Abstract:
:There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how the adhesion molecules CD11b and CD62L, surface markers indicative of priming, are altered as neutrophils extravasate, and whether surface density of CD11b and CD62L differs between long-term tobacco smokers (LTS) with and without COPD compared with healthy never-smokers (HNS). Unstimulated blood neutrophils from LTS with (n = 5) and without (n = 9) COPD displayed lower surface density of CD62L compared with HNS (n = 8). In addition, surface density of CD11b was higher in bronchoalveolar lavage (BAL) neutrophils from LTS without COPD compared with those with COPD and HNS. Moreover, in BAL neutrophils from all study groups, CD62L was lower compared with matched blood neutrophils. In addition, BAL neutrophils responded with a further decrease in CD62L to ex vivo TNF stimulation. Thus, neutrophils in the airway lumen display a higher state of priming than systemic neutrophils and bear the potential to be further primed by local cytokines even with no smoking or the presence of COPD, findings that may represent a universal host defense mechanism against local bacteria. Moreover, systemic neutrophils are primed in LTS regardless of COPD. Further studies in larger materials are warranted to determine whether the priming of neutrophils is protective against COPD or merely preceding it.
journal_name
J Innate Immunjournal_title
Journal of innate immunityauthors
Stockfelt M,Christenson K,Andersson A,Björkman L,Padra M,Brundin B,Ganguly K,Asgeirsdottir H,Lindén S,Qvarfordt I,Bylund J,Lindén Adoi
10.1159/000509715subject
Has Abstractpub_date
2020-01-01 00:00:00pages
480-489issue
6eissn
1662-811Xissn
1662-8128pii
000509715journal_volume
12pub_type
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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pub_type: 杂志文章,评审
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000336025
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journal_title:Journal of innate immunity
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
doi:10.1159/000296915
更新日期:2010-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000345909
更新日期:2013-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000339826
更新日期:2013-01-01 00:00:00
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journal_title:Journal of innate immunity
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doi:10.1159/000346706
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journal_title:Journal of innate immunity
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doi:10.1159/000371517
更新日期:2015-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章
doi:10.1159/000368048
更新日期:2015-01-01 00:00:00
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journal_title:Journal of innate immunity
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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journal_title:Journal of innate immunity
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of innate immunity
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更新日期:2009-01-01 00:00:00
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journal_title:Journal of innate immunity
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更新日期:2016-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
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