The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections.

abstract：:To protect against viral infection, the immune response is critically dependent on innate sensing mechanisms to provide rapid detection of pathogens and allow for the development of an appropriate adaptive immune response. Mounting evidence suggests that mechanistic differences in the sensing of viruses by the innate ...

journal_title：Journal of innate immunity

authors： Richer MJ,Horwitz MS

更新日期：2009-01-01 00:00:00

abstract：:The phagocyte NADPH oxidase, crucial for innate immunity, is dormant in resting cells, but becomes activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. In activation of the oxidase, the multidomain protein p67(phox)plays a central role: it translocates to the membrane as a ternary...

journal_title：Journal of innate immunity

authors： Yuzawa S,Miyano K,Honbou K,Inagaki F,Sumimoto H

更新日期：2009-01-01 00:00:00

abstract：:There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental d...

journal_title：Journal of innate immunity

authors： Mavroudis PD,Scheff JD,Calvano SE,Androulakis IP

更新日期：2013-01-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclerosis can perturb normal immune function. Natural killer T (NKT) cells are a spec...

journal_title：Journal of innate immunity

authors： Braun NA,Covarrubias R,Major AS

更新日期：2010-01-01 00:00:00

abstract：:NK cells play a central role in innate immunity, acting directly through cell-mediated cytotoxicity and by secreting cytokines. TNFα activation of TNFR2 enhances NK cell cytotoxicity, but its effects on the other essential function of NK cells - cytokine production, for which IFNγ is paramount - are poorly defined. We...

journal_title：Journal of innate immunity

authors： Almishri W,Santodomingo-Garzon T,Le T,Stack D,Mody CH,Swain MG

更新日期：2016-01-01 00:00:00

abstract：:The concept that macrophages play an active role in inflammatory responses began its development in the late 1800s with the now iconic studies by Elie Metchnikoff using starfish larvae and Daphnia [reviewed in Kaufmann SHE: Nat Immunol 2008;9:705-712 and Cavaillon JM: J Leukoc Biol 2011;90:413-424]. Based on his obser...

journal_title：Journal of innate immunity

authors： Dasgupta P,Keegan AD

更新日期：2012-01-01 00:00:00

abstract：:Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted by goblet cells. In addition, mucosal epithelial cells express cell-bound...

journal_title：Journal of innate immunity

authors： van Putten JPM,Strijbis K

更新日期：2017-01-01 00:00:00

abstract：:Urinary tract infection (UTI) is a prominent global health care burden. Although UTI is readily treated with antibiotics in healthy adults, complicated cases in immune-compromised individuals and the emerging antibiotic resistance of several uropathogens have accelerated the need for new treatment strategies. Here, we...

journal_title：Journal of innate immunity

authors： Patras KA,Ha AD,Rooholfada E,Olson J,Ramachandra Rao SP,Lin AE,Nizet V

更新日期：2019-01-01 00:00:00

abstract：:Previously, a novel cell type, the multinucleated giant hemocyte (MGH) was identified in the ananassae subgroup of Drosophilidae. These cells share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. We were able to show that MGHs also differ...

journal_title：Journal of innate immunity

authors： Cinege G,Lerner Z,Magyar LB,Soós B,Tóth R,Kristó I,Vilmos P,Juhász G,Kovács AL,Hegedűs Z,Sensen CW,Kurucz É,Andó I

更新日期：2020-01-01 00:00:00

abstract：:There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as ne...

journal_title：Journal of innate immunity

authors： Stockfelt M,Christenson K,Andersson A,Björkman L,Padra M,Brundin B,Ganguly K,Asgeirsdottir H,Lindén S,Qvarfordt I,Bylund J,Lindén A

更新日期：2020-01-01 00:00:00

abstract：:As a key molecule in the antiviral innate immune response, the activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation. Knockdown of PLA1A expression suppressed the innate imm...

journal_title：Journal of innate immunity

authors： Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

更新日期：2018-01-01 00:00:00

abstract：:We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...

journal_title：Journal of innate immunity

authors： Kakani P,Kajla M,Choudhury TP,Gupta L,Kumar S

更新日期：2019-01-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) recognize class I major histocompatibility complex molecules and participate in the calibration of activation thresholds during human natural killer (NK) cell development. The stochastic expression pattern of the KIR repertoire follows the product rule, meaning that the prob...

journal_title：Journal of innate immunity

authors： Cichocki F,Miller JS,Anderson SK

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. Our study aimed to assess the overall immunological consequences of ex vivo infection of ...

journal_title：Journal of innate immunity

authors： Tomczyk T,Wróbel G,Chaber R,Siemieniec I,Piasecki E,Krzystek-Korpacka M,Orzechowska BU

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Alpha-synuclein (αS) is a nerve cell protein associated with Parkinson disease (PD). Accumulation of αS within the enteric nervous system (ENS) and its traffic from the gut to the brain are implicated in the pathogenesis and progression of PD. αS has no known function in humans and the reason for its accumul...

journal_title：Journal of innate immunity

authors： Stolzenberg E,Berry D,Yang,Lee EY,Kroemer A,Kaufman S,Wong GCL,Oppenheim JJ,Sen S,Fishbein T,Bax A,Harris B,Barbut D,Zasloff MA

更新日期：2017-01-01 00:00:00

abstract：:Calcium-independent phospholipase A2 (iPLA2) has been suggested to play an important role in the activation of caspase-1 induced by lipopolysaccharides (LPS). Here, we used pharmacological and genetic approaches to study the role of iPLA 2 in the activation of caspase-1. Bromoenol lactone (BEL), an inhibitor that was ...

journal_title：Journal of innate immunity

authors： Franchi L,Chen G,Marina-Garcia N,Abe A,Qu Y,Bao S,Shayman JA,Turk J,Dubyak GR,Núñez G

更新日期：2009-01-01 00:00:00

abstract：:The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice wit...

journal_title：Journal of innate immunity

authors： Issara-Amphorn J,Chancharoenthana W,Visitchanakun P,Leelahavanichkul A

更新日期：2020-01-01 00:00:00

abstract：:Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...

journal_title：Journal of innate immunity

authors： Hertzén E,Johansson L,Wallin R,Schmidt H,Kroll M,Rehn AP,Kotb M,Mörgelin M,Norrby-Teglund A

更新日期：2010-01-01 00:00:00

abstract：:Different liver cell types are endowed with immunological properties, including cell-intrinsic innate immune functions that are important to initially control pathogen infections. However, a full landscape of expression and functionality of the innate immune signaling pathways in the major human liver cells is still m...

journal_title：Journal of innate immunity

authors： Faure-Dupuy S,Vegna S,Aillot L,Dimier L,Esser K,Broxtermann M,Bonnin M,Bendriss-Vermare N,Rivoire M,Passot G,Lesurtel M,Mabrut JY,Ducerf C,Salvetti A,Protzer U,Zoulim F,Durantel D,Lucifora J

更新日期：2018-01-01 00:00:00

abstract：:Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...

journal_title：Journal of innate immunity

authors： Takashima K,Oshiumi H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00

abstract：:Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known about where eiger is produced. Here, we show that eiger is made in the fly's fat body during a Salmonel...

journal_title：Journal of innate immunity

authors： Mabery EM,Schneider DS

更新日期：2010-01-01 00:00:00

abstract：:Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...

journal_title：Journal of innate immunity

authors： García-Laorden MI,Stroo I,Blok DC,Florquin S,Medema JP,de Vos AF,van der Poll T

更新日期：2016-01-01 00:00:00

abstract：:Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the ...

journal_title：Journal of innate immunity

authors： Espinasse MA,Pépin A,Virault-Rocroy P,Szely N,Chollet-Martin S,Pallardy M,Biola-Vidamment A

更新日期：2016-01-01 00:00:00

abstract：:Human immunodeficiency virus-1 (HIV-1) infection and the acquired immune deficiency syndrome (AIDS) pandemic remain global threats in the absence of a protective or a therapeutic vaccine. HIV-1 replication is reportedly inhibited by some cellular factors, including APOBEC3G (A3G) and APOBEC3F (A3F), which are well kno...

journal_title：Journal of innate immunity

authors： Chang MO,Suzuki T,Yamamoto N,Watanabe M,Takaku H

更新日期：2012-01-01 00:00:00

abstract：:γδ T cells function at the interface between innate and adaptive immunity and have well-demonstrated roles in response to infection, autoimmunity and tumors. A common characteristic of these seemingly disparate conditions may be cellular stress or death. However, the conditions under which ligands for γδ T cells are i...

journal_title：Journal of innate immunity

authors： Collins CC,Bashant K,Erikson C,Thwe PM,Fortner KA,Wang H,Morita CT,Budd RC

更新日期：2016-01-01 00:00:00

abstract：:Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...

journal_title：Journal of innate immunity

authors： Friesenhagen J,Viemann D,Börgeling Y,Schmolke M,Spiekermann C,Kirschnek S,Ludwig S,Roth J

更新日期：2013-01-01 00:00:00

abstract：:L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during vi...

journal_title：Journal of innate immunity

authors： Pan Q,Chen H,Wang F,Jeza VT,Hou W,Zhao Y,Xiang T,Zhu Y,Endo Y,Fujita T,Zhang XL

更新日期：2012-01-01 00:00:00

abstract：:Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapid...

journal_title：Journal of innate immunity

authors： Armitage AE,Lim PJ,Frost JN,Pasricha SR,Soilleux EJ,Evans E,Morovat A,Santos A,Diaz R,Biggs D,Davies B,Gileadi U,Robbins PA,Lakhal-Littleton S,Drakesmith H

更新日期：2016-01-01 00:00:00

abstract：:The host innate immune response, including the production of type-I IFN, represents the primary line of defense against invading viral pathogens. Of the hundreds of IFN-stimulated genes (ISGs) discovered to date, ISG15 was one of the first identified and shown to encode a ubiquitin-like protein that functions, in part...

journal_title：Journal of innate immunity

authors： Harty RN,Pitha PM,Okumura A

更新日期：2009-01-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL deficiency due to MBL2 polymorphisms, which potentially increases susceptibility t...

journal_title：Journal of innate immunity

authors： Eisen DP

更新日期：2010-01-01 00:00:00