Abstract:
:Elevated inflammation and altered immune responses are features found in atopic asthmatic airways. Recent studies indicate γ-tocopherol (GT) supplementation can suppress airway inflammation in allergic asthma. We studied the effects of in vitro GT supplementation on receptor-mediated phagocytosis and expression of cell surface molecules associated with innate and adaptive immunity on sputum-derived macrophages. Cells from nonsmoking healthy (n = 6) and mild house dust mite-sensitive allergic asthmatics (n = 6) were treated ex vivo with GT (300 µM) or saline (control). Phagocytosis of opsonized zymosan A bioparticles (Saccharomyces cerevisiae) and expression of surface molecules associated with innate and adaptive immunity were assessed using flow cytometry. GT caused significantly decreased (p < 0.05) internalization of attached zymosan bioparticles and decreased (p < 0.05) macrophage expression of CD206, CD36 and CD86 in allergic asthmatics but not in controls. Overall, GT caused downregulation of both innate and adaptive immune response elements, and atopic status appears to be an important factor.
journal_name
J Innate Immunjournal_title
Journal of innate immunityauthors
Geiser M,Lay JC,Bennett WD,Zhou H,Wang X,Peden DB,Alexis NEdoi
10.1159/000350234subject
Has Abstractpub_date
2013-01-01 00:00:00pages
613-24issue
6eissn
1662-811Xissn
1662-8128pii
000350234journal_volume
5pub_type
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000203700
更新日期:2009-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000451055
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000346706
更新日期:2013-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000350242
更新日期:2013-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000329226
更新日期:2012-01-01 00:00:00
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journal_title:Journal of innate immunity
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doi:10.1159/000345255
更新日期:2013-01-01 00:00:00
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journal_title:Journal of innate immunity
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doi:10.1159/000439052
更新日期:2016-01-01 00:00:00
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
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journal_title:Journal of innate immunity
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of innate immunity
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更新日期:2012-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000345909
更新日期:2013-01-01 00:00:00
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journal_title:Journal of innate immunity
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
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