Immune Consequences of in vitro Infection of Human Peripheral Blood Leukocytes with Vesicular Stomatitis Virus.

abstract：BACKGROUND:Pseudomonas aeruginosa (PS) infection results in severe morbidity and mortality, especially in immune-deficient populations. Aerobic exercise (AE) modulates the immune system, but its effects on the outcomes of pulmonary PS infection in elderly mice are unknown. METHODS:BALB/c mice (24 weeks old) were rando...

journal_title：Journal of innate immunity

authors： Stravinskas Durigon T,MacKenzie B,Carneiro Oliveira-Junior M,Santos-Dias A,De Angelis K,Malfitano C,Kelly da Palma R,Moreno Guerra J,Damaceno-Rodrigues NR,Garcia Caldini E,de Almeida FM,Aquino-Santos HC,Rigonato-Oliveira NC,Lea

更新日期：2018-01-01 00:00:00

abstract：:Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted by goblet cells. In addition, mucosal epithelial cells express cell-bound...

journal_title：Journal of innate immunity

authors： van Putten JPM,Strijbis K

更新日期：2017-01-01 00:00:00

abstract：:Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug relea...

journal_title：Journal of innate immunity

authors： Moghimi SM,Parhamifar L,Ahmadvand D,Wibroe PP,Andresen TL,Farhangrazi ZS,Hunter AC

更新日期：2012-01-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL deficiency due to MBL2 polymorphisms, which potentially increases susceptibility t...

journal_title：Journal of innate immunity

authors： Eisen DP

更新日期：2010-01-01 00:00:00

abstract：:There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as ne...

journal_title：Journal of innate immunity

authors： Stockfelt M,Christenson K,Andersson A,Björkman L,Padra M,Brundin B,Ganguly K,Asgeirsdottir H,Lindén S,Qvarfordt I,Bylund J,Lindén A

更新日期：2020-01-01 00:00:00

abstract：:We demonstrated recently that Francisella tularensis profoundly impairs human neutrophil apoptosis, but how this is achieved is largely unknown. Herein we used human oligonucleotide microarrays to test the hypothesis that changes in neutrophil gene expression contribute to this phenotype, and now demonstrate that F. t...

journal_title：Journal of innate immunity

authors： Schwartz JT,Bandyopadhyay S,Kobayashi SD,McCracken J,Whitney AR,Deleo FR,Allen LA

更新日期：2013-01-01 00:00:00

abstract：:Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programmed cell death that prevents the release of neutrophil histotoxic contents, is t...

journal_title：Journal of innate immunity

authors： Fox S,Leitch AE,Duffin R,Haslett C,Rossi AG

更新日期：2010-01-01 00:00:00

abstract：:Human immunodeficiency virus-1 (HIV-1) infection and the acquired immune deficiency syndrome (AIDS) pandemic remain global threats in the absence of a protective or a therapeutic vaccine. HIV-1 replication is reportedly inhibited by some cellular factors, including APOBEC3G (A3G) and APOBEC3F (A3F), which are well kno...

journal_title：Journal of innate immunity

authors： Chang MO,Suzuki T,Yamamoto N,Watanabe M,Takaku H

更新日期：2012-01-01 00:00:00

abstract：:Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more c...

journal_title：Journal of innate immunity

authors： Portela J,Duval D,Rognon A,Galinier R,Boissier J,Coustau C,Mitta G,Théron A,Gourbal B

更新日期：2013-01-01 00:00:00

abstract：:A family of phosphoinositide-3 kinase (PI3K) isoenzymes catalyzes the production of second messengers that recruit critical regulators of cell growth, survival, proliferation and motility. Conversely, 3'-(phosphatase and tensin homolog) and 5'-inositol polyphosphatases (SH2-containing inositol phosphatases 1/2, SHIP1/...

journal_title：Journal of innate immunity

authors： Kerr WG,Colucci F

更新日期：2011-01-01 00:00:00

abstract：:The role of the transcription factor nuclear factor of activated T cells (NFAT) was initially identified in T and B cell gene expression, but its role in regulating gene expression in macrophages during sepsis is not known. Our data show that NFATc3 regulates expression of inducible nitric oxide synthase (iNOS) in mac...

journal_title：Journal of innate immunity

authors： Ranjan R,Deng J,Chung S,Lee YG,Park GY,Xiao L,Joo M,Christman JW,Karpurapu M

更新日期：2014-01-01 00:00:00

abstract：:After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-t...

journal_title：Journal of innate immunity

authors： Koziel J,Chmiest D,Bryzek D,Kmiecik K,Mizgalska D,Maciag-Gudowska A,Shaw LN,Potempa J

更新日期：2015-01-01 00:00:00

abstract：:Neutrophil-derived antimicrobial peptides and proteins (AMPs) play an important role in the defense against microbes. Absence of defense is illustrated by neutropenic patients with frequent bacterial and fungal infections. However, the specificity of the antimicrobial effects has not been adequately described. We set ...

journal_title：Journal of innate immunity

authors： Cederlund A,Agerberth B,Bergman P

更新日期：2010-01-01 00:00:00

abstract：:The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice wit...

journal_title：Journal of innate immunity

authors： Issara-Amphorn J,Chancharoenthana W,Visitchanakun P,Leelahavanichkul A

更新日期：2020-01-01 00:00:00

abstract：:Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart fro...

journal_title：Journal of innate immunity

authors： Oehmcke S,Mörgelin M,Herwald H

更新日期：2009-01-01 00:00:00

abstract：:As a key molecule in the antiviral innate immune response, the activation of TANK-binding kinase 1 (TBK1) is under tight regulation. In this report, we identified phosphatidylserine-specific phospholipase PLA1A as a host factor that modulates the TBK1 activation. Knockdown of PLA1A expression suppressed the innate imm...

journal_title：Journal of innate immunity

authors： Gao X,Chen D,Hu X,Zhou Y,Wang Y,Wu C,Chen J,Wang Y,Pei R,Chen X

更新日期：2018-01-01 00:00:00

abstract：:Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...

journal_title：Journal of innate immunity

authors： Takashima K,Oshiumi H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00

abstract：:Fibroblasts are known to eliminate intracellular bacteria, but the lethal hit of the bactericidal mechanism has not been defined. We show that primary embryonic and established fibroblasts can be induced by interferons or by intracellular bacterial infection to express a perforin-like mRNA previously described as macr...

journal_title：Journal of innate immunity

authors： McCormack R,de Armas LR,Shiratsuchi M,Ramos JE,Podack ER

更新日期：2013-01-01 00:00:00

abstract：:Infections with highly pathogenic avian influenza viruses (HPAIV) in humans lead to systemic disease associated with cytokine storm and multiorgan failure. In this study we aimed to identify the role of monocytes for the host response to HPAIV infection. Using genome-wide microarray analysis, we surprisingly demonstra...

journal_title：Journal of innate immunity

authors： Friesenhagen J,Viemann D,Börgeling Y,Schmolke M,Spiekermann C,Kirschnek S,Ludwig S,Roth J

更新日期：2013-01-01 00:00:00

abstract：:Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the...

journal_title：Journal of innate immunity

authors： Batalla EI,Pino Martínez AM,Poncini CV,Duffy T,Schijman AG,González Cappa SM,Alba Soto CD

更新日期：2013-01-01 00:00:00

abstract：:The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has been implicated that the translocation of myeloperoxidase (MPO) from neutrophilic granules to the nucleus is crucial to this process. Under di...

journal_title：Journal of innate immunity

authors： Neumann A,Papareddy P,Westman J,Hyldegaard O,Snäll J,Norrby-Teglund A,Herwald H

更新日期：2018-01-01 00:00:00

abstract：:The complement-like protein thioester-containing protein 1 (TEP1) is the hallmark effector molecule against Plasmodium ookinetes in the malaria vector Anopheles gambiae. We have previously shown that the knockdown of the noncatalytic clip domain serine protease CLIPA2 increased TEP1-mediated killing rendering mosquito...

journal_title：Journal of innate immunity

authors： Kamareddine L,Nakhleh J,Osta MA

更新日期：2016-01-01 00:00:00

abstract：:In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...

journal_title：Journal of innate immunity

authors： Bobryshev YV,Orekhov AN,Killingsworth MC,Lu J

更新日期：2011-01-01 00:00:00

abstract：:We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding doma...

journal_title：Journal of innate immunity

authors： Kakani P,Kajla M,Choudhury TP,Gupta L,Kumar S

更新日期：2019-01-01 00:00:00

abstract：:Listeria monocytogenes is a facultative intracellular pathogen which can infect Drosophila melanogaster. Upon infection, Drosophila mounts an immune response including antimicrobial peptide production and autophagy activation. A set of previously published results prompted us to study the role of the deubiquitinating ...

journal_title：Journal of innate immunity

authors： Taillebourg E,Schneider DS,Fauvarque MO

更新日期：2014-01-01 00:00:00

abstract：:Histones are small basic proteins and highly conserved among eukaryotes. Their main function is binding, packaging and organizing of DNA in the nucleus, but extracellular histones are also potent antimicrobial proteins. Here we found that Streptococcus pyogenes - an important human pathogen - protects itself from hist...

journal_title：Journal of innate immunity

authors： Nitzsche R,Köhler J,Kreikemeyer B,Oehmcke-Hecht S

更新日期：2016-01-01 00:00:00

abstract：:Elevated inflammation and altered immune responses are features found in atopic asthmatic airways. Recent studies indicate γ-tocopherol (GT) supplementation can suppress airway inflammation in allergic asthma. We studied the effects of in vitro GT supplementation on receptor-mediated phagocytosis and expression of cel...

journal_title：Journal of innate immunity

authors： Geiser M,Lay JC,Bennett WD,Zhou H,Wang X,Peden DB,Alexis NE

更新日期：2013-01-01 00:00:00

abstract：:Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known ...

journal_title：Journal of innate immunity

authors： Tobin AM,Lynch L,Kirby B,O'Farrelly C

更新日期：2011-01-01 00:00:00

abstract：:Urinary tract infection (UTI) is a prominent global health care burden. Although UTI is readily treated with antibiotics in healthy adults, complicated cases in immune-compromised individuals and the emerging antibiotic resistance of several uropathogens have accelerated the need for new treatment strategies. Here, we...

journal_title：Journal of innate immunity

authors： Patras KA,Ha AD,Rooholfada E,Olson J,Ramachandra Rao SP,Lin AE,Nizet V

更新日期：2019-01-01 00:00:00

abstract：:To protect against viral infection, the immune response is critically dependent on innate sensing mechanisms to provide rapid detection of pathogens and allow for the development of an appropriate adaptive immune response. Mounting evidence suggests that mechanistic differences in the sensing of viruses by the innate ...

journal_title：Journal of innate immunity

authors： Richer MJ,Horwitz MS

更新日期：2009-01-01 00:00:00