Abstract：
:γδ T cells function at the interface between innate and adaptive immunity and have well-demonstrated roles in response to infection, autoimmunity and tumors. A common characteristic of these seemingly disparate conditions may be cellular stress or death. However, the conditions under which ligands for γδ T cells are induced or exposed remain largely undefined. We observed that induction of necroptosis of murine or human dendritic cells (DC) by inhibition of caspase activity paradoxically augments their ability to activate γδ T cells. Furthermore, upregulation of the stabilizer of caspase-8 activity, c-FLIP, by IL-4, not only greatly reduced the susceptibility of DC to necroptosis, but also considerably decreased their ability to activate γδ T cells. Collectively, these findings suggest that the induction of necroptosis in DC upregulates or exposes the expression of γδ T cell ligands, and they support the view that γδ T cells function in the immune surveillance of cell stress.
journal_name
J Innate Immunjournal_title
Journal of innate immunityauthors
Collins CC,Bashant K,Erikson C,Thwe PM,Fortner KA,Wang H,Morita CT,Budd RCdoi
10.1159/000446498subject
Has Abstractpub_date
2016-01-01 00:00:00pages
479-92issue
5eissn
1662-811Xissn
1662-8128pii
000446498journal_volume
8pub_type
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