Abstract:
:Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an important immune regulator involved in macrophage activation, modulation of its expression by all known TLR agonists has never been documented. In this study, we present for the first time that in human monocyte-derived macrophages all TLR agonists, except CpG, markedly induced the expression of MCPIP1. The level of the induced transcript, as well as the protein and time of their appearance varied depending on the agonist. Furthermore, we confirmed the strong and differential upregulation of MCPIP1 during bacteria, virus and fungus infection. MCPIP1 belongs to a group of early-response genes; however, in the present study, we show for the first time the sustained high level of MCPIP1 expression during long-term Staphylococcus aureus infection. Taken together, our results implicate MCPIP1 as a potent regulator of innate immunity, which can be strongly engaged in the pathogenesis of acute and chronic infective diseases.
journal_name
J Innate Immunjournal_title
Journal of innate immunityauthors
Blazusiak E,Florczyk D,Jura J,Potempa J,Koziel Jdoi
10.1159/000339826subject
Has Abstractpub_date
2013-01-01 00:00:00pages
15-23issue
1eissn
1662-811Xissn
1662-8128pii
000339826journal_volume
5pub_type
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000439052
更新日期:2016-01-01 00:00:00
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000489832
更新日期:2018-01-01 00:00:00
abstract::Withdrawal of iron from serum (hypoferraemia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapid...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000447713
更新日期:2016-01-01 00:00:00
abstract::The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has been implicated that the translocation of myeloperoxidase (MPO) from neutrophilic granules to the nucleus is crucial to this process. Under di...
journal_title:Journal of innate immunity
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doi:10.1159/000480386
更新日期:2018-01-01 00:00:00
abstract::Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing and regenerative properties among othe...
journal_title:Journal of innate immunity
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000350234
更新日期:2013-01-01 00:00:00
abstract::In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000327522
更新日期:2011-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000477990
更新日期:2017-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000509715
更新日期:2020-01-01 00:00:00
abstract::Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known ...
journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000328011
更新日期:2011-01-01 00:00:00
abstract::Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000480740
更新日期:2018-01-01 00:00:00
abstract::Listeria monocytogenes is a facultative intracellular pathogen which can infect Drosophila melanogaster. Upon infection, Drosophila mounts an immune response including antimicrobial peptide production and autophagy activation. A set of previously published results prompted us to study the role of the deubiquitinating ...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000360293
更新日期:2014-01-01 00:00:00
abstract::Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000317635
更新日期:2010-01-01 00:00:00
abstract::Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more c...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000345909
更新日期:2013-01-01 00:00:00
abstract::The complement-like protein thioester-containing protein 1 (TEP1) is the hallmark effector molecule against Plasmodium ookinetes in the malaria vector Anopheles gambiae. We have previously shown that the knockdown of the noncatalytic clip domain serine protease CLIPA2 increased TEP1-mediated killing rendering mosquito...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000443883
更新日期:2016-01-01 00:00:00
abstract::Hemolytic uremic syndrome (HUS), a vascular disease characterized by hemolytic anemia, thrombocytopenia, and acute renal failure, is caused by enterohemorrhagic Shiga toxin (Stx)-producing bacteria, which mainly affect children. Besides Stx, the inflammatory response mediated by neutrophils (PMN) is essential to HUS e...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000445770
更新日期:2016-01-01 00:00:00
abstract::Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000346706
更新日期:2013-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000499342
更新日期:2019-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000398799
更新日期:2015-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000446498
更新日期:2016-01-01 00:00:00
abstract::L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during vi...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000335670
更新日期:2012-01-01 00:00:00
abstract::Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known about where eiger is produced. Here, we show that eiger is made in the fly's fat body during a Salmonel...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000315050
更新日期:2010-01-01 00:00:00
abstract::Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis throughout the world. A majority (approx. 60%) of patients with IgAN experience disease exacerbations associated with an acute respiratory or gastrointestinal illness that appears to represent a viral infection. However, the exact mechan...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000345255
更新日期:2013-01-01 00:00:00
abstract::The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice wit...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000509111
更新日期:2020-01-01 00:00:00
abstract::Despite the extensive efforts that have been made to combat acquired immune deficiency syndrome (AIDS), the number of people infected each year with human immunodeficiency virus type 1 (HIV-1) is still increasing worldwide, and a safe and effective vaccine to control HIV infection is urgently needed. Recently, the nat...
journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000329226
更新日期:2012-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000488953
更新日期:2018-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000443401
更新日期:2016-01-01 00:00:00