Systems biology of circadian-immune interactions.

Abstract:

:There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental data indicate that circadian information reaches immune tissues mainly through diurnal patterns of autonomic and endocrine rhythms. In addition, immune factors such as cytokines can also influence the phase of the circadian clock, providing bidirectional flow of circadian information between the neuroendocrine and immune systems. This network of neuroendocrine-immune interactions consists of complexly integrated molecular feedback and feedforward loops that function in synchrony in order to optimize immune response. Chronic stress can disrupt this intrinsic orchestration, as several endocrine signals of chronically stressed patients present blunted rhythmic characteristics. Reprogramming of biological rhythms has recently gained much attention as a potent method to leverage homeostatic circadian controls to ultimately improve clinical outcomes. Elucidation of the intrinsic properties of such complex systems and optimization of intervention strategies require not only an accurate identification of the signaling pathways that mediate host responses, but also a system-level description and evaluation.

journal_name

J Innate Immun

authors

Mavroudis PD,Scheff JD,Calvano SE,Androulakis IP

doi

10.1159/000342427

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

153-62

issue

2

eissn

1662-811X

issn

1662-8128

pii

000342427

journal_volume

5

pub_type

杂志文章,评审
  • Effects of ex vivo γ-tocopherol on airway macrophage function in healthy and mild allergic asthmatics.

    abstract::Elevated inflammation and altered immune responses are features found in atopic asthmatic airways. Recent studies indicate γ-tocopherol (GT) supplementation can suppress airway inflammation in allergic asthma. We studied the effects of in vitro GT supplementation on receptor-mediated phagocytosis and expression of cel...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000350234

    authors: Geiser M,Lay JC,Bennett WD,Zhou H,Wang X,Peden DB,Alexis NE

    更新日期:2013-01-01 00:00:00

  • PLA1A Participates in the Antiviral Innate Immune Response by Facilitating the Recruitment of TANK-Binding Kinase 1 to Mitochondria.

    abstract::As a key molecule in the antiviral innate immune response, the activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation. Knockdown of PLA1A expression suppressed the innate imm...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000489832

    authors: Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

    更新日期:2018-01-01 00:00:00

  • Streptococcus pyogenes Escapes Killing from Extracellular Histones through Plasminogen Binding and Activation by Streptokinase.

    abstract::Histones are small basic proteins and highly conserved among eukaryotes. Their main function is binding, packaging and organizing of DNA in the nucleus, but extracellular histones are also potent antimicrobial proteins. Here we found that Streptococcus pyogenes - an important human pathogen - protects itself from hist...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000448039

    authors: Nitzsche R,Köhler J,Kreikemeyer B,Oehmcke-Hecht S

    更新日期:2016-01-01 00:00:00

  • Decreased expression of liver X receptor-α in macrophages infected with Chlamydia pneumoniae in human atherosclerotic arteries in situ.

    abstract::In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000327522

    authors: Bobryshev YV,Orekhov AN,Killingsworth MC,Lu J

    更新日期:2011-01-01 00:00:00

  • HIV-1 Gag-virus-like particles induce natural killer cell immune responses via activation and maturation of dendritic cells.

    abstract::Despite the extensive efforts that have been made to combat acquired immune deficiency syndrome (AIDS), the number of people infected each year with human immunodeficiency virus type 1 (HIV-1) is still increasing worldwide, and a safe and effective vaccine to control HIV infection is urgently needed. Recently, the nat...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000329226

    authors: Chang MO,Suzuki T,Suzuki H,Takaku H

    更新日期:2012-01-01 00:00:00

  • The c-src homologue Src64B is sufficient to activate the Drosophila cellular immune response.

    abstract::The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src6...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000191216

    authors: Williams MJ

    更新日期:2009-01-01 00:00:00

  • Natural killer cells in psoriasis.

    abstract::Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章,评审

    doi:10.1159/000328011

    authors: Tobin AM,Lynch L,Kirby B,O'Farrelly C

    更新日期:2011-01-01 00:00:00

  • Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines.

    abstract::Different liver cell types are endowed with immunological properties, including cell-intrinsic innate immune functions that are important to initially control pathogen infections. However, a full landscape of expression and functionality of the innate immune signaling pathways in the major human liver cells is still m...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000489966

    authors: Faure-Dupuy S,Vegna S,Aillot L,Dimier L,Esser K,Broxtermann M,Bonnin M,Bendriss-Vermare N,Rivoire M,Passot G,Lesurtel M,Mabrut JY,Ducerf C,Salvetti A,Protzer U,Zoulim F,Durantel D,Lucifora J

    更新日期:2018-01-01 00:00:00

  • Particulate systems for targeting of macrophages: basic and therapeutic concepts.

    abstract::Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug relea...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章,评审

    doi:10.1159/000339153

    authors: Moghimi SM,Parhamifar L,Ahmadvand D,Wibroe PP,Andresen TL,Farhangrazi ZS,Hunter AC

    更新日期:2012-01-01 00:00:00

  • L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo.

    abstract::L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during vi...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000335670

    authors: Pan Q,Chen H,Wang F,Jeza VT,Hou W,Zhao Y,Xiang T,Zhu Y,Endo Y,Fujita T,Zhang XL

    更新日期:2012-01-01 00:00:00

  • Thrombospondin 1 Modulates Monocyte Properties to Suppress Intestinal Mucosal Inflammation.

    abstract::Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of T...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000398799

    authors: Fang LL,Yu HQ,Wu RJ,He C,Li M,Yan H,Li JJ,Wang S,Liu ZG,Liu ZJ,Yang PC

    更新日期:2015-01-01 00:00:00

  • Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease.

    abstract:BACKGROUND:Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000451055

    authors: Chowdhury IH,Koo SJ,Gupta S,Liang LY,Bahar B,Silla L,Nuñez-Burgos J,Barrientos N,Zago MP,Garg NJ

    更新日期:2017-01-01 00:00:00

  • Activation of the human contact system on neutrophil extracellular traps.

    abstract::Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart fro...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000203700

    authors: Oehmcke S,Mörgelin M,Herwald H

    更新日期:2009-01-01 00:00:00

  • Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.

    abstract::Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000443401

    authors: García-Laorden MI,Stroo I,Blok DC,Florquin S,Medema JP,de Vos AF,van der Poll T

    更新日期:2016-01-01 00:00:00

  • The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response.

    abstract::Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known about where eiger is produced. Here, we show that eiger is made in the fly's fat body during a Salmonel...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000315050

    authors: Mabery EM,Schneider DS

    更新日期:2010-01-01 00:00:00

  • M1 protein-dependent intracellular trafficking promotes persistence and replication of Streptococcus pyogenes in macrophages.

    abstract::Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000317635

    authors: Hertzén E,Johansson L,Wallin R,Schmidt H,Kroll M,Rehn AP,Kotb M,Mörgelin M,Norrby-Teglund A

    更新日期:2010-01-01 00:00:00

  • Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease.

    abstract::Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programmed cell death that prevents the release of neutrophil histotoxic contents, is t...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章,评审

    doi:10.1159/000284367

    authors: Fox S,Leitch AE,Duffin R,Haslett C,Rossi AG

    更新日期:2010-01-01 00:00:00

  • The TLR2 Antagonist Staphylococcal Superantigen-Like Protein 3 Acts as a Virulence Factor to Promote Bacterial Pathogenicity in vivo.

    abstract::Toll-like receptor (TLR) signaling is important in the initiation of immune responses and subsequent instigation of adaptive immunity. TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus. Many studies have dem...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000479100

    authors: Koymans KJ,Goldmann O,Karlsson CAQ,Sital W,Thänert R,Bisschop A,Vrieling M,Malmström J,van Kessel KPM,de Haas CJC,van Strijp JAG,Medina E

    更新日期:2017-01-01 00:00:00

  • Highly pathogenic influenza viruses inhibit inflammatory response in monocytes via activation of rar-related orphan receptor RORα.

    abstract::Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000346706

    authors: Friesenhagen J,Viemann D,Börgeling Y,Schmolke M,Spiekermann C,Kirschnek S,Ludwig S,Roth J

    更新日期:2013-01-01 00:00:00

  • Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells.

    abstract::γδ T cells function at the interface between innate and adaptive immunity and have well-demonstrated roles in response to infection, autoimmunity and tumors. A common characteristic of these seemingly disparate conditions may be cellular stress or death. However, the conditions under which ligands for γδ T cells are i...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000446498

    authors: Collins CC,Bashant K,Erikson C,Thwe PM,Fortner KA,Wang H,Morita CT,Budd RC

    更新日期:2016-01-01 00:00:00

  • Inositol phospholipid signaling and the biology of natural killer cells.

    abstract::A family of phosphoinositide-3 kinase (PI3K) isoenzymes catalyzes the production of second messengers that recruit critical regulators of cell growth, survival, proliferation and motility. Conversely, 3'-(phosphatase and tensin homolog) and 5'-inositol polyphosphatases (SH2-containing inositol phosphatases 1/2, SHIP1/...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章,评审

    doi:10.1159/000323920

    authors: Kerr WG,Colucci F

    更新日期:2011-01-01 00:00:00

  • The Janus face of α-toxin: a potent mediator of cytoprotection in staphylococci-infected macrophages.

    abstract::After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-t...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000368048

    authors: Koziel J,Chmiest D,Bryzek D,Kmiecik K,Mizgalska D,Maciag-Gudowska A,Shaw LN,Potempa J

    更新日期:2015-01-01 00:00:00

  • The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes.

    abstract::The phagocyte NADPH oxidase, crucial for innate immunity, is dormant in resting cells, but becomes activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. In activation of the oxidase, the multidomain protein p67(phox)plays a central role: it translocates to the membrane as a ternary...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000235656

    authors: Yuzawa S,Miyano K,Honbou K,Inagaki F,Sumimoto H

    更新日期:2009-01-01 00:00:00

  • Mannose-binding lectin deficiency and respiratory tract infection.

    abstract::Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL deficiency due to MBL2 polymorphisms, which potentially increases susceptibility t...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章,评审

    doi:10.1159/000228159

    authors: Eisen DP

    更新日期:2010-01-01 00:00:00

  • Anopheles stephensi Dual Oxidase Silencing Activates the Thioester-Containing Protein 1 Pathway to Suppress Plasmodium Development.

    abstract::We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000497417

    authors: Kakani P,Kajla M,Choudhury TP,Gupta L,Kumar S

    更新日期:2019-01-01 00:00:00

  • Glucocorticoid-Induced Leucine Zipper Is Expressed in Human Neutrophils and Promotes Apoptosis through Mcl-1 Down-Regulation.

    abstract::Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein, the expression of which is mainly induced by glucocorticoids (GCs) in haematopoietic cells. GILZ regulates signal transduction pathways of inflammation and plays a role in cell survival. The objective of this study was to evaluate the ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000439052

    authors: Espinasse MA,Pépin A,Virault-Rocroy P,Szely N,Chollet-Martin S,Pallardy M,Biola-Vidamment A

    更新日期:2016-01-01 00:00:00

  • Immune Consequences of in vitro Infection of Human Peripheral Blood Leukocytes with Vesicular Stomatitis Virus.

    abstract:BACKGROUND:Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. Our study aimed to assess the overall immunological consequences of ex vivo infection of ...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000485143

    authors: Tomczyk T,Wróbel G,Chaber R,Siemieniec I,Piasecki E,Krzystek-Korpacka M,Orzechowska BU

    更新日期:2018-01-01 00:00:00

  • Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice.

    abstract:BACKGROUND:Pseudomonas aeruginosa (PS) infection results in severe morbidity and mortality, especially in immune-deficient populations. Aerobic exercise (AE) modulates the immune system, but its effects on the outcomes of pulmonary PS infection in elderly mice are unknown. METHODS:BALB/c mice (24 weeks old) were rando...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000488953

    authors: Stravinskas Durigon T,MacKenzie B,Carneiro Oliveira-Junior M,Santos-Dias A,De Angelis K,Malfitano C,Kelly da Palma R,Moreno Guerra J,Damaceno-Rodrigues NR,Garcia Caldini E,de Almeida FM,Aquino-Santos HC,Rigonato-Oliveira NC,Lea

    更新日期:2018-01-01 00:00:00

  • Induction of Neutrophil Extracellular Traps in Shiga Toxin-Associated Hemolytic Uremic Syndrome.

    abstract::Hemolytic uremic syndrome (HUS), a vascular disease characterized by hemolytic anemia, thrombocytopenia, and acute renal failure, is caused by enterohemorrhagic Shiga toxin (Stx)-producing bacteria, which mainly affect children. Besides Stx, the inflammatory response mediated by neutrophils (PMN) is essential to HUS e...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000445770

    authors: Ramos MV,Mejias MP,Sabbione F,Fernandez-Brando RJ,Santiago AP,Amaral MM,Exeni R,Trevani AS,Palermo MS

    更新日期:2016-01-01 00:00:00

  • Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study.

    abstract:BACKGROUND:We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of "hub genes" and upstream regulators during...

    journal_title:Journal of innate immunity

    pub_type: 杂志文章

    doi:10.1159/000492301

    authors: Francis A,Bosio E,Stone SF,Fatovich DM,Arendts G,MacDonald SPJ,Burrows S,Brown SGA

    更新日期:2019-01-01 00:00:00