Abstract:
:Histones are small basic proteins and highly conserved among eukaryotes. Their main function is binding, packaging and organizing of DNA in the nucleus, but extracellular histones are also potent antimicrobial proteins. Here we found that Streptococcus pyogenes - an important human pathogen - protects itself from histone-killing by the acquisition of plasminogen. Plasminogen, bound to the streptococcal surface, efficiently prevents histone-mediated killing. Moreover, the streptokinase/plasminogen complex degrades all classes of histones and abrogates their antibacterial and hemolytic effects. This novel streptokinase-mediated virulence mechanism may contribute to the escape of S. pyogenes from the human innate immune system.
journal_name
J Innate Immunjournal_title
Journal of innate immunityauthors
Nitzsche R,Köhler J,Kreikemeyer B,Oehmcke-Hecht Sdoi
10.1159/000448039subject
Has Abstractpub_date
2016-01-01 00:00:00pages
589-600issue
6eissn
1662-811Xissn
1662-8128pii
000448039journal_volume
8pub_type
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