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis.

    abstract：:The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice wit...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000509111

    authors： Issara-Amphorn J,Chancharoenthana W,Visitchanakun P,Leelahavanichkul A

    更新日期：2020-01-01 00:00:00

  • Francisella tularensis alters human neutrophil gene expression: insights into the molecular basis of delayed neutrophil apoptosis.

    abstract：:We demonstrated recently that Francisella tularensis profoundly impairs human neutrophil apoptosis, but how this is achieved is largely unknown. Herein we used human oligonucleotide microarrays to test the hypothesis that changes in neutrophil gene expression contribute to this phenotype, and now demonstrate that F. t...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000342430

    authors： Schwartz JT,Bandyopadhyay S,Kobayashi SD,McCracken J,Whitney AR,Deleo FR,Allen LA

    更新日期：2013-01-01 00:00:00

  • L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo.

    abstract：:L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during vi...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000335670

    authors： Pan Q,Chen H,Wang F,Jeza VT,Hou W,Zhao Y,Xiang T,Zhu Y,Endo Y,Fujita T,Zhang XL

    更新日期：2012-01-01 00:00:00

  • Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease.

    abstract：:Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programmed cell death that prevents the release of neutrophil histotoxic contents, is t...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章,评审

    doi：10.1159/000284367

    authors： Fox S,Leitch AE,Duffin R,Haslett C,Rossi AG

    更新日期：2010-01-01 00:00:00

  • Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis strain 381.

    abstract：:Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 min. This observation sugg...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000181015

    authors： Carlisle MD,Srikantha RN,Brogden KA

    更新日期：2009-01-01 00:00:00

  • Functional Interaction between Apolipophorins and Complement Regulate the Mosquito Immune Response to Systemic Infections.

    abstract：:The complement-like protein thioester-containing protein 1 (TEP1) is the hallmark effector molecule against Plasmodium ookinetes in the malaria vector Anopheles gambiae. We have previously shown that the knockdown of the noncatalytic clip domain serine protease CLIPA2 increased TEP1-mediated killing rendering mosquito...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000443883

    authors： Kamareddine L,Nakhleh J,Osta MA

    更新日期：2016-01-01 00:00:00

  • Activation of the human contact system on neutrophil extracellular traps.

    abstract：:Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart fro...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000203700

    authors： Oehmcke S,Mörgelin M,Herwald H

    更新日期：2009-01-01 00:00:00

  • Systems biology of circadian-immune interactions.

    abstract：:There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental d...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章,评审

    doi：10.1159/000342427

    authors： Mavroudis PD,Scheff JD,Calvano SE,Androulakis IP

    更新日期：2013-01-01 00:00:00

  • The Janus face of α-toxin: a potent mediator of cytoprotection in staphylococci-infected macrophages.

    abstract：:After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-t...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000368048

    authors： Koziel J,Chmiest D,Bryzek D,Kmiecik K,Mizgalska D,Maciag-Gudowska A,Shaw LN,Potempa J

    更新日期：2015-01-01 00:00:00

  • Differential regulation by Toll-like receptor agonists reveals that MCPIP1 is the potent regulator of innate immunity in bacterial and viral infections.

    abstract：:Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an im...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000339826

    authors： Blazusiak E,Florczyk D,Jura J,Potempa J,Koziel J

    更新日期：2013-01-01 00:00:00

  • Induction of Neutrophil Extracellular Traps in Shiga Toxin-Associated Hemolytic Uremic Syndrome.

    abstract：:Hemolytic uremic syndrome (HUS), a vascular disease characterized by hemolytic anemia, thrombocytopenia, and acute renal failure, is caused by enterohemorrhagic Shiga toxin (Stx)-producing bacteria, which mainly affect children. Besides Stx, the inflammatory response mediated by neutrophils (PMN) is essential to HUS e...

    journal_title：Journal of innate immunity

    pub_type： 杂志文章

    doi：10.1159/000445770

    authors： Ramos MV,Mejias MP,Sabbione F,Fernandez-Brando RJ,Santiago AP,Amaral MM,Exeni R,Trevani AS,Palermo MS

    更新日期：2016-01-01 00:00:00