The c-src homologue Src64B is sufficient to activate the Drosophila cellular immune response.

abstract：:The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has been implicated that the translocation of myeloperoxidase (MPO) from neutrophilic granules to the nucleus is crucial to this process. Under di...

journal_title：Journal of innate immunity

authors： Neumann A,Papareddy P,Westman J,Hyldegaard O,Snäll J,Norrby-Teglund A,Herwald H

更新日期：2018-01-01 00:00:00

abstract：:Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emph...

journal_title：Journal of innate immunity

authors： Hertzén E,Johansson L,Wallin R,Schmidt H,Kroll M,Rehn AP,Kotb M,Mörgelin M,Norrby-Teglund A

更新日期：2010-01-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclerosis can perturb normal immune function. Natural killer T (NKT) cells are a spec...

journal_title：Journal of innate immunity

authors： Braun NA,Covarrubias R,Major AS

更新日期：2010-01-01 00:00:00

abstract：:Neutrophil-derived antimicrobial peptides and proteins (AMPs) play an important role in the defense against microbes. Absence of defense is illustrated by neutropenic patients with frequent bacterial and fungal infections. However, the specificity of the antimicrobial effects has not been adequately described. We set ...

journal_title：Journal of innate immunity

authors： Cederlund A,Agerberth B,Bergman P

更新日期：2010-01-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) recognize class I major histocompatibility complex molecules and participate in the calibration of activation thresholds during human natural killer (NK) cell development. The stochastic expression pattern of the KIR repertoire follows the product rule, meaning that the prob...

journal_title：Journal of innate immunity

authors： Cichocki F,Miller JS,Anderson SK

更新日期：2011-01-01 00:00:00

abstract：:Calcium-independent phospholipase A2 (iPLA2) has been suggested to play an important role in the activation of caspase-1 induced by lipopolysaccharides (LPS). Here, we used pharmacological and genetic approaches to study the role of iPLA 2 in the activation of caspase-1. Bromoenol lactone (BEL), an inhibitor that was ...

journal_title：Journal of innate immunity

authors： Franchi L,Chen G,Marina-Garcia N,Abe A,Qu Y,Bao S,Shayman JA,Turk J,Dubyak GR,Núñez G

更新日期：2009-01-01 00:00:00

abstract：:Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing and regenerative properties among othe...

journal_title：Journal of innate immunity

authors： Barnum SR

更新日期：2015-01-01 00:00:00

abstract：:The phagocyte NADPH oxidase, crucial for innate immunity, is dormant in resting cells, but becomes activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. In activation of the oxidase, the multidomain protein p67(phox)plays a central role: it translocates to the membrane as a ternary...

journal_title：Journal of innate immunity

authors： Yuzawa S,Miyano K,Honbou K,Inagaki F,Sumimoto H

更新日期：2009-01-01 00:00:00

abstract：:Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted by goblet cells. In addition, mucosal epithelial cells express cell-bound...

journal_title：Journal of innate immunity

authors： van Putten JPM,Strijbis K

更新日期：2017-01-01 00:00:00

abstract：:Klebsiella pneumoniae is a common cause of hospital-acquired pneumonia. Granzymes (gzms), mainly found in cytotoxic lymphocytes, have been implicated as mediators of infection and inflammation. We here sought to investigate the role of gzmA and gzmB in the host response to K. pneumoniae-induced airway infection and se...

journal_title：Journal of innate immunity

authors： García-Laorden MI,Stroo I,Blok DC,Florquin S,Medema JP,de Vos AF,van der Poll T

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host's signature of the inflammatory/oxidative state and provide information regarding the progression of ...

journal_title：Journal of innate immunity

authors： Chowdhury IH,Koo SJ,Gupta S,Liang LY,Bahar B,Silla L,Nuñez-Burgos J,Barrientos N,Zago MP,Garg NJ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Alpha-synuclein (αS) is a nerve cell protein associated with Parkinson disease (PD). Accumulation of αS within the enteric nervous system (ENS) and its traffic from the gut to the brain are implicated in the pathogenesis and progression of PD. αS has no known function in humans and the reason for its accumul...

journal_title：Journal of innate immunity

authors： Stolzenberg E,Berry D,Yang,Lee EY,Kroemer A,Kaufman S,Wong GCL,Oppenheim JJ,Sen S,Fishbein T,Bax A,Harris B,Barbut D,Zasloff MA

更新日期：2017-01-01 00:00:00

abstract：:Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of T...

journal_title：Journal of innate immunity

authors： Fang LL,Yu HQ,Wu RJ,He C,Li M,Yan H,Li JJ,Wang S,Liu ZG,Liu ZJ,Yang PC

更新日期：2015-01-01 00:00:00

abstract：:There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as ne...

journal_title：Journal of innate immunity

authors： Stockfelt M,Christenson K,Andersson A,Björkman L,Padra M,Brundin B,Ganguly K,Asgeirsdottir H,Lindén S,Qvarfordt I,Bylund J,Lindén A

更新日期：2020-01-01 00:00:00

abstract：:Different liver cell types are endowed with immunological properties, including cell-intrinsic innate immune functions that are important to initially control pathogen infections. However, a full landscape of expression and functionality of the innate immune signaling pathways in the major human liver cells is still m...

journal_title：Journal of innate immunity

authors： Faure-Dupuy S,Vegna S,Aillot L,Dimier L,Esser K,Broxtermann M,Bonnin M,Bendriss-Vermare N,Rivoire M,Passot G,Lesurtel M,Mabrut JY,Ducerf C,Salvetti A,Protzer U,Zoulim F,Durantel D,Lucifora J

更新日期：2018-01-01 00:00:00

abstract：:Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programmed cell death that prevents the release of neutrophil histotoxic contents, is t...

journal_title：Journal of innate immunity

authors： Fox S,Leitch AE,Duffin R,Haslett C,Rossi AG

更新日期：2010-01-01 00:00:00

abstract：:Toll-like receptor (TLR) signaling is important in the initiation of immune responses and subsequent instigation of adaptive immunity. TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus. Many studies have dem...

journal_title：Journal of innate immunity

authors： Koymans KJ,Goldmann O,Karlsson CAQ,Sital W,Thänert R,Bisschop A,Vrieling M,Malmström J,van Kessel KPM,de Haas CJC,van Strijp JAG,Medina E

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of "hub genes" and upstream regulators during...

journal_title：Journal of innate immunity

authors： Francis A,Bosio E,Stone SF,Fatovich DM,Arendts G,MacDonald SPJ,Burrows S,Brown SGA

更新日期：2019-01-01 00:00:00

abstract：:Melanoma differentiation-associated gene 5 (MDA5) is a pattern recognition receptor that recognizes cytoplasmic viral double-stranded RNA (dsRNA) and initiates rapid innate antiviral responses. MDA5 forms a filament-like multimer along the dsRNA leading to oligomerization, which in turn activates the adaptor protein m...

journal_title：Journal of innate immunity

authors： Takashima K,Oshiumi H,Matsumoto M,Seya T

更新日期：2018-01-01 00:00:00

abstract：:γδ T cells function at the interface between innate and adaptive immunity and have well-demonstrated roles in response to infection, autoimmunity and tumors. A common characteristic of these seemingly disparate conditions may be cellular stress or death. However, the conditions under which ligands for γδ T cells are i...

journal_title：Journal of innate immunity

authors： Collins CC,Bashant K,Erikson C,Thwe PM,Fortner KA,Wang H,Morita CT,Budd RC

更新日期：2016-01-01 00:00:00

abstract：:There is increasing evidence that the immune system is regulated by circadian rhythms. A wide range of immune parameters, such as the number of red blood cells and peripheral blood mononuclear cells as well as the level of critical immune mediators, such as cytokines, undergo daily fluctuations. Current experimental d...

journal_title：Journal of innate immunity

authors： Mavroudis PD,Scheff JD,Calvano SE,Androulakis IP

更新日期：2013-01-01 00:00:00

abstract：:L-ficolin, one of the complement lectins found in human serum, is a novel pattern recognition molecule that can specifically bind to microbial carbohydrates, thereby activating the lectin complement pathway and mounting a protective innate immune response. However, little is known about the role of L-ficolin during vi...

journal_title：Journal of innate immunity

authors： Pan Q,Chen H,Wang F,Jeza VT,Hou W,Zhao Y,Xiang T,Zhu Y,Endo Y,Fujita T,Zhang XL

更新日期：2012-01-01 00:00:00

abstract：:The complement-like protein thioester-containing protein 1 (TEP1) is the hallmark effector molecule against Plasmodium ookinetes in the malaria vector Anopheles gambiae. We have previously shown that the knockdown of the noncatalytic clip domain serine protease CLIPA2 increased TEP1-mediated killing rendering mosquito...

journal_title：Journal of innate immunity

authors： Kamareddine L,Nakhleh J,Osta MA

更新日期：2016-01-01 00:00:00

abstract：:After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-t...

journal_title：Journal of innate immunity

authors： Koziel J,Chmiest D,Bryzek D,Kmiecik K,Mizgalska D,Maciag-Gudowska A,Shaw LN,Potempa J

更新日期：2015-01-01 00:00:00

abstract：:The role of the transcription factor nuclear factor of activated T cells (NFAT) was initially identified in T and B cell gene expression, but its role in regulating gene expression in macrophages during sepsis is not known. Our data show that NFATc3 regulates expression of inducible nitric oxide synthase (iNOS) in mac...

journal_title：Journal of innate immunity

authors： Ranjan R,Deng J,Chung S,Lee YG,Park GY,Xiao L,Joo M,Christman JW,Karpurapu M

更新日期：2014-01-01 00:00:00

abstract：:In in vitro experiments, Chlamydia pneumoniae has been shown to infect macrophages and to accelerate foam cell formation. It has been hypothesized that the C. pneumoniae infection affects foam cell formation by suppressing the expression of liver X receptors (LXR), but whether such an event occurs in human atheroscler...

journal_title：Journal of innate immunity

authors： Bobryshev YV,Orekhov AN,Killingsworth MC,Lu J

更新日期：2011-01-01 00:00:00

abstract：:Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the...

journal_title：Journal of innate immunity

authors： Batalla EI,Pino Martínez AM,Poncini CV,Duffy T,Schijman AG,González Cappa SM,Alba Soto CD

更新日期：2013-01-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression of immune modifiers. Despite the fact that MCPIP1 is reported as an im...

journal_title：Journal of innate immunity

authors： Blazusiak E,Florczyk D,Jura J,Potempa J,Koziel J

更新日期：2013-01-01 00:00:00

abstract：:Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis throughout the world. A majority (approx. 60%) of patients with IgAN experience disease exacerbations associated with an acute respiratory or gastrointestinal illness that appears to represent a viral infection. However, the exact mechan...

journal_title：Journal of innate immunity

authors： Yamashita M,Millward CA,Inoshita H,Saikia P,Chattopadhyay S,Sen GC,Emancipator SN

更新日期：2013-01-01 00:00:00

abstract：:Historically, the prevailing view in the field of invertebrate immunity was that invertebrates that do not possess acquired adaptive immunity rely on innate mechanisms with low specificity and no memory. Several recent studies have shaken this paradigm and suggested that the immune defenses of invertebrates are more c...

journal_title：Journal of innate immunity

authors： Portela J,Duval D,Rognon A,Galinier R,Boissier J,Coustau C,Mitta G,Théron A,Gourbal B

更新日期：2013-01-01 00:00:00